PCR array profiling of antiviral genes in human embryonic kidney cells expressing human coronavirus OC43 structural and accessory proteins
Identifieur interne : 000866 ( Main/Curation ); précédent : 000865; suivant : 000867PCR array profiling of antiviral genes in human embryonic kidney cells expressing human coronavirus OC43 structural and accessory proteins
Auteurs : Meshal Beidas ; Wassim ChehadehSource :
- Archives of Virology [ 0304-8608 ] ; 2018.
Descripteurs français
- KwdFr :
- Coronavirus humain OC43 (génétique), Coronavirus humain OC43 (isolement et purification), Coronavirus humain OC43 (physiologie), Humains, Immunité innée, Infections à coronavirus (génétique), Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Interactions hôte-pathogène, Lignée cellulaire, Protéines virales non structurales (génétique), Protéines virales non structurales (métabolisme), Protéines virales régulatrices ou accessoires (génétique), Protéines virales régulatrices ou accessoires (métabolisme), Rein (cytologie), Rein (immunologie), Rein (virologie), Réaction de polymérisation en chaîne (), Régulation négative, Réplication virale.
- MESH :
- cytologie : Rein.
- génétique : Coronavirus humain OC43, Infections à coronavirus, Protéines virales non structurales, Protéines virales régulatrices ou accessoires.
- immunologie : Infections à coronavirus, Rein.
- isolement et purification : Coronavirus humain OC43.
- métabolisme : Protéines virales non structurales, Protéines virales régulatrices ou accessoires.
- physiologie : Coronavirus humain OC43.
- virologie : Infections à coronavirus, Rein.
- Humains, Immunité innée, Interactions hôte-pathogène, Lignée cellulaire, Réaction de polymérisation en chaîne, Régulation négative, Réplication virale.
English descriptors
- KwdEn :
- Cell Line, Coronavirus Infections (genetics), Coronavirus Infections (immunology), Coronavirus Infections (virology), Coronavirus OC43, Human (genetics), Coronavirus OC43, Human (isolation & purification), Coronavirus OC43, Human (physiology), Down-Regulation, Host-Pathogen Interactions, Humans, Immunity, Innate, Kidney (cytology), Kidney (immunology), Kidney (virology), Polymerase Chain Reaction (methods), Viral Nonstructural Proteins (genetics), Viral Nonstructural Proteins (metabolism), Viral Regulatory and Accessory Proteins (genetics), Viral Regulatory and Accessory Proteins (metabolism), Virus Replication.
- MESH :
- chemical , genetics : Viral Nonstructural Proteins, Viral Regulatory and Accessory Proteins.
- cytology : Kidney.
- genetics : Coronavirus Infections, Coronavirus OC43, Human.
- immunology : Coronavirus Infections, Kidney.
- isolation & purification : Coronavirus OC43, Human.
- chemical , metabolism : Viral Nonstructural Proteins, Viral Regulatory and Accessory Proteins.
- methods : Polymerase Chain Reaction.
- physiology : Coronavirus OC43, Human.
- virology : Coronavirus Infections, Kidney.
- Cell Line, Down-Regulation, Host-Pathogen Interactions, Humans, Immunity, Innate, Virus Replication.
Abstract
Human coronavirus OC43 (HCoV-OC43) is a respiratory virus that usually causes a common cold. However, it has the potential to cause severe infection in young children and immunocompromised adults. Both SARS-CoV and MERS-CoV were shown to express proteins with the potential to evade early innate immune responses. However, the ability of HCoV-OC43 to antagonise the intracellular antiviral defences has not yet been investigated. The potential role of the HCoV-OC43 structural (M and N) and accessory proteins (ns2a and ns5a) in the alteration of antiviral gene expression was investigated in this study. HCoV-OC43M, N, ns2a and ns5a proteins were expressed in human embryonic kidney 293 (HEK-293) cells before challenge with Sendai virus. The Human Antiviral Response PCR array was used to profile the antiviral gene expression in HEK-293 cells. Over 30 genes were downregulated in the presence of one of the HCoV-OC43 proteins, e.g. genes representing mitogen-activated protein kinases, toll-like receptors, interferons, interleukins, and signaling transduction proteins. Our findings suggest that similarly to SARS-CoV and MERS-CoV, HCoV-OC43 has the ability to downregulate the transcription of genes critical for the activation of different antiviral signaling pathways. Further studies are needed to confirm the role of HCoV-OC43 structural and accessory proteins in antagonising antiviral gene expression.
Url:
DOI: 10.1007/s00705-018-3832-8
PubMed: 29619598
PubMed Central: 7086905
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(metabolism)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Coronavirus humain OC43 (génétique)</term><term>Coronavirus humain OC43 (isolement et purification)</term><term>Coronavirus humain OC43 (physiologie)</term><term>Humains</term><term>Immunité innée</term><term>Infections à coronavirus (génétique)</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (virologie)</term><term>Interactions hôte-pathogène</term><term>Lignée cellulaire</term><term>Protéines virales non structurales (génétique)</term><term>Protéines virales non structurales (métabolisme)</term><term>Protéines virales régulatrices ou accessoires (génétique)</term><term>Protéines virales régulatrices ou accessoires (métabolisme)</term><term>Rein (cytologie)</term><term>Rein (immunologie)</term><term>Rein (virologie)</term><term>Réaction de polymérisation en chaîne ()</term><term>Régulation négative</term><term>Réplication virale</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Nonstructural Proteins</term><term>Viral Regulatory and Accessory Proteins</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Rein</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Kidney</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus Infections</term><term>Coronavirus OC43, Human</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus humain OC43</term><term>Infections à coronavirus</term><term>Protéines virales non structurales</term><term>Protéines virales régulatrices ou accessoires</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Rein</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term><term>Kidney</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus OC43, Human</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus humain OC43</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Viral Nonstructural Proteins</term><term>Viral Regulatory and Accessory Proteins</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines virales non structurales</term><term>Protéines virales régulatrices ou accessoires</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus humain OC43</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus OC43, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Rein</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Kidney</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Down-Regulation</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Immunity, Innate</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Immunité innée</term><term>Interactions hôte-pathogène</term><term>Lignée cellulaire</term><term>Réaction de polymérisation en chaîne</term><term>Régulation négative</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Human coronavirus OC43 (HCoV-OC43) is a respiratory virus that usually causes a common cold. However, it has the potential to cause severe infection in young children and immunocompromised adults. Both SARS-CoV and MERS-CoV were shown to express proteins with the potential to evade early innate immune responses. However, the ability of HCoV-OC43 to antagonise the intracellular antiviral defences has not yet been investigated. The potential role of the HCoV-OC43 structural (M and N) and accessory proteins (ns2a and ns5a) in the alteration of antiviral gene expression was investigated in this study. HCoV-OC43M, N, ns2a and ns5a proteins were expressed in human embryonic kidney 293 (HEK-293) cells before challenge with Sendai virus. The Human Antiviral Response PCR array was used to profile the antiviral gene expression in HEK-293 cells. Over 30 genes were downregulated in the presence of one of the HCoV-OC43 proteins, e.g. genes representing mitogen-activated protein kinases, toll-like receptors, interferons, interleukins, and signaling transduction proteins. Our findings suggest that similarly to SARS-CoV and MERS-CoV, HCoV-OC43 has the ability to downregulate the transcription of genes critical for the activation of different antiviral signaling pathways. Further studies are needed to confirm the role of HCoV-OC43 structural and accessory proteins in antagonising antiviral gene expression.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cavanagh, D" uniqKey="Cavanagh D">D Cavanagh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vijgen, L" uniqKey="Vijgen L">L Vijgen</name></author><author><name sortKey="Keyaerts, E" uniqKey="Keyaerts E">E Keyaerts</name></author><author><name sortKey="Lemey, P" uniqKey="Lemey P">P Lemey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Larson, He" uniqKey="Larson H">HE Larson</name></author><author><name sortKey="Reed, Se" uniqKey="Reed S">SE Reed</name></author><author><name sortKey="Tyrrell, Da" uniqKey="Tyrrell D">DA Tyrrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lepiller, Q" uniqKey="Lepiller Q">Q 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Mu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Netland, J" uniqKey="Netland J">J Netland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dai, L" uniqKey="Dai L">L Dai</name></author><author><name sortKey="Aye Thu, C" uniqKey="Aye Thu C">C Aye Thu</name></author><author><name sortKey="Liu, X Y" uniqKey="Liu X">X-Y Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, Z" uniqKey="Jiang Z">Z Jiang</name></author><author><name sortKey="Zamanian Daryoush, M" uniqKey="Zamanian Daryoush M">M Zamanian-Daryoush</name></author><author><name sortKey="Nie, H" uniqKey="Nie H">H Nie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogolla, Ps" uniqKey="Ogolla P">PS Ogolla</name></author><author><name sortKey="Portillo, J Ac" uniqKey="Portillo J">J-AC Portillo</name></author><author><name sortKey="White, Cl" uniqKey="White C">CL White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheung, Cy" uniqKey="Cheung C">CY Cheung</name></author><author><name sortKey="Poon, Llm" uniqKey="Poon L">LLM Poon</name></author><author><name sortKey="Ng, Ihy" uniqKey="Ng I">IHY Ng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Skp" uniqKey="Lau S">SKP Lau</name></author><author><name sortKey="Lau, Ccy" uniqKey="Lau C">CCY Lau</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K-H Chan</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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