Ultrastructure of Highly Ordered Granules in Alveolar Type II Cells in Several Species.
Identifieur interne : 000767 ( Main/Exploration ); précédent : 000766; suivant : 000768Ultrastructure of Highly Ordered Granules in Alveolar Type II Cells in Several Species.
Auteurs : Marian L. Miller [États-Unis] ; Aleksey Porollo [États-Unis] ; Susan Wert [États-Unis]Source :
- Anatomical record (Hoboken, N.J. : 2007) [ 1932-8494 ] ; 2018.
Abstract
Alveolar Type II cells from seven mammalian species were examined for a protein in the rough endoplasmic reticulum (RER), which showed a multilayered, repeating motif. Each motif, 100 nm in width, comprised two parallel outer dense layers, a less dense central layer, and often 1-3 faint layers on either side of the latter. Outer layers showed periodicities at 3-4 densities/100 nm of width, while layers on either side of the central layer showed 5-7 densities/100 nm of width. RER membranes were ribosome-free when parallel to these layers, but showed four ribosomes per motif at the growing ends: one ribosome at each outer dense layer, and one on either side of the less dense central layer. Granules appeared as single or as multiple motifs, stacked, curved, folded, or branching together within the same RER profile. Hexagons of around 30 nm in diameter with central densities were seen in tangential cuts of outer dense layers. Granule incidence varied: guinea pig > ferret > dog. Possible homologous structures occurred in rabbit and cat, but not in rat or mouse. Surfactant protein A (SP-A), a C-type lectin produced in Type II cells, forms trimers and bouquet-like 18-mer and can oligomerize further. Two pairs of SP-A 18-mers with carbohydrate recognition domains pointing inwardly and outwardly, stacked vertically as a column of four molecules, then repeated side by side in rows, approximated the size and layering patterns observed in these granules. Sequence analyses of SP-A from these species showed phylogenetic distances consistent with the observed occurrence and frequency of patterned granules. Anat Rec, 301:1290-1302, 2018. © 2018 Wiley Periodicals, Inc.
DOI: 10.1002/ar.23805
PubMed: 29544026
Affiliations:
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Miller</name><affiliation wicri:level="2"><nlm:affiliation>Department of Environmental Health, University of Cincinnati, College of Medicine, Cincinnati, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Environmental Health, University of Cincinnati, College of Medicine, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Porollo, Aleksey" sort="Porollo, Aleksey" uniqKey="Porollo A" first="Aleksey" last="Porollo">Aleksey Porollo</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Wert, Susan" sort="Wert, Susan" uniqKey="Wert S" first="Susan" last="Wert">Susan Wert</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati</wicri:cityArea></affiliation></author></analytic><series><title level="j">Anatomical record (Hoboken, N.J. : 2007)</title><idno type="eISSN">1932-8494</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alveolar Type II cells from seven mammalian species were examined for a protein in the rough endoplasmic reticulum (RER), which showed a multilayered, repeating motif. Each motif, 100 nm in width, comprised two parallel outer dense layers, a less dense central layer, and often 1-3 faint layers on either side of the latter. Outer layers showed periodicities at 3-4 densities/100 nm of width, while layers on either side of the central layer showed 5-7 densities/100 nm of width. RER membranes were ribosome-free when parallel to these layers, but showed four ribosomes per motif at the growing ends: one ribosome at each outer dense layer, and one on either side of the less dense central layer. Granules appeared as single or as multiple motifs, stacked, curved, folded, or branching together within the same RER profile. Hexagons of around 30 nm in diameter with central densities were seen in tangential cuts of outer dense layers. Granule incidence varied: guinea pig > ferret > dog. Possible homologous structures occurred in rabbit and cat, but not in rat or mouse. Surfactant protein A (SP-A), a C-type lectin produced in Type II cells, forms trimers and bouquet-like 18-mer and can oligomerize further. Two pairs of SP-A 18-mers with carbohydrate recognition domains pointing inwardly and outwardly, stacked vertically as a column of four molecules, then repeated side by side in rows, approximated the size and layering patterns observed in these granules. Sequence analyses of SP-A from these species showed phylogenetic distances consistent with the observed occurrence and frequency of patterned granules. Anat Rec, 301:1290-1302, 2018. © 2018 Wiley Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Miller, Marian L" sort="Miller, Marian L" uniqKey="Miller M" first="Marian L" last="Miller">Marian L. Miller</name></region><name sortKey="Porollo, Aleksey" sort="Porollo, Aleksey" uniqKey="Porollo A" first="Aleksey" last="Porollo">Aleksey Porollo</name><name sortKey="Wert, Susan" sort="Wert, Susan" uniqKey="Wert S" first="Susan" last="Wert">Susan Wert</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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