Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides
Identifieur interne : 002257 ( Istex/Curation ); précédent : 002256; suivant : 002258Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides
Auteurs : Ekambar R. Kandimalla [États-Unis] ; Sudhir Agrawal [États-Unis]Source :
- Advances in Polymer Science [ 0065-3195 ]
Abstract
Abstract: Toll-like receptors (TLRs) 7, 8, and 9 belong to a family of endosomal receptors that are known to detect pathogen-associated nucleic acid molecular patterns and induce appropriate immune responses. Viral single-stranded RNA is the ligand for TLR7 and TLR8, and bacterial and viral DNA containing unmethylated CpG motifs is the ligand for TLR9. We have extensively studied the structure–activity relationships of synthetic oligonucleotides towards the goal of creating novel agonists of TLRs 7, 8, and 9 to modulate immune responses mediated through targeted receptors. Agonists of TLRs 7, 8, and 9 are being studied as therapeutic agents for various diseases, including cancers, allergies, asthma, and infectious diseases, and also as adjuvants with vaccines. In addition, under certain pathological conditions, TLR7 and TLR9 are shown to recognize immune complexes containing self-nucleic acids and contribute to the progression of autoimmune diseases, including lupus, arthritis, psoriasis, and multiple sclerosis. Using the insights gained by studying the interactions of oligonucleotides with endosomal TLRs, we have created oligonucleotide-based antagonists that inhibit both TLR7- and TLR9-mediated immune responses for the treatment of autoimmune and inflammatory diseases. Out of the large portfolio of oligonucleotide-based TLR agonists and antagonists designed, four candidates are currently being evaluated in clinical trials for a broad range of disease indications.
Url:
DOI: 10.1007/12_2011_138
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002257
Links to Exploration step
ISTEX:0DA4D782E265BF06733BBBC34359C59143CD2079Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides</title>
<author><name sortKey="Kandimalla, Ekambar R" sort="Kandimalla, Ekambar R" uniqKey="Kandimalla E" first="Ekambar R." last="Kandimalla">Ekambar R. Kandimalla</name>
<affiliation wicri:level="1"><mods:affiliation>Idera Pharmaceuticals, 167 Sidney Street, 02139, Cambridge, MA, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Idera Pharmaceuticals, 167 Sidney Street, 02139, Cambridge, MA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Agrawal, Sudhir" sort="Agrawal, Sudhir" uniqKey="Agrawal S" first="Sudhir" last="Agrawal">Sudhir Agrawal</name>
<affiliation wicri:level="1"><mods:affiliation>Idera Pharmaceuticals, 167 Sidney Street, 02139, Cambridge, MA, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Idera Pharmaceuticals, 167 Sidney Street, 02139, Cambridge, MA</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>E-mail: sagrawal@iderapharma.com</mods:affiliation>
<wicri:noCountry code="no comma">E-mail: sagrawal@iderapharma.com</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:0DA4D782E265BF06733BBBC34359C59143CD2079</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1007/12_2011_138</idno>
<idno type="url">https://api.istex.fr/ark:/67375/HCB-5PTFH70V-G/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002257</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002257</idno>
<idno type="wicri:Area/Istex/Curation">002257</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides</title>
<author><name sortKey="Kandimalla, Ekambar R" sort="Kandimalla, Ekambar R" uniqKey="Kandimalla E" first="Ekambar R." last="Kandimalla">Ekambar R. Kandimalla</name>
<affiliation wicri:level="1"><mods:affiliation>Idera Pharmaceuticals, 167 Sidney Street, 02139, Cambridge, MA, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Idera Pharmaceuticals, 167 Sidney Street, 02139, Cambridge, MA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Agrawal, Sudhir" sort="Agrawal, Sudhir" uniqKey="Agrawal S" first="Sudhir" last="Agrawal">Sudhir Agrawal</name>
<affiliation wicri:level="1"><mods:affiliation>Idera Pharmaceuticals, 167 Sidney Street, 02139, Cambridge, MA, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Idera Pharmaceuticals, 167 Sidney Street, 02139, Cambridge, MA</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>E-mail: sagrawal@iderapharma.com</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="s" type="main" xml:lang="en">Advances in Polymer Science</title>
<title level="s" type="abbrev">Advs Polymer Science</title>
<idno type="ISSN">0065-3195</idno>
<idno type="eISSN">1436-5030</idno>
<idno type="ISSN">0065-3195</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0065-3195</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Toll-like receptors (TLRs) 7, 8, and 9 belong to a family of endosomal receptors that are known to detect pathogen-associated nucleic acid molecular patterns and induce appropriate immune responses. Viral single-stranded RNA is the ligand for TLR7 and TLR8, and bacterial and viral DNA containing unmethylated CpG motifs is the ligand for TLR9. We have extensively studied the structure–activity relationships of synthetic oligonucleotides towards the goal of creating novel agonists of TLRs 7, 8, and 9 to modulate immune responses mediated through targeted receptors. Agonists of TLRs 7, 8, and 9 are being studied as therapeutic agents for various diseases, including cancers, allergies, asthma, and infectious diseases, and also as adjuvants with vaccines. In addition, under certain pathological conditions, TLR7 and TLR9 are shown to recognize immune complexes containing self-nucleic acids and contribute to the progression of autoimmune diseases, including lupus, arthritis, psoriasis, and multiple sclerosis. Using the insights gained by studying the interactions of oligonucleotides with endosomal TLRs, we have created oligonucleotide-based antagonists that inhibit both TLR7- and TLR9-mediated immune responses for the treatment of autoimmune and inflammatory diseases. Out of the large portfolio of oligonucleotide-based TLR agonists and antagonists designed, four candidates are currently being evaluated in clinical trials for a broad range of disease indications.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002257 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 002257 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:0DA4D782E265BF06733BBBC34359C59143CD2079 |texte= Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides }}
This area was generated with Dilib version V0.6.33. |