MAGE-A3 and MAGE-A4 specific CD4+ T cells in head and neck cancer patients: detection of naturally acquired responses and identification of new epitopes
Identifieur interne : 002705 ( Main/Exploration ); précédent : 002704; suivant : 002706MAGE-A3 and MAGE-A4 specific CD4+ T cells in head and neck cancer patients: detection of naturally acquired responses and identification of new epitopes
Auteurs : Valérie Cesson [Suisse] ; Jean-Paul Rivals [Suisse] ; Anette Escher [Suisse] ; Elsa Piotet [Suisse] ; Kris Thielemans [Belgique] ; Vilmos Posevitz [Suisse] ; Danijel Dojcinovic [Suisse] ; Philippe Monnier [Suisse] ; Daniel Speiser [Suisse] ; Luc Bron [Suisse] ; Pedro Romero [Suisse]Source :
- Cancer Immunology, Immunotherapy [ 0340-7004 ] ; 2011-01-01.
English descriptors
- KwdEn :
Abstract
Abstract: Frequent expression of cancer testis antigens (CTA) has been consistently observed in head and neck squamous cell carcinomas (HNSCC). For instance, in 52 HNSCC patients, MAGE-A3 and -A4 CTA were expressed in over 75% of tumors, regardless of the sites of primary tumors such as oral cavity or hypopharynx. Yet, T-cell responses against these CTA in tumor-bearing patients have not been investigated in detail. In this study, we assessed the naturally acquired T-cell response against MAGE-A3 and -A4 in nonvaccinated HNSCC patients. Autologous antigen-presenting cells pulsed with overlapping peptide pools were used to detect and isolate MAGE-A3 and MAGE-A4 specific CD4+ T cells from healthy donors and seven head and neck cancer patients. CD4+ T-cell clones were characterized by cytokine secretion. We could detect and isolate MAGE-A3 and MAGE-A4 specific CD4+ T cells from 7/7 cancer patients analyzed. Moreover, we identified six previously described and three new epitopes for MAGE-A3. Among them, the MAGE-A3111–125 and MAGE-A3161–175 epitopes were shown to be naturally processed and presented by DC in association with HLA-DP and DR, respectively. All of the detected MAGE-A4 responses were specific for new helper epitopes. These data suggest that naturally acquired CD4+ T-cell responses against CT antigens often occur in vivo in HNSCC cancer patients and provide a rationale for the development of active immunotherapeutic approaches in this type of tumor.
Url:
DOI: 10.1007/s00262-010-0916-z
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001937
- to stream Istex, to step Curation: 001937
- to stream Istex, to step Checkpoint: 000576
- to stream Main, to step Merge: 002730
- to stream Main, to step Curation: 002705
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">MAGE-A3 and MAGE-A4 specific CD4+ T cells in head and neck cancer patients: detection of naturally acquired responses and identification of new epitopes</title>
<author><name sortKey="Cesson, Valerie" sort="Cesson, Valerie" uniqKey="Cesson V" first="Valérie" last="Cesson">Valérie Cesson</name>
</author>
<author><name sortKey="Rivals, Jean Paul" sort="Rivals, Jean Paul" uniqKey="Rivals J" first="Jean-Paul" last="Rivals">Jean-Paul Rivals</name>
</author>
<author><name sortKey="Escher, Anette" sort="Escher, Anette" uniqKey="Escher A" first="Anette" last="Escher">Anette Escher</name>
</author>
<author><name sortKey="Piotet, Elsa" sort="Piotet, Elsa" uniqKey="Piotet E" first="Elsa" last="Piotet">Elsa Piotet</name>
</author>
<author><name sortKey="Thielemans, Kris" sort="Thielemans, Kris" uniqKey="Thielemans K" first="Kris" last="Thielemans">Kris Thielemans</name>
</author>
<author><name sortKey="Posevitz, Vilmos" sort="Posevitz, Vilmos" uniqKey="Posevitz V" first="Vilmos" last="Posevitz">Vilmos Posevitz</name>
</author>
<author><name sortKey="Dojcinovic, Danijel" sort="Dojcinovic, Danijel" uniqKey="Dojcinovic D" first="Danijel" last="Dojcinovic">Danijel Dojcinovic</name>
</author>
<author><name sortKey="Monnier, Philippe" sort="Monnier, Philippe" uniqKey="Monnier P" first="Philippe" last="Monnier">Philippe Monnier</name>
</author>
<author><name sortKey="Speiser, Daniel" sort="Speiser, Daniel" uniqKey="Speiser D" first="Daniel" last="Speiser">Daniel Speiser</name>
</author>
<author><name sortKey="Bron, Luc" sort="Bron, Luc" uniqKey="Bron L" first="Luc" last="Bron">Luc Bron</name>
</author>
<author><name sortKey="Romero, Pedro" sort="Romero, Pedro" uniqKey="Romero P" first="Pedro" last="Romero">Pedro Romero</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:3A4A3B34C01B3AD7842CE77579F8A589999C5B65</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1007/s00262-010-0916-z</idno>
