Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26
Identifieur interne : 001F37 ( Main/Exploration ); précédent : 001F36; suivant : 001F38Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26
Auteurs : Guangwen Lu [République populaire de Chine] ; Yawei Hu [République populaire de Chine] ; Qihui Wang [République populaire de Chine] ; Jianxun Qi [République populaire de Chine] ; Feng Gao [République populaire de Chine] ; Yan Li [République populaire de Chine] ; Yanfang Zhang [République populaire de Chine] ; Wei Zhang [République populaire de Chine] ; Yuan Yuan [République populaire de Chine] ; Jinku Bao ; Buchang Zhang [République populaire de Chine] ; Yi Shi [République populaire de Chine] ; Jinghua Yan [République populaire de Chine] ; George F. Gao [République populaire de Chine]Source :
- Nature [ 0028-0836 ] ; 2013.
Descripteurs français
- KwdFr :
- Attachement viral, Coronavirus (), Coronavirus (génétique), Coronavirus (métabolisme), Dipeptidyl peptidase 4 (), Dipeptidyl peptidase 4 (métabolisme), Humains, Liaison aux protéines, Motifs et domaines d'intéraction protéique (génétique), Récepteurs viraux (), Récepteurs viraux (métabolisme), Structure tertiaire des protéines (génétique), Séquence conservée (génétique).
- MESH :
- génétique : Coronavirus, Motifs et domaines d'intéraction protéique, Structure tertiaire des protéines, Séquence conservée.
- métabolisme : Coronavirus, Dipeptidyl peptidase 4, Récepteurs viraux.
- Attachement viral, Coronavirus, Dipeptidyl peptidase 4, Humains, Liaison aux protéines, Récepteurs viraux.
English descriptors
- KwdEn :
- Conserved Sequence (genetics), Coronavirus (chemistry), Coronavirus (genetics), Coronavirus (metabolism), Dipeptidyl Peptidase 4 (chemistry), Dipeptidyl Peptidase 4 (metabolism), Humans, Protein Binding, Protein Interaction Domains and Motifs (genetics), Protein Structure, Tertiary (genetics), Receptors, Virus (chemistry), Receptors, Virus (metabolism), Virus Attachment.
- MESH :
- chemical , chemistry : Dipeptidyl Peptidase 4, Receptors, Virus.
- chemistry : Coronavirus.
- genetics : Conserved Sequence, Coronavirus, Protein Interaction Domains and Motifs, Protein Structure, Tertiary.
- metabolism : Coronavirus, Dipeptidyl Peptidase 4, Receptors, Virus.
- Humans, Protein Binding, Virus Attachment.
Abstract
MERS-CoV is a newly emerged coronavirus that is related to SARS-CoV and has proven fatal in half of the people it has infected to date: here the crystal structure of the MERS-CoV receptor binding domain is presented in complex with its receptor on human cells, CD26.
The online version of this article (doi:10.1038/nature12328) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/nature12328
PubMed: 23831647
PubMed Central: 7095341
Affiliations:
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Le document en format XML
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China,</institution></institution-wrap>,</nlm:aff></affiliation></author><author><name sortKey="Zhang, Buchang" sort="Zhang, Buchang" uniqKey="Zhang B" first="Buchang" last="Zhang">Buchang Zhang</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.252245.6</institution-id><institution-id institution-id-type="ISNI">0000 0001 0085 4987</institution-id><institution>School of Life Sciences, Anhui University,</institution></institution-wrap>Hefei, 230039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hefei</wicri:regionArea></affiliation></author><author><name sortKey="Shi, Yi" sort="Shi, Yi" uniqKey="Shi Y" first="Yi" last="Shi">Yi Shi</name><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.9227.e</institution-id><institution-id institution-id-type="ISNI">0000000119573309</institution-id><institution>Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences,</institution></institution-wrap>Beijing, 100101 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Yan, Jinghua" sort="Yan, Jinghua" uniqKey="Yan J" first="Jinghua" last="Yan">Jinghua Yan</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.458488.d</institution-id><institution-id institution-id-type="ISNI">0000 0004 0627 1442</institution-id><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences,</institution></institution-wrap>Beijing, 100101 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.458488.d</institution-id><institution-id institution-id-type="ISNI">0000 0004 0627 1442</institution-id><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences,</institution></institution-wrap>Beijing, 100101 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.458513.e</institution-id><institution-id institution-id-type="ISNI">0000 0004 1763 3963</institution-id><institution>Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology,</institution></institution-wrap>Tianjin, 300308 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tianjin</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.59053.3a</institution-id><institution-id institution-id-type="ISNI">0000000121679639</institution-id><institution>School of Life Sciences, University of Science and Technology of China,</institution></institution-wrap>Hefei, 230026 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hefei</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.9227.e</institution-id><institution-id institution-id-type="ISNI">0000000119573309</institution-id><institution>Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences,</institution></institution-wrap>Beijing, 100101 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="GRID">grid.198530.6</institution-id><institution-id institution-id-type="ISNI">0000 0000 8803 2373</institution-id><institution>Chinese Center for Disease Control and Prevention (China CDC),</institution></institution-wrap>Beijing, 102206 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature</title><idno