The Middle East Respiratory Syndrome—How Worried Should We Be?
Identifieur interne : 001E94 ( Main/Exploration ); précédent : 001E93; suivant : 001E95The Middle East Respiratory Syndrome—How Worried Should We Be?
Auteurs : Stanley PerlmanSource :
- mBio [ 2150-7511 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Coronavirus (isolement et purification), Coronavirus (pathogénicité), Flambées de maladies, Humains, Infections à coronavirus (anatomopathologie), Infections à coronavirus (mortalité), Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Moyen Orient (épidémiologie), Pneumopathie virale (anatomopathologie), Pneumopathie virale (mortalité), Pneumopathie virale (virologie), Pneumopathie virale (épidémiologie), Prévalence, Zoonoses (anatomopathologie), Zoonoses (mortalité), Zoonoses (virologie), Zoonoses (épidémiologie).
- MESH :
- anatomopathologie : Infections à coronavirus, Pneumopathie virale, Zoonoses.
- isolement et purification : Coronavirus.
- mortalité : Infections à coronavirus, Pneumopathie virale, Zoonoses.
- pathogénicité : Coronavirus.
- virologie : Infections à coronavirus, Pneumopathie virale, Zoonoses.
- épidémiologie : Infections à coronavirus, Moyen Orient, Pneumopathie virale, Zoonoses.
- Animaux, Flambées de maladies, Humains, Prévalence.
English descriptors
- KwdEn :
- Animals, Coronavirus (isolation & purification), Coronavirus (pathogenicity), Coronavirus Infections (epidemiology), Coronavirus Infections (mortality), Coronavirus Infections (pathology), Coronavirus Infections (virology), Disease Outbreaks, Humans, Middle East (epidemiology), Pneumonia, Viral (epidemiology), Pneumonia, Viral (mortality), Pneumonia, Viral (pathology), Pneumonia, Viral (virology), Prevalence, Zoonoses (epidemiology), Zoonoses (mortality), Zoonoses (pathology), Zoonoses (virology).
- MESH :
- geographic , epidemiology : Middle East.
- epidemiology : Coronavirus Infections, Pneumonia, Viral, Zoonoses.
- isolation & purification : Coronavirus.
- mortality : Coronavirus Infections, Pneumonia, Viral, Zoonoses.
- pathogenicity : Coronavirus.
- pathology : Coronavirus Infections, Pneumonia, Viral, Zoonoses.
- virology : Coronavirus Infections, Pneumonia, Viral, Zoonoses.
- Animals, Disease Outbreaks, Humans, Prevalence.
Abstract
Ten years after the severe acute respiratory syndrome epidemic, a second coronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV), has been identified as the cause of a highly lethal pneumonia in patients in the Middle East and in travelers from this region. Over the past 9 months, since the virus was first isolated, much has been learned about the biology of the virus. It is now clear that MERS-CoV is transmissible from person to person, and its close relationship with several bat coronaviruses suggests that these animals may be the ultimate source of the infection. However, many key issues need to be addressed, including identification of the proximate, presumably zoonotic, source of the infection, the prevalence of the infection in human populations, details regarding clinical and pathological features of the human infection, the establishment of a small rodent model for the infection, and the virological and immune basis for the severe disease observed in most patients. Most importantly, we do not know whether a MERS-CoV epidemic is likely or not. Infection with the virus has so far resulted in only 91 cases and 46 deaths (as of 29 July 2013), but it is nonetheless setting off alarm bells among public health officials, including Margaret Chan, Director-General of the World Health Organization, who called MERS-CoV “a threat to the entire world.” This article reviews some of the progress that has been made and discusses some of the questions that need to be answered.
