MersV1, Main, Exploration, bibRecord, 001272

Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia

Identifieur interne : 001272 ( Main/Exploration ); précédent : 001271; suivant : 001273

Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia

Auteurs : Abdullah M. Assiri ; Claire M. Midgley [Géorgie (pays)] ; Glen R. Abedi ; Abdulaziz Bin Saeed ; Malak M. Almasri ; Xiaoyan Lu ; Hail M. Al-Abdely ; Osman Abdalla ; Mutaz Mohammed ; Homoud S. Algarni ; Raafat F. Alhakeem ; Senthilkumar K. Sakthivel ; Randa Nooh ; Zainab Alshayab ; Mohammad Alessa ; Ganesh Srinivasamoorthy ; Saeed Yahya Alqahtani ; Ali Kheyami ; Waleed Husein Hajomar ; Talib M. Banaser ; Ahmad Esmaeel ; Aron J. Hall ; Aaron T. Curns ; Azaibi Tamin ; Ali Abraheem Alsharef ; Dean Erdman ; John T. Watson ; Susan I. Gerber

Source :

The Journal of Infectious Diseases [ 0022-1899 ] ; 2016.

RBID : PMC:5712457

Descripteurs français

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Cluster Analysis, Coronavirus Infections (epidemiology), Female, Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (classification), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Molecular Epidemiology, Phylogeny, Saudi Arabia (epidemiology), Sequence Analysis, DNA, Sequence Homology, Spike Glycoprotein, Coronavirus (genetics), Young Adult.
MESH :
- chemical , genetics : Spike Glycoprotein, Coronavirus.
- classification : Middle East Respiratory Syndrome Coronavirus.
- epidemiology : Coronavirus Infections, Saudi Arabia.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- Adult, Aged, Aged, 80 and over, Cluster Analysis, Female, Humans, Male, Middle Aged, Molecular Epidemiology, Phylogeny, Sequence Analysis, DNA, Sequence Homology, Young Adult.

Abstract

Background. Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans. Fundamental questions about circulating viruses and transmission routes remain.

Methods. We assessed routinely collected epidemiologic data for MERS-CoV cases reported in Saudi Arabia during 1 January–30 June 2015 and conducted a more detailed investigation of cases reported during February 2015. Available respiratory specimens were obtained for sequencing.

Results. During the study period, 216 MERS-CoV cases were reported. Full genome (n = 17) or spike gene sequences (n = 82) were obtained from 99 individuals. Most sequences (72 of 99 [73%]) formed a discrete, novel recombinant subclade (NRC-2015), which was detected in 6 regions and became predominant by June 2015. No clinical differences were noted between clades. Among 87 cases reported during February 2015, 13 had no recognized risks for secondary acquisition; 12 of these 13 also denied camel contact. Most viruses (8 of 9) from these 13 individuals belonged to NRC-2015.

Discussions. Our findings document the spread and eventual predominance of NRC-2015 in humans in Saudi Arabia during the first half of 2015. Our identification of cases without recognized risk factors but with similar virus sequences indicates the need for better understanding of risk factors for MERS-CoV transmission.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712457

DOI: 10.1093/infdis/jiw236
PubMed: 27302191
PubMed Central: 5712457

Affiliations:

Géorgie (pays)

Le document en format XML

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<author><name sortKey="Sakthivel, Senthilkumar K" sort="Sakthivel, Senthilkumar K" uniqKey="Sakthivel S" first="Senthilkumar K." last="Sakthivel">Senthilkumar K. Sakthivel</name>
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<author><name sortKey="Banaser, Talib M" sort="Banaser, Talib M" uniqKey="Banaser T" first="Talib M." last="Banaser">Talib M. Banaser</name>
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<author><name sortKey="Tamin, Azaibi" sort="Tamin, Azaibi" uniqKey="Tamin A" first="Azaibi" last="Tamin">Azaibi Tamin</name>
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<author><name sortKey="Alsharef, Ali Abraheem" sort="Alsharef, Ali Abraheem" uniqKey="Alsharef A" first="Ali Abraheem" last="Alsharef">Ali Abraheem Alsharef</name>
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<author><name sortKey="Erdman, Dean" sort="Erdman, Dean" uniqKey="Erdman D" first="Dean" last="Erdman">Dean Erdman</name>
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</affiliation>
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<author><name sortKey="Gerber, Susan I" sort="Gerber, Susan I" uniqKey="Gerber S" first="Susan I." last="Gerber">Susan I. Gerber</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia</title>
<author><name sortKey="Assiri, Abdullah M" sort="Assiri, Abdullah M" uniqKey="Assiri A" first="Abdullah M." last="Assiri">Abdullah M. Assiri</name>
<affiliation><nlm:aff id="af1"><institution>Ministry of Health</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Midgley, Claire M" sort="Midgley, Claire M" uniqKey="Midgley C" first="Claire M." last="Midgley">Claire M. Midgley</name>
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</nlm:aff>
<wicri:noCountry code="subfield">National Center for Immunization and Respiratory Diseases</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Epidemic Intelligence Service</addr-line>
,<institution>Centers for Disease Control and Prevention</institution>
,<addr-line>Atlanta, Georgia</addr-line>
</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Atlanta</wicri:regionArea>
</affiliation>
</author>
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<wicri:noCountry code="subfield">National Center for Immunization and Respiratory Diseases</wicri:noCountry>
</affiliation>
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</nlm:aff>
</affiliation>
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<author><name sortKey="Lu, Xiaoyan" sort="Lu, Xiaoyan" uniqKey="Lu X" first="Xiaoyan" last="Lu">Xiaoyan Lu</name>
<affiliation><nlm:aff id="af4"><addr-line>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">National Center for Immunization and Respiratory Diseases</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Al Abdely, Hail M" sort="Al Abdely, Hail M" uniqKey="Al Abdely H" first="Hail M." last="Al-Abdely">Hail M. Al-Abdely</name>
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</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Abdalla, Osman" sort="Abdalla, Osman" uniqKey="Abdalla O" first="Osman" last="Abdalla">Osman Abdalla</name>
<affiliation><nlm:aff id="af1"><institution>Ministry of Health</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mohammed, Mutaz" sort="Mohammed, Mutaz" uniqKey="Mohammed M" first="Mutaz" last="Mohammed">Mutaz Mohammed</name>
<affiliation><nlm:aff id="af1"><institution>Ministry of Health</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Algarni, Homoud S" sort="Algarni, Homoud S" uniqKey="Algarni H" first="Homoud S." last="Algarni">Homoud S. Algarni</name>
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</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alhakeem, Raafat F" sort="Alhakeem, Raafat F" uniqKey="Alhakeem R" first="Raafat F." last="Alhakeem">Raafat F. Alhakeem</name>
<affiliation><nlm:aff id="af1"><institution>Ministry of Health</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sakthivel, Senthilkumar K" sort="Sakthivel, Senthilkumar K" uniqKey="Sakthivel S" first="Senthilkumar K." last="Sakthivel">Senthilkumar K. Sakthivel</name>
<affiliation><nlm:aff id="af4"><addr-line>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">National Center for Immunization and Respiratory Diseases</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Nooh, Randa" sort="Nooh, Randa" uniqKey="Nooh R" first="Randa" last="Nooh">Randa Nooh</name>
<affiliation><nlm:aff id="af1"><institution>Ministry of Health</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af3"><addr-line>Field Epidemiology Training Program, Ministry of Health, Riyadh</addr-line>
,<country>Kingdom of Saudi Arabia</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Alshayab, Zainab" sort="Alshayab, Zainab" uniqKey="Alshayab Z" first="Zainab" last="Alshayab">Zainab Alshayab</name>
<affiliation><nlm:aff id="af1"><institution>Ministry of Health</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af3"><addr-line>Field Epidemiology Training Program, Ministry of Health, Riyadh</addr-line>
,<country>Kingdom of Saudi Arabia</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Alessa, Mohammad" sort="Alessa, Mohammad" uniqKey="Alessa M" first="Mohammad" last="Alessa">Mohammad Alessa</name>
<affiliation><nlm:aff id="af1"><institution>Ministry of Health</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af3"><addr-line>Field Epidemiology Training Program, Ministry of Health, Riyadh</addr-line>
,<country>Kingdom of Saudi Arabia</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Srinivasamoorthy, Ganesh" sort="Srinivasamoorthy, Ganesh" uniqKey="Srinivasamoorthy G" first="Ganesh" last="Srinivasamoorthy">Ganesh Srinivasamoorthy</name>
<affiliation><nlm:aff id="af4"><addr-line>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">National Center for Immunization and Respiratory Diseases</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Alqahtani, Saeed Yahya" sort="Alqahtani, Saeed Yahya" uniqKey="Alqahtani S" first="Saeed Yahya" last="Alqahtani">Saeed Yahya Alqahtani</name>
<affiliation><nlm:aff id="af1"><institution>Ministry of Health</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kheyami, Ali" sort="Kheyami, Ali" uniqKey="Kheyami A" first="Ali" last="Kheyami">Ali Kheyami</name>
<affiliation><nlm:aff id="af1"><institution>Ministry of Health</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hajomar, Waleed Husein" sort="Hajomar, Waleed Husein" uniqKey="Hajomar W" first="Waleed Husein" last="Hajomar">Waleed Husein Hajomar</name>
<affiliation><nlm:aff id="af1"><institution>Ministry of Health</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Banaser, Talib M" sort="Banaser, Talib M" uniqKey="Banaser T" first="Talib M." last="Banaser">Talib M. Banaser</name>
<affiliation><nlm:aff id="af1"><institution>Ministry of Health</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Esmaeel, Ahmad" sort="Esmaeel, Ahmad" uniqKey="Esmaeel A" first="Ahmad" last="Esmaeel">Ahmad Esmaeel</name>
<affiliation><nlm:aff id="af1"><institution>Ministry of Health</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hall, Aron J" sort="Hall, Aron J" uniqKey="Hall A" first="Aron J." last="Hall">Aron J. Hall</name>
<affiliation><nlm:aff id="af4"><addr-line>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">National Center for Immunization and Respiratory Diseases</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Curns, Aaron T" sort="Curns, Aaron T" uniqKey="Curns A" first="Aaron T." last="Curns">Aaron T. Curns</name>
<affiliation><nlm:aff id="af4"><addr-line>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">National Center for Immunization and Respiratory Diseases</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Tamin, Azaibi" sort="Tamin, Azaibi" uniqKey="Tamin A" first="Azaibi" last="Tamin">Azaibi Tamin</name>
<affiliation><nlm:aff id="af4"><addr-line>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">National Center for Immunization and Respiratory Diseases</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Alsharef, Ali Abraheem" sort="Alsharef, Ali Abraheem" uniqKey="Alsharef A" first="Ali Abraheem" last="Alsharef">Ali Abraheem Alsharef</name>
<affiliation><nlm:aff id="af1"><institution>Ministry of Health</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Erdman, Dean" sort="Erdman, Dean" uniqKey="Erdman D" first="Dean" last="Erdman">Dean Erdman</name>
<affiliation><nlm:aff id="af4"><addr-line>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">National Center for Immunization and Respiratory Diseases</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Watson, John T" sort="Watson, John T" uniqKey="Watson J" first="John T." last="Watson">John T. Watson</name>