<idno type="url">https://api.istex.fr/ark:/67375/VQC-3ZW35RQQ-9/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001937</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001937</idno>
<idno type="wicri:Area/Istex/Curation">001937</idno>
<idno type="wicri:Area/Istex/Checkpoint">000576</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000576</idno>
<idno type="wicri:doubleKey">0340-7004:2010:Cesson V:mage:a:and</idno>
<idno type="wicri:Area/Main/Merge">002730</idno>
<idno type="wicri:Area/Main/Curation">002705</idno>
<idno type="wicri:Area/Main/Exploration">002705</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">MAGE-A3 and MAGE-A4 specific CD4+ T cells in head and neck cancer patients: detection of naturally acquired responses and identification of new epitopes</title>
<author><name sortKey="Cesson, Valerie" sort="Cesson, Valerie" uniqKey="Cesson V" first="Valérie" last="Cesson">Valérie Cesson</name>
<affiliation wicri:level="3"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>Ludwig Institute for Cancer Research Ltd., Lausanne Branch, University Hospital (CHUV), Hôpital Orthopédique Niv. 5, aile est, Av. Pierre Decker 4, 1011, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rivals, Jean Paul" sort="Rivals, Jean Paul" uniqKey="Rivals J" first="Jean-Paul" last="Rivals">Jean-Paul Rivals</name>
<affiliation wicri:level="3"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>Service of Head and Neck Surgery, University Hospital, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Escher, Anette" sort="Escher, Anette" uniqKey="Escher A" first="Anette" last="Escher">Anette Escher</name>
<affiliation wicri:level="3"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>Service of Head and Neck Surgery, University Hospital, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Piotet, Elsa" sort="Piotet, Elsa" uniqKey="Piotet E" first="Elsa" last="Piotet">Elsa Piotet</name>
<affiliation wicri:level="3"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>Service of Head and Neck Surgery, University Hospital, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thielemans, Kris" sort="Thielemans, Kris" uniqKey="Thielemans K" first="Kris" last="Thielemans">Kris Thielemans</name>
<affiliation wicri:level="3"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Physiology-Immunology, Medical School of the Vrje Universiteit Brussel, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Posevitz, Vilmos" sort="Posevitz, Vilmos" uniqKey="Posevitz V" first="Vilmos" last="Posevitz">Vilmos Posevitz</name>
<affiliation wicri:level="3"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>Ludwig Institute for Cancer Research Ltd., Lausanne Branch, University Hospital (CHUV), Hôpital Orthopédique Niv. 5, aile est, Av. Pierre Decker 4, 1011, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dojcinovic, Danijel" sort="Dojcinovic, Danijel" uniqKey="Dojcinovic D" first="Danijel" last="Dojcinovic">Danijel Dojcinovic</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>Ludwig Institute for Cancer Research Ltd., Lausanne Branch, 1066, Epalinges</wicri:regionArea>
<wicri:noRegion>Epalinges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Monnier, Philippe" sort="Monnier, Philippe" uniqKey="Monnier P" first="Philippe" last="Monnier">Philippe Monnier</name>
<affiliation wicri:level="3"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>Service of Head and Neck Surgery, University Hospital, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Speiser, Daniel" sort="Speiser, Daniel" uniqKey="Speiser D" first="Daniel" last="Speiser">Daniel Speiser</name>
<affiliation wicri:level="3"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>Ludwig Institute for Cancer Research Ltd., Lausanne Branch, University Hospital (CHUV), Hôpital Orthopédique Niv. 5, aile est, Av. Pierre Decker 4, 1011, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bron, Luc" sort="Bron, Luc" uniqKey="Bron L" first="Luc" last="Bron">Luc Bron</name>
<affiliation wicri:level="3"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>Service of Head and Neck Surgery, University Hospital, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Romero, Pedro" sort="Romero, Pedro" uniqKey="Romero P" first="Pedro" last="Romero">Pedro Romero</name>
<affiliation wicri:level="3"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>Ludwig Institute for Cancer Research Ltd., Lausanne Branch, University Hospital (CHUV), Hôpital Orthopédique Niv. 5, aile est, Av. Pierre Decker 4, 1011, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Suisse</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Cancer Immunology, Immunotherapy</title>
