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DNA microarrays in the clinic: infectious diseases

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DNA microarrays in the clinic: infectious diseases

Auteurs : Vladimir Mikhailovich [Russie] ; Dmitry Gryadunov [Russie] ; Alexander Kolchinsky [États-Unis] ; Alexander A. Makarov [Russie] ; Alexander Zasedatelev [Russie]

Source :

BioEssays [ 0265-9247 ] ; 2008-07.

RBID : ISTEX:A5B68143C35CF30FA7A7661DC60D0FF3F0B6F0F2

Abstract

We argue that the most‐promising area of clinical application of microarrays in the foreseeable future is the diagnostics and monitoring of infectious diseases. Microarrays for the detection and characterization of human pathogens have already found their way into clinical practice in some countries. After discussing the persistent, yet often underestimated, importance of infectious diseases for public health, we consider the technologies that are best suited for the detection and clinical investigation of pathogens. Clinical application of microarray technologies for the detection of mycobacteria, Bacillus anthracis, HIV, hepatitis and influenza viruses, and other major pathogens, as well as the analysis of their drug‐resistance patterns, illustrate our main thesis. BioEssays 30:673–682, 2008. © 2008 Wiley Periodicals, Inc.

Url:

https://api.istex.fr/ark:/67375/WNG-Z1S8PFX9-J/fulltext.pdf

DOI: 10.1002/bies.20781

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ISTEX:A5B68143C35CF30FA7A7661DC60D0FF3F0B6F0F2

Le document en format XML

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<front><div type="abstract" xml:lang="en">We argue that the most‐promising area of clinical application of microarrays in the foreseeable future is the diagnostics and monitoring of infectious diseases. Microarrays for the detection and characterization of human pathogens have already found their way into clinical practice in some countries. After discussing the persistent, yet often underestimated, importance of infectious diseases for public health, we consider the technologies that are best suited for the detection and clinical investigation of pathogens. Clinical application of microarray technologies for the detection of mycobacteria, Bacillus anthracis, HIV, hepatitis and influenza viruses, and other major pathogens, as well as the analysis of their drug‐resistance patterns, illustrate our main thesis. BioEssays 30:673–682, 2008. © 2008 Wiley Periodicals, Inc.</div>
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DNA microarrays in the clinic: infectious diseases

DNA microarrays in the clinic: infectious diseases

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Abstract

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