Sensitivity of SARS/MERS CoV to interferons and other drugs based on achievable serum concentrations in humans.
Identifieur interne : 001A88 ( Main/Curation ); précédent : 001A87; suivant : 001A89Sensitivity of SARS/MERS CoV to interferons and other drugs based on achievable serum concentrations in humans.
Auteurs : David R. Strayer ; Robert Dickey ; William A. Carter [États-Unis]Source :
- Infectious disorders drug targets [ 2212-3989 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (administration et posologie), Antiviraux (sang), Calcul des posologies, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Facteurs immunologiques (administration et posologie), Facteurs immunologiques (sang), Humains, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Interférons (administration et posologie), Interférons (sang), Lignée cellulaire, Modèles animaux de maladie humaine, Muqueuse respiratoire (), Muqueuse respiratoire (virologie), Relation dose-effet des médicaments, Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie), Tests de sensibilité microbienne, Virus du SRAS (), Virus du SRAS (pathogénicité).
- MESH :
- administration et posologie : Antiviraux, Facteurs immunologiques, Interférons.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- sang : Antiviraux, Facteurs immunologiques, Interférons.
- traitement médicamenteux : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- virologie : Infections à coronavirus, Muqueuse respiratoire, Syndrome respiratoire aigu sévère.
- Animaux, Calcul des posologies, Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Lignée cellulaire, Modèles animaux de maladie humaine, Muqueuse respiratoire, Relation dose-effet des médicaments, Tests de sensibilité microbienne, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (administration & dosage), Antiviral Agents (blood), Cell Line, Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Disease Models, Animal, Dose-Response Relationship, Drug, Drug Dosage Calculations, Humans, Immunologic Factors (administration & dosage), Immunologic Factors (blood), Interferons (administration & dosage), Interferons (blood), Microbial Sensitivity Tests, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (pathogenicity), Respiratory Mucosa (drug effects), Respiratory Mucosa (virology), SARS Virus (drug effects), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (virology).
- MESH :
- chemical , administration & dosage : Antiviral Agents, Immunologic Factors, Interferons.
- chemical , blood : Antiviral Agents, Immunologic Factors, Interferons.
- drug effects : Middle East Respiratory Syndrome Coronavirus, Respiratory Mucosa, SARS Virus.
- drug therapy : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- virology : Coronavirus Infections, Respiratory Mucosa, Severe Acute Respiratory Syndrome.
- Animals, Cell Line, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Dosage Calculations, Humans, Microbial Sensitivity Tests.
Abstract
A novel coronavirus (MERS-CoV) related to SARS-CoV recently emerged in the Middle East causing more than 400 deaths with a mortality rate of about 30%, much higher than SARS-CoV. Both viruses target epithelial cells in the respiratory tract, although utilizing different cellular receptors. Because of the sporadic nature of the MERS outbreak and difficulty in collecting randomized, controlled clinical data, the objective of this review was to focus on published in vitro and in vivo drug sensitivity data using both cell lines and available animal models of SARS/MERS CoV infection. Determination of drug activity was based on achievable serum levels in humans relative to in vitro IC50 (50% inhibitory concentration) or EC50 (50% effective concentration) drug concentrations. The most active drugs against SARS/MERS CoV at clinically achievable serum levels were type I interferons and a TLR3 agonist, interferon inducer/activator.
DOI: 10.2174/1871526514666140713152858
PubMed: 25019238
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pubmed:25019238Le document en format XML
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<term>Coronavirus Infections (virology)</term>
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<term>Antiviraux (sang)</term>
<term>Calcul des posologies</term>
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<term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term>
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<term>Facteurs immunologiques (sang)</term>
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<term>Infections à coronavirus (virologie)</term>
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<term>Syndrome respiratoire aigu sévère (virologie)</term>
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<term>SARS Virus</term>
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<term>Drug Dosage Calculations</term>
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<term>Microbial Sensitivity Tests</term>
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<term>Calcul des posologies</term>
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<term>Lignée cellulaire</term>
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<term>Muqueuse respiratoire</term>
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<front><div type="abstract" xml:lang="en">A novel coronavirus (MERS-CoV) related to SARS-CoV recently emerged in the Middle East causing more than 400 deaths with a mortality rate of about 30%, much higher than SARS-CoV. Both viruses target epithelial cells in the respiratory tract, although utilizing different cellular receptors. Because of the sporadic nature of the MERS outbreak and difficulty in collecting randomized, controlled clinical data, the objective of this review was to focus on published in vitro and in vivo drug sensitivity data using both cell lines and available animal models of SARS/MERS CoV infection. Determination of drug activity was based on achievable serum levels in humans relative to in vitro IC50 (50% inhibitory concentration) or EC50 (50% effective concentration) drug concentrations. The most active drugs against SARS/MERS CoV at clinically achievable serum levels were type I interferons and a TLR3 agonist, interferon inducer/activator. </div>
</front>
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