MersV1, Main, Exploration, bibRecord, 002431

Specific and nonspecific metal ion-nucleotide interactions at aqueous/solid interfaces functionalized with adenine, thymine, guanine, and cytosine oligomers.

Identifieur interne : 002431 ( Main/Exploration ); précédent : 002430; suivant : 002432

Specific and nonspecific metal ion-nucleotide interactions at aqueous/solid interfaces functionalized with adenine, thymine, guanine, and cytosine oligomers.

Auteurs : Joseph G. Holland [États-Unis] ; Jessica N. Malin ; David S. Jordan ; Esmeralda Morales ; Franz M. Geiger

Source :

Journal of the American Chemical Society [ 1520-5126 ] ; 2011.

RBID : pubmed:21291217

Descripteurs français

KwdFr :
- Adénine (), Cytosine (), Eau (), Guanine (), Ions (), Magnésium (), Nucléotides (), Thermodynamique, Thymine ().
MESH :
- Adénine, Cytosine, Eau, Guanine, Ions, Magnésium, Nucléotides, Thermodynamique, Thymine.

English descriptors

KwdEn :
- Adenine (chemistry), Cytosine (chemistry), Guanine (chemistry), Ions (chemistry), Magnesium (chemistry), Nucleotides (chemistry), Thermodynamics, Thymine (chemistry), Water (chemistry).
MESH :
- chemical , chemistry : Adenine, Cytosine, Guanine, Ions, Magnesium, Nucleotides, Thymine, Water.
- Thermodynamics.

Abstract

This article reports nonlinear optical measurements that quantify, for the first time directly and without labels, how many Mg(2+) cations are bound to DNA 21-mers covalently linked to fused silica/water interfaces maintained at pH 7 and 10 mM NaCl, and what the thermodynamics are of these interactions. The overall interaction of Mg(2+) with adenine, thymine, guanine, and cytosine is found to involve -10.0 ± 0.3, -11.2 ± 0.3, -14.0 ± 0.4, and -14.9 ± 0.4 kJ/mol, and nonspecific interactions with the phosphate and sugar backbone are found to contribute -21.0 ± 0.6 kJ/mol for each Mg(2+) ion bound. The specific and nonspecific contributions to the interaction energy of Mg(2+) with oligonucleotide single strands is found to be additive, which suggests that within the uncertainty of these surface-specific experiments, the Mg(2+) ions are evenly distributed over the oligomers and not isolated to the most strongly binding nucleobase. The nucleobases adenine and thymine are found to bind only three Mg(2+) ions per 21-mer oligonucleotide, while the bases cytosine and guanine are found to bind eleven Mg(2+) ions per 21-mer oligonucleotide.

DOI: 10.1021/ja107883x
PubMed: 21291217

Affiliations:

États-Unis

Le document en format XML

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<term>Magnesium (chemistry)</term>
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<term>Thermodynamics</term>
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<term>Magnésium ()</term>
<term>Nucléotides ()</term>
<term>Thermodynamique</term>
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<term>Ions</term>
<term>Magnesium</term>
<term>Nucleotides</term>
<term>Thymine</term>
<term>Water</term>
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<term>Eau</term>
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<term>Ions</term>
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<front><div type="abstract" xml:lang="en">This article reports nonlinear optical measurements that quantify, for the first time directly and without labels, how many Mg(2+) cations are bound to DNA 21-mers covalently linked to fused silica/water interfaces maintained at pH 7 and 10 mM NaCl, and what the thermodynamics are of these interactions. The overall interaction of Mg(2+) with adenine, thymine, guanine, and cytosine is found to involve -10.0 ± 0.3, -11.2 ± 0.3, -14.0 ± 0.4, and -14.9 ± 0.4 kJ/mol, and nonspecific interactions with the phosphate and sugar backbone are found to contribute -21.0 ± 0.6 kJ/mol for each Mg(2+) ion bound. The specific and nonspecific contributions to the interaction energy of Mg(2+) with oligonucleotide single strands is found to be additive, which suggests that within the uncertainty of these surface-specific experiments, the Mg(2+) ions are evenly distributed over the oligomers and not isolated to the most strongly binding nucleobase. The nucleobases adenine and thymine are found to bind only three Mg(2+) ions per 21-mer oligonucleotide, while the bases cytosine and guanine are found to bind eleven Mg(2+) ions per 21-mer oligonucleotide.</div>
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Specific and nonspecific metal ion-nucleotide interactions at aqueous/solid interfaces functionalized with adenine, thymine, guanine, and cytosine oligomers.

Specific and nonspecific metal ion-nucleotide interactions at aqueous/solid interfaces functionalized with adenine, thymine, guanine, and cytosine oligomers.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
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