[Pharmacotherapeutics for the New Coronavirus Pneumonia].
Identifieur interne : 000009 ( Main/Curation ); précédent : 000008; suivant : 000010[Pharmacotherapeutics for the New Coronavirus Pneumonia].
Auteurs : B. Du [République populaire de Chine] ; H B Qiu [République populaire de Chine] ; X. Zhan [République populaire de Chine] ; Y S Wang [République populaire de Chine] ; H Y J. Kang [République populaire de Chine] ; X Y Li [République populaire de Chine] ; F. Wang [République populaire de Chine] ; B. Sun [République populaire de Chine] ; Z H Tong [République populaire de Chine]Source :
- Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases [ 1001-0939 ] ; 2020.
Descripteurs français
- KwdFr :
- Adénosine (analogues et dérivés), Adénosine (usage thérapeutique), Alanine (analogues et dérivés), Alanine (usage thérapeutique), Antibactériens (usage thérapeutique), Antiviraux, Association de médicaments, Chine, Humains, Infections à coronavirus (traitement médicamenteux), Inhibiteurs du cytochrome P-450 CYP3A (usage thérapeutique), Lopinavir (usage thérapeutique), Pneumopathie virale (traitement médicamenteux), Ribonucléotides (usage thérapeutique), Ritonavir (usage thérapeutique), Études rétrospectives.
- MESH :
- analogues et dérivés : Adénosine, Alanine.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Adénosine, Alanine, Antibactériens, Inhibiteurs du cytochrome P-450 CYP3A, Lopinavir, Ribonucléotides, Ritonavir.
- Antiviraux, Association de médicaments, Chine, Humains, Études rétrospectives.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Adenosine (analogs & derivatives), Adenosine (therapeutic use), Alanine (analogs & derivatives), Alanine (therapeutic use), Anti-Bacterial Agents (therapeutic use), Antiviral Agents, China, Coronavirus Infections (drug therapy), Cytochrome P-450 CYP3A Inhibitors (therapeutic use), Drug Therapy, Combination, Humans, Lopinavir (therapeutic use), Pneumonia, Viral (drug therapy), Retrospective Studies, Ribonucleotides (therapeutic use), Ritonavir (therapeutic use).
- MESH :
- chemical , analogs & derivatives : Adenosine, Alanine.
- chemical , therapeutic use : Adenosine, Alanine, Anti-Bacterial Agents, Cytochrome P-450 CYP3A Inhibitors, Lopinavir, Ribonucleotides, Ritonavir.
- chemical : Antiviral Agents.
- geographic : China.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- Drug Therapy, Combination, Humans, Retrospective Studies.
Abstract
The New Coronavirus Pneumonia (NCP, also named as COVID-19 by WHO on Feb 11 2020, is now causing a severe public health emergency in China since. The number of diagnosed cases is more than 40,000 until the submission of this manuscript. Coronavirus has caused several epidemic situations world widely, but the present contagious disease caused by 2019 new Coronavirus is unprecedentedly fulminating. The published cohorts of 2019 new Coronavirus (n-Cov) are single-center studies, or retrospective studies. We here share the therapeutic experiences of NCP treatment with literature review. Combination of Ribavirin and Interferon-α is recommended by the 5(th) edition National Health Commission's Regimen (Revised Edition) because of the effect on MERS (Middle East Respiratory Syndrome), and the effectiveness of Lopinavir/Ritonavir and Remdisivir needs to be confirmed by randomized controlled trial (RCT), given the situation of no specific antivirus drug on NCP is unavailable. Systemic glucocorticosteroid is recommended as a short term use (1~2 mg.kg(-1).d(-1), 3~5d ) by the 5(th) edition National Health Commission's Regimen (Revised Edition) yet RCTs are expected to confirm the effectiveness. Inappropriate application of antibiotics should be avoided, especially the combination of broad-spectrum antibiotics, for the NCP is not often complicated with bacterial infection.
DOI: 10.3760/cma.j.issn.1001-0939.2020.0012
PubMed: 32057209
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pubmed:32057209Le document en format XML
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<front><div type="abstract" xml:lang="en">The New Coronavirus Pneumonia (NCP, also named as COVID-19 by WHO on Feb 11 2020, is now causing a severe public health emergency in China since. The number of diagnosed cases is more than 40,000 until the submission of this manuscript. Coronavirus has caused several epidemic situations world widely, but the present contagious disease caused by 2019 new Coronavirus is unprecedentedly fulminating. The published cohorts of 2019 new Coronavirus (n-Cov) are single-center studies, or retrospective studies. We here share the therapeutic experiences of NCP treatment with literature review. Combination of Ribavirin and Interferon-α is recommended by the 5(th) edition National Health Commission's Regimen (Revised Edition) because of the effect on MERS (Middle East Respiratory Syndrome), and the effectiveness of Lopinavir/Ritonavir and Remdisivir needs to be confirmed by randomized controlled trial (RCT), given the situation of no specific antivirus drug on NCP is unavailable. Systemic glucocorticosteroid is recommended as a short term use (1~2 mg.kg(-1).d(-1), 3~5d ) by the 5(th) edition National Health Commission's Regimen (Revised Edition) yet RCTs are expected to confirm the effectiveness. Inappropriate application of antibiotics should be avoided, especially the combination of broad-spectrum antibiotics, for the NCP is not often complicated with bacterial infection.</div>
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<double idat="1001-0939:2020:Du B:pharmacotherapeutics:for:the"><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Pharmacotherapeutics for the New Coronavirus Pneumonia].</title>
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<author><name sortKey="Qiu, H B" sort="Qiu, H B" uniqKey="Qiu H" first="H B" last="Qiu">H B Qiu</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009</wicri:regionArea>
<wicri:noRegion>Nanjing 210009</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhan, X" sort="Zhan, X" uniqKey="Zhan X" first="X" last="Zhan">X. Zhan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Y S" sort="Wang, Y S" uniqKey="Wang Y" first="Y S" last="Wang">Y S Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kang, H Y J" sort="Kang, H Y J" uniqKey="Kang H" first="H Y J" last="Kang">H Y J. Kang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, X Y" sort="Li, X Y" uniqKey="Li X" first="X Y" last="Li">X Y Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, F" sort="Wang, F" uniqKey="Wang F" first="F" last="Wang">F. Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sun, B" sort="Sun, B" uniqKey="Sun B" first="B" last="Sun">B. Sun</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tong, Z H" sort="Tong, Z H" uniqKey="Tong Z" first="Z H" last="Tong">Z H Tong</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
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<date when="2020">2020</date>
<idno type="RBID">pubmed:32057209</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">[Pharmacotherapeutics for the New Coronavirus Pneumonia].</title>
<author><name sortKey="Du, B" sort="Du, B" uniqKey="Du B" first="B" last="Du">B. Du</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Qiu, H B" sort="Qiu, H B" uniqKey="Qiu H" first="H B" last="Qiu">H B Qiu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009</wicri:regionArea>
<wicri:noRegion>Nanjing 210009</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhan, X" sort="Zhan, X" uniqKey="Zhan X" first="X" last="Zhan">X. Zhan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Y S" sort="Wang, Y S" uniqKey="Wang Y" first="Y S" last="Wang">Y S Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kang, H Y J" sort="Kang, H Y J" uniqKey="Kang H" first="H Y J" last="Kang">H Y J. Kang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, X Y" sort="Li, X Y" uniqKey="Li X" first="X Y" last="Li">X Y Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, F" sort="Wang, F" uniqKey="Wang F" first="F" last="Wang">F. Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sun, B" sort="Sun, B" uniqKey="Sun B" first="B" last="Sun">B. Sun</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tong, Z H" sort="Tong, Z H" uniqKey="Tong Z" first="Z H" last="Tong">Z H Tong</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases</title>
<idno type="ISSN">1001-0939</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The New Coronavirus Pneumonia (NCP, also named as COVID-19 by WHO on Feb 11 2020, is now causing a severe public health emergency in China since. The number of diagnosed cases is more than 40,000 until the submission of this manuscript. Coronavirus has caused several epidemic situations world widely, but the present contagious disease caused by 2019 new Coronavirus is unprecedentedly fulminating. The published cohorts of 2019 new Coronavirus (n-Cov) are single-center studies, or retrospective studies. We here share the therapeutic experiences of NCP treatment with literature review. Combination of Ribavirin and Interferon-α is recommended by the 5(th) edition National Health Commission's Regimen (Revised Edition) because of the effect on MERS (Middle East Respiratory Syndrome), and the effectiveness of Lopinavir/Ritonavir and Remdisivir needs to be confirmed by randomized controlled trial (RCT), given the situation of no specific antivirus drug on NCP is unavailable. Systemic glucocorticosteroid is recommended as a short term use (1~2 mg.kg(-1).d(-1), 3~5d ) by the 5(th) edition National Health Commission's Regimen (Revised Edition) yet RCTs are expected to confirm the effectiveness. Inappropriate application of antibiotics should be avoided, especially the combination of broad-spectrum antibiotics, for the NCP is not often complicated with bacterial infection.</div>
</front>
</TEI>
</PubMed>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Pharmacotherapeutics for the new coronavirus pneumonia].</title>
<author><name sortKey="Du, B" sort="Du, B" uniqKey="Du B" first="B" last="Du">B. Du</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Qiu, H B" sort="Qiu, H B" uniqKey="Qiu H" first="H B" last="Qiu">H B Qiu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009</wicri:regionArea>
<wicri:noRegion>Nanjing 210009</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhan, X" sort="Zhan, X" uniqKey="Zhan X" first="X" last="Zhan">X. Zhan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Y S" sort="Wang, Y S" uniqKey="Wang Y" first="Y S" last="Wang">Y S Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kang, H Y J" sort="Kang, H Y J" uniqKey="Kang H" first="H Y J" last="Kang">H Y J. Kang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, X Y" sort="Li, X Y" uniqKey="Li X" first="X Y" last="Li">X Y Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, F" sort="Wang, F" uniqKey="Wang F" first="F" last="Wang">F. Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sun, B" sort="Sun, B" uniqKey="Sun B" first="B" last="Sun">B. Sun</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tong, Z H" sort="Tong, Z H" uniqKey="Tong Z" first="Z H" last="Tong">Z H Tong</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
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<date when="2020">2020</date>
<idno type="RBID">pubmed:32164081</idno>
<idno type="pmid">32164081</idno>
<idno type="doi">10.3760/cma.j.issn.1001-0939.2020.03.005</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">[Pharmacotherapeutics for the new coronavirus pneumonia].</title>
<author><name sortKey="Du, B" sort="Du, B" uniqKey="Du B" first="B" last="Du">B. Du</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Qiu, H B" sort="Qiu, H B" uniqKey="Qiu H" first="H B" last="Qiu">H B Qiu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009</wicri:regionArea>
<wicri:noRegion>Nanjing 210009</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhan, X" sort="Zhan, X" uniqKey="Zhan X" first="X" last="Zhan">X. Zhan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Y S" sort="Wang, Y S" uniqKey="Wang Y" first="Y S" last="Wang">Y S Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kang, H Y J" sort="Kang, H Y J" uniqKey="Kang H" first="H Y J" last="Kang">H Y J. Kang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, X Y" sort="Li, X Y" uniqKey="Li X" first="X Y" last="Li">X Y Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, F" sort="Wang, F" uniqKey="Wang F" first="F" last="Wang">F. Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sun, B" sort="Sun, B" uniqKey="Sun B" first="B" last="Sun">B. Sun</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tong, Z H" sort="Tong, Z H" uniqKey="Tong Z" first="Z H" last="Tong">Z H Tong</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases</title>
<idno type="ISSN">1001-0939</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine (analogs & derivatives)</term>
<term>Adenosine (therapeutic use)</term>
<term>Alanine (analogs & derivatives)</term>
<term>Alanine (therapeutic use)</term>
<term>Anti-Bacterial Agents (therapeutic use)</term>
<term>Antiviral Agents</term>
<term>China</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Cytochrome P-450 CYP3A Inhibitors (therapeutic use)</term>
<term>Drug Therapy, Combination</term>
<term>Humans</term>
<term>Lopinavir (therapeutic use)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Retrospective Studies</term>
<term>Ribonucleotides (therapeutic use)</term>
<term>Ritonavir (therapeutic use)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adénosine (analogues et dérivés)</term>
<term>Adénosine (usage thérapeutique)</term>
<term>Alanine (analogues et dérivés)</term>
<term>Alanine (usage thérapeutique)</term>
<term>Antibactériens (usage thérapeutique)</term>
<term>Antiviraux</term>
<term>Association de médicaments</term>
<term>Chine</term>
<term>Humains</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Inhibiteurs du cytochrome P-450 CYP3A (usage thérapeutique)</term>
<term>Lopinavir (usage thérapeutique)</term>
<term>Pneumopathie virale (traitement médicamenteux)</term>
<term>Ribonucléotides (usage thérapeutique)</term>
<term>Ritonavir (usage thérapeutique)</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenosine</term>
<term>Alanine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adenosine</term>
<term>Alanine</term>
<term>Anti-Bacterial Agents</term>
<term>Cytochrome P-450 CYP3A Inhibitors</term>
<term>Lopinavir</term>
<term>Ribonucleotides</term>
<term>Ritonavir</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antiviral Agents</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adénosine</term>
<term>Alanine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Adénosine</term>
<term>Alanine</term>
<term>Antibactériens</term>
<term>Inhibiteurs du cytochrome P-450 CYP3A</term>
<term>Lopinavir</term>
<term>Ribonucléotides</term>
<term>Ritonavir</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Drug Therapy, Combination</term>
<term>Humans</term>
<term>Retrospective Studies</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Antiviraux</term>
<term>Association de médicaments</term>
<term>Chine</term>
<term>Humains</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
</keywords>
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<front><div type="abstract" xml:lang="en">The new coronavirus pneumonia (NCP), also named as COVID-19 by WHO on Feb 11 2020, is now causing a severe public health emergency in China since. The number of diagnosed cases is more than 40,000 until the submission of this manuscript. Coronavirus has caused several epidemic situations world widely, but the present contagious disease caused by 2019 new coronavirus is unprecedentedly fulminating. The published cohorts of 2019 new coronavirus (n-Cov) are single-center studies, or retrospective studies. We here share the therapeutic experiences of NCP treatment with literature review. Combination of Ribavirin and interferon-α is recommended by the 5(th) edition National Health Commission's Regimen (Revised Edition) because of the effect on Middle East respiratory syndrome (MERS), and the effectiveness of Lopinavir/Ritonavir and Remdisivir needs to be confirmed by randomized controlled trial (RCT), given the situation of no specific antivirus drug on NCP is unavailable. Systemic glucocorticosteroid is recommended as a short term use (1~2 mg·kg(-1)·d(-1), 3~5 d) by the 5(th) edition National Health Commission's Regimen (Revised Edition) yet RCTs are expected to confirm the effectiveness. Inappropriate application of antibiotics should be avoided, especially the combination of broad-spectrum antibiotics, for the NCP is not often complicated with bacterial infection.</div>
</front>
</TEI>
</PubMed>
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