Comparative experimental subcutaneous glanders and melioidosis in the common marmoset (Callithrix jacchus)
Identifieur interne : 001E22 ( Main/Exploration ); précédent : 001E21; suivant : 001E23Comparative experimental subcutaneous glanders and melioidosis in the common marmoset (Callithrix jacchus)
Auteurs : Michelle Nelson [Royaume-Uni] ; Francisco J. Salguero [Royaume-Uni] ; Rachel E. Dean [Royaume-Uni] ; Sarah A. Ngugi [Royaume-Uni] ; Sophie J. Smither [Royaume-Uni] ; Timothy P. Atkins [Royaume-Uni] ; Mark S. Lever [Royaume-Uni]Source :
- International Journal of Experimental Pathology [ 0959-9673 ] ; 2014-12.
Abstract
Glanders and melioidosis are caused by two distinct Burkholderia species and have generally been considered to have similar disease progression. While both of these pathogens are HHS/CDC Tier 1 agents, natural infection with both these pathogens is primarily through skin inoculation. The common marmoset (Callithrix jacchus) was used to compare disease following experimental subcutaneous challenge. Acute, lethal disease was observed in marmosets following challenge with between 26 and 1.2 × 108 cfu Burkholderia pseudomallei within 22–85 h. The reproducibility and progression of the disease were assessed following a challenge of 1 × 102 cfu of B. pseudomallei. Melioidosis was characterised by high levels of bacteraemia, focal microgranuloma progressing to non‐necrotic multifocal solid lesions in the livers and spleens and multi‐organ failure. Lethal disease was observed in 93% of animals challenged with Burkholderia mallei, occurring between 5 and 10.6 days. Following challenge with 1 × 102 cfu of B. mallei, glanders was characterised with lymphatic spread of the bacteria and non‐necrotic, multifocal solid lesions progressing to a multifocal lesion with severe necrosis and pneumonia. The experimental results confirmed that the disease pathology and presentation is strikingly different between the two pathogens. The marmoset provides a model of the human syndrome for both diseases facilitating the development of medical countermeasures.
Url:
DOI: 10.1111/iep.12105
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000B85
- to stream Istex, to step Curation: 000B85
- to stream Istex, to step Checkpoint: 000206
- to stream Main, to step Merge: 001E37
- to stream Main, to step Curation: 001E22
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative experimental subcutaneous glanders and melioidosis in the common marmoset (Callithrix jacchus)</title>
<author><name sortKey="Nelson, Michelle" sort="Nelson, Michelle" uniqKey="Nelson M" first="Michelle" last="Nelson">Michelle Nelson</name>
</author>
<author><name sortKey="Salguero, Francisco J" sort="Salguero, Francisco J" uniqKey="Salguero F" first="Francisco J." last="Salguero">Francisco J. Salguero</name>
</author>
<author><name sortKey="Dean, Rachel E" sort="Dean, Rachel E" uniqKey="Dean R" first="Rachel E." last="Dean">Rachel E. Dean</name>
</author>
<author><name sortKey="Ngugi, Sarah A" sort="Ngugi, Sarah A" uniqKey="Ngugi S" first="Sarah A." last="Ngugi">Sarah A. Ngugi</name>
</author>
<author><name sortKey="Smither, Sophie J" sort="Smither, Sophie J" uniqKey="Smither S" first="Sophie J." last="Smither">Sophie J. Smither</name>
</author>
<author><name sortKey="Atkins, Timothy P" sort="Atkins, Timothy P" uniqKey="Atkins T" first="Timothy P." last="Atkins">Timothy P. Atkins</name>
</author>
<author><name sortKey="Lever, Mark S" sort="Lever, Mark S" uniqKey="Lever M" first="Mark S." last="Lever">Mark S. Lever</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:92C20115D903ABD93C12C5ABDA1E0C4E935CAECC</idno>
<date when="2014" year="2014">2014</date>
<idno type="doi">10.1111/iep.12105</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-PG0G01XK-M/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000B85</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B85</idno>
<idno type="wicri:Area/Istex/Curation">000B85</idno>
<idno type="wicri:Area/Istex/Checkpoint">000206</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000206</idno>
<idno type="wicri:doubleKey">0959-9673:2014:Nelson M:comparative:experimental:subcutaneous</idno>
<idno type="wicri:Area/Main/Merge">001E37</idno>
<idno type="wicri:Area/Main/Curation">001E22</idno>
<idno type="wicri:Area/Main/Exploration">001E22</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Comparative experimental subcutaneous glanders and melioidosis in the common marmoset (Callithrix jacchus)</title>
<author><name sortKey="Nelson, Michelle" sort="Nelson, Michelle" uniqKey="Nelson M" first="Michelle" last="Nelson">Michelle Nelson</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Biomedical Sciences, Defence Science and Technology Laboratory (Dstl), Wiltshire, Salisbury</wicri:regionArea>
<wicri:noRegion>Salisbury</wicri:noRegion>
</affiliation>
<affiliation></affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Salguero, Francisco J" sort="Salguero, Francisco J" uniqKey="Salguero F" first="Francisco J." last="Salguero">Francisco J. Salguero</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Animal Health Veterinary Laboratories Agency, Surrey, WeybridgeAddlestone</wicri:regionArea>
<wicri:noRegion>WeybridgeAddlestone</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Current Address: School of Veterinary Medicine, University of Surrey, Surrey, GU2 7TE, Guildford</wicri:regionArea>