type="ISSN">0028-0836</idno><idno type="eISSN">1476-4687</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Conserved Sequence (genetics)</term><term>Coronavirus (chemistry)</term><term>Coronavirus (genetics)</term><term>Coronavirus (metabolism)</term><term>Dipeptidyl Peptidase 4 (chemistry)</term><term>Dipeptidyl Peptidase 4 (metabolism)</term><term>Humans</term><term>Protein Binding</term><term>Protein Interaction Domains and Motifs (genetics)</term><term>Protein Structure, Tertiary (genetics)</term><term>Receptors, Virus (chemistry)</term><term>Receptors, Virus (metabolism)</term><term>Virus Attachment</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Attachement viral</term><term>Coronavirus ()</term><term>Coronavirus (génétique)</term><term>Coronavirus (métabolisme)</term><term>Dipeptidyl peptidase 4 ()</term><term>Dipeptidyl peptidase 4 (métabolisme)</term><term>Humains</term><term>Liaison aux protéines</term><term>Motifs et domaines d'intéraction protéique (génétique)</term><term>Récepteurs viraux ()</term><term>Récepteurs viraux (métabolisme)</term><term>Structure tertiaire des protéines (génétique)</term><term>Séquence conservée (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Dipeptidyl Peptidase 4</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Conserved Sequence</term><term>Coronavirus</term><term>Protein Interaction Domains and Motifs</term><term>Protein Structure, Tertiary</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term><term>Motifs et domaines d'intéraction protéique</term><term>Structure tertiaire des protéines</term><term>Séquence conservée</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Coronavirus</term><term>Dipeptidyl Peptidase 4</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Coronavirus</term><term>Dipeptidyl peptidase 4</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Protein Binding</term><term>Virus Attachment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Attachement viral</term><term>Coronavirus</term><term>Dipeptidyl peptidase 4</term><term>Humains</term><term>Liaison aux protéines</term><term>Récepteurs viraux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">MERS-CoV is a newly emerged coronavirus that is related to SARS-CoV and has proven fatal in half of the people it has infected to date: here the crystal structure of the MERS-CoV receptor binding domain is presented in complex with its receptor on human cells, CD26.</p><sec><title>Supplementary information</title><p>The online version of this article (doi:10.1038/nature12328) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bermingham, A" uniqKey="Bermingham A">A Bermingham</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author><author><name sortKey="Navas Martin, S" uniqKey="Navas Martin S">S Navas-Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van 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sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name></author><author><name sortKey="Wiley, Dc" uniqKey="Wiley D">DC Wiley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, J" uniqKey="Zhu J">J Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peng, G" uniqKey="Peng G">G Peng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author><author><name sortKey="Harrison, Sc" uniqKey="Harrison S">SC Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, K" uniqKey="Wu K">K Wu</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Peng, G" uniqKey="Peng G">G Peng</name></author><author><name sortKey="Li, F" uniqKey="Li 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Read</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cowtan, Kd" uniqKey="Cowtan K">KD Cowtan</name></author><author><name sortKey="Zhang, Ky" uniqKey="Zhang K">KY Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adams, Pd" uniqKey="Adams P">PD Adams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emsley, P" uniqKey="Emsley P">P Emsley</name></author><author><name sortKey="Cowtan, K" uniqKey="Cowtan K">K Cowtan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laskowski, Ra" uniqKey="Laskowski R">RA Laskowski</name></author><author><name sortKey="Macarthur, Mw" uniqKey="Macarthur M">MW MacArthur</name></author><author><name sortKey="Moss, Ds" uniqKey="Moss D">DS Moss</name></author><author><name sortKey="Thornton, Jm" uniqKey="Thornton J">JM Thornton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gouet, 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Gao</name><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><name sortKey="Hu, Yawei" sort="Hu, Yawei" uniqKey="Hu Y" first="Yawei" last="Hu">Yawei Hu</name><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><name sortKey="Qi, Jianxun" sort="Qi, Jianxun" uniqKey="Qi J" first="Jianxun" last="Qi">Jianxun Qi</name><name sortKey="Shi, Yi" sort="Shi, Yi" uniqKey="Shi Y" first="Yi" last="Shi">Yi Shi</name><name sortKey="Wang, Qihui" sort="Wang, Qihui" uniqKey="Wang Q" first="Qihui" last="Wang">Qihui Wang</name><name sortKey="Yan, Jinghua" sort="Yan, Jinghua" uniqKey="Yan J" first="Jinghua" last="Yan">Jinghua Yan</name><name sortKey="Yuan, Yuan" sort="Yuan, Yuan" uniqKey="Yuan Y" first="Yuan" last="Yuan">Yuan Yuan</name><name sortKey="Yuan, Yuan" sort="Yuan, Yuan" uniqKey="Yuan Y" first="Yuan" last="Yuan">Yuan Yuan</name><name sortKey="Zhang, Buchang" sort="Zhang, Buchang" uniqKey="Zhang B" first="Buchang" last="Zhang">Buchang Zhang</name><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name><name sortKey="Zhang, Yanfang" sort="Zhang, Yanfang" uniqKey="Zhang Y" first="Yanfang" last="Zhang">Yanfang Zhang</name><name sortKey="Zhang, Yanfang" sort="Zhang, Yanfang" uniqKey="Zhang Y" first="Yanfang" last="Zhang">Yanfang Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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