MersV1, Main, Curation, bibRecord, 004576

High-performance liquid chromatography and capillary gel electrophoresis as applied to antisense DNA

Identifieur interne : 004576 ( Main/Curation ); précédent : 004575; suivant : 004577

High-performance liquid chromatography and capillary gel electrophoresis as applied to antisense DNA

Auteurs : Aharon S. Cohen [États-Unis] ; Maria Vilenchik [États-Unis] ; Judith L. Dudley [États-Unis] ; Mark W. Gemborys [États-Unis] ; André J. Bourque [États-Unis]

Source :

Journal of Chromatography A [ 0021-9673 ] ; 1993.

RBID : ISTEX:8923F74E7086A1A9AD4297F02AA880608D7F03D3

English descriptors

Teeft :
- Analogue, Antisense, Antisense pharmaceuticals, Artificial mixture, Base length, Base sequence, Chromatogr, Cohen, Effective length, Electric field, Electrophoretic methods, Experimental conditions, Failure sequence, Failure sequences, Formic acid, Hpce, Hpce separation, Hplc, Laser densitometer, Liquid chromatography, Migration time, Mobile phase, Mobile phases, Nucleic acids, Oligomers, Oxygen atom, Peak numbers, Power supply, Rapid separation, Retention times, Sequencing, Sodn, Sodn analogues, Sodns, Total length.

Abstract

Abstract: Reversed-phase and ion-exchange HPLC are compared with both slab gel and capillary gel electrophoresis for the separation of antisense phosphorothioate oligomers. The chromatographic separations were found to be markedly inferior to the electrophoretic separations, especially for oligomers greater than 20 bases in length. The potential of gel high-performance capillary electrophoresis for the analysis of phosphorothioate analogues is shown.

Url:

https://api.istex.fr/ark:/67375/6H6-J1GNV6FW-8/fulltext.pdf

DOI: 10.1016/0021-9673(93)83441-T

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ISTEX:8923F74E7086A1A9AD4297F02AA880608D7F03D3

Le document en format XML

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<term>Base length</term>
<term>Base sequence</term>
<term>Chromatogr</term>
<term>Cohen</term>
<term>Effective length</term>
<term>Electric field</term>
<term>Electrophoretic methods</term>
<term>Experimental conditions</term>
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<term>Peak numbers</term>
<term>Power supply</term>
<term>Rapid separation</term>
<term>Retention times</term>
<term>Sequencing</term>
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<front><div type="abstract" xml:lang="en">Abstract: Reversed-phase and ion-exchange HPLC are compared with both slab gel and capillary gel electrophoresis for the separation of antisense phosphorothioate oligomers. The chromatographic separations were found to be markedly inferior to the electrophoretic separations, especially for oligomers greater than 20 bases in length. The potential of gel high-performance capillary electrophoresis for the analysis of phosphorothioate analogues is shown.</div>
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High-performance liquid chromatography and capillary gel electrophoresis as applied to antisense DNA

High-performance liquid chromatography and capillary gel electrophoresis as applied to antisense DNA

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri