Molecular Characteristics, Functions, and Related Pathogenicity of MERS-CoV Proteins
Identifieur interne : 000456 ( Main/Exploration ); précédent : 000455; suivant : 000457Molecular Characteristics, Functions, and Related Pathogenicity of MERS-CoV Proteins
Auteurs : Yan-Hua Li [République populaire de Chine] ; Chen-Yu Hu [République populaire de Chine] ; Nan-Ping Wu [République populaire de Chine] ; Hang-Ping Yao [République populaire de Chine] ; Lan-Juan Li [République populaire de Chine]Source :
- Engineering (Beijing, China) [ 2095-8099 ] ; 2019.
Abstract
Middle East respiratory syndrome (MERS) is a viral respiratory disease caused by a
Url:
DOI: 10.1016/j.eng.2018.11.035
PubMed: 32288963
PubMed Central: 7104727
Affiliations:
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Proteins</title><author><name sortKey="Li, Yan Hua" sort="Li, Yan Hua" uniqKey="Li Y" first="Yan-Hua" last="Li">Yan-Hua Li</name><affiliation wicri:level="1"><nlm:aff id="af005">State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="af010">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 31003, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 31003</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Hu, Chen Yu" sort="Hu, Chen Yu" uniqKey="Hu C" first="Chen-Yu" last="Hu">Chen-Yu Hu</name><affiliation wicri:level="1"><nlm:aff id="af005">State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="af010">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 31003, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 31003</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Wu, Nan Ping" sort="Wu, Nan Ping" uniqKey="Wu N" first="Nan-Ping" last="Wu">Nan-Ping Wu</name><affiliation wicri:level="1"><nlm:aff id="af005">State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="af010">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 31003, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 31003</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Yao, Hang Ping" sort="Yao, Hang Ping" uniqKey="Yao H" first="Hang-Ping" last="Yao">Hang-Ping Yao</name><affiliation wicri:level="1"><nlm:aff id="af005">State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="af010">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 31003, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 31003</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Li, Lan Juan" sort="Li, Lan Juan" uniqKey="Li L" first="Lan-Juan" last="Li">Lan-Juan Li</name><affiliation wicri:level="1"><nlm:aff id="af005">State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="af010">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 31003, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 31003</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author></analytic><series><title level="j">Engineering (Beijing, China)</title><idno type="ISSN">2095-8099</idno><idno type="eISSN">2096-0026</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome (MERS) is a viral respiratory disease caused by a <italic>de novo</italic> coronavirus—MERS-CoV—that is associated with high mortality. However, the mechanism by which MERS-CoV infects humans remains unclear. To date, there is no effective vaccine or antibody for human immunity and treatment, other than the safety and tolerability of the fully human polyclonal Immunoglobulin G (IgG) antibody (SAB-301) as a putative therapeutic agent specific for MERS. Although rapid diagnostic and public health measures are currently being implemented, new cases of MERS-CoV infection are still being reported. Therefore, various effective measures should be taken to prevent the serious impact of similar epidemics in the future. Further investigation of the epidemiology and pathogenesis of the virus, as well as the development of effective therapeutic and prophylactic anti-MERS-CoV infections, is necessary. For this purpose, detailed information on MERS-CoV proteins is needed. In this review, we describe the major structural and nonstructural proteins of MERS-CoV and summarize different potential strategies for limiting the outbreak of MERS-CoV. The combination of computational biology and virology can accelerate the advanced design and development of effective peptide therapeutics against MERS-CoV. In summary, this review provides important information about the progress of the elimination of MERS, from prevention to treatment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hui, D S" uniqKey="Hui D">D.S. Hui</name></author><author><name sortKey="Azhar, E I" uniqKey="Azhar E">E.I. Azhar</name></author><author><name sortKey="Kim, Y J" uniqKey="Kim Y">Y.J. Kim</name></author><author><name sortKey="Memish, Z A" uniqKey="Memish Z">Z.A. Memish</name></author><author><name sortKey="Oh, M D" uniqKey="Oh M">M.D. Oh</name></author><author><name sortKey="Zumla, A" uniqKey="Zumla A">A. 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Kuroyama</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Zhejiang</li></region><settlement><li>Hangzhou</li></settlement><orgName><li>Université de Zhejiang</li></orgName></list><tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Li, Yan Hua" sort="Li, Yan Hua" uniqKey="Li Y" first="Yan-Hua" last="Li">Yan-Hua Li</name></region><name sortKey="Hu, Chen Yu" sort="Hu, Chen Yu" uniqKey="Hu C" first="Chen-Yu" last="Hu">Chen-Yu Hu</name><name sortKey="Hu, Chen Yu" sort="Hu, Chen Yu" uniqKey="Hu C" first="Chen-Yu" last="Hu">Chen-Yu Hu</name><name sortKey="Li, Lan Juan" sort="Li, Lan Juan" uniqKey="Li L" first="Lan-Juan" last="Li">Lan-Juan Li</name><name sortKey="Li, Lan Juan" sort="Li, Lan Juan" uniqKey="Li L" first="Lan-Juan" last="Li">Lan-Juan Li</name><name sortKey="Li, Yan Hua" sort="Li, Yan Hua" uniqKey="Li Y" first="Yan-Hua" last="Li">Yan-Hua Li</name><name sortKey="Wu, Nan Ping" sort="Wu, Nan Ping" uniqKey="Wu N" first="Nan-Ping" last="Wu">Nan-Ping Wu</name><name sortKey="Wu, Nan Ping" sort="Wu, Nan Ping" uniqKey="Wu N" first="Nan-Ping" last="Wu">Nan-Ping Wu</name><name sortKey="Yao, Hang Ping" sort="Yao, Hang Ping" uniqKey="Yao H" first="Hang-Ping" last="Yao">Hang-Ping Yao</name><name sortKey="Yao, Hang Ping" sort="Yao, Hang Ping" uniqKey="Yao H" first="Hang-Ping" last="Yao">Hang-Ping Yao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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