A study of vaccine-induced immune pressure on breakthrough infections in the Phambili phase 2b HIV-1 vaccine efficacy trial.
Identifieur interne : 001396 ( Main/Exploration ); précédent : 001395; suivant : 001397A study of vaccine-induced immune pressure on breakthrough infections in the Phambili phase 2b HIV-1 vaccine efficacy trial.
Auteurs : T. Hertz [États-Unis] ; M G Logan [Afrique du Sud] ; M. Rolland [États-Unis] ; C A Magaret [États-Unis] ; C. Rademeyer [Afrique du Sud] ; A. Fiore-Gartland [États-Unis] ; P T Edlefsen [États-Unis] ; A. Decamp [États-Unis] ; H. Ahmed [États-Unis] ; N. Ngandu [Afrique du Sud] ; B B Larsen [États-Unis] ; N. Frahm [États-Unis] ; J. Marais [Afrique du Sud] ; R. Thebus [Afrique du Sud] ; D. Geraghty [États-Unis] ; J. Hural [États-Unis] ; L. Corey [États-Unis] ; J. Kublin [États-Unis] ; G. Gray [Afrique du Sud] ; M J Mcelrath [États-Unis] ; J I Mullins [États-Unis] ; P B Gilbert [États-Unis] ; C. Williamson [Afrique du Sud]Source :
- Vaccine [ 1873-2518 ] ; 2016.
Descripteurs français
- KwdFr :
- Adenoviridae, Antigène HLA-A2 (génétique), Antigène HLA-A2 (immunologie), Femelle, Fréquence d'allèle, Humains, Immunité active, Infections à VIH (), Mâle, Méthode en double aveugle, Produits du gène gag du virus de l'immunodéficience humaine (génétique), Produits du gène gag du virus de l'immunodéficience humaine (immunologie), Produits du gène nef du virus de l'immunodéficience humaine (génétique), Produits du gène nef du virus de l'immunodéficience humaine (immunologie), Produits du gène pol du virus de l'immunodéficience humaine (génétique), Produits du gène pol du virus de l'immunodéficience humaine (immunologie), Taille d'échantillon, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie), Vaccins contre le SIDA (administration et posologie), Vaccins contre le SIDA (immunologie), Vaccins synthétiques (administration et posologie), Vaccins synthétiques (immunologie), Épitopes (génétique), Épitopes (immunologie), Études de cohortes.
- MESH :
- administration et posologie : Vaccins contre le SIDA, Vaccins synthétiques.
- génétique : Antigène HLA-A2, Produits du gène gag du virus de l'immunodéficience humaine, Produits du gène nef du virus de l'immunodéficience humaine, Produits du gène pol du virus de l'immunodéficience humaine, Épitopes.
- immunologie : Antigène HLA-A2, Produits du gène gag du virus de l'immunodéficience humaine, Produits du gène nef du virus de l'immunodéficience humaine, Produits du gène pol du virus de l'immunodéficience humaine, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Vaccins contre le SIDA, Vaccins synthétiques, Épitopes.
- Adenoviridae, Femelle, Fréquence d'allèle, Humains, Immunité active, Infections à VIH, Mâle, Méthode en double aveugle, Taille d'échantillon, Études de cohortes.
English descriptors
- KwdEn :
- AIDS Vaccines (administration & dosage), AIDS Vaccines (immunology), Adenoviridae, Cohort Studies, Double-Blind Method, Epitopes (genetics), Epitopes (immunology), Female, Gene Frequency, HIV Infections (prevention & control), HIV-1 (immunology), HLA-A2 Antigen (genetics), HLA-A2 Antigen (immunology), Humans, Immunity, Active, Male, Sample Size, Vaccination Coverage, Vaccines, Synthetic (administration & dosage), Vaccines, Synthetic (immunology), gag Gene Products, Human Immunodeficiency Virus (genetics), gag Gene Products, Human Immunodeficiency Virus (immunology), nef Gene Products, Human Immunodeficiency Virus (genetics), nef Gene Products, Human Immunodeficiency Virus (immunology), pol Gene Products, Human Immunodeficiency Virus (genetics), pol Gene Products, Human Immunodeficiency Virus (immunology).
- MESH :
- chemical , administration & dosage : AIDS Vaccines, Vaccines, Synthetic.
- chemical , genetics : Epitopes, HLA-A2 Antigen, gag Gene Products, Human Immunodeficiency Virus, nef Gene Products, Human Immunodeficiency Virus, pol Gene Products, Human Immunodeficiency Virus.
- chemical , immunology : AIDS Vaccines, Epitopes, HLA-A2 Antigen, Vaccines, Synthetic, gag Gene Products, Human Immunodeficiency Virus, nef Gene Products, Human Immunodeficiency Virus, pol Gene Products, Human Immunodeficiency Virus.
- immunology : HIV-1.
