Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro)
Identifieur interne : 001719 ( Main/Exploration ); précédent : 001718; suivant : 001720Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro)
Auteurs : Sakshi Tomar ; Melanie L. Johnston [États-Unis] ; Sarah E. St. John ; Heather L. Osswald [États-Unis] ; Prasanth R. Nyalapatla [États-Unis] ; Lake N. Paul ; Arun K. Ghosh [États-Unis] ; Mark R. Denison ; Andrew D. Mesecar [États-Unis]Source :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2015.
Descripteurs français
- KwdFr :
- Alignement de séquences, Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Cinétique, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (enzymologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Cristallographie aux rayons X, Cysteine endopeptidases (), Cysteine endopeptidases (génétique), Cysteine endopeptidases (métabolisme), Données de séquences moléculaires, Escherichia coli (génétique), Escherichia coli (métabolisme), Expression des gènes, Interactions hydrophobes et hydrophiles, Ligands, Multimérisation de protéines (), Peptidomimétiques (), Peptidomimétiques (pharmacologie), Peptidomimétiques (synthèse chimique), Protéines recombinantes (), Protéines recombinantes (génétique), Protéines recombinantes (métabolisme), Protéines virales (), Protéines virales (antagonistes et inhibiteurs), Protéines virales (génétique), Protéines virales (métabolisme), Simulation de docking moléculaire, Spécificité du substrat, Séquence d'acides aminés.
- MESH :
- antagonistes et inhibiteurs : Protéines virales.
- enzymologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Cysteine endopeptidases, Escherichia coli, Protéines recombinantes, Protéines virales.
- métabolisme : Cysteine endopeptidases, Escherichia coli, Protéines recombinantes, Protéines virales.
- pharmacologie : Antiviraux, Peptidomimétiques.
- synthèse chimique : Antiviraux, Peptidomimétiques.
- Alignement de séquences, Antiviraux, Cinétique, Coronavirus du syndrome respiratoire du Moyen-Orient, Cristallographie aux rayons X, Cysteine endopeptidases, Données de séquences moléculaires, Expression des gènes, Interactions hydrophobes et hydrophiles, Ligands, Multimérisation de protéines, Peptidomimétiques, Protéines recombinantes, Protéines virales, Simulation de docking moléculaire, Spécificité du substrat, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Crystallography, X-Ray, Cysteine Endopeptidases (chemistry), Cysteine Endopeptidases (genetics), Cysteine Endopeptidases (metabolism), Escherichia coli (genetics), Escherichia coli (metabolism), Gene Expression, Hydrophobic and Hydrophilic Interactions, Kinetics, Ligands, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (enzymology), Middle East Respiratory Syndrome Coronavirus (genetics), Molecular Docking Simulation, Molecular Sequence Data, Peptidomimetics (chemical synthesis), Peptidomimetics (chemistry), Peptidomimetics (pharmacology), Protein Multimerization (drug effects), Recombinant Proteins (chemistry), Recombinant Proteins (genetics), Recombinant Proteins (metabolism), Sequence Alignment, Substrate Specificity, Viral Proteins (antagonists & inhibitors), Viral Proteins (chemistry), Viral Proteins (genetics), Viral Proteins (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , chemical synthesis : Antiviral Agents, Peptidomimetics.
- chemical , chemistry : Antiviral Agents, Cysteine Endopeptidases, Peptidomimetics, Recombinant Proteins, Viral Proteins.
- chemical , genetics : Cysteine Endopeptidases, Recombinant Proteins, Viral Proteins.
- chemical , metabolism : Cysteine Endopeptidases, Recombinant Proteins, Viral Proteins.
- chemical , pharmacology : Antiviral Agents, Peptidomimetics.
- drug effects : Middle East Respiratory Syndrome Coronavirus, Protein Multimerization.
- enzymology : Middle East Respiratory Syndrome Coronavirus.
- genetics : Escherichia coli, Middle East Respiratory Syndrome Coronavirus.
- metabolism : Escherichia coli.
- Amino Acid Sequence, Crystallography, X-Ray, Gene Expression, Hydrophobic and Hydrophilic Interactions, Kinetics, Ligands, Molecular Docking Simulation, Molecular Sequence Data, Sequence Alignment, Substrate Specificity.
