The battle against SARS and MERS coronaviruses: Reservoirs and Animal Models
Identifieur interne : 000781 ( Main/Exploration ); précédent : 000780; suivant : 000782The battle against SARS and MERS coronaviruses: Reservoirs and Animal Models
Auteurs : Shu-Ran Gong ; Lin-Lin BaoSource :
- Animal Models and Experimental Medicine [ 2096-5451 ] ; 2018.
Abstract
In humans, infection with the coronavirus, especially the severe acute respiratory syndrome coronavirus (
Url:
DOI: 10.1002/ame2.12017
PubMed: 30891557
PubMed Central: 6388065
Affiliations:
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coronaviruses: Reservoirs and Animal Models</title>
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<series><title level="j">Animal Models and Experimental Medicine</title>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>In humans, infection with the coronavirus, especially the severe acute respiratory syndrome coronavirus (<styled-content style="fixed-case" toggle="no">SARS</styled-content>
‐CoV) and the emerging Middle East respiratory syndrome coronavirus (<styled-content style="fixed-case" toggle="no">MERS</styled-content>
‐CoV), induces acute respiratory failure, resulting in high mortality. Irregular coronavirus related epidemics indicate that the evolutionary origins of these two pathogens need to be identified urgently and there are still questions related to suitable laboratory animal models. Thus, in this review we aim to highlight key discoveries concerning the animal origin of the virus and summarize and compare current animal models.</p>
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