Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus
Identifieur interne : 001303 ( Main/Exploration ); précédent : 001302; suivant : 001304Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus
Auteurs : Timothy M. Uyeki ; Karl J. Erlandson ; George Korch ; Michael O Ara ; Michael Wathen ; Jean Hu-Primmer ; Sally Hojvat ; Erik J. Stemmy ; Armen DonabedianSource :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Vaccins antiviraux.
- médecine vétérinaire : Infections à coronavirus.
- virologie : Infections à coronavirus.
- Animaux, Chameaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Infections à coronavirus, Modèles animaux de maladie humaine.
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Viral Vaccines.
- prevention & control : Coronavirus Infections.
- veterinary : Coronavirus Infections.
- virology : Coronavirus Infections.
- Animals, Camelus, Disease Models, Animal, Humans, Middle East Respiratory Syndrome Coronavirus.
Abstract
Preclinical development of and research on potential Middle East respiratory syndrome coronavirus (MERS-CoV) medical countermeasures remain preliminary; advancements are needed before most countermeasures are ready to be tested in human clinical trials. Research priorities include standardization of animal models and virus stocks for studying disease pathogenesis and efficacy of medical countermeasures; development of MERS-CoV diagnostics; improved access to nonhuman primates to support preclinical research; studies to better understand and control MERS-CoV disease, including vaccination studies in camels; and development of a standardized clinical trial protocol. Partnering with clinical trial networks in affected countries to evaluate safety and efficacy of investigational therapeutics will strengthen efforts to identify successful medical countermeasures.
Url:
DOI: 10.3201/eid2207.160022
PubMed: 27191188
PubMed Central: 4918159
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000074
- to stream Pmc, to step Curation: 000074
- to stream Pmc, to step Checkpoint: 000C00
- to stream PubMed, to step Corpus: 001114
- to stream PubMed, to step Curation: 001114
- to stream PubMed, to step Checkpoint: 001149
- to stream Ncbi, to step Merge: 001631
- to stream Ncbi, to step Curation: 001631
- to stream Ncbi, to step Checkpoint: 001631
- to stream Main, to step Merge: 001307
- to stream Main, to step Curation: 001303
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus</title>
<author><name sortKey="Uyeki, Timothy M" sort="Uyeki, Timothy M" uniqKey="Uyeki T" first="Timothy M." last="Uyeki">Timothy M. Uyeki</name>
</author>
<author><name sortKey="Erlandson, Karl J" sort="Erlandson, Karl J" uniqKey="Erlandson K" first="Karl J." last="Erlandson">Karl J. Erlandson</name>
</author>
<author><name sortKey="Korch, George" sort="Korch, George" uniqKey="Korch G" first="George" last="Korch">George Korch</name>
</author>
<author><name sortKey="O Ara, Michael" sort="O Ara, Michael" uniqKey="O Ara M" first="Michael" last="O Ara">Michael O Ara</name>
</author>
<author><name sortKey="Wathen, Michael" sort="Wathen, Michael" uniqKey="Wathen M" first="Michael" last="Wathen">Michael Wathen</name>
</author>
<author><name sortKey="Hu Primmer, Jean" sort="Hu Primmer, Jean" uniqKey="Hu Primmer J" first="Jean" last="Hu-Primmer">Jean Hu-Primmer</name>
</author>
<author><name sortKey="Hojvat, Sally" sort="Hojvat, Sally" uniqKey="Hojvat S" first="Sally" last="Hojvat">Sally Hojvat</name>
</author>
<author><name sortKey="Stemmy, Erik J" sort="Stemmy, Erik J" uniqKey="Stemmy E" first="Erik J." last="Stemmy">Erik J. Stemmy</name>
</author>
<author><name sortKey="Donabedian, Armen" sort="Donabedian, Armen" uniqKey="Donabedian A" first="Armen" last="Donabedian">Armen Donabedian</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27191188</idno>
<idno type="pmc">4918159</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918159</idno>
<idno type="RBID">PMC:4918159</idno>
<idno type="doi">10.3201/eid2207.160022</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000074</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000074</idno>
<idno type="wicri:Area/Pmc/Curation">000074</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000074</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000C00</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C00</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:27191188</idno>
<idno type="wicri:Area/PubMed/Corpus">001114</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001114</idno>
<idno type="wicri:Area/PubMed/Curation">001114</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001114</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001149</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001149</idno>
<idno type="wicri:Area/Ncbi/Merge">001631</idno>
<idno type="wicri:Area/Ncbi/Curation">001631</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001631</idno>
