The influence of base sequence on the immunostimulatory properties of DNA
Identifieur interne : 001102 ( Istex/Curation ); précédent : 001101; suivant : 001103