<affiliation><nlm:aff id="af4"><addr-line>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">National Center for Immunization and Respiratory Diseases</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gerber, Susan I" sort="Gerber, Susan I" uniqKey="Gerber S" first="Susan I." last="Gerber">Susan I. Gerber</name>
<affiliation><nlm:aff id="af4"><addr-line>Division of Viral Diseases, National Center for Immunization and Respiratory Diseases</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">National Center for Immunization and Respiratory Diseases</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Infectious Diseases</title>
<idno type="ISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cluster Analysis</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Middle East Respiratory Syndrome Coronavirus (classification)</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term>
<term>Molecular Epidemiology</term>
<term>Phylogeny</term>
<term>Saudi Arabia (epidemiology)</term>
<term>Sequence Analysis, DNA</term>
<term>Sequence Homology</term>
<term>Spike Glycoprotein, Coronavirus (genetics)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de regroupements</term>
<term>Analyse de séquence d'ADN</term>
<term>Arabie saoudite (épidémiologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term>
<term>Femelle</term>
<term>Glycoprotéine de spicule des coronavirus (génétique)</term>
<term>Humains</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Phylogénie</term>
<term>Similitude de séquences</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Épidémiologie moléculaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Spike Glycoprotein, Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Saudi Arabia</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Arabie saoudite</term>
<term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cluster Analysis</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Molecular Epidemiology</term>
<term>Phylogeny</term>
<term>Sequence Analysis, DNA</term>
<term>Sequence Homology</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de regroupements</term>
<term>Analyse de séquence d'ADN</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Phylogénie</term>
<term>Similitude de séquences</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Épidémiologie moléculaire</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><bold><italic>Background.</italic>
</bold>
 Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans. Fundamental questions about circulating viruses and transmission routes remain.</p>
<p><bold><italic>Methods.</italic>
</bold>
 We assessed routinely collected epidemiologic data for MERS-CoV cases reported in Saudi Arabia during 1 January–30 June 2015 and conducted a more detailed investigation of cases reported during February 2015. Available respiratory specimens were obtained for sequencing.</p>
<p><bold><italic>Results.</italic>
</bold>
 During the study period, 216 MERS-CoV cases were reported. Full genome (n = 17) or spike gene sequences (n = 82) were obtained from 99 individuals. Most sequences (72 of 99 [73%]) formed a discrete, novel recombinant subclade (NRC-2015), which was detected in 6 regions and became predominant by June 2015. No clinical differences were noted between clades. Among 87 cases reported during February 2015, 13 had no recognized risks for secondary acquisition; 12 of these 13 also denied camel contact. Most viruses (8 of 9) from these 13 individuals belonged to NRC-2015.</p>
<p><bold><italic>Discussions.</italic>
</bold>
 Our findings document the spread and eventual predominance of NRC-2015 in humans in Saudi Arabia during the first half of 2015. Our identification of cases without recognized risk factors but with similar virus sequences indicates the need for better understanding of risk factors for MERS-CoV transmission.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
<author><name sortKey="Al Dhahiry, Sh" uniqKey="Al Dhahiry S">SH Al Dhahiry</name>
</author>
<author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
<author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
<author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Azhar, Ei" uniqKey="Azhar E">EI Azhar</name>
</author>
<author><name sortKey="El Kafrawy, Sa" uniqKey="El Kafrawy S">SA El-Kafrawy</name>
</author>
<author><name sortKey="Farraj, Sa" uniqKey="Farraj S">SA Farraj</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nowotny, N" uniqKey="Nowotny N">N Nowotny</name>
</author>
<author><name sortKey="Kolodziejek, J" uniqKey="Kolodziejek J">J Kolodziejek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
<author><name sortKey="Farag, Ea" uniqKey="Farag E">EA Farag</name>
</author>
<author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chu, Dk" uniqKey="Chu D">DK Chu</name>
</author>
<author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Gomaa, Mm" uniqKey="Gomaa M">MM Gomaa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name>
</author>
<author><name sortKey="Cotten, M" uniqKey="Cotten M">M Cotten</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alraddadi, B" uniqKey="Alraddadi B">B Alraddadi</name>
</author>
<author><name sortKey="Watson, Jt" uniqKey="Watson J">JT Watson</name>
</author>
<author><name sortKey="Almarashi, A" uniqKey="Almarashi A">A Almarashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name>
</author>
<author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A McGeer</name>
</author>
<author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oboho, Ik" uniqKey="Oboho I">IK Oboho</name>
</author>
<author><name sortKey="Tomczyk, Sm" uniqKey="Tomczyk S">SM Tomczyk</name>
</author>
<author><name sortKey="Al Asmari, Am" uniqKey="Al Asmari A">AM Al-Asmari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name>
</author>
<author><name sortKey="Abedi, Gr" uniqKey="Abedi G">GR Abedi</name>
</author>
<author><name sortKey="Bin Saeed, Aa" uniqKey="Bin Saeed A">AA Bin Saeed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name>
</author>
<author><name sortKey="Zumla, Ai" uniqKey="Zumla A">AI Zumla</name>
</author>
<author><name sortKey="Al Hakeem, Rf" uniqKey="Al Hakeem R">RF Al-Hakeem</name>
</author>
<author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name>
</author>
<author><name sortKey="Stephens, Gm" uniqKey="Stephens G">GM Stephens</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Al Gethamy, M" uniqKey="Al Gethamy M">M Al-Gethamy</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Hussain, R" uniqKey="Hussain R">R Hussain</name>
</author>
<author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name>
</author>
<author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name>
</author>
<author><name sortKey="Matin, Ma" uniqKey="Matin M">MA Matin</name>
</author>
<author><name sortKey="Haddad, Q" uniqKey="Haddad Q">Q Haddad</name>
</author>
<author><name sortKey="Al Nakhli, D" uniqKey="Al Nakhli D">D Al-Nakhli</name>
</author>
<author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name>
</author>
<author><name sortKey="Albarrak, Am" uniqKey="Albarrak A">AM Albarrak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Breban, R" uniqKey="Breban R">R Breban</name>
</author>
<author><name sortKey="Riou, J" uniqKey="Riou J">J Riou</name>
</author>
<author><name sortKey="Fontanet, A" uniqKey="Fontanet A">A Fontanet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cotten, M" uniqKey="Cotten M">M Cotten</name>
</author>
<author><name sortKey="Watson, Sj" uniqKey="Watson S">SJ Watson</name>
</author>
<author><name sortKey="Kellam, P" uniqKey="Kellam P">P Kellam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cotten, M" uniqKey="Cotten M">M Cotten</name>
</author>
<author><name sortKey="Watson, Sj" uniqKey="Watson S">SJ Watson</name>
</author>
<author><name sortKey="Zumla, Ai" uniqKey="Zumla A">AI Zumla</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Madani, Ta" uniqKey="Madani T">TA Madani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name>
</author>
<author><name sortKey="Costabel, U" uniqKey="Costabel U">U Costabel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name>
</author>
<author><name sortKey="Whitaker, B" uniqKey="Whitaker B">B Whitaker</name>
</author>
<author><name sortKey="Sakthivel, Sk" uniqKey="Sakthivel S">SK Sakthivel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tamura, K" uniqKey="Tamura K">K Tamura</name>
</author>
<author><name sortKey="Stecher, G" uniqKey="Stecher G">G Stecher</name>
</author>
<author><name sortKey="Peterson, D" uniqKey="Peterson D">D Peterson</name>
</author>
<author><name sortKey="Filipski, A" uniqKey="Filipski A">A Filipski</name>
</author>
<author><name sortKey="Kumar, S" uniqKey="Kumar S">S Kumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huelsenbeck, Jp" uniqKey="Huelsenbeck J">JP Huelsenbeck</name>
</author>
<author><name sortKey="Ronquist, F" uniqKey="Ronquist F">F Ronquist</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martin, Dp" uniqKey="Martin D">DP Martin</name>
</author>
<author><name sortKey="Mb" uniqKey="Mb">MB</name>
</author>
<author><name sortKey="Golden, M" uniqKey="Golden M">M Golden</name>
</author>
<author><name sortKey="Khoosal, A" uniqKey="Khoosal A">A Khoosal</name>
</author>
<author><name sortKey="Muhire, B" uniqKey="Muhire B">B Muhire</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drummond, Aj" uniqKey="Drummond A">AJ Drummond</name>
</author>
<author><name sortKey="Suchard, Ma" uniqKey="Suchard M">MA Suchard</name>
</author>
<author><name sortKey="Xie, D" uniqKey="Xie D">D Xie</name>
</author>
<author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Somily, A" uniqKey="Somily A">A Somily</name>
</author>
<author><name sortKey="Barry, M" uniqKey="Barry M">M Barry</name>
</author>
<author><name sortKey="Al Subaie, Ss" uniqKey="Al Subaie S">SS Al Subaie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, R" uniqKey="Lu R">R Lu</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Yj" uniqKey="Kim Y">YJ Kim</name>
</author>
<author><name sortKey="Cho, Yj" uniqKey="Cho Y">YJ Cho</name>
</author>
<author><name sortKey="Kim, Dw" uniqKey="Kim D">DW Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Liu, D" uniqKey="Liu D">D Liu</name>
</author>
<author><name sortKey="Shi, W" uniqKey="Shi W">W Shi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wargo, Ar" uniqKey="Wargo A">AR Wargo</name>
</author>
<author><name sortKey="Kurath, G" uniqKey="Kurath G">G Kurath</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Al Hammadi, Zm" uniqKey="Al Hammadi Z">ZM Al Hammadi</name>
</author>
<author><name sortKey="Chu, Dkw" uniqKey="Chu D">DKW Chu</name>
</author>
<author><name sortKey="Eltahir, Ym" uniqKey="Eltahir Y">YM Eltahir</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sabir, Js" uniqKey="Sabir J">JS Sabir</name>
</author>
<author><name sortKey="Lam, Tt" uniqKey="Lam T">TT Lam</name>
</author>
<author><name sortKey="Ahmed, Mm" uniqKey="Ahmed M">MM Ahmed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Terada, Y" uniqKey="Terada Y">Y Terada</name>
</author>
<author><name sortKey="Matsui, N" uniqKey="Matsui N">N Matsui</name>
</author>
<author><name sortKey="Noguchi, K" uniqKey="Noguchi K">K Noguchi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jackwood, Mw" uniqKey="Jackwood M">MW Jackwood</name>
</author>
<author><name sortKey="Bt" uniqKey="Bt">BT</name>
</author>
<author><name sortKey="Hilt, Da" uniqKey="Hilt D">DA Hilt</name>
</author>
<author><name sortKey="Mckinley, Et" uniqKey="Mckinley E">ET McKinley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, K" uniqKey="Zhao K">K Zhao</name>
</author>
<author><name sortKey="Ye, C" uniqKey="Ye C">C Ye</name>
</author>
<author><name sortKey="Chang, Xb" uniqKey="Chang X">XB Chang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name>
</author>
<author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dominguez, Sr" uniqKey="Dominguez S">SR Dominguez</name>
</author>
<author><name sortKey="Sims, Ge" uniqKey="Sims G">GE Sims</name>
</author>
<author><name sortKey="Wentworth, De" uniqKey="Wentworth D">DE Wentworth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name>
</author>
<author><name sortKey="Lp" uniqKey="Lp">LP</name>
</author>
<author><name sortKey="Tsang, Ak" uniqKey="Tsang A">AK Tsang</name>
</author>
<author><name sortKey="Yip, Cc" uniqKey="Yip C">CC Yip</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dudas, G" uniqKey="Dudas G">G Dudas</name>
</author>
<author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Géorgie (pays)</li>
</country>
</list>
<tree><noCountry><name sortKey="Abdalla, Osman" sort="Abdalla, Osman" uniqKey="Abdalla O" first="Osman" last="Abdalla">Osman Abdalla</name>
<name sortKey="Abedi, Glen R" sort="Abedi, Glen R" uniqKey="Abedi G" first="Glen R." last="Abedi">Glen R. Abedi</name>
<name sortKey="Al Abdely, Hail M" sort="Al Abdely, Hail M" uniqKey="Al Abdely H" first="Hail M." last="Al-Abdely">Hail M. Al-Abdely</name>
<name sortKey="Alessa, Mohammad" sort="Alessa, Mohammad" uniqKey="Alessa M" first="Mohammad" last="Alessa">Mohammad Alessa</name>
<name sortKey="Algarni, Homoud S" sort="Algarni, Homoud S" uniqKey="Algarni H" first="Homoud S." last="Algarni">Homoud S. Algarni</name>
<name sortKey="Alhakeem, Raafat F" sort="Alhakeem, Raafat F" uniqKey="Alhakeem R" first="Raafat F." last="Alhakeem">Raafat F. Alhakeem</name>
<name sortKey="Almasri, Malak M" sort="Almasri, Malak M" uniqKey="Almasri M" first="Malak M." last="Almasri">Malak M. Almasri</name>
<name sortKey="Alqahtani, Saeed Yahya" sort="Alqahtani, Saeed Yahya" uniqKey="Alqahtani S" first="Saeed Yahya" last="Alqahtani">Saeed Yahya Alqahtani</name>
<name sortKey="Alsharef, Ali Abraheem" sort="Alsharef, Ali Abraheem" uniqKey="Alsharef A" first="Ali Abraheem" last="Alsharef">Ali Abraheem Alsharef</name>
<name sortKey="Alshayab, Zainab" sort="Alshayab, Zainab" uniqKey="Alshayab Z" first="Zainab" last="Alshayab">Zainab Alshayab</name>
<name sortKey="Assiri, Abdullah M" sort="Assiri, Abdullah M" uniqKey="Assiri A" first="Abdullah M." last="Assiri">Abdullah M. Assiri</name>
<name sortKey="Banaser, Talib M" sort="Banaser, Talib M" uniqKey="Banaser T" first="Talib M." last="Banaser">Talib M. Banaser</name>
<name sortKey="Bin Saeed, Abdulaziz" sort="Bin Saeed, Abdulaziz" uniqKey="Bin Saeed A" first="Abdulaziz" last="Bin Saeed">Abdulaziz Bin Saeed</name>
<name sortKey="Curns, Aaron T" sort="Curns, Aaron T" uniqKey="Curns A" first="Aaron T." last="Curns">Aaron T. Curns</name>
<name sortKey="Erdman, Dean" sort="Erdman, Dean" uniqKey="Erdman D" first="Dean" last="Erdman">Dean Erdman</name>
<name sortKey="Esmaeel, Ahmad" sort="Esmaeel, Ahmad" uniqKey="Esmaeel A" first="Ahmad" last="Esmaeel">Ahmad Esmaeel</name>
<name sortKey="Gerber, Susan I" sort="Gerber, Susan I" uniqKey="Gerber S" first="Susan I." last="Gerber">Susan I. Gerber</name>
<name sortKey="Hajomar, Waleed Husein" sort="Hajomar, Waleed Husein" uniqKey="Hajomar W" first="Waleed Husein" last="Hajomar">Waleed Husein Hajomar</name>
<name sortKey="Hall, Aron J" sort="Hall, Aron J" uniqKey="Hall A" first="Aron J." last="Hall">Aron J. Hall</name>
<name sortKey="Kheyami, Ali" sort="Kheyami, Ali" uniqKey="Kheyami A" first="Ali" last="Kheyami">Ali Kheyami</name>
<name sortKey="Lu, Xiaoyan" sort="Lu, Xiaoyan" uniqKey="Lu X" first="Xiaoyan" last="Lu">Xiaoyan Lu</name>
<name sortKey="Mohammed, Mutaz" sort="Mohammed, Mutaz" uniqKey="Mohammed M" first="Mutaz" last="Mohammed">Mutaz Mohammed</name>
<name sortKey="Nooh, Randa" sort="Nooh, Randa" uniqKey="Nooh R" first="Randa" last="Nooh">Randa Nooh</name>
<name sortKey="Sakthivel, Senthilkumar K" sort="Sakthivel, Senthilkumar K" uniqKey="Sakthivel S" first="Senthilkumar K." last="Sakthivel">Senthilkumar K. Sakthivel</name>
<name sortKey="Srinivasamoorthy, Ganesh" sort="Srinivasamoorthy, Ganesh" uniqKey="Srinivasamoorthy G" first="Ganesh" last="Srinivasamoorthy">Ganesh Srinivasamoorthy</name>
<name sortKey="Tamin, Azaibi" sort="Tamin, Azaibi" uniqKey="Tamin A" first="Azaibi" last="Tamin">Azaibi Tamin</name>
<name sortKey="Watson, John T" sort="Watson, John T" uniqKey="Watson J" first="John T." last="Watson">John T. Watson</name>
</noCountry>
<country name="Géorgie (pays)"><noRegion><name sortKey="Midgley, Claire M" sort="Midgley, Claire M" uniqKey="Midgley C" first="Claire M." last="Midgley">Claire M. Midgley</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

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HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001272 | SxmlIndent | more

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Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:5712457
   |texte=   Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:27302191" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

Serveur d'exploration MERS

Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia

Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia

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	Serveur d'exploration MERS
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