<idno type="wicri:doubleKey">1080-6040:2016:Uyeki T:development:of:medical</idno>
<idno type="wicri:Area/Main/Merge">001307</idno>
<idno type="wicri:Area/Main/Curation">001303</idno>
<idno type="wicri:Area/Main/Exploration">001303</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus</title>
<author><name sortKey="Uyeki, Timothy M" sort="Uyeki, Timothy M" uniqKey="Uyeki T" first="Timothy M." last="Uyeki">Timothy M. Uyeki</name>
</author>
<author><name sortKey="Erlandson, Karl J" sort="Erlandson, Karl J" uniqKey="Erlandson K" first="Karl J." last="Erlandson">Karl J. Erlandson</name>
</author>
<author><name sortKey="Korch, George" sort="Korch, George" uniqKey="Korch G" first="George" last="Korch">George Korch</name>
</author>
<author><name sortKey="O Ara, Michael" sort="O Ara, Michael" uniqKey="O Ara M" first="Michael" last="O Ara">Michael O Ara</name>
</author>
<author><name sortKey="Wathen, Michael" sort="Wathen, Michael" uniqKey="Wathen M" first="Michael" last="Wathen">Michael Wathen</name>
</author>
<author><name sortKey="Hu Primmer, Jean" sort="Hu Primmer, Jean" uniqKey="Hu Primmer J" first="Jean" last="Hu-Primmer">Jean Hu-Primmer</name>
</author>
<author><name sortKey="Hojvat, Sally" sort="Hojvat, Sally" uniqKey="Hojvat S" first="Sally" last="Hojvat">Sally Hojvat</name>
</author>
<author><name sortKey="Stemmy, Erik J" sort="Stemmy, Erik J" uniqKey="Stemmy E" first="Erik J." last="Stemmy">Erik J. Stemmy</name>
</author>
<author><name sortKey="Donabedian, Armen" sort="Donabedian, Armen" uniqKey="Donabedian A" first="Armen" last="Donabedian">Armen Donabedian</name>
</author>
</analytic>
<series><title level="j">Emerging Infectious Diseases</title>
<idno type="ISSN">1080-6040</idno>
<idno type="eISSN">1080-6059</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Camelus</term>
<term>Coronavirus Infections (prevention & control)</term>
<term>Coronavirus Infections (veterinary)</term>
<term>Coronavirus Infections (virology)</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Viral Vaccines (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Chameaux</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Humains</term>
<term>Infections à coronavirus ()</term>
<term>Infections à coronavirus (médecine vétérinaire)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Vaccins antiviraux (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Camelus</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Chameaux</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Humains</term>
<term>Infections à coronavirus</term>
<term>Modèles animaux de maladie humaine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Preclinical development of and research on potential Middle East respiratory syndrome coronavirus (MERS-CoV) medical countermeasures remain preliminary; advancements are needed before most countermeasures are ready to be tested in human clinical trials. Research priorities include standardization of animal models and virus stocks for studying disease pathogenesis and efficacy of medical countermeasures; development of MERS-CoV diagnostics; improved access to nonhuman primates to support preclinical research; studies to better understand and control MERS-CoV disease, including vaccination studies in camels; and development of a standardized clinical trial protocol. Partnering with clinical trial networks in affected countries to evaluate safety and efficacy of investigational therapeutics will strengthen efforts to identify successful medical countermeasures.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Donabedian, Armen" sort="Donabedian, Armen" uniqKey="Donabedian A" first="Armen" last="Donabedian">Armen Donabedian</name>
<name sortKey="Erlandson, Karl J" sort="Erlandson, Karl J" uniqKey="Erlandson K" first="Karl J." last="Erlandson">Karl J. Erlandson</name>
<name sortKey="Hojvat, Sally" sort="Hojvat, Sally" uniqKey="Hojvat S" first="Sally" last="Hojvat">Sally Hojvat</name>
<name sortKey="Hu Primmer, Jean" sort="Hu Primmer, Jean" uniqKey="Hu Primmer J" first="Jean" last="Hu-Primmer">Jean Hu-Primmer</name>
<name sortKey="Korch, George" sort="Korch, George" uniqKey="Korch G" first="George" last="Korch">George Korch</name>
<name sortKey="O Ara, Michael" sort="O Ara, Michael" uniqKey="O Ara M" first="Michael" last="O Ara">Michael O Ara</name>
<name sortKey="Stemmy, Erik J" sort="Stemmy, Erik J" uniqKey="Stemmy E" first="Erik J." last="Stemmy">Erik J. Stemmy</name>
<name sortKey="Uyeki, Timothy M" sort="Uyeki, Timothy M" uniqKey="Uyeki T" first="Timothy M." last="Uyeki">Timothy M. Uyeki</name>
<name sortKey="Wathen, Michael" sort="Wathen, Michael" uniqKey="Wathen M" first="Michael" last="Wathen">Michael Wathen</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001303 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001303 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4918159 |texte= Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27191188" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |