Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014
Identifieur interne : 001337 ( Main/Exploration ); précédent : 001336; suivant : 001338Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014
Auteurs : Dianna L. Ng [Géorgie (pays)] ; Farida Al Hosani [Émirats arabes unis] ; M. Kelly Keating [Géorgie (pays)] ; Susan I. Gerber [Géorgie (pays)] ; Tara L. Jones [Géorgie (pays)] ; Maureen G. Metcalfe [Géorgie (pays)] ; Suxiang Tong [Géorgie (pays)] ; Ying Tao [Géorgie (pays)] ; Negar N. Alami [Géorgie (pays)] ; Lia M. Haynes [Géorgie (pays)] ; Mowafaq Ali Mutei [Émirats arabes unis] ; Laila Abdel-Wareth [Émirats arabes unis] ; Timothy M. Uyeki [Géorgie (pays)] ; David L. Swerdlow [Géorgie (pays)] ; Maha Barakat [Émirats arabes unis] ; Sherif R. Zaki [Géorgie (pays)]Source :
- The American Journal of Pathology [ 0002-9440 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Dipeptidyl peptidase 4 (immunologie), Humains, Immunohistochimie, Infections à coronavirus (anatomopathologie), Issue fatale, Mâle, Poumon (anatomopathologie), Poumon (imagerie diagnostique), Poumon (ultrastructure), Radiographie, Émirats arabes unis.
- MESH :
- anatomopathologie : Infections à coronavirus, Poumon.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- imagerie diagnostique : Poumon.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Dipeptidyl peptidase 4.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- ultrastructure : Adulte d'âge moyen, Humains, Immunohistochimie, Issue fatale, Mâle, Poumon, Radiographie, Émirats arabes unis.
English descriptors
- KwdEn :
- Coronavirus Infections (pathology), Dipeptidyl Peptidase 4 (immunology), Fatal Outcome, Humans, Immunohistochemistry, Lung (diagnostic imaging), Lung (pathology), Lung (ultrastructure), Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Radiography, United Arab Emirates.
- MESH :
- chemical , immunology : Dipeptidyl Peptidase 4.
- diagnostic imaging : Lung.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- immunology : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- pathology : Coronavirus Infections, Lung.
- ultrastructure : Lung.
- Fatal Outcome, Humans, Immunohistochemistry, Male, Middle Aged, Radiography, United Arab Emirates.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) infection causes an acute respiratory illness and is associated with a high case fatality rate; however, the pathogenesis of severe and fatal MERS-CoV infection is unknown. We describe the histopathologic, immunohistochemical, and ultrastructural findings from the first autopsy performed on a fatal case of MERS-CoV in the world, which was related to a hospital outbreak in the United Arab Emirates in April 2014. The main histopathologic finding in the lungs was diffuse alveolar damage. Evidence of chronic disease, including severe peripheral vascular disease, patchy cardiac fibrosis, and hepatic steatosis, was noted in the other organs. Double staining immunoassays that used anti–MERS-CoV antibodies paired with immunohistochemistry for cytokeratin and surfactant identified pneumocytes and epithelial syncytial cells as important targets of MERS-CoV antigen; double immunostaining with dipeptidyl peptidase 4 showed colocalization in scattered pneumocytes and syncytial cells. No evidence of extrapulmonary MERS-CoV antigens were detected, including the kidney. These results provide critical insights into the pathogenesis of MERS-CoV in humans.
Url:
DOI: 10.1016/j.ajpath.2015.10.024
PubMed: 26857507
PubMed Central: 7093852
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000A48
- to stream Pmc, to step Curation: 000A48
- to stream Pmc, to step Checkpoint: 000C22
- to stream PubMed, to step Corpus: 001267
- to stream PubMed, to step Curation: 001267
- to stream PubMed, to step Checkpoint: 001184
- to stream Ncbi, to step Merge: 001474
- to stream Ncbi, to step Curation: 001474
- to stream Ncbi, to step Checkpoint: 001474
- to stream Main, to step Merge: 001342
- to stream Main, to step Curation: 001337
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014</title><author><name sortKey="Ng, Dianna L" sort="Ng, Dianna L" uniqKey="Ng D" first="Dianna L." last="Ng">Dianna L. Ng</name><affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Al Hosani, Farida" sort="Al Hosani, Farida" uniqKey="Al Hosani F" first="Farida" last="Al Hosani">Farida Al Hosani</name><affiliation wicri:level="1"><nlm:aff id="aff9">Communicable Diseases Department, Abu Dhabi, United Arab Emirates</nlm:aff><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Communicable Diseases Department, Abu Dhabi</wicri:regionArea><wicri:noRegion>Abu Dhabi</wicri:noRegion></affiliation></author><author><name sortKey="Keating, M Kelly" sort="Keating, M Kelly" uniqKey="Keating M" first="M. Kelly" last="Keating">M. Kelly Keating</name><affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Gerber, Susan I" sort="Gerber, Susan I" uniqKey="Gerber S" first="Susan I." last="Gerber">Susan I. Gerber</name><affiliation wicri:level="1"><nlm:aff id="aff2">Epidemiology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Epidemiology Branch, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Tara L" sort="Jones, Tara L" uniqKey="Jones T" first="Tara L." last="Jones">Tara L. Jones</name><affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Metcalfe, Maureen G" sort="Metcalfe, Maureen G" uniqKey="Metcalfe M" first="Maureen G." last="Metcalfe">Maureen G. Metcalfe</name><affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Tong, Suxiang" sort="Tong, Suxiang" uniqKey="Tong S" first="Suxiang" last="Tong">Suxiang Tong</name><affiliation wicri:level="1"><nlm:aff id="aff3">Gastroenteritis and Respiratory Virus Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Gastroenteritis and Respiratory Virus Laboratory Branch, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Tao, Ying" sort="Tao, Ying" uniqKey="Tao Y" first="Ying" last="Tao">Ying Tao</name><affiliation wicri:level="1"><nlm:aff id="aff3">Gastroenteritis and Respiratory Virus Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Gastroenteritis and Respiratory Virus Laboratory Branch, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Alami, Negar N" sort="Alami, Negar N" uniqKey="Alami N" first="Negar N." last="Alami">Negar N. Alami</name><affiliation wicri:level="1"><nlm:aff id="aff4">Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8">International Research and Programs Branch, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>International Research and Programs Branch, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Haynes, Lia M" sort="Haynes, Lia M" uniqKey="Haynes L" first="Lia M." last="Haynes">Lia M. Haynes</name><affiliation wicri:level="1"><nlm:aff id="aff6">Office of the Director, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Office of the Director, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Mutei, Mowafaq Ali" sort="Mutei, Mowafaq Ali" uniqKey="Mutei M" first="Mowafaq Ali" last="Mutei">Mowafaq Ali Mutei</name><affiliation wicri:level="1"><nlm:aff id="aff10">Emergency and Disaster Department, Abu Dhabi, United Arab Emirates</nlm:aff><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Emergency and Disaster Department, Abu Dhabi</wicri:regionArea><wicri:noRegion>Abu Dhabi</wicri:noRegion></affiliation></author><author><name sortKey="Abdel Wareth, Laila" sort="Abdel Wareth, Laila" uniqKey="Abdel Wareth L" first="Laila" last="Abdel-Wareth">Laila Abdel-Wareth</name><affiliation wicri:level="1"><nlm:aff id="aff12">Pathology and Laboratory Medicine Institute, Cleveland Clinic, Abu Dhabi, United Arab Emirates</nlm:aff><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Pathology and Laboratory Medicine Institute, Cleveland Clinic, Abu Dhabi</wicri:regionArea><wicri:noRegion>Abu Dhabi</wicri:noRegion></affiliation></author><author><name sortKey="Uyeki, Timothy M" sort="Uyeki, Timothy M" uniqKey="Uyeki T" first="Timothy M." last="Uyeki">Timothy M. Uyeki</name><affiliation wicri:level="1"><nlm:aff id="aff5">Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Influenza Division, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Swerdlow, David L" sort="Swerdlow, David L" uniqKey="Swerdlow D" first="David L." last="Swerdlow">David L. Swerdlow</name><affiliation wicri:level="1"><nlm:aff id="aff7">National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Barakat, Maha" sort="Barakat, Maha" uniqKey="Barakat M" first="Maha" last="Barakat">Maha Barakat</name><affiliation wicri:level="1"><nlm:aff id="aff11">Health Authority-Abu Dhabi, Abu Dhabi, United Arab Emirates</nlm:aff><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Health Authority-Abu Dhabi, Abu Dhabi</wicri:regionArea><wicri:noRegion>Abu Dhabi</wicri:noRegion></affiliation></author><author><name sortKey="Zaki, Sherif R" sort="Zaki, Sherif R" uniqKey="Zaki S" first="Sherif R." last="Zaki">Sherif R. Zaki</name><affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26857507</idno><idno type="pmc">7093852</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093852</idno><idno type="RBID">PMC:7093852</idno><idno type="doi">10.1016/j.ajpath.2015.10.024</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000A48</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A48</idno><idno type="wicri:Area/Pmc/Curation">000A48</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A48</idno><idno type="wicri:Area/Pmc/Checkpoint">000C22</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C22</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:26857507</idno><idno type="wicri:Area/PubMed/Corpus">001267</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001267</idno><idno type="wicri:Area/PubMed/Curation">001267</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001267</idno><idno type="wicri:Area/PubMed/Checkpoint">001184</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001184</idno><idno type="wicri:Area/Ncbi/Merge">001474</idno><idno type="wicri:Area/Ncbi/Curation">001474</idno><idno type="wicri:Area/Ncbi/Checkpoint">001474</idno><idno type="wicri:doubleKey">0002-9440:2016:Ng D:clinicopathologic:immunohistochemical:and</idno><idno type="wicri:Area/Main/Merge">001342</idno><idno type="wicri:Area/Main/Curation">001337</idno><idno type="wicri:Area/Main/Exploration">001337</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014</title><author><name sortKey="Ng, Dianna L" sort="Ng, Dianna L" uniqKey="Ng D" first="Dianna L." last="Ng">Dianna L. Ng</name><affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Al Hosani, Farida" sort="Al Hosani, Farida" uniqKey="Al Hosani F" first="Farida" last="Al Hosani">Farida Al Hosani</name><affiliation wicri:level="1"><nlm:aff id="aff9">Communicable Diseases Department, Abu Dhabi, United Arab Emirates</nlm:aff><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Communicable Diseases Department, Abu Dhabi</wicri:regionArea><wicri:noRegion>Abu Dhabi</wicri:noRegion></affiliation></author><author><name sortKey="Keating, M Kelly" sort="Keating, M Kelly" uniqKey="Keating M" first="M. Kelly" last="Keating">M. Kelly Keating</name><affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Gerber, Susan I" sort="Gerber, Susan I" uniqKey="Gerber S" first="Susan I." last="Gerber">Susan I. Gerber</name><affiliation wicri:level="1"><nlm:aff id="aff2">Epidemiology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Epidemiology Branch, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Tara L" sort="Jones, Tara L" uniqKey="Jones T" first="Tara L." last="Jones">Tara L. Jones</name><affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Metcalfe, Maureen G" sort="Metcalfe, Maureen G" uniqKey="Metcalfe M" first="Maureen G." last="Metcalfe">Maureen G. Metcalfe</name><affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Tong, Suxiang" sort="Tong, Suxiang" uniqKey="Tong S" first="Suxiang" last="Tong">Suxiang Tong</name><affiliation wicri:level="1"><nlm:aff id="aff3">Gastroenteritis and Respiratory Virus Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Gastroenteritis and Respiratory Virus Laboratory