<title level="j" type="abbrev">Cancer Immunol Immunother</title>
<idno type="ISSN">0340-7004</idno>
<idno type="eISSN">1432-0851</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="2011-01-01">2011-01-01</date>
<biblScope unit="volume">60</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="23">23</biblScope>
<biblScope unit="page" to="35">35</biblScope>
</imprint>
<idno type="ISSN">0340-7004</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0340-7004</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CD4+ T cells</term>
<term>HNSCC</term>
<term>MAGE-A3</term>
<term>MAGE-A4</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Frequent expression of cancer testis antigens (CTA) has been consistently observed in head and neck squamous cell carcinomas (HNSCC). For instance, in 52 HNSCC patients, MAGE-A3 and -A4 CTA were expressed in over 75% of tumors, regardless of the sites of primary tumors such as oral cavity or hypopharynx. Yet, T-cell responses against these CTA in tumor-bearing patients have not been investigated in detail. In this study, we assessed the naturally acquired T-cell response against MAGE-A3 and -A4 in nonvaccinated HNSCC patients. Autologous antigen-presenting cells pulsed with overlapping peptide pools were used to detect and isolate MAGE-A3 and MAGE-A4 specific CD4+ T cells from healthy donors and seven head and neck cancer patients. CD4+ T-cell clones were characterized by cytokine secretion. We could detect and isolate MAGE-A3 and MAGE-A4 specific CD4+ T cells from 7/7 cancer patients analyzed. Moreover, we identified six previously described and three new epitopes for MAGE-A3. Among them, the MAGE-A3111–125 and MAGE-A3161–175 epitopes were shown to be naturally processed and presented by DC in association with HLA-DP and DR, respectively. All of the detected MAGE-A4 responses were specific for new helper epitopes. These data suggest that naturally acquired CD4+ T-cell responses against CT antigens often occur in vivo in HNSCC cancer patients and provide a rationale for the development of active immunotherapeutic approaches in this type of tumor.</div>
</front>
</TEI>
<affiliations><list><country><li>Belgique</li>
<li>Suisse</li>
</country>
<region><li>Canton de Vaud</li>
<li>Région de Bruxelles-Capitale</li>
</region>
<settlement><li>Bruxelles</li>
<li>Lausanne</li>
</settlement>
</list>
<tree><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Cesson, Valerie" sort="Cesson, Valerie" uniqKey="Cesson V" first="Valérie" last="Cesson">Valérie Cesson</name>
</region>
<name sortKey="Bron, Luc" sort="Bron, Luc" uniqKey="Bron L" first="Luc" last="Bron">Luc Bron</name>
<name sortKey="Dojcinovic, Danijel" sort="Dojcinovic, Danijel" uniqKey="Dojcinovic D" first="Danijel" last="Dojcinovic">Danijel Dojcinovic</name>
<name sortKey="Escher, Anette" sort="Escher, Anette" uniqKey="Escher A" first="Anette" last="Escher">Anette Escher</name>
<name sortKey="Monnier, Philippe" sort="Monnier, Philippe" uniqKey="Monnier P" first="Philippe" last="Monnier">Philippe Monnier</name>
<name sortKey="Piotet, Elsa" sort="Piotet, Elsa" uniqKey="Piotet E" first="Elsa" last="Piotet">Elsa Piotet</name>
<name sortKey="Posevitz, Vilmos" sort="Posevitz, Vilmos" uniqKey="Posevitz V" first="Vilmos" last="Posevitz">Vilmos Posevitz</name>
<name sortKey="Rivals, Jean Paul" sort="Rivals, Jean Paul" uniqKey="Rivals J" first="Jean-Paul" last="Rivals">Jean-Paul Rivals</name>
<name sortKey="Romero, Pedro" sort="Romero, Pedro" uniqKey="Romero P" first="Pedro" last="Romero">Pedro Romero</name>
<name sortKey="Romero, Pedro" sort="Romero, Pedro" uniqKey="Romero P" first="Pedro" last="Romero">Pedro Romero</name>
<name sortKey="Speiser, Daniel" sort="Speiser, Daniel" uniqKey="Speiser D" first="Daniel" last="Speiser">Daniel Speiser</name>
</country>
<country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Thielemans, Kris" sort="Thielemans, Kris" uniqKey="Thielemans K" first="Kris" last="Thielemans">Kris Thielemans</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002705 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002705 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:3A4A3B34C01B3AD7842CE77579F8A589999C5B65 |texte= MAGE-A3 and MAGE-A4 specific CD4+ T cells in head and neck cancer patients: detection of naturally acquired responses and identification of new epitopes }}
This area was generated with Dilib version V0.6.33. |