<wicri:noRegion>Guildford</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dean, Rachel E" sort="Dean, Rachel E" uniqKey="Dean R" first="Rachel E." last="Dean">Rachel E. Dean</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Biomedical Sciences, Defence Science and Technology Laboratory (Dstl), Wiltshire, Salisbury</wicri:regionArea>
<wicri:noRegion>Salisbury</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ngugi, Sarah A" sort="Ngugi, Sarah A" uniqKey="Ngugi S" first="Sarah A." last="Ngugi">Sarah A. Ngugi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Biomedical Sciences, Defence Science and Technology Laboratory (Dstl), Wiltshire, Salisbury</wicri:regionArea>
<wicri:noRegion>Salisbury</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smither, Sophie J" sort="Smither, Sophie J" uniqKey="Smither S" first="Sophie J." last="Smither">Sophie J. Smither</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Biomedical Sciences, Defence Science and Technology Laboratory (Dstl), Wiltshire, Salisbury</wicri:regionArea>
<wicri:noRegion>Salisbury</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Atkins, Timothy P" sort="Atkins, Timothy P" uniqKey="Atkins T" first="Timothy P." last="Atkins">Timothy P. Atkins</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Biomedical Sciences, Defence Science and Technology Laboratory (Dstl), Wiltshire, Salisbury</wicri:regionArea>
<wicri:noRegion>Salisbury</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lever, Mark S" sort="Lever, Mark S" uniqKey="Lever M" first="Mark S." last="Lever">Mark S. Lever</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Biomedical Sciences, Defence Science and Technology Laboratory (Dstl), Wiltshire, Salisbury</wicri:regionArea>
<wicri:noRegion>Salisbury</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">International Journal of Experimental Pathology</title>
<title level="j" type="alt">INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY</title>
<idno type="ISSN">0959-9673</idno>
<idno type="eISSN">1365-2613</idno>
<imprint><biblScope unit="vol">95</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="378">378</biblScope>
<biblScope unit="page" to="391">391</biblScope>
<biblScope unit="page-count">14</biblScope>
<date type="published" when="2014-12">2014-12</date>
</imprint>
<idno type="ISSN">0959-9673</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0959-9673</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Glanders and melioidosis are caused by two distinct Burkholderia species and have generally been considered to have similar disease progression. While both of these pathogens are HHS/CDC Tier 1 agents, natural infection with both these pathogens is primarily through skin inoculation. The common marmoset (Callithrix jacchus) was used to compare disease following experimental subcutaneous challenge. Acute, lethal disease was observed in marmosets following challenge with between 26 and 1.2 × 108 cfu Burkholderia pseudomallei within 22–85 h. The reproducibility and progression of the disease were assessed following a challenge of 1 × 102 cfu of B. pseudomallei. Melioidosis was characterised by high levels of bacteraemia, focal microgranuloma progressing to non‐necrotic multifocal solid lesions in the livers and spleens and multi‐organ failure. Lethal disease was observed in 93% of animals challenged with Burkholderia mallei, occurring between 5 and 10.6 days. Following challenge with 1 × 102 cfu of B. mallei, glanders was characterised with lymphatic spread of the bacteria and non‐necrotic, multifocal solid lesions progressing to a multifocal lesion with severe necrosis and pneumonia. The experimental results confirmed that the disease pathology and presentation is strikingly different between the two pathogens. The marmoset provides a model of the human syndrome for both diseases facilitating the development of medical countermeasures.</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
</list>
<tree><country name="Royaume-Uni"><noRegion><name sortKey="Nelson, Michelle" sort="Nelson, Michelle" uniqKey="Nelson M" first="Michelle" last="Nelson">Michelle Nelson</name>
</noRegion>
<name sortKey="Atkins, Timothy P" sort="Atkins, Timothy P" uniqKey="Atkins T" first="Timothy P." last="Atkins">Timothy P. Atkins</name>
<name sortKey="Dean, Rachel E" sort="Dean, Rachel E" uniqKey="Dean R" first="Rachel E." last="Dean">Rachel E. Dean</name>
<name sortKey="Lever, Mark S" sort="Lever, Mark S" uniqKey="Lever M" first="Mark S." last="Lever">Mark S. Lever</name>
<name sortKey="Nelson, Michelle" sort="Nelson, Michelle" uniqKey="Nelson M" first="Michelle" last="Nelson">Michelle Nelson</name>
<name sortKey="Ngugi, Sarah A" sort="Ngugi, Sarah A" uniqKey="Ngugi S" first="Sarah A." last="Ngugi">Sarah A. Ngugi</name>
<name sortKey="Salguero, Francisco J" sort="Salguero, Francisco J" uniqKey="Salguero F" first="Francisco J." last="Salguero">Francisco J. Salguero</name>
<name sortKey="Salguero, Francisco J" sort="Salguero, Francisco J" uniqKey="Salguero F" first="Francisco J." last="Salguero">Francisco J. Salguero</name>
<name sortKey="Smither, Sophie J" sort="Smither, Sophie J" uniqKey="Smither S" first="Sophie J." last="Smither">Sophie J. Smither</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E22 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E22 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:92C20115D903ABD93C12C5ABDA1E0C4E935CAECC |texte= Comparative experimental subcutaneous glanders and melioidosis in the common marmoset (Callithrix jacchus) }}
This area was generated with Dilib version V0.6.33. |