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Three-way and four-way junctions in DNA: a conformational viewpoint

Identifieur interne : 002553 ( Istex/Curation ); précédent : 002552; suivant : 002554

Three-way and four-way junctions in DNA: a conformational viewpoint

Auteurs : Cornelis Altona [Pays-Bas] ; Jeroen A. Pikkemaat [Pays-Bas] ; Franc Jj Overmars [Pays-Bas]

Source :

RBID : ISTEX:6FA34B1117A63CC049432062B82B56DA6C614259

English descriptors

Abstract

Abstract: DNA junctions are potential intermediates in various important genetic processes, including mutagenesis and recombination. The quantity of research carried out in this area is rapidly increasing. Examples of three-way and four-way junctions are now relatively well characterized and a few common properties have been recognized, of which the most important is the tendency of junctions to fold into one or more coaxially stacked helical conformations or cross-over structures.

Url:
DOI: 10.1016/S0959-440X(96)80048-0

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ISTEX:6FA34B1117A63CC049432062B82B56DA6C614259

Le document en format XML

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<term>Altona</term>
<term>Authors report</term>
<term>Backbone strands</term>
<term>Base pair</term>
<term>Base pairing</term>
<term>Base pairs</term>
<term>Base sequence</term>
<term>Base sequences</term>
<term>Biochemistry</term>
<term>Biol</term>
<term>Biological function</term>
<term>Biophys</term>
<term>Biophys biomol struct</term>
<term>Branch migration</term>
<term>Branch point</term>
<term>Capital letters</term>
<term>Central base pairs</term>
<term>Central residues</term>
<term>Centre</term>
<term>Chazin</term>
<term>Chemical attack</term>
<term>Chen chazin</term>
<term>Chen heffron</term>
<term>Clear preference</term>
<term>Coaxial</term>
<term>Coaxial base</term>
<term>Conformation</term>
<term>Conformational</term>
<term>Conformational analysis</term>
<term>Conformational aspects</term>
<term>Conformational choice</term>
<term>Conformational preference</term>
<term>Conformational selection</term>
<term>Conformational selectivity</term>
<term>Conformational viewpoint altona</term>
<term>Conformer</term>
<term>Conformer selection</term>
<term>Conformers</term>
<term>Continuous helical axes</term>
<term>Continuous strands</term>
<term>Critical amount</term>
<term>Direct evidence</term>
<term>Divalent ions</term>
<term>Double helices</term>
<term>Double helix</term>
<term>Duckett</term>
<term>Equimolar quantities</term>
<term>First time</term>
<term>Fluorescence resonance energy transfer</term>
<term>Fluorescence resonance energy transfer analysis</term>
<term>Further progress</term>
<term>Genetic recombination</term>
<term>Groove</term>
<term>Hairpin</term>
<term>Hairpin loop</term>
<term>Hairpin loops</term>
<term>Hela cells</term>
<term>Helical</term>
<term>Helical arms</term>
<term>Helix</term>
<term>Holliday</term>
<term>Holliday junction</term>
<term>Interhelical noes</term>
<term>International union</term>
<term>Interresidue noes</term>
<term>Ionic conditions</term>
<term>Ionic strength</term>
<term>Junction</term>
<term>Junction folds</term>
<term>Junctions exhibit</term>
<term>Junctions show</term>
<term>Kallenbach</term>
<term>Ladder motifs</term>
<term>Leontis</term>
<term>Lilley</term>
<term>Local conformation</term>
<term>Lond biol</term>
<term>Long arms</term>
<term>Magnesium</term>
<term>Magnesium ions</term>
<term>Migration</term>
<term>Minihairpin loops</term>
<term>Minor amount</term>
<term>Minor groove</term>
<term>Model compounds</term>
<term>Modelling study</term>
<term>Molecular biology</term>
<term>Molecular dynamics</term>
<term>More base pairs</term>
<term>Murchie</term>
<term>Mutual angle</term>
<term>Noesy spectra</term>
<term>Novel type</term>
<term>Nucleic</term>
<term>Nucleic acids</term>
<term>Other form</term>
<term>Other techniques</term>
<term>Overmars</term>
<term>Pikkemaat</term>
<term>Polyvalent</term>
<term>Polyvalent cations</term>
<term>Polyvalent ions</term>
<term>Proton</term>
<term>Proton resonances</term>
<term>Recombination</term>
<term>Relative orientation</term>
<term>Relative stabilities</term>
<term>Resonance assignments</term>
<term>Right angles</term>
<term>Salt conditions</term>
<term>Schematic representation</term>
<term>Seeman</term>
<term>Single strand</term>
<term>Single strands</term>
<term>Small angle</term>
<term>Solution structure</term>
<term>Spectroscopy</term>
<term>Spontaneous branch migration</term>
<term>Stacks</term>
<term>Stacks collinearly</term>
<term>Step time</term>
<term>Strand</term>
<term>Strand exchange</term>
<term>Strong preference</term>
<term>Structural biology</term>
<term>Sugar protons</term>
<term>Synthetic immobile holliday junctions</term>
<term>Tertiary constraints</term>
<term>Thymidine bases</term>
<term>Transition state</term>
<term>Twj1</term>
<term>Twj2</term>
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<div type="abstract" xml:lang="en">Abstract: DNA junctions are potential intermediates in various important genetic processes, including mutagenesis and recombination. The quantity of research carried out in this area is rapidly increasing. Examples of three-way and four-way junctions are now relatively well characterized and a few common properties have been recognized, of which the most important is the tendency of junctions to fold into one or more coaxially stacked helical conformations or cross-over structures.</div>
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