In vitro and in vivo action of antisense RNA
Identifieur interne : 001114 ( Istex/Curation ); précédent : 001113; suivant : 001115In vitro and in vivo action of antisense RNA
Auteurs : Wolfgang Nellen [Allemagne] ; Georg Sczakiel [Allemagne]Source :
- Molecular Biotechnology [ 1073-6085 ] ; 1996-08-01.
English descriptors
- KwdEn :
- Teeft :
- Annealing, Antisense, Antisense machinery, Antisense mechanisms, Antisense rnas, Antisense transcripts, Artificial antisense, Biol, Cellular proteins, Complementary sequences, Complementary strands, Degradation, Dictyostelium, Dsrna, Duplex, Duplex formation, Endogenous, Gene expression, High levels, Human immunodeficiency virus type, Hybrid, Intramolecular interactions, Mrna, Natural antisense rnas, Nucleic acids, Pacl, Personal communication, Rna, Selectivity.
Abstract
Abstract: The transient or permanent expression of antisense RNA represents one option to apply antisense techniques in biotechnology and medical research. Despite the increasing importance and use of antisense nucleic acids as well as their significant antisense-specific phenotypic effects in vivo, there is an obvious lack of explanation for the mechanism of their action. By studying naturally occurring antisense RNA and analyzing their mechanism of action we attempt to learn more about the design, the use, and the critical parameters of artificial antisense RNA. Attempts to derive models from biochemical and structural studies for the interactions between antisense RNAs and their targets will be discussed.
Url:
DOI: 10.1007/BF02762319
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Kassel, Heinrich-Plett-Str. 40, 34109, Kassel</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: nellen@hrz.uni-kassel.de</mods:affiliation><country wicri:rule="url">Allemagne</country></affiliation></author><author><name sortKey="Sczakiel, Georg" sort="Sczakiel, Georg" uniqKey="Sczakiel G" first="Georg" last="Sczakiel">Georg Sczakiel</name><affiliation wicri:level="1"><mods:affiliation>Deutsches Krebsforschungszentrum, Angewandte Tumorvirologie, Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Deutsches Krebsforschungszentrum, Angewandte Tumorvirologie, Heidelberg</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6AE2E79B5BEDD1AEA926F33C8F5EE61EF7951DD7</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1007/BF02762319</idno><idno type="url">https://api.istex.fr/ark:/67375/1BB-WQXKTH5S-K/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001114</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001114</idno><idno type="wicri:Area/Istex/Curation">001114</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">In vitro and in vivo action of antisense RNA</title><author><name sortKey="Nellen, Wolfgang" sort="Nellen, Wolfgang" uniqKey="Nellen W" first="Wolfgang" last="Nellen">Wolfgang Nellen</name><affiliation><mods:affiliation>MPI f. Biochemie, 82152, Martinsried</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>Dept. of Genetics, Univ. Kassel, Heinrich-Plett-Str. 40, 34109, Kassel, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept. of Genetics, Univ. Kassel, Heinrich-Plett-Str. 40, 34109, Kassel</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: nellen@hrz.uni-kassel.de</mods:affiliation><country wicri:rule="url">Allemagne</country></affiliation></author><author><name sortKey="Sczakiel, Georg" sort="Sczakiel, Georg" uniqKey="Sczakiel G" first="Georg" last="Sczakiel">Georg Sczakiel</name><affiliation wicri:level="1"><mods:affiliation>Deutsches Krebsforschungszentrum, Angewandte Tumorvirologie, Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Deutsches Krebsforschungszentrum, Angewandte Tumorvirologie, Heidelberg</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Molecular Biotechnology</title><title level="j" type="abbrev">Mol Biotechnol</title><idno type="ISSN">1073-6085</idno><idno type="eISSN">1559-0305</idno><imprint><publisher>Humana Press</publisher><pubPlace>Totowa</pubPlace><date type="published" when="1996-08-01">1996-08-01</date><biblScope unit="volume">6</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="7">7</biblScope><biblScope unit="page" to="15">15</biblScope></imprint><idno type="ISSN">1073-6085</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1073-6085</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antisense RNA</term><term>RNA annealing</term><term>RNA-modifying proteins</term><term>antisense RNA in vivo</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Annealing</term><term>Antisense</term><term>Antisense machinery</term><term>Antisense mechanisms</term><term>Antisense rnas</term><term>Antisense transcripts</term><term>Artificial antisense</term><term>Biol</term><term>Cellular proteins</term><term>Complementary sequences</term><term>Complementary strands</term><term>Degradation</term><term>Dictyostelium</term><term>Dsrna</term><term>Duplex</term><term>Duplex formation</term><term>Endogenous</term><term>Gene expression</term><term>High levels</term><term>Human immunodeficiency virus type</term><term>Hybrid</term><term>Intramolecular interactions</term><term>Mrna</term><term>Natural antisense rnas</term><term>Nucleic acids</term><term>Pacl</term><term>Personal communication</term><term>Rna</term><term>Selectivity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The transient or permanent expression of antisense RNA represents one option to apply antisense techniques in biotechnology and medical research. Despite the increasing importance and use of antisense nucleic acids as well as their significant antisense-specific phenotypic effects in vivo, there is an obvious lack of explanation for the mechanism of their action. By studying naturally occurring antisense RNA and analyzing their mechanism of action we attempt to learn more about the design, the use, and the critical parameters of artificial antisense RNA. Attempts to derive models from biochemical and structural studies for the interactions between antisense RNAs and their targets will be discussed.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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