Generating New Molecular Function: A Lesson from Nature

Generating New Molecular Function: A Lesson from Nature

Source :

• Angewandte Chemie International Edition [ 1433-7851 ] ; 1999-01-15.

English descriptors

• Teeft :
  • Acad, Acyl transfer reactions, Amino, Amino acid, Amino acids, Amplification, Angew, Antibody, Antibody diversity, Antibody molecule, Bacterial expression, Bind, Bind antibodies, Binding affinities, Binding affinity, Binding site, Biological properties, Biosynthetic machinery, Broader range, Building blocks, Carbon carbon bond, Catalysis, Catalyst, Catalytic, Catalytic activity, Catalytic antibodies, Catalytic function, Catalyze, Chem, Chemical properties, Chemical structures, Chemical synthesis, Combinatorial, Combinatorial approaches, Combinatorial arrays, Combinatorial association, Combinatorial libraries, Combinatorial library, Combinatorial methods, Combinatorial processes, Combinatorial strategies, Combinatorial synthesis, Computational methods, Conformational diversity, Crystal structure, Cyclic peptides, Diverse collections, Diverse populations, Dower, Drug discovery, Extracellular domain, Ferroelectric materials, Filamentous phage, General scheme, Hapten, High affinity, High sensitivity, Howard hughes, Hydrogen bonds, Immune, Immune system, Immunological diversity, Important role, Impressive examples, Ketone substrate, Large libraries, Large number, Lerner, Ligand, Major impact, Materials science, Metal oxides, Molecular diversity, Molecular diversity reviews, Molecular structure, Molecule, Monomer, Multipin synthesis, Mutant, Mutant proteins, Mutation, Natl, Natural diversity, Natural ligand, Natural products, Nonpolymeric molecules, Novel properties, Nucleic, Nucleic acids, Oligomeric molecules, Oligonucleotide, Oligonucleotide probes, Other receptors, Peptide, Peptide sequences, Pericyclic reactions, Personal communication, Phage, Phage display, Phage display techniques, Physical properties, Polypeptide, Polypeptide chain, Porphyrin ring, Prebiotic world, Proc, Protein catalysts, Protein function, Protein sequence, Recent example, Receptor, Ribozyme, Rna, Schematic representation, Schultz, Selective ligands, Side chains, Significant impact, Similar approaches, Small molecules, Small number, Solid support, Somatic mutation, Somatic mutations, Structural basis, Structural information, Successful isolation, Such example, Synthetic diversity, Synthetic molecules, Szostak, Tangent loss, Tetrahedron lett, Transition state, Unpublished results, Wang, Wide array, Wide variety, Xiang.

Abstract

• https://api.istex.fr/ark:/67375/WNG-R8G1JBSV-3/fulltext.pdf

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