Crystal structure of XMRV protease differs from the structures of other retropepsins
Identifieur interne : 001A01 ( Istex/Curation ); précédent : 001A00; suivant : 001A02Crystal structure of XMRV protease differs from the structures of other retropepsins
Auteurs : Mi Li [États-Unis] ; Frank Dimaio [États-Unis] ; Dongwen Zhou [États-Unis] ; Alla Gustchina [États-Unis] ; Jacek Lubkowski [États-Unis] ; Zbigniew Dauter [États-Unis] ; David Baker [États-Unis] ; Alexander Wlodawer [États-Unis]Source :
- Nature Structural & Molecular Biology [ 1545-9993 ] ; 2011-02.
Abstract
XMRV is a retrovirus that has been linked to prostate cancer and chronic fatigue syndrome. The crystal structure of the XMRV protease differs from the structures of other retropepsins and instead resembles those of pepsin-like enzymes, suggesting that this protease may represent a distinct evolutionary branch of the aspartic proteases.
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DOI: 10.1038/nsmb.1964
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retropepsins</title><author><name sortKey="Li, Mi" sort="Li, Mi" uniqKey="Li M" first="Mi" last="Li">Mi Li</name><affiliation wicri:level="1"><mods:affiliation>Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland, USA.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Basic Research Program, SAIC-Frederick, Frederick, Maryland, USA.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Basic Research Program, SAIC-Frederick, Frederick, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Dimaio, Frank" sort="Dimaio, Frank" uniqKey="Dimaio F" first="Frank" last="Dimaio">Frank 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wlodawer@nih.gov</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Nature Structural & Molecular Biology</title><idno type="ISSN">1545-9993</idno><idno type="eISSN">1545-9985</idno><imprint><publisher>Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</publisher><date when="2011-02">2011-02</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="227">227</biblScope><biblScope unit="page" to="229">229</biblScope><date type="Copyright" when="2011">2011</date></imprint><idno type="ISSN">1545-9993</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1545-9993</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">XMRV is a retrovirus that has been linked to prostate cancer and chronic fatigue syndrome. The crystal structure of the XMRV protease differs from the structures of other retropepsins and instead resembles those of pepsin-like enzymes, suggesting that this protease may represent a distinct evolutionary branch of the aspartic proteases.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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