Application of aptamers in therapeutics and for small-molecule detection.
Identifieur interne : 002D50 ( Main/Curation ); précédent : 002D49; suivant : 002D51Application of aptamers in therapeutics and for small-molecule detection.
Auteurs : M. Menger [Allemagne] ; J. Glökler ; M. RimmeleSource :
- Handbook of experimental pharmacology [ 0171-2004 ] ; 2006.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Acides nucléiques.
- usage thérapeutique : Acides nucléiques.
- Acides nucléiques, Animaux, Biotechnologie, Humains, Techniques de biocapteur.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Nucleic Acids.
- chemical , pharmacology : Nucleic Acids.
- chemical , therapeutic use : Nucleic Acids.
- Animals, Biosensing Techniques, Biotechnology, Humans.
Abstract
Nucleic acids that can bind with high affinity and specificity to target molecules are called "apta mers". Aptamers recognise a large variety of different molecule classes. The main focus of this chapter is small molecules as targets. Aptamers are applied complementarily to antibody technologies and can substitute antibodies or small molecules wherever their different properties, such as biochemical nature or highly discriminating capacities, are advantageous. Examples of promising applications of these versatile molecules are discussed in the field of therapeutics and biotechnology with a special view to small-molecule detection.
DOI: 10.1007/3-540-27262-3_18
PubMed: 16594625
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pubmed:16594625Le document en format XML
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<term>Humains</term>
<term>Techniques de biocapteur</term>
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<front><div type="abstract" xml:lang="en">Nucleic acids that can bind with high affinity and specificity to target molecules are called "apta mers". Aptamers recognise a large variety of different molecule classes. The main focus of this chapter is small molecules as targets. Aptamers are applied complementarily to antibody technologies and can substitute antibodies or small molecules wherever their different properties, such as biochemical nature or highly discriminating capacities, are advantageous. Examples of promising applications of these versatile molecules are discussed in the field of therapeutics and biotechnology with a special view to small-molecule detection.</div>
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