Abstract
Url:
DOI: 10.1074/jbc.M115.651463
PubMed: 26055715
PubMed Central: 4528106
Affiliations:
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Le document en format XML
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(MERS) Coronavirus nsp5 Protease (3CL<sup>pro</sup>)</title><author><name sortKey="Tomar, Sakshi" sort="Tomar, Sakshi" uniqKey="Tomar S" first="Sakshi" last="Tomar">Sakshi Tomar</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Johnston, Melanie L" sort="Johnston, Melanie L" uniqKey="Johnston M" first="Melanie L." last="Johnston">Melanie L. Johnston</name><affiliation wicri:level="2"><nlm:aff id="aff2">Chemistry, Purdue University, West Lafayette, Indiana 47907,</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Chemistry, Purdue University, West Lafayette</wicri:cityArea></affiliation></author><author><name sortKey="St John, Sarah E" sort="St John, Sarah E" uniqKey="St John S" first="Sarah E." last="St. John">Sarah E. St. John</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Osswald, Heather L" sort="Osswald, Heather L" uniqKey="Osswald H" first="Heather L." last="Osswald">Heather L. Osswald</name><affiliation wicri:level="2"><nlm:aff id="aff2">Chemistry, Purdue University, West Lafayette, Indiana 47907,</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Chemistry, Purdue University, West Lafayette</wicri:cityArea></affiliation></author><author><name sortKey="Nyalapatla, Prasanth R" sort="Nyalapatla, Prasanth R" uniqKey="Nyalapatla P" first="Prasanth R." last="Nyalapatla">Prasanth R. Nyalapatla</name><affiliation wicri:level="2"><nlm:aff id="aff2">Chemistry, Purdue University, West Lafayette, Indiana 47907,</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Chemistry, Purdue University, West Lafayette</wicri:cityArea></affiliation></author><author><name sortKey="Paul, Lake N" sort="Paul, Lake N" uniqKey="Paul L" first="Lake N." last="Paul">Lake N. Paul</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Ghosh, Arun K" sort="Ghosh, Arun K" uniqKey="Ghosh A" first="Arun K." last="Ghosh">Arun K. Ghosh</name><affiliation wicri:level="2"><nlm:aff id="aff2">Chemistry, Purdue University, West Lafayette, Indiana 47907,</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Chemistry, Purdue University, West Lafayette</wicri:cityArea></affiliation></author><author><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R." last="Denison">Mark R. Denison</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Mesecar, Andrew D" sort="Mesecar, Andrew D" uniqKey="Mesecar A" first="Andrew D." last="Mesecar">Andrew D. Mesecar</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Chemistry, Purdue University, West Lafayette, Indiana 47907,</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Chemistry, Purdue University, West Lafayette</wicri:cityArea></affiliation></author></analytic><series><title level="j">The Journal of Biological Chemistry</title><idno type="ISSN">0021-9258</idno><idno type="eISSN">1083-351X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Antiviral Agents (chemical synthesis)</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Crystallography, X-Ray</term><term>Cysteine Endopeptidases (chemistry)</term><term>Cysteine Endopeptidases (genetics)</term><term>Cysteine Endopeptidases (metabolism)</term><term>Escherichia coli (genetics)</term><term>Escherichia coli (metabolism)</term><term>Gene Expression</term><term>Hydrophobic and Hydrophilic Interactions</term><term>Kinetics</term><term>Ligands</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Middle East Respiratory Syndrome Coronavirus (enzymology)</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Molecular Docking Simulation</term><term>Molecular Sequence Data</term><term>Peptidomimetics (chemical synthesis)</term><term>Peptidomimetics (chemistry)</term><term>Peptidomimetics (pharmacology)</term><term>Protein Multimerization (drug effects)</term><term>Recombinant Proteins (chemistry)</term><term>Recombinant Proteins (genetics)</term><term>Recombinant Proteins (metabolism)</term><term>Sequence Alignment</term><term>Substrate Specificity</term><term>Viral Proteins (antagonists & inhibitors)</term><term>Viral Proteins (chemistry)</term><term>Viral Proteins (genetics)</term><term>Viral Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (synthèse chimique)</term><term>Cinétique</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (enzymologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Cristallographie aux rayons X</term><term>Cysteine endopeptidases ()</term><term>Cysteine endopeptidases (génétique)</term><term>Cysteine endopeptidases (métabolisme)</term><term>Données de séquences moléculaires</term><term>Escherichia coli (génétique)</term><term>Escherichia coli (métabolisme)</term><term>Expression des gènes</term><term>Interactions hydrophobes et hydrophiles</term><term>Ligands</term><term>Multimérisation de protéines ()</term><term>Peptidomimétiques ()</term><term>Peptidomimétiques (pharmacologie)</term><term>Peptidomimétiques (synthèse chimique)</term><term>Protéines recombinantes ()</term><term>Protéines recombinantes (génétique)</term><term>Protéines recombinantes (métabolisme)</term><term>Protéines virales ()</term><term>Protéines virales (antagonistes et inhibiteurs)</term><term>Protéines virales (génétique)</term><term>Protéines virales (métabolisme)</term><term>Simulation de docking moléculaire</term><term>Spécificité du substrat</term><term>Séquence d'acides aminés</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Antiviral Agents</term><term>Peptidomimetics</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Cysteine Endopeptidases</term><term>Peptidomimetics</term><term>Recombinant Proteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cysteine Endopeptidases</term><term>Recombinant Proteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cysteine Endopeptidases</term><term>Recombinant Proteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Peptidomimetics</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>Protein Multimerization</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Escherichia coli</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Cysteine endopeptidases</term><term>Escherichia coli</term><term>Protéines recombinantes</term><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Escherichia coli</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cysteine endopeptidases</term><term>Escherichia coli</term><term>Protéines recombinantes</term><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Peptidomimétiques</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Antiviraux</term><term>Peptidomimétiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Crystallography, X-Ray</term><term>Gene Expression</term><term>Hydrophobic and Hydrophilic Interactions</term><term>Kinetics</term><term>Ligands</term><term>Molecular Docking Simulation</term><term>Molecular Sequence Data</term><term>Sequence Alignment</term><term>Substrate Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Antiviraux</term><term>Cinétique</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Cristallographie aux rayons X</term><term>Cysteine endopeptidases</term><term>Données de séquences moléculaires</term><term>Expression des gènes</term><term>Interactions hydrophobes et hydrophiles</term><term>Ligands</term><term>Multimérisation de protéines</term><term>Peptidomimétiques</term><term>Protéines recombinantes</term><term>Protéines virales</term><term>Simulation de docking moléculaire</term><term>Spécificité du substrat</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> 3CL<sup>pro</sup> protease is required for coronaviral
polyprotein processing and is only active as a dimer.</p><p><bold>Results:</bold> MERS-CoV 3CL<sup>pro</sup> is a weakly associated dimer
requiring ligand binding for dimer formation.</p><p><bold>Conclusion:</bold> Ligand-induced dimerization is a key mechanism for
regulating the enzymatic activity of MERS-CoV 3CL<sup>pro</sup> during
polyprotein processing.</p><p><bold>Significance:</bold> Activation via ligand-induced dimerization may add
complexity for the development of MERS-CoV 3CL<sup>pro</sup> inhibitors as
antivirals.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alenius, S" uniqKey="Alenius S">S. Alenius</name></author><author><name sortKey="Niskanen, R" uniqKey="Niskanen R">R. Niskanen</name></author><author><name sortKey="Juntti, N" uniqKey="Juntti N">N. Juntti</name></author><author><name sortKey="Larsson, B" uniqKey="Larsson B">B. Larsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barber, D M" uniqKey="Barber D">D. M. Barber</name></author><author><name sortKey="Nettleton, P F" uniqKey="Nettleton P">P. F. Nettleton</name></author><author><name sortKey="Herring, J A" uniqKey="Herring J">J. A. Herring</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author><author><name sortKey="Netland, J" uniqKey="Netland J">J. 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Robert</name></author><author><name sortKey="Gouet, P" uniqKey="Gouet P">P. Gouet</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Indiana</li></region></list><tree><noCountry><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R." last="Denison">Mark R. Denison</name><name sortKey="Paul, Lake N" sort="Paul, Lake N" uniqKey="Paul L" first="Lake N." last="Paul">Lake N. Paul</name><name sortKey="St John, Sarah E" sort="St John, Sarah E" uniqKey="St John S" first="Sarah E." last="St. John">Sarah E. St. John</name><name sortKey="Tomar, Sakshi" sort="Tomar, Sakshi" uniqKey="Tomar S" first="Sakshi" last="Tomar">Sakshi Tomar</name></noCountry><country name="États-Unis"><region name="Indiana"><name sortKey="Johnston, Melanie L" sort="Johnston, Melanie L" uniqKey="Johnston M" first="Melanie L." last="Johnston">Melanie L. Johnston</name></region><name sortKey="Ghosh, Arun K" sort="Ghosh, Arun K" uniqKey="Ghosh A" first="Arun K." last="Ghosh">Arun K. Ghosh</name><name sortKey="Mesecar, Andrew D" sort="Mesecar, Andrew D" uniqKey="Mesecar A" first="Andrew D." last="Mesecar">Andrew D. Mesecar</name><name sortKey="Nyalapatla, Prasanth R" sort="Nyalapatla, Prasanth R" uniqKey="Nyalapatla P" first="Prasanth R." last="Nyalapatla">Prasanth R. Nyalapatla</name><name sortKey="Osswald, Heather L" sort="Osswald, Heather L" uniqKey="Osswald H" first="Heather L." last="Osswald">Heather L. Osswald</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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