Branch, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Tao, Ying" sort="Tao, Ying" uniqKey="Tao Y" first="Ying" last="Tao">Ying Tao</name><affiliation wicri:level="1"><nlm:aff id="aff3">Gastroenteritis and Respiratory Virus Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Gastroenteritis and Respiratory Virus Laboratory Branch, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Alami, Negar N" sort="Alami, Negar N" uniqKey="Alami N" first="Negar N." last="Alami">Negar N. Alami</name><affiliation wicri:level="1"><nlm:aff id="aff4">Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8">International Research and Programs Branch, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>International Research and Programs Branch, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Haynes, Lia M" sort="Haynes, Lia M" uniqKey="Haynes L" first="Lia M." last="Haynes">Lia M. Haynes</name><affiliation wicri:level="1"><nlm:aff id="aff6">Office of the Director, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Office of the Director, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Mutei, Mowafaq Ali" sort="Mutei, Mowafaq Ali" uniqKey="Mutei M" first="Mowafaq Ali" last="Mutei">Mowafaq Ali Mutei</name><affiliation wicri:level="1"><nlm:aff id="aff10">Emergency and Disaster Department, Abu Dhabi, United Arab Emirates</nlm:aff><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Emergency and Disaster Department, Abu Dhabi</wicri:regionArea><wicri:noRegion>Abu Dhabi</wicri:noRegion></affiliation></author><author><name sortKey="Abdel Wareth, Laila" sort="Abdel Wareth, Laila" uniqKey="Abdel Wareth L" first="Laila" last="Abdel-Wareth">Laila Abdel-Wareth</name><affiliation wicri:level="1"><nlm:aff id="aff12">Pathology and Laboratory Medicine Institute, Cleveland Clinic, Abu Dhabi, United Arab Emirates</nlm:aff><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Pathology and Laboratory Medicine Institute, Cleveland Clinic, Abu Dhabi</wicri:regionArea><wicri:noRegion>Abu Dhabi</wicri:noRegion></affiliation></author><author><name sortKey="Uyeki, Timothy M" sort="Uyeki, Timothy M" uniqKey="Uyeki T" first="Timothy M." last="Uyeki">Timothy M. Uyeki</name><affiliation wicri:level="1"><nlm:aff id="aff5">Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Influenza Division, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Swerdlow, David L" sort="Swerdlow, David L" uniqKey="Swerdlow D" first="David L." last="Swerdlow">David L. Swerdlow</name><affiliation wicri:level="1"><nlm:aff id="aff7">National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Barakat, Maha" sort="Barakat, Maha" uniqKey="Barakat M" first="Maha" last="Barakat">Maha Barakat</name><affiliation wicri:level="1"><nlm:aff id="aff11">Health Authority-Abu Dhabi, Abu Dhabi, United Arab Emirates</nlm:aff><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Health Authority-Abu Dhabi, Abu Dhabi</wicri:regionArea><wicri:noRegion>Abu Dhabi</wicri:noRegion></affiliation></author><author><name sortKey="Zaki, Sherif R" sort="Zaki, Sherif R" uniqKey="Zaki S" first="Sherif R." last="Zaki">Sherif R. Zaki</name><affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Infectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author></analytic><series><title level="j">The American Journal of Pathology</title><idno type="ISSN">0002-9440</idno><idno type="eISSN">1525-2191</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus Infections (pathology)</term><term>Dipeptidyl Peptidase 4 (immunology)</term><term>Fatal Outcome</term><term>Humans</term><term>Immunohistochemistry</term><term>Lung (diagnostic imaging)</term><term>Lung (pathology)</term><term>Lung (ultrastructure)</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Radiography</term><term>United Arab Emirates</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Dipeptidyl peptidase 4 (immunologie)</term><term>Humains</term><term>Immunohistochimie</term><term>Infections à coronavirus (anatomopathologie)</term><term>Issue fatale</term><term>Mâle</term><term>Poumon (anatomopathologie)</term><term>Poumon (imagerie diagnostique)</term><term>Poumon (ultrastructure)</term><term>Radiographie</term><term>Émirats arabes unis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Dipeptidyl Peptidase 4</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Dipeptidyl peptidase 4</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Fatal Outcome</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Radiography</term><term>United Arab Emirates</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Humains</term><term>Immunohistochimie</term><term>Issue fatale</term><term>Mâle</term><term>Poumon</term><term>Radiographie</term><term>Émirats arabes unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome coronavirus (MERS-CoV) infection causes an acute respiratory illness and is associated with a high case fatality rate; however, the pathogenesis of severe and fatal MERS-CoV infection is unknown. We describe the histopathologic, immunohistochemical, and ultrastructural findings from the first autopsy performed on a fatal case of MERS-CoV in the world, which was related to a hospital outbreak in the United Arab Emirates in April 2014. The main histopathologic finding in the lungs was diffuse alveolar damage. Evidence of chronic disease, including severe peripheral vascular disease, patchy cardiac fibrosis, and hepatic steatosis, was noted in the other organs. Double staining immunoassays that used anti–MERS-CoV antibodies paired with immunohistochemistry for cytokeratin and surfactant identified pneumocytes and epithelial syncytial cells as important targets of MERS-CoV antigen; double immunostaining with dipeptidyl peptidase 4 showed colocalization in scattered pneumocytes and syncytial cells. No evidence of extrapulmonary MERS-CoV antigens were detected, including the kidney. These results provide critical insights into the pathogenesis of MERS-CoV in humans.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M. Bestebroer</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Azhar, E I" uniqKey="Azhar E">E.I. Azhar</name></author><author><name sortKey="El Kafrawy, S A" uniqKey="El Kafrawy S">S.A. El-Kafrawy</name></author><author><name sortKey="Farraj, S A" uniqKey="Farraj S">S.A. Farraj</name></author><author><name sortKey="Hassan, A M" uniqKey="Hassan A">A.M. Hassan</name></author><author><name sortKey="Al Saeed, M S" uniqKey="Al Saeed M">M.S. Al-Saeed</name></author><author><name sortKey="Hashem, A M" uniqKey="Hashem A">A.M. Hashem</name></author><author><name sortKey="Madani, T A" uniqKey="Madani T">T.A. Madani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L. Haagmans</name></author><author><name sortKey="Al Dhahiry, S H" uniqKey="Al Dhahiry S">S.H. Al Dhahiry</name></author><author><name sortKey="Reusken, C B" uniqKey="Reusken C">C.B. Reusken</name></author><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S. Raj</name></author><author><name sortKey="Galiano, M" uniqKey="Galiano M">M. Galiano</name></author><author><name sortKey="Myers, R" uniqKey="Myers R">R. Myers</name></author><author><name sortKey="Godeke, G J" uniqKey="Godeke G">G.J. Godeke</name></author><author><name sortKey="Jonges, M" uniqKey="Jonges M">M. Jonges</name></author><author><name sortKey="Farag, E" uniqKey="Farag E">E. Farag</name></author><author><name sortKey="Diab, A" uniqKey="Diab A">A. Diab</name></author><author><name sortKey="Ghobashy, H" uniqKey="Ghobashy H">H. Ghobashy</name></author><author><name sortKey="Alhajri, F" uniqKey="Alhajri F">F. Alhajri</name></author><author><name sortKey="Al Thani, M" uniqKey="Al Thani M">M. Al-Thani</name></author><author><name sortKey="Al Marri, S A" uniqKey="Al Marri S">S.A. Al-Marri</name></author><author><name sortKey="Al Romaihi, H E" uniqKey="Al Romaihi H">H.E. Al Romaihi</name></author><author><name sortKey="Al Khal, A" uniqKey="Al Khal A">A. Al Khal</name></author><author><name sortKey="Bermingham, A" uniqKey="Bermingham A">A. Bermingham</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Alhajri, M M" uniqKey="Alhajri M">M.M. AlHajri</name></author><author><name sortKey="Koopmans, M P" uniqKey="Koopmans M">M.P. Koopmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A. Assiri</name></author><author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A. McGeer</name></author><author><name sortKey="Perl, T M" uniqKey="Perl T">T.M. Perl</name></author><author><name sortKey="Price, C S" uniqKey="Price C">C.S. Price</name></author><author><name sortKey="Al Rabeeah, A A" uniqKey="Al Rabeeah A">A.A. Al Rabeeah</name></author><author><name sortKey="Cummings, D A" uniqKey="Cummings D">D.A. Cummings</name></author><author><name sortKey="Alabdullatif, Z N" uniqKey="Alabdullatif Z">Z.N. Alabdullatif</name></author><author><name sortKey="Assad, M" uniqKey="Assad M">M. Assad</name></author><author><name sortKey="Almulhim, A" uniqKey="Almulhim A">A. Almulhim</name></author><author><name sortKey="Makhdoom, H" uniqKey="Makhdoom H">H. Makhdoom</name></author><author><name sortKey="Madani, H" uniqKey="Madani H">H. Madani</name></author><author><name sortKey="Alhakeem, R" uniqKey="Alhakeem R">R. Alhakeem</name></author><author><name sortKey="Al Tawfiq, J A" uniqKey="Al Tawfiq J">J.A. Al-Tawfiq</name></author><author><name sortKey="Cotten, M" uniqKey="Cotten M">M. Cotten</name></author><author><name sortKey="Watson, S J" uniqKey="Watson S">S.J. Watson</name></author><author><name sortKey="Kellam, P" uniqKey="Kellam P">P. Kellam</name></author><author><name sortKey="Zumla, A I" uniqKey="Zumla A">A.I. Zumla</name></author><author><name sortKey="Memish, Z A" uniqKey="Memish Z">Z.A. Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Abdallat, M M" uniqKey="Al Abdallat M">M.M. Al-Abdallat</name></author><author><name sortKey="Payne, D C" uniqKey="Payne D">D.C. Payne</name></author><author><name sortKey="Alqasrawi, S" uniqKey="Alqasrawi S">S. Alqasrawi</name></author><author><name sortKey="Rha, B" uniqKey="Rha B">B. Rha</name></author><author><name sortKey="Tohme, R A" uniqKey="Tohme R">R.A. Tohme</name></author><author><name sortKey="Abedi, G R" uniqKey="Abedi G">G.R. Abedi</name></author><author><name sortKey="Al Nsour, M" uniqKey="Al Nsour M">M. Al Nsour</name></author><author><name sortKey="Iblan, I" uniqKey="Iblan I">I. Iblan</name></author><author><name sortKey="Jarour, N" uniqKey="Jarour N">N. Jarour</name></author><author><name sortKey="Farag, N H" uniqKey="Farag N">N.H. Farag</name></author><author><name sortKey="Haddadin, A" uniqKey="Haddadin A">A. Haddadin</name></author><author><name sortKey="Al Sanouri, T" uniqKey="Al Sanouri T">T. Al-Sanouri</name></author><author><name sortKey="Tamin, A" uniqKey="Tamin A">A. Tamin</name></author><author><name sortKey="Harcourt, J L" uniqKey="Harcourt J">J.L. Harcourt</name></author><author><name sortKey="Kuhar, D T" uniqKey="Kuhar D">D.T. Kuhar</name></author><author><name sortKey="Swerdlow, D L" uniqKey="Swerdlow D">D.L. Swerdlow</name></author><author><name sortKey="Erdman, D D" uniqKey="Erdman D">D.D. Erdman</name></author><author><name sortKey="Pallansch, M A" uniqKey="Pallansch M">M.A. Pallansch</name></author><author><name sortKey="Haynes, L M" uniqKey="Haynes L">L.M. Haynes</name></author><author><name sortKey="Gerber, S I" uniqKey="Gerber S">S.I. Gerber</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A. Assiri</name></author><author><name sortKey="Al Tawfiq, J A" uniqKey="Al Tawfiq J">J.A. Al-Tawfiq</name></author><author><name sortKey="Al Rabeeah, A A" uniqKey="Al Rabeeah A">A.A. Al-Rabeeah</name></author><author><name sortKey="Al Rabiah, F A" uniqKey="Al Rabiah F">F.A. Al-Rabiah</name></author><author><name sortKey="Al Hajjar, S" uniqKey="Al Hajjar S">S. Al-Hajjar</name></author><author><name sortKey="Al Barrak, A" uniqKey="Al Barrak A">A. Al-Barrak</name></author><author><name sortKey="Flemban, H" uniqKey="Flemban H">H. Flemban</name></author><author><name sortKey="Al Nassir, W N" uniqKey="Al Nassir W">W.N. Al-Nassir</name></author><author><name sortKey="Balkhy, H H" uniqKey="Balkhy H">H.H. Balkhy</name></author><author><name sortKey="Al Hakeem, R F" uniqKey="Al Hakeem R">R.F. Al-Hakeem</name></author><author><name sortKey="Makhdoom, H Q" uniqKey="Makhdoom H">H.Q. Makhdoom</name></author><author><name sortKey="Zumla, A I" uniqKey="Zumla A">A.I. Zumla</name></author><author><name sortKey="Memish, Z A" uniqKey="Memish Z">Z.A. Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saad, M" uniqKey="Saad M">M. Saad</name></author><author><name sortKey="Omrani, A S" uniqKey="Omrani A">A.S. Omrani</name></author><author><name sortKey="Baig, K" uniqKey="Baig K">K. Baig</name></author><author><name sortKey="Bahloul, A" uniqKey="Bahloul A">A. Bahloul</name></author><author><name sortKey="Elzein, F" uniqKey="Elzein F">F. Elzein</name></author><author><name sortKey="Matin, M A" uniqKey="Matin M">M.A. Matin</name></author><author><name sortKey="Selim, M A" uniqKey="Selim M">M.A. Selim</name></author><author><name sortKey="Al Mutairi, M" uniqKey="Al Mutairi M">M. Al Mutairi</name></author><author><name sortKey="Al Nakhli, D" uniqKey="Al Nakhli D">D. Al Nakhli</name></author><author><name sortKey="Al Aidaroos, A Y" uniqKey="Al Aidaroos A">A.Y. Al Aidaroos</name></author><author><name sortKey="Al Sherbeeni, N" uniqKey="Al Sherbeeni N">N. Al Sherbeeni</name></author><author><name sortKey="Al Khashan, H I" uniqKey="Al Khashan H">H.I. Al-Khashan</name></author><author><name sortKey="Memish, Z A" uniqKey="Memish Z">Z.A. Memish</name></author><author><name sortKey="Albarrak, A M" uniqKey="Albarrak A">A.M. Albarrak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arabi, Y M" uniqKey="Arabi Y">Y.M. Arabi</name></author><author><name sortKey="Arifi, A A" uniqKey="Arifi A">A.A. Arifi</name></author><author><name sortKey="Balkhy, H H" uniqKey="Balkhy H">H.H. Balkhy</name></author><author><name sortKey="Najm, H" uniqKey="Najm H">H. Najm</name></author><author><name sortKey="Aldawood, A S" uniqKey="Aldawood A">A.S. Aldawood</name></author><author><name sortKey="Ghabashi, A" uniqKey="Ghabashi A">A. Ghabashi</name></author><author><name sortKey="Hawa, H" uniqKey="Hawa H">H. Hawa</name></author><author><name sortKey="Alothman, A" uniqKey="Alothman A">A. Alothman</name></author><author><name sortKey="Khaldi, A" uniqKey="Khaldi A">A. Khaldi</name></author><author><name sortKey="Al Raiy, B" uniqKey="Al Raiy B">B. Al Raiy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S. Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H. Mou</name></author><author><name sortKey="Smits, S L" uniqKey="Smits S">S.L. Smits</name></author><author><name sortKey="Dekkers, D H" uniqKey="Dekkers D">D.H. Dekkers</name></author><author><name sortKey="Muller, M A" uniqKey="Muller M">M.A. Müller</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R. Dijkman</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D. Muth</name></author><author><name sortKey="Demmers, J A" uniqKey="Demmers J">J.A. Demmers</name></author><author><name sortKey="Zaki, A" uniqKey="Zaki A">A. Zaki</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Rottier, P J" uniqKey="Rottier P">P.J. Rottier</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B.J. Bosch</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L. Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Engel, R M" uniqKey="Engel R">R.M. Engel</name></author><author><name sortKey="Morris, M" uniqKey="Morris M">M. Morris</name></author><author><name sortKey="Henning, T" uniqKey="Henning T">T. Henning</name></author><author><name sortKey="Ritter, J M" uniqKey="Ritter J">J.M. Ritter</name></author><author><name sortKey="Jones, T L" uniqKey="Jones T">T.L. Jones</name></author><author><name sortKey="Dietz, S" uniqKey="Dietz S">S. Dietz</name></author><author><name sortKey="Ayers, J" uniqKey="Ayers J">J. Ayers</name></author><author><name sortKey="Vishwanathan, S A" uniqKey="Vishwanathan S">S.A. Vishwanathan</name></author><author><name sortKey="Jenkins, L" uniqKey="Jenkins L">L. Jenkins</name></author><author><name sortKey="Zaki, S" uniqKey="Zaki S">S. Zaki</name></author><author><name sortKey="Wildemeersch, D" uniqKey="Wildemeersch D">D. Wildemeersch</name></author><author><name sortKey="Garber, D" uniqKey="Garber D">D. Garber</name></author><author><name sortKey="Powell, N" uniqKey="Powell N">N. Powell</name></author><author><name sortKey="Hendry, R M" uniqKey="Hendry R">R.M. Hendry</name></author><author><name sortKey="Mcnicholl, J" uniqKey="Mcnicholl J">J. McNicholl</name></author><author><name sortKey="Kersh, E N" uniqKey="Kersh E">E.N. Kersh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paddock, C D" uniqKey="Paddock C">C.D. Paddock</name></author><author><name sortKey="Sanden, G N" uniqKey="Sanden G">G.N. Sanden</name></author><author><name sortKey="Cherry, J D" uniqKey="Cherry J">J.D. Cherry</name></author><author><name sortKey="Gal, A A" uniqKey="Gal A">A.A. Gal</name></author><author><name sortKey="Langston, C" uniqKey="Langston C">C. Langston</name></author><author><name sortKey="Tatti, K M" uniqKey="Tatti K">K.M. Tatti</name></author><author><name sortKey="Wu, K H" uniqKey="Wu K">K.H. Wu</name></author><author><name sortKey="Goldsmith, C S" uniqKey="Goldsmith C">C.S. Goldsmith</name></author><author><name sortKey="Greer, P W" uniqKey="Greer P">P.W. Greer</name></author><author><name sortKey="Montague, J L" uniqKey="Montague J">J.L. Montague</name></author><author><name sortKey="Eliason, M T" uniqKey="Eliason M">M.T. Eliason</name></author><author><name sortKey="Holman, R C" uniqKey="Holman R">R.C. Holman</name></author><author><name sortKey="Guarner, J" uniqKey="Guarner J">J. Guarner</name></author><author><name sortKey="Shieh, W J" uniqKey="Shieh W">W.J. Shieh</name></author><author><name sortKey="Zaki, S R" uniqKey="Zaki S">S.R. Zaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cotten, M" uniqKey="Cotten M">M. Cotten</name></author><author><name sortKey="Lam, T T" uniqKey="Lam T">T.T. Lam</name></author><author><name sortKey="Watson, S J" uniqKey="Watson S">S.J. Watson</name></author><author><name sortKey="Palser, A