MersV1, Main, Exploration, bibRecord, 000D19

Lipid raft ER signalosome malfunctions in menopause and Alzheimer's disease.

Identifieur interne : 000D19 ( Main/Exploration ); précédent : 000D18; suivant : 000D20

Lipid raft ER signalosome malfunctions in menopause and Alzheimer's disease.

Auteurs : Ana Canerina-Amaro ; Luis G. Hernandez-Abad ; Isidre Ferrer ; David Quinto-Alemany ; Fatima Mesa-Herrera ; Carla Ferri ; Ricardo A. Puertas-Avendano [Espagne] ; Mario Diaz [Espagne] ; Raquel Marin [Espagne]

Source :

Frontiers in bioscience (Scholar edition) [ 1945-0524 ] ; 2017.

RBID : pubmed:27814578

Descripteurs français

KwdFr :
- Adulte d'âge moyen, Canal anionique-1 voltage-dépendant (métabolisme), Cavéoline-1, Femelle, Humains, Lobe frontal (métabolisme), Maladie d'Alzheimer (métabolisme), Microdomaines membranaires (métabolisme), Ménopause (métabolisme), Phosphorylation, Récepteur alpha des oestrogènes (métabolisme), Sujet âgé.
MESH :
- métabolisme : Canal anionique-1 voltage-dépendant, Lobe frontal, Maladie d'Alzheimer, Microdomaines membranaires, Ménopause, Récepteur alpha des oestrogènes.
- Adulte d'âge moyen, Cavéoline-1, Femelle, Humains, Phosphorylation, Sujet âgé.

English descriptors

KwdEn :
- Aged, Alzheimer Disease (metabolism), Caveolin 1, Estrogen Receptor alpha (metabolism), Female, Frontal Lobe (metabolism), Humans, Membrane Microdomains (metabolism), Menopause (metabolism), Middle Aged, Phosphorylation, Voltage-Dependent Anion Channel 1 (metabolism).
MESH :
- chemical , metabolism : Estrogen Receptor alpha, Voltage-Dependent Anion Channel 1.
- chemical : Caveolin 1.
- metabolism : Alzheimer Disease, Frontal Lobe, Membrane Microdomains, Menopause.
- Aged, Female, Humans, Middle Aged, Phosphorylation.

Abstract

The increase in the incidence of Alzheimer's disease (AD) in old women may be attributable to estrogen deficiency, and estrogen replacement therapy may be useful in preventing or delaying the onset of this disease. In neuronal membranes, 17 beta-estradiol interacts with estrogen receptors (mERs) located in lipid raft signalosomes which trigger neuroprotective responses by anchoring to scaffolding caveolin-1 complexed with other proteins. We suggest that mER-signalosome malfunctions in AD and by menopause due to development of aberrations in these microstructures. Here, we report that mER dissociates from a voltage-dependent anion channel (VDAC), and that progressive dephosphorylation of VDAC1 enhances neurotoxicity. mER dissociates from caveolin-1 and other neuroprotective proteins, including insulin-like growth factor 1 receptor beta. Similar signalosome disarrangements are observed in AD patients. Moreover, in AD, lipid rafts exhibit alterations in lipid composition, and these changes cause an increase in liquid-ordered as compared to controls. Together, the data show that AD and menopause lead to disruption in the lipid raft structure, and disfunctioning of ER alpha and other neuroprotectors integrated into these signalosomes.

DOI: 10.2741/s476
PubMed: 27814578

Affiliations:

Espagne

Le document en format XML

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<author><name sortKey="Canerina Amaro, Ana" sort="Canerina Amaro, Ana" uniqKey="Canerina Amaro A" first="Ana" last="Canerina-Amaro">Ana Canerina-Amaro</name>
<affiliation><nlm:affiliation>Laboratory of Cellular Neurobiology, Department of Basic Medical Sciences, Medicine Section, Faculty of Health Sciences, University of La Laguna, Santa Cruz de Tenerife; Spain.</nlm:affiliation>
<wicri:noCountry code="subField">Santa Cruz de Tenerife; Spain</wicri:noCountry>
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<author><name sortKey="Hernandez Abad, Luis G" sort="Hernandez Abad, Luis G" uniqKey="Hernandez Abad L" first="Luis G" last="Hernandez-Abad">Luis G. Hernandez-Abad</name>
<affiliation><nlm:affiliation>Laboratory of Cellular Neurobiology, Department of Basic Medical Sciences, Medicine Section, Faculty of Health Sciences, University of La Laguna, Santa Cruz de Tenerife; Spain.</nlm:affiliation>
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<author><name sortKey="Ferrer, Isidre" sort="Ferrer, Isidre" uniqKey="Ferrer I" first="Isidre" last="Ferrer">Isidre Ferrer</name>
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<author><name sortKey="Quinto Alemany, David" sort="Quinto Alemany, David" uniqKey="Quinto Alemany D" first="David" last="Quinto-Alemany">David Quinto-Alemany</name>
<affiliation><nlm:affiliation>Associate Research Unit ULL-CSIC, Membrane Physiology and Biophysics, University of La Laguna, Sta. Cruz de Tenerife, Spain, Laboratory of Membrane Physiology and Biophysics, Department of Animal Biology, Edaphology and Geology, Biology Section, Faculty o.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Lipid raft ER signalosome malfunctions in menopause and Alzheimer's disease.</title>
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<author><name sortKey="Quinto Alemany, David" sort="Quinto Alemany, David" uniqKey="Quinto Alemany D" first="David" last="Quinto-Alemany">David Quinto-Alemany</name>
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<wicri:noCountry code="subField">Biology</wicri:noCountry>
</affiliation>
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<author><name sortKey="Ferri, Carla" sort="Ferri, Carla" uniqKey="Ferri C" first="Carla" last="Ferri">Carla Ferri</name>
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<author><name sortKey="Puertas Avendano, Ricardo A" sort="Puertas Avendano, Ricardo A" uniqKey="Puertas Avendano R" first="Ricardo A" last="Puertas-Avendano">Ricardo A. Puertas-Avendano</name>
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<author><name sortKey="Diaz, Mario" sort="Diaz, Mario" uniqKey="Diaz M" first="Mario" last="Diaz">Mario Diaz</name>
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<author><name sortKey="Marin, Raquel" sort="Marin, Raquel" uniqKey="Marin R" first="Raquel" last="Marin">Raquel Marin</name>
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<series><title level="j">Frontiers in bioscience (Scholar edition)</title>
<idno type="eISSN">1945-0524</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Alzheimer Disease (metabolism)</term>
<term>Caveolin 1</term>
<term>Estrogen Receptor alpha (metabolism)</term>
<term>Female</term>
<term>Frontal Lobe (metabolism)</term>
<term>Humans</term>
<term>Membrane Microdomains (metabolism)</term>
<term>Menopause (metabolism)</term>
<term>Middle Aged</term>
<term>Phosphorylation</term>
<term>Voltage-Dependent Anion Channel 1 (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Canal anionique-1 voltage-dépendant (métabolisme)</term>
<term>Cavéoline-1</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lobe frontal (métabolisme)</term>
<term>Maladie d'Alzheimer (métabolisme)</term>
<term>Microdomaines membranaires (métabolisme)</term>
<term>Ménopause (métabolisme)</term>
<term>Phosphorylation</term>
<term>Récepteur alpha des oestrogènes (métabolisme)</term>
<term>Sujet âgé</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Estrogen Receptor alpha</term>
<term>Voltage-Dependent Anion Channel 1</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Caveolin 1</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alzheimer Disease</term>
<term>Frontal Lobe</term>
<term>Membrane Microdomains</term>
<term>Menopause</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Canal anionique-1 voltage-dépendant</term>
<term>Lobe frontal</term>
<term>Maladie d'Alzheimer</term>
<term>Microdomaines membranaires</term>
<term>Ménopause</term>
<term>Récepteur alpha des oestrogènes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Phosphorylation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Cavéoline-1</term>
<term>Femelle</term>
<term>Humains</term>
<term>Phosphorylation</term>
<term>Sujet âgé</term>
</keywords>
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<front><div type="abstract" xml:lang="en">The increase in the incidence of Alzheimer's disease (AD) in old women may be attributable to estrogen deficiency, and estrogen replacement therapy may be useful in preventing or delaying the onset of this disease. In neuronal membranes, 17 beta-estradiol interacts with estrogen receptors (mERs) located in lipid raft signalosomes which trigger neuroprotective responses by anchoring to scaffolding caveolin-1 complexed with other proteins. We suggest that mER-signalosome malfunctions in AD and by menopause due to development of aberrations in these microstructures. Here, we report that mER dissociates from a voltage-dependent anion channel (VDAC), and that progressive dephosphorylation of VDAC1 enhances neurotoxicity. mER dissociates from caveolin-1 and other neuroprotective proteins, including insulin-like growth factor 1 receptor beta. Similar signalosome disarrangements are observed in AD patients. Moreover, in AD, lipid rafts exhibit alterations in lipid composition, and these changes cause an increase in liquid-ordered as compared to controls. Together, the data show that AD and menopause lead to disruption in the lipid raft structure, and disfunctioning of ER alpha and other neuroprotectors integrated into these signalosomes.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
</country>
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<tree><noCountry><name sortKey="Canerina Amaro, Ana" sort="Canerina Amaro, Ana" uniqKey="Canerina Amaro A" first="Ana" last="Canerina-Amaro">Ana Canerina-Amaro</name>
<name sortKey="Ferrer, Isidre" sort="Ferrer, Isidre" uniqKey="Ferrer I" first="Isidre" last="Ferrer">Isidre Ferrer</name>
<name sortKey="Ferri, Carla" sort="Ferri, Carla" uniqKey="Ferri C" first="Carla" last="Ferri">Carla Ferri</name>
<name sortKey="Hernandez Abad, Luis G" sort="Hernandez Abad, Luis G" uniqKey="Hernandez Abad L" first="Luis G" last="Hernandez-Abad">Luis G. Hernandez-Abad</name>
<name sortKey="Mesa Herrera, Fatima" sort="Mesa Herrera, Fatima" uniqKey="Mesa Herrera F" first="Fatima" last="Mesa-Herrera">Fatima Mesa-Herrera</name>
<name sortKey="Quinto Alemany, David" sort="Quinto Alemany, David" uniqKey="Quinto Alemany D" first="David" last="Quinto-Alemany">David Quinto-Alemany</name>
</noCountry>
<country name="Espagne"><noRegion><name sortKey="Puertas Avendano, Ricardo A" sort="Puertas Avendano, Ricardo A" uniqKey="Puertas Avendano R" first="Ricardo A" last="Puertas-Avendano">Ricardo A. Puertas-Avendano</name>
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<name sortKey="Diaz, Mario" sort="Diaz, Mario" uniqKey="Diaz M" first="Mario" last="Diaz">Mario Diaz</name>
<name sortKey="Marin, Raquel" sort="Marin, Raquel" uniqKey="Marin R" first="Raquel" last="Marin">Raquel Marin</name>
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</record>

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Serveur d'exploration MERS

Lipid raft ER signalosome malfunctions in menopause and Alzheimer's disease.

Lipid raft ER signalosome malfunctions in menopause and Alzheimer's disease.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
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