Accurate Prediction of ncRNA-Protein Interactions From the Integration of Sequence and Evolutionary Information.
Identifieur interne : 000A77 ( Main/Exploration ); précédent : 000A76; suivant : 000A78Accurate Prediction of ncRNA-Protein Interactions From the Integration of Sequence and Evolutionary Information.
Auteurs : Zhao-Hui Zhan [République populaire de Chine] ; Zhu-Hong You [République populaire de Chine] ; Li-Ping Li [République populaire de Chine] ; Yong Zhou [République populaire de Chine] ; Hai-Cheng Yi [République populaire de Chine]Source :
- Frontiers in genetics [ 1664-8021 ] ; 2018.
Abstract
Non-coding RNA (ncRNA) plays a crucial role in numerous biological processes including gene expression and post-transcriptional gene regulation. The biological function of ncRNA is mostly realized by binding with related proteins. Therefore, an accurate understanding of interactions between ncRNA and protein has a significant impact on current biological research. The major challenge at this stage is the waste of a great deal of redundant time and resource consumed on classification in traditional interaction pattern prediction methods. Fortunately, an efficient classifier named LightGBM can solve this difficulty of long time consumption. In this study, we employed LightGBM as the integrated classifier and proposed a novel computational model for predicting ncRNA and protein interactions. More specifically, the pseudo-Zernike Moments and singular value decomposition algorithm are employed to extract the discriminative features from protein and ncRNA sequences. On four widely used datasets RPI369, RPI488, RPI1807, and RPI2241, we evaluated the performance of LGBM and obtained an superior performance with AUC of 0.799, 0.914, 0.989, and 0.762, respectively. The experimental results of 10-fold cross-validation shown that the proposed method performs much better than existing methods in predicting ncRNA-protein interaction patterns, which could be used as a useful tool in proteomics research.
DOI: 10.3389/fgene.2018.00458
PubMed: 30349558
Affiliations:
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type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Non-coding RNA (ncRNA) plays a crucial role in numerous biological processes including gene expression and post-transcriptional gene regulation. The biological function of ncRNA is mostly realized by binding with related proteins. Therefore, an accurate understanding of interactions between ncRNA and protein has a significant impact on current biological research. The major challenge at this stage is the waste of a great deal of redundant time and resource consumed on classification in traditional interaction pattern prediction methods. Fortunately, an efficient classifier named LightGBM can solve this difficulty of long time consumption. In this study, we employed LightGBM as the integrated classifier and proposed a novel computational model for predicting ncRNA and protein interactions. More specifically, the pseudo-Zernike Moments and singular value decomposition algorithm are employed to extract the discriminative features from protein and ncRNA sequences. On four widely used datasets RPI369, RPI488, RPI1807, and RPI2241, we evaluated the performance of LGBM and obtained an superior performance with AUC of 0.799, 0.914, 0.989, and 0.762, respectively. The experimental results of 10-fold cross-validation shown that the proposed method performs much better than existing methods in predicting ncRNA-protein interaction patterns, which could be used as a useful tool in proteomics research.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhan, Zhao Hui" sort="Zhan, Zhao Hui" uniqKey="Zhan Z" first="Zhao-Hui" last="Zhan">Zhao-Hui Zhan</name></noRegion><name sortKey="Li, Li Ping" sort="Li, Li Ping" uniqKey="Li L" first="Li-Ping" last="Li">Li-Ping Li</name><name sortKey="Yi, Hai Cheng" sort="Yi, Hai Cheng" uniqKey="Yi H" first="Hai-Cheng" last="Yi">Hai-Cheng Yi</name><name sortKey="You, Zhu Hong" sort="You, Zhu Hong" uniqKey="You Z" first="Zhu-Hong" last="You">Zhu-Hong You</name><name sortKey="Zhou, Yong" sort="Zhou, Yong" uniqKey="Zhou Y" first="Yong" last="Zhou">Yong Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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