- prevention & control : HIV Infections.
- Adenoviridae, Cohort Studies, Double-Blind Method, Female, Gene Frequency, Humans, Immunity, Active, Male, Sample Size, Vaccination Coverage.
Abstract
The Merck Adenovirus-5 Gag/Pol/Nef HIV-1 subtype-B vaccine evaluated in predominately subtype B epidemic regions (Step Study), while not preventing infection, exerted vaccine-induced immune pressure on HIV-1 breakthrough infections. Here we investigated if the same vaccine exerted immune pressure when tested in the Phambili Phase 2b study in a subtype C epidemic.
DOI: 10.1016/j.vaccine.2016.09.054
PubMed: 27756485
Affiliations:
- Afrique du Sud, États-Unis
- Gauteng, Maryland, Washington (État)
- Johannesbourg, Seattle
- Université de Washington, Université du Witwatersrand
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Le document en format XML
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Gray</name><affiliation wicri:level="4"><nlm:affiliation>Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg</wicri:regionArea><orgName type="university">Université du Witwatersrand</orgName><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName></affiliation></author><author><name sortKey="Mcelrath, M J" sort="Mcelrath, M J" uniqKey="Mcelrath M" first="M J" last="Mcelrath">M J Mcelrath</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Mullins, J I" sort="Mullins, J I" uniqKey="Mullins J" first="J I" last="Mullins">J I Mullins</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology, University of Washington, Seattle, WA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Gilbert, P B" sort="Gilbert, P B" uniqKey="Gilbert P" first="P B" last="Gilbert">P B Gilbert</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Williamson, C" sort="Williamson, C" uniqKey="Williamson C" first="C" last="Williamson">C. 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Hertz</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Logan, M G" sort="Logan, M G" uniqKey="Logan M" first="M G" last="Logan">M G Logan</name><affiliation wicri:level="1"><nlm:affiliation>Division of Medical Virology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town 7925, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Medical Virology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town 7925</wicri:regionArea><wicri:noRegion>Cape Town 7925</wicri:noRegion></affiliation></author><author><name sortKey="Rolland, M" sort="Rolland, M" uniqKey="Rolland M" first="M" last="Rolland">M. Rolland</name><affiliation wicri:level="2"><nlm:affiliation>Henry M. Jackson Foundation, U.S. Military HIV Research Program, Bethesda, MD 20817, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Henry M. Jackson Foundation, U.S. Military HIV Research Program, Bethesda, MD 20817</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Magaret, C A" sort="Magaret, C A" uniqKey="Magaret C" first="C A" last="Magaret">C A Magaret</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Rademeyer, C" sort="Rademeyer, C" uniqKey="Rademeyer C" first="C" last="Rademeyer">C. Rademeyer</name><affiliation wicri:level="1"><nlm:affiliation>Division of Medical Virology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town 7925, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Medical Virology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town 7925</wicri:regionArea><wicri:noRegion>Cape Town 7925</wicri:noRegion></affiliation></author><author><name sortKey="Fiore Gartland, A" sort="Fiore Gartland, A" uniqKey="Fiore Gartland A" first="A" last="Fiore-Gartland">A. Fiore-Gartland</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Edlefsen, P T" sort="Edlefsen, P T" uniqKey="Edlefsen P" first="P T" last="Edlefsen">P T Edlefsen</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Decamp, A" sort="Decamp, A" uniqKey="Decamp A" first="A" last="Decamp">A. Decamp</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Ahmed, H" sort="Ahmed, H" uniqKey="Ahmed H" first="H" last="Ahmed">H. Ahmed</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Ngandu, N" sort="Ngandu, N" uniqKey="Ngandu N" first="N" last="Ngandu">N. Ngandu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Medical Virology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town 7925, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Medical Virology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town 7925</wicri:regionArea><wicri:noRegion>Cape Town 7925</wicri:noRegion></affiliation></author><author><name sortKey="Larsen, B B" sort="Larsen, B B" uniqKey="Larsen B" first="B B" last="Larsen">B B Larsen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology, University of Washington, Seattle, WA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Frahm, N" sort="Frahm, N" uniqKey="Frahm N" first="N" last="Frahm">N. Frahm</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Marais, J" sort="Marais, J" uniqKey="Marais J" first="J" last="Marais">J. Marais</name><affiliation wicri:level="1"><nlm:affiliation>Division of Medical Virology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town 7925, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Medical Virology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town 7925</wicri:regionArea><wicri:noRegion>Cape Town 7925</wicri:noRegion></affiliation></author><author><name sortKey="Thebus, R" sort="Thebus, R" uniqKey="Thebus R" first="R" last="Thebus">R. Thebus</name><affiliation wicri:level="1"><nlm:affiliation>Division of Medical Virology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town 7925, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Medical Virology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town 7925</wicri:regionArea><wicri:noRegion>Cape Town 7925</wicri:noRegion></affiliation></author><author><name sortKey="Geraghty, D" sort="Geraghty, D" uniqKey="Geraghty D" first="D" last="Geraghty">D. Geraghty</name><affiliation wicri:level="2"><nlm:affiliation>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Hural, J" sort="Hural, J" uniqKey="Hural J" first="J" last="Hural">J. Hural</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Corey, L" sort="Corey, L" uniqKey="Corey L" first="L" last="Corey">L. Corey</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Kublin, J" sort="Kublin, J" uniqKey="Kublin J" first="J" last="Kublin">J. Kublin</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Gray, G" sort="Gray, G" uniqKey="Gray G" first="G" last="Gray">G. Gray</name><affiliation wicri:level="4"><nlm:affiliation>Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg</wicri:regionArea><orgName type="university">Université du Witwatersrand</orgName><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName></affiliation></author><author><name sortKey="Mcelrath, M J" sort="Mcelrath, M J" uniqKey="Mcelrath M" first="M J" last="Mcelrath">M J Mcelrath</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Mullins, J I" sort="Mullins, J I" uniqKey="Mullins J" first="J I" last="Mullins">J I Mullins</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology, University of Washington, Seattle, WA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Gilbert, P B" sort="Gilbert, P B" uniqKey="Gilbert P" first="P B" last="Gilbert">P B Gilbert</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Williamson, C" sort="Williamson, C" uniqKey="Williamson C" first="C" last="Williamson">C. Williamson</name><affiliation wicri:level="1"><nlm:affiliation>Division of Medical Virology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town 7925, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Medical Virology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town 7925</wicri:regionArea><wicri:noRegion>Cape Town 7925</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="eISSN">1873-2518</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS Vaccines (administration & dosage)</term><term>AIDS Vaccines (immunology)</term><term>Adenoviridae</term><term>Cohort Studies</term><term>Double-Blind Method</term><term>Epitopes (genetics)</term><term>Epitopes (immunology)</term><term>Female</term><term>Gene Frequency</term><term>HIV Infections (prevention & control)</term><term>HIV-1 (immunology)</term><term>HLA-A2 Antigen (genetics)</term><term>HLA-A2 Antigen (immunology)</term><term>Humans</term><term>Immunity, Active</term><term>Male</term><term>Sample Size</term><term>Vaccination Coverage</term><term>Vaccines, Synthetic (administration & dosage)</term><term>Vaccines, Synthetic (immunology)</term><term>gag Gene Products, Human Immunodeficiency Virus (genetics)</term><term>gag Gene Products, Human Immunodeficiency Virus (immunology)</term><term>nef Gene Products, Human Immunodeficiency Virus (genetics)</term><term>nef Gene Products, Human Immunodeficiency Virus (immunology)</term><term>pol Gene Products, Human Immunodeficiency Virus (genetics)</term><term>pol Gene Products, Human Immunodeficiency Virus (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae</term><term>Antigène HLA-A2 (génétique)</term><term>Antigène HLA-A2 (immunologie)</term><term>Femelle</term><term>Fréquence d'allèle</term><term>Humains</term><term>Immunité active</term><term>Infections à VIH ()</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Produits du gène gag du virus de l'immunodéficience humaine (génétique)</term><term>Produits du gène gag du virus de l'immunodéficience humaine (immunologie)</term><term>Produits du gène nef du virus de l'immunodéficience humaine (génétique)</term><term>Produits du gène nef du virus de l'immunodéficience humaine (immunologie)</term><term>Produits du gène pol du virus de l'immunodéficience humaine (génétique)</term><term>Produits du gène pol du virus de l'immunodéficience humaine (immunologie)</term><term>Taille d'échantillon</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie)</term><term>Vaccins contre le SIDA (administration et posologie)</term><term>Vaccins contre le SIDA (immunologie)</term><term>Vaccins synthétiques (administration et posologie)</term><term>Vaccins synthétiques (immunologie)</term><term>Épitopes (génétique)</term><term>Épitopes (immunologie)</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>AIDS Vaccines</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Epitopes</term><term>HLA-A2 Antigen</term><term>gag Gene Products, Human Immunodeficiency Virus</term><term>nef Gene Products, Human Immunodeficiency Virus</term><term>pol Gene Products, Human Immunodeficiency Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>AIDS Vaccines</term><term>Epitopes</term><term>HLA-A2 Antigen</term><term>Vaccines, Synthetic</term><term>gag Gene Products, Human Immunodeficiency Virus</term><term>nef Gene Products, Human Immunodeficiency Virus</term><term>pol Gene Products, Human Immunodeficiency Virus</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins contre le SIDA</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigène HLA-A2</term><term>Produits du gène gag du virus de l'immunodéficience humaine</term><term>Produits du gène nef du virus de l'immunodéficience humaine</term><term>Produits du gène pol du virus de l'immunodéficience humaine</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigène HLA-A2</term><term>Produits du gène gag du virus de l'immunodéficience humaine</term><term>Produits du gène nef du virus de l'immunodéficience humaine</term><term>Produits du gène pol du virus de l'immunodéficience humaine</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>Vaccins contre le SIDA</term><term>Vaccins synthétiques</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adenoviridae</term><term>Cohort Studies</term><term>Double-Blind Method</term><term>Female</term><term>Gene Frequency</term><term>Humans</term><term>Immunity, Active</term><term>Male</term><term>Sample Size</term><term>Vaccination Coverage</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adenoviridae</term><term>Femelle</term><term>Fréquence d'allèle</term><term>Humains</term><term>Immunité active</term><term>Infections à VIH</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Taille d'échantillon</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Merck Adenovirus-5 Gag/Pol/Nef HIV-1 subtype-B vaccine evaluated in predominately subtype B epidemic regions (Step Study), while not preventing infection, exerted vaccine-induced immune pressure on HIV-1 breakthrough infections. Here we investigated if the same vaccine exerted immune pressure when tested in the Phambili Phase 2b study in a subtype C epidemic.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>États-Unis</li></country><region><li>Gauteng</li><li>Maryland</li><li>Washington (État)</li></region><settlement><li>Johannesbourg</li><li>Seattle</li></settlement><orgName><li>Université de Washington</li><li>Université du Witwatersrand</li></orgName></list><tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Hertz, T" sort="Hertz, T" uniqKey="Hertz T" first="T" last="Hertz">T. Hertz</name></region><name sortKey="Ahmed, H" sort="Ahmed, H" uniqKey="Ahmed H" first="H" last="Ahmed">H. Ahmed</name><name sortKey="Corey, L" sort="Corey, L" uniqKey="Corey L" first="L" last="Corey">L. Corey</name><name sortKey="Decamp, A" sort="Decamp, A" uniqKey="Decamp A" first="A" last="Decamp">A. Decamp</name><name sortKey="Edlefsen, P T" sort="Edlefsen, P T" uniqKey="Edlefsen P" first="P T" last="Edlefsen">P T Edlefsen</name><name sortKey="Fiore Gartland, A" sort="Fiore Gartland, A" uniqKey="Fiore Gartland A" first="A" last="Fiore-Gartland">A. Fiore-Gartland</name><name sortKey="Frahm, N" sort="Frahm, N" uniqKey="Frahm N" first="N" last="Frahm">N. Frahm</name><name sortKey="Geraghty, D" sort="Geraghty, D" uniqKey="Geraghty D" first="D" last="Geraghty">D. Geraghty</name><name sortKey="Gilbert, P B" sort="Gilbert, P B" uniqKey="Gilbert P" first="P B" last="Gilbert">P B Gilbert</name><name sortKey="Hural, J" sort="Hural, J" uniqKey="Hural J" first="J" last="Hural">J. Hural</name><name sortKey="Kublin, J" sort="Kublin, J" uniqKey="Kublin J" first="J" last="Kublin">J. Kublin</name><name sortKey="Larsen, B B" sort="Larsen, B B" uniqKey="Larsen B" first="B B" last="Larsen">B B Larsen</name><name sortKey="Magaret, C A" sort="Magaret, C A" uniqKey="Magaret C" first="C A" last="Magaret">C A Magaret</name><name sortKey="Mcelrath, M J" sort="Mcelrath, M J" uniqKey="Mcelrath M" first="M J" last="Mcelrath">M J Mcelrath</name><name sortKey="Mullins, J I" sort="Mullins, J I" uniqKey="Mullins J" first="J I" last="Mullins">J I Mullins</name><name sortKey="Rolland, M" sort="Rolland, M" uniqKey="Rolland M" first="M" last="Rolland">M. Rolland</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Logan, M G" sort="Logan, M G" uniqKey="Logan M" first="M G" last="Logan">M G Logan</name></noRegion><name sortKey="Gray, G" sort="Gray, G" uniqKey="Gray G" first="G" last="Gray">G. Gray</name><name sortKey="Marais, J" sort="Marais, J" uniqKey="Marais J" first="J" last="Marais">J. Marais</name><name sortKey="Ngandu, N" sort="Ngandu, N" uniqKey="Ngandu N" first="N" last="Ngandu">N. Ngandu</name><name sortKey="Rademeyer, C" sort="Rademeyer, C" uniqKey="Rademeyer C" first="C" last="Rademeyer">C. Rademeyer</name><name sortKey="Thebus, R" sort="Thebus, R" uniqKey="Thebus R" first="R" last="Thebus">R. Thebus</name><name sortKey="Williamson, C" sort="Williamson, C" uniqKey="Williamson C" first="C" last="Williamson">C. Williamson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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