Url:
DOI: 10.1128/mBio.00531-13
PubMed: 23963179
PubMed Central: 3747588
Affiliations:
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Le document en format XML
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Worried Should We Be?</title><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name></author></analytic><series><title level="j">mBio</title><idno type="eISSN">2150-7511</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Coronavirus (isolation & purification)</term><term>Coronavirus (pathogenicity)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (pathology)</term><term>Coronavirus Infections (virology)</term><term>Disease Outbreaks</term><term>Humans</term><term>Middle East (epidemiology)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (pathology)</term><term>Pneumonia, Viral 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(épidémiologie)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Middle East</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Moyen Orient</term><term>Pneumopathie virale</term><term>Zoonoses</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Outbreaks</term><term>Humans</term><term>Prevalence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Flambées de maladies</term><term>Humains</term><term>Prévalence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>Ten years after the severe acute respiratory syndrome epidemic, a second coronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV), has been identified as the cause of a highly lethal pneumonia in patients in the Middle East and in travelers from this region. Over the past 9 months, since the virus was first isolated, much has been learned about the biology of the virus. It is now clear that MERS-CoV is transmissible from person to person, and its close relationship with several bat coronaviruses suggests that these animals may be the ultimate source of the infection. However, many key issues need to be addressed, including identification of the proximate, presumably zoonotic, source of the infection, the prevalence of the infection in human populations, details regarding clinical and pathological features of the human infection, the establishment of a small rodent model for the infection, and the virological and immune basis for the severe disease observed in most patients. Most importantly, we do not know whether a MERS-CoV epidemic is likely or not. Infection with the virus has so far resulted in only 91 cases and 46 deaths (as of 29 July 2013), but it is nonetheless setting off alarm bells among public health officials, including Margaret Chan, Director-General of the World Health Organization, who called MERS-CoV “a threat to the entire world.” This article reviews some of the progress that has been made and discusses some of the questions that need to be answered.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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sortKey="Eckerle, Ld" uniqKey="Eckerle L">LD Eckerle</name></author><author><name sortKey="Becker, Mm" uniqKey="Becker M">MM Becker</name></author><author><name sortKey="Halpin, Ra" uniqKey="Halpin R">RA Halpin</name></author><author><name sortKey="Li, K" uniqKey="Li K">K Li</name></author><author><name sortKey="Venter, E" uniqKey="Venter E">E Venter</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Scherbakova, S" uniqKey="Scherbakova S">S Scherbakova</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Stockwell, Tb" uniqKey="Stockwell T">TB Stockwell</name></author><author><name sortKey="Spiro, Dj" uniqKey="Spiro D">DJ Spiro</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Reusken, Cbem" uniqKey="Reusken C">CBEM Reusken</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author><author><name sortKey="Gutierrez, C" uniqKey="Gutierrez C">C Gutierrez</name></author><author><name sortKey="Godeke, G J" uniqKey="Godeke G">G-J Godeke</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Raj, Sr" uniqKey="Raj S">SR Raj</name></author><author><name sortKey="Smits De Vries, L" uniqKey="Smits De Vries L">L Smits-De Vries</name></author><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author><author><name sortKey="Drexler, J F" uniqKey="Drexler J">J-F Drexler</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="El Tahir, Ee" uniqKey="El Tahir E">EE El Tahir</name></author><author><name sortKey="De Sousa, R" uniqKey="De Sousa R">R De Sousa</name></author><author><name sortKey="Van Beek, J" uniqKey="Van Beek J">J van Beek</name></author><author><name sortKey="Nowotny, N" uniqKey="Nowotny N">N Nowotny</name></author><author><name sortKey="Van Maanen, K" uniqKey="Van Maanen K">K van Maanen</name></author><author><name sortKey="Hidalgo Hermoso, E" uniqKey="Hidalgo Hermoso E">E Hidalgo-Hermoso</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B-J Bosch</name></author><author><name sortKey="Rottier, P" uniqKey="Rottier P">P Rottier</name></author><author><name sortKey="Osterhaus, A" uniqKey="Osterhaus A">A Osterhaus</name></author><author><name sortKey="Gortazar Schmidt, C" uniqKey="Gortazar Schmidt C">C Gortazar-Schmidt</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Koopmans, Mpg" uniqKey="Koopmans M">MPG Koopmans</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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