Marked elevation of urinary β2-microglobulin in patients with reversible splenial lesions: A small case series.
Identifieur interne : 001153 ( Main/Exploration ); précédent : 001152; suivant : 001154Marked elevation of urinary β2-microglobulin in patients with reversible splenial lesions: A small case series.
Auteurs : Junji Azuma [Japon] ; Shin Nabatame [Japon] ; Toshiya Katsura [Japon] ; Kyoko Yamamoto [Japon] ; Hiroshi Kaneno [Japon] ; Eri Kijima [Japon] ; Yoshimi Mizoguchi [Japon] ; Tunesuke Shimotsuji [Japon] ; Takehisa Yamamoto [Japon] ; Keiichi Ozono [Japon]Source :
- Journal of the neurological sciences [ 1878-5883 ] ; 2016.
Descripteurs français
- KwdFr :
- Corps calleux (imagerie diagnostique), Encéphalopathies (imagerie diagnostique), Encéphalopathies (traitement médicamenteux), Encéphalopathies (urine), Enfant, Enfant d'âge préscolaire, Femelle, Humains, Imagerie par résonance magnétique de diffusion, Marqueurs biologiques (urine), Mâle, bêta-2-Microglobuline (urine).
- MESH :
- imagerie diagnostique : Corps calleux, Encéphalopathies.
- traitement médicamenteux : Encéphalopathies.
- urine : Encéphalopathies, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Imagerie par résonance magnétique de diffusion, Marqueurs biologiques, Mâle, bêta-2-Microglobuline.
English descriptors
- KwdEn :
- MESH :
- chemical , urine : Biomarkers, beta 2-Microglobulin.
- diagnostic imaging : Brain Diseases, Corpus Callosum.
- drug therapy : Brain Diseases.
- urine : Brain Diseases.
- Child, Child, Preschool, Diffusion Magnetic Resonance Imaging, Female, Humans, Male.
Abstract
The magnetic resonance imaging findings of reversible isolated lesions with transiently reduced diffusion in the splenium of corpus callosum of patients with a wide spectrum of pathological conditions are referred to as reversible splenial lesion syndrome (RESLES). Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is probably included within the spectrum of RESLES; however, its exact pathophysiology is not known. Here, we describe three patients with MERS and one patient with RESLES, all of whom showed elevated urinary β2-microglobulin regardless of diagnosis and presence of pathogens. Elevated urinary β2-microglobulin suggested that an excessive immune response might play a role in the pathophysiology of reversible splenial lesions.
DOI: 10.1016/j.jns.2016.06.066
PubMed: 27538611
Affiliations:
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Minoh</wicri:regionArea><wicri:noRegion>Minoh</wicri:noRegion></affiliation></author><author><name sortKey="Ozono, Keiichi" sort="Ozono, Keiichi" uniqKey="Ozono K" first="Keiichi" last="Ozono">Keiichi Ozono</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Osaka University Graduate School of Medicine, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of the neurological sciences</title><idno type="eISSN">1878-5883</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biomarkers (urine)</term><term>Brain Diseases (diagnostic imaging)</term><term>Brain Diseases (drug therapy)</term><term>Brain 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Diseases</term><term>Corpus Callosum</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Brain Diseases</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Corps calleux</term><term>Encéphalopathies</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Encéphalopathies</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="en"><term>Brain Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Child, Preschool</term><term>Diffusion Magnetic Resonance Imaging</term><term>Female</term><term>Humans</term><term>Male</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>Encéphalopathies</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique de diffusion</term><term>Marqueurs biologiques</term><term>Mâle</term><term>bêta-2-Microglobuline</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The magnetic resonance imaging findings of reversible isolated lesions with transiently reduced diffusion in the splenium of corpus callosum of patients with a wide spectrum of pathological conditions are referred to as reversible splenial lesion syndrome (RESLES). Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is probably included within the spectrum of RESLES; however, its exact pathophysiology is not known. Here, we describe three patients with MERS and one patient with RESLES, all of whom showed elevated urinary β2-microglobulin regardless of diagnosis and presence of pathogens. Elevated urinary β2-microglobulin suggested that an excessive immune response might play a role in the pathophysiology of reversible splenial lesions. </div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Azuma, Junji" sort="Azuma, Junji" uniqKey="Azuma J" first="Junji" last="Azuma">Junji Azuma</name></noRegion><name sortKey="Kaneno, Hiroshi" sort="Kaneno, Hiroshi" uniqKey="Kaneno H" first="Hiroshi" last="Kaneno">Hiroshi Kaneno</name><name sortKey="Katsura, Toshiya" sort="Katsura, Toshiya" uniqKey="Katsura T" first="Toshiya" last="Katsura">Toshiya Katsura</name><name sortKey="Kijima, Eri" sort="Kijima, Eri" uniqKey="Kijima E" first="Eri" last="Kijima">Eri Kijima</name><name sortKey="Mizoguchi, Yoshimi" sort="Mizoguchi, Yoshimi" uniqKey="Mizoguchi Y" first="Yoshimi" last="Mizoguchi">Yoshimi Mizoguchi</name><name sortKey="Nabatame, Shin" sort="Nabatame, Shin" uniqKey="Nabatame S" first="Shin" last="Nabatame">Shin Nabatame</name><name sortKey="Ozono, Keiichi" sort="Ozono, Keiichi" uniqKey="Ozono K" first="Keiichi" last="Ozono">Keiichi Ozono</name><name sortKey="Shimotsuji, Tunesuke" sort="Shimotsuji, Tunesuke" uniqKey="Shimotsuji T" first="Tunesuke" last="Shimotsuji">Tunesuke Shimotsuji</name><name sortKey="Yamamoto, Kyoko" sort="Yamamoto, Kyoko" uniqKey="Yamamoto K" first="Kyoko" last="Yamamoto">Kyoko Yamamoto</name><name sortKey="Yamamoto, Takehisa" sort="Yamamoto, Takehisa" uniqKey="Yamamoto T" first="Takehisa" last="Yamamoto">Takehisa Yamamoto</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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