L" uniqKey="Palser A">A.L. Palser</name></author><author><name sortKey="Petrova, V" uniqKey="Petrova V">V. Petrova</name></author><author><name sortKey="Grant, P" uniqKey="Grant P">P. Grant</name></author><author><name sortKey="Pybus, O G" uniqKey="Pybus O">O.G. Pybus</name></author><author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A. Rambaut</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Pillay, D" uniqKey="Pillay D">D. Pillay</name></author><author><name sortKey="Kellam, P" uniqKey="Kellam P">P. Kellam</name></author><author><name sortKey="Nastouli, E" uniqKey="Nastouli E">E. Nastouli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Larkin, M A" uniqKey="Larkin M">M.A. Larkin</name></author><author><name sortKey="Blackshields, G" uniqKey="Blackshields G">G. Blackshields</name></author><author><name sortKey="Brown, N P" uniqKey="Brown N">N.P. Brown</name></author><author><name sortKey="Chenna, R" uniqKey="Chenna R">R. Chenna</name></author><author><name sortKey="Mcgettigan, P A" uniqKey="Mcgettigan P">P.A. McGettigan</name></author><author><name sortKey="Mcwilliam, H" uniqKey="Mcwilliam H">H. McWilliam</name></author><author><name sortKey="Valentin, F" uniqKey="Valentin F">F. Valentin</name></author><author><name sortKey="Wallace, I M" uniqKey="Wallace I">I.M. Wallace</name></author><author><name sortKey="Wilm, A" uniqKey="Wilm A">A. Wilm</name></author><author><name sortKey="Lopez, R" uniqKey="Lopez R">R. Lopez</name></author><author><name sortKey="Thompson, J D" uniqKey="Thompson J">J.D. Thompson</name></author><author><name sortKey="Gibson, T J" uniqKey="Gibson T">T.J. Gibson</name></author><author><name sortKey="Higgins, D G" uniqKey="Higgins D">D.G. Higgins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huelsenbeck, J P" uniqKey="Huelsenbeck J">J.P. Huelsenbeck</name></author><author><name sortKey="Ronquist, F" uniqKey="Ronquist F">F. Ronquist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name></author><author><name sortKey="Whitaker, B" uniqKey="Whitaker B">B. Whitaker</name></author><author><name sortKey="Sakthivel, S K" uniqKey="Sakthivel S">S.K. Sakthivel</name></author><author><name sortKey="Kamili, S" uniqKey="Kamili S">S. Kamili</name></author><author><name sortKey="Rose, L E" uniqKey="Rose L">L.E. Rose</name></author><author><name sortKey="Lowe, L" uniqKey="Lowe L">L. Lowe</name></author><author><name sortKey="Mohareb, E" uniqKey="Mohareb E">E. Mohareb</name></author><author><name sortKey="Elassal, E M" uniqKey="Elassal E">E.M. Elassal</name></author><author><name sortKey="Al Sanouri, T" uniqKey="Al Sanouri T">T. Al-sanouri</name></author><author><name sortKey="Haddadin, A" uniqKey="Haddadin A">A. Haddadin</name></author><author><name sortKey="Erdman, D D" uniqKey="Erdman D">D.D. Erdman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hocke, A C" uniqKey="Hocke A">A.C. Hocke</name></author><author><name sortKey="Becher, A" uniqKey="Becher A">A. Becher</name></author><author><name sortKey="Knepper, J" uniqKey="Knepper J">J. Knepper</name></author><author><name sortKey="Peter, A" uniqKey="Peter A">A. Peter</name></author><author><name sortKey="Holland, G" uniqKey="Holland G">G. Holland</name></author><author><name sortKey="Tonnies, M" uniqKey="Tonnies M">M. Tonnies</name></author><author><name sortKey="Bauer, T T" uniqKey="Bauer T">T.T. Bauer</name></author><author><name sortKey="Schneider, P" uniqKey="Schneider P">P. Schneider</name></author><author><name sortKey="Neudecker, J" uniqKey="Neudecker J">J. Neudecker</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D. Muth</name></author><author><name sortKey="Wendtner, C M" uniqKey="Wendtner C">C.M. Wendtner</name></author><author><name sortKey="Ruckert, J C" uniqKey="Ruckert J">J.C. Ruckert</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Gruber, A D" uniqKey="Gruber A">A.D. Gruber</name></author><author><name sortKey="Laue, M" uniqKey="Laue M">M. Laue</name></author><author><name sortKey="Suttorp, N" uniqKey="Suttorp N">N. Suttorp</name></author><author><name sortKey="Hippenstiel, S" uniqKey="Hippenstiel S">S. Hippenstiel</name></author><author><name sortKey="Wolff, T" uniqKey="Wolff T">T. Wolff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poissy, J" uniqKey="Poissy J">J. Poissy</name></author><author><name sortKey="Goffard, A" uniqKey="Goffard A">A. Goffard</name></author><author><name sortKey="Parmentier Decrucq, E" uniqKey="Parmentier Decrucq E">E. Parmentier-Decrucq</name></author><author><name sortKey="Favory, R" uniqKey="Favory R">R. Favory</name></author><author><name sortKey="Kauv, M" uniqKey="Kauv M">M. Kauv</name></author><author><name sortKey="Kipnis, E" uniqKey="Kipnis E">E. Kipnis</name></author><author><name sortKey="Mathieu, D" uniqKey="Mathieu D">D. Mathieu</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S. van der Werf</name></author><author><name sortKey="Guery, B" uniqKey="Guery B">B. Guery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Seilmaier, M" uniqKey="Seilmaier M">M. Seilmaier</name></author><author><name sortKey="Corman, V M" uniqKey="Corman V">V.M. Corman</name></author><author><name sortKey="Hartmann, W" uniqKey="Hartmann W">W. Hartmann</name></author><author><name sortKey="Scheible, G" uniqKey="Scheible G">G. Scheible</name></author><author><name sortKey="Sack, S" uniqKey="Sack S">S. Sack</name></author><author><name sortKey="Guggemos, W" uniqKey="Guggemos W">W. Guggemos</name></author><author><name sortKey="Kallies, R" uniqKey="Kallies R">R. Kallies</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D. Muth</name></author><author><name sortKey="Junglen, S" uniqKey="Junglen S">S. Junglen</name></author><author><name sortKey="Muller, M A" uniqKey="Muller M">M.A. Müller</name></author><author><name sortKey="Haas, W" uniqKey="Haas W">W. Haas</name></author><author><name sortKey="Guberina, H" uniqKey="Guberina H">H. Guberina</name></author><author><name sortKey="Rohnisch, T" uniqKey="Rohnisch T">T. Röhnisch</name></author><author><name sortKey="Schmid Wendtner, M" uniqKey="Schmid Wendtner M">M. Schmid-Wendtner</name></author><author><name sortKey="Aldabbagh, S" uniqKey="Aldabbagh S">S. Aldabbagh</name></author><author><name sortKey="Dittmer, U" uniqKey="Dittmer U">U. Dittmer</name></author><author><name sortKey="Gold, H" uniqKey="Gold H">H. Gold</name></author><author><name sortKey="Graf, P" uniqKey="Graf P">P. Graf</name></author><author><name sortKey="Bonin, F" uniqKey="Bonin F">F. Bonin</name></author><author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A. Rambaut</name></author><author><name sortKey="Wendtner, C" uniqKey="Wendtner C">C. Wendtner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nicholls, J M" uniqKey="Nicholls J">J.M. Nicholls</name></author><author><name sortKey="Butany, J" uniqKey="Butany J">J. Butany</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Beh, S L" uniqKey="Beh S">S.L. Beh</name></author><author><name sortKey="Poutanen, S" uniqKey="Poutanen S">S. Poutanen</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Wong, M" uniqKey="Wong M">M. Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, R W" uniqKey="Chan R">R.W. Chan</name></author><author><name sortKey="Hemida, M G" uniqKey="Hemida M">M.G. Hemida</name></author><author><name sortKey="Kayali, G" uniqKey="Kayali G">G. Kayali</name></author><author><name sortKey="Chu, D K" uniqKey="Chu D">D.K. Chu</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Alnaeem, A" uniqKey="Alnaeem A">A. Alnaeem</name></author><author><name sortKey="Ali, M A" uniqKey="Ali M">M.A. Ali</name></author><author><name sortKey="Tao, K P" uniqKey="Tao K">K.P. Tao</name></author><author><name sortKey="Ng, H Y" uniqKey="Ng H">H.Y. Ng</name></author><author><name sortKey="Chan, M C" uniqKey="Chan M">M.C. Chan</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Nicholls, J M" uniqKey="Nicholls J">J.M. Nicholls</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Moore, M J" uniqKey="Moore M">M.J. Moore</name></author><author><name sortKey="Vasilieva, N" uniqKey="Vasilieva N">N. Vasilieva</name></author><author><name sortKey="Sui, J" uniqKey="Sui J">J. Sui</name></author><author><name sortKey="Wong, S K" uniqKey="Wong S">S.K. Wong</name></author><author><name sortKey="Berne, M A" uniqKey="Berne M">M.A. Berne</name></author><author><name sortKey="Somasundaran, M" uniqKey="Somasundaran M">M. Somasundaran</name></author><author><name sortKey="Sullivan, J L" uniqKey="Sullivan J">J.L. Sullivan</name></author><author><name sortKey="Luzuriaga, K" uniqKey="Luzuriaga K">K. Luzuriaga</name></author><author><name sortKey="Greenough, T C" uniqKey="Greenough T">T.C. Greenough</name></author><author><name sortKey="Choe, H" uniqKey="Choe H">H. Choe</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M. Farzan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamming, I" uniqKey="Hamming I">I. Hamming</name></author><author><name sortKey="Timens, W" uniqKey="Timens W">W. Timens</name></author><author><name sortKey="Bulthuis, M L" uniqKey="Bulthuis M">M.L. Bulthuis</name></author><author><name sortKey="Lely, A T" uniqKey="Lely A">A.T. Lely</name></author><author><name sortKey="Navis, G" uniqKey="Navis G">G. Navis</name></author><author><name sortKey="Van Goor, H" uniqKey="Van Goor H">H. van Goor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mossel, E C" uniqKey="Mossel E">E.C. Mossel</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author><author><name sortKey="Jeffers, S" uniqKey="Jeffers S">S. Jeffers</name></author><author><name sortKey="Edeen, K E" uniqKey="Edeen K">K.E. Edeen</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name></author><author><name sortKey="Cosgrove, G P" uniqKey="Cosgrove G">G.P. Cosgrove</name></author><author><name sortKey="Funk, C J" uniqKey="Funk C">C.J. Funk</name></author><author><name sortKey="Manzer, R" uniqKey="Manzer R">R. Manzer</name></author><author><name sortKey="Miura, T A" uniqKey="Miura T">T.A. Miura</name></author><author><name sortKey="Pearson, L D" uniqKey="Pearson L">L.D. Pearson</name></author><author><name sortKey="Holmes, K V" uniqKey="Holmes K">K.V. Holmes</name></author><author><name sortKey="Mason, R J" uniqKey="Mason R">R.J. Mason</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shieh, W J" uniqKey="Shieh W">W.J. Shieh</name></author><author><name sortKey="Hsiao, C H" uniqKey="Hsiao C">C.H. Hsiao</name></author><author><name sortKey="Paddock, C D" uniqKey="Paddock C">C.D. Paddock</name></author><author><name sortKey="Guarner, J" uniqKey="Guarner J">J. Guarner</name></author><author><name sortKey="Goldsmith, C S" uniqKey="Goldsmith C">C.S. Goldsmith</name></author><author><name sortKey="Tatti, K" uniqKey="Tatti K">K. Tatti</name></author><author><name sortKey="Packard, M" uniqKey="Packard M">M. Packard</name></author><author><name sortKey="Mueller, L" uniqKey="Mueller L">L. Mueller</name></author><author><name sortKey="Wu, M Z" uniqKey="Wu M">M.Z. Wu</name></author><author><name sortKey="Rollin, P" uniqKey="Rollin P">P. Rollin</name></author><author><name sortKey="Su, I J" uniqKey="Su I">I.J. Su</name></author><author><name sortKey="Zaki, S R" uniqKey="Zaki S">S.R. Zaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gu, J" uniqKey="Gu J">J. Gu</name></author><author><name sortKey="Gong, E" uniqKey="Gong E">E. Gong</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B. Zhang</name></author><author><name sortKey="Zheng, J" uniqKey="Zheng J">J. Zheng</name></author><author><name sortKey="Gao, Z" uniqKey="Gao Z">Z. Gao</name></author><author><name sortKey="Zhong, Y" uniqKey="Zhong Y">Y. Zhong</name></author><author><name sortKey="Zou, W" uniqKey="Zou W">W. Zou</name></author><author><name sortKey="Zhan, J" uniqKey="Zhan J">J. Zhan</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name></author><author><name sortKey="Xie, Z" uniqKey="Xie Z">Z. Xie</name></author><author><name sortKey="Zhuang, H" uniqKey="Zhuang H">H. Zhuang</name></author><author><name sortKey="Wu, B" uniqKey="Wu B">B. Wu</name></author><author><name sortKey="Zhong, H" uniqKey="Zhong H">H. Zhong</name></author><author><name sortKey="Shao, H" uniqKey="Shao H">H. Shao</name></author><author><name sortKey="Fang, W" uniqKey="Fang W">W. Fang</name></author><author><name sortKey="Gao, D" uniqKey="Gao D">D. Gao</name></author><author><name sortKey="Pei, F" uniqKey="Pei F">F. Pei</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="He, Z" uniqKey="He Z">Z. He</name></author><author><name sortKey="Xu, D" uniqKey="Xu D">D. Xu</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X. Shi</name></author><author><name sortKey="Anderson, V M" uniqKey="Anderson V">V.M. Anderson</name></author><author><name sortKey="Leong, A S" uniqKey="Leong A">A.S. Leong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dellinger, R P" uniqKey="Dellinger R">R.P. Dellinger</name></author><author><name sortKey="Levy, M M" uniqKey="Levy M">M.M. Levy</name></author><author><name sortKey="Rhodes, A" uniqKey="Rhodes A">A. Rhodes</name></author><author><name sortKey="Annane, D" uniqKey="Annane D">D. Annane</name></author><author><name sortKey="Gerlach, H" uniqKey="Gerlach H">H. Gerlach</name></author><author><name sortKey="Opal, S M" uniqKey="Opal S">S.M. Opal</name></author><author><name sortKey="Sevransky, J E" uniqKey="Sevransky J">J.E. Sevransky</name></author><author><name sortKey="Sprung, C L" uniqKey="Sprung C">C.L. Sprung</name></author><author><name sortKey="Douglas, I S" uniqKey="Douglas I">I.S. Douglas</name></author><author><name sortKey="Jaeschke, R" uniqKey="Jaeschke R">R. Jaeschke</name></author><author><name sortKey="Osborn, T M" uniqKey="Osborn T">T.M. Osborn</name></author><author><name sortKey="Nunnally, M E" uniqKey="Nunnally M">M.E. Nunnally</name></author><author><name sortKey="Townsend, S R" uniqKey="Townsend S">S.R. Townsend</name></author><author><name sortKey="Reinhart, K" uniqKey="Reinhart K">K. Reinhart</name></author><author><name sortKey="Kleinpell, R M" uniqKey="Kleinpell R">R.M. Kleinpell</name></author><author><name sortKey="Angus, D C" uniqKey="Angus D">D.C. Angus</name></author><author><name sortKey="Deutschman, C S" uniqKey="Deutschman C">C.S. Deutschman</name></author><author><name sortKey="Machado, F R" uniqKey="Machado F">F.R. Machado</name></author><author><name sortKey="Rubenfeld, G D" uniqKey="Rubenfeld G">G.D. Rubenfeld</name></author><author><name sortKey="Webb, S" uniqKey="Webb S">S. Webb</name></author><author><name sortKey="Beale, R J" uniqKey="Beale R">R.J. Beale</name></author><author><name sortKey="Vincent, J L" uniqKey="Vincent J">J.L. Vincent</name></author><author><name sortKey="Moreno, R" uniqKey="Moreno R">R. Moreno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stockman, L J" uniqKey="Stockman L">L.J. Stockman</name></author><author><name sortKey="Bellamy, R" uniqKey="Bellamy R">R. Bellamy</name></author><author><name sortKey="Garner, P" uniqKey="Garner P">P. Garner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Sun, W" uniqKey="Sun W">W. Sun</name></author><author><name sortKey="Svendsen, E R" uniqKey="Svendsen E">E.R. Svendsen</name></author><author><name sortKey="Tang, S" uniqKey="Tang S">S. Tang</name></author><author><name sortKey="Macintyre, R C" uniqKey="Macintyre R">R.C. MacIntyre</name></author><author><name sortKey="Yang, P" uniqKey="Yang P">P. Yang</name></author><author><name sortKey="Zhang, D" uniqKey="Zhang D">D. Zhang</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q. Wang</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Géorgie (pays)</li><li>Émirats arabes unis</li></country></list><tree><country name="Géorgie (pays)"><noRegion><name sortKey="Ng, Dianna L" sort="Ng, Dianna L" uniqKey="Ng D" first="Dianna L." last="Ng">Dianna L. Ng</name></noRegion><name sortKey="Alami, Negar N" sort="Alami, Negar N" uniqKey="Alami N" first="Negar N." last="Alami">Negar N. Alami</name><name sortKey="Alami, Negar N" sort="Alami, Negar N" uniqKey="Alami N" first="Negar N." last="Alami">Negar N. Alami</name><name sortKey="Gerber, Susan I" sort="Gerber, Susan I" uniqKey="Gerber S" first="Susan I." last="Gerber">Susan I. Gerber</name><name sortKey="Haynes, Lia M" sort="Haynes, Lia M" uniqKey="Haynes L" first="Lia M." last="Haynes">Lia M. Haynes</name><name sortKey="Jones, Tara L" sort="Jones, Tara L" uniqKey="Jones T" first="Tara L." last="Jones">Tara L. Jones</name><name sortKey="Keating, M Kelly" sort="Keating, M Kelly" uniqKey="Keating M" first="M. Kelly" last="Keating">M. Kelly Keating</name><name sortKey="Metcalfe, Maureen G" sort="Metcalfe, Maureen G" uniqKey="Metcalfe M" first="Maureen G." last="Metcalfe">Maureen G. Metcalfe</name><name sortKey="Swerdlow, David L" sort="Swerdlow, David L" uniqKey="Swerdlow D" first="David L." last="Swerdlow">David L. Swerdlow</name><name sortKey="Tao, Ying" sort="Tao, Ying" uniqKey="Tao Y" first="Ying" last="Tao">Ying Tao</name><name sortKey="Tong, Suxiang" sort="Tong, Suxiang" uniqKey="Tong S" first="Suxiang" last="Tong">Suxiang Tong</name><name sortKey="Uyeki, Timothy M" sort="Uyeki, Timothy M" uniqKey="Uyeki T" first="Timothy M." last="Uyeki">Timothy M. Uyeki</name><name sortKey="Zaki, Sherif R" sort="Zaki, Sherif R" uniqKey="Zaki S" first="Sherif R." last="Zaki">Sherif R. Zaki</name></country><country name="Émirats arabes unis"><noRegion><name sortKey="Al Hosani, Farida" sort="Al Hosani, Farida" uniqKey="Al Hosani F" first="Farida" last="Al Hosani">Farida Al Hosani</name></noRegion><name sortKey="Abdel Wareth, Laila" sort="Abdel Wareth, Laila" uniqKey="Abdel Wareth L" first="Laila" last="Abdel-Wareth">Laila Abdel-Wareth</name><name sortKey="Barakat, Maha" sort="Barakat, Maha" uniqKey="Barakat M" first="Maha" last="Barakat">Maha Barakat</name><name sortKey="Mutei, Mowafaq Ali" sort="Mutei, Mowafaq Ali" uniqKey="Mutei M" first="Mowafaq Ali" last="Mutei">Mowafaq Ali Mutei</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001337 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001337 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:7093852
|texte= Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26857507" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |