An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus
Identifieur interne : 002055 ( Main/Curation ); précédent : 002054; suivant : 002056An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus
Auteurs : Yanfeng Yao ; Linlin Bao ; Wei Deng ; Lili Xu ; Fengdi Li ; Qi Lv ; Pin Yu ; Ting Chen ; Yanfeng Xu ; Hua Zhu ; Jing Yuan ; Songzhi Gu ; Qiang Wei ; Honglin Chen [République populaire de Chine] ; Kwok-Yung Yuen [République populaire de Chine] ; Chuan QinSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Infections à coronavirus.
- physiologie : Coronavirus.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- virologie : Infections à coronavirus.
- Animaux, Histocytochimie, Macaca mulatta, Modèles animaux de maladie humaine, Réplication virale.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- pathology : Coronavirus Infections.
- physiology : Coronavirus.
- virology : Coronavirus Infections.
- Animals, Disease Models, Animal, Histocytochemistry, Macaca mulatta, Virus Replication.
Abstract
In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East respiratory syndrome (MERS-CoV; previously known as human coronavirus–Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of MERS-CoV have been reported, with 54 fatalities. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. In this study, we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection.
Url:
DOI: 10.1093/infdis/jit590
PubMed: 24218506
PubMed Central: 7107340
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PMC:7107340Le document en format XML
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<author><name sortKey="Xu, Yanfeng" sort="Xu, Yanfeng" uniqKey="Xu Y" first="Yanfeng" last="Xu">Yanfeng Xu</name>
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<author><name sortKey="Zhu, Hua" sort="Zhu, Hua" uniqKey="Zhu H" first="Hua" last="Zhu">Hua Zhu</name>
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<author><name sortKey="Gu, Songzhi" sort="Gu, Songzhi" uniqKey="Gu S" first="Songzhi" last="Gu">Songzhi Gu</name>
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<term>Coronavirus Infections (pathology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Disease Models, Animal</term>
<term>Histocytochemistry</term>
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</keywords>
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<term>Anticorps antiviraux (sang)</term>
<term>Anticorps neutralisants (sang)</term>
<term>Coronavirus (physiologie)</term>
<term>Histocytochimie</term>
<term>Infections à coronavirus (anatomopathologie)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Macaca mulatta</term>
<term>Modèles animaux de maladie humaine</term>
<term>Réplication virale</term>
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<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East respiratory syndrome (MERS-CoV; previously known as human coronavirus–Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of MERS-CoV have been reported, with 54 fatalities. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. In this study, we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection.</p>
</div>
</front>
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</author>
<author><name sortKey="Li, Ks" uniqKey="Li K">KS Li</name>
</author>
<author><name sortKey="To, Kk" uniqKey="To K">KK To</name>
</author>
<author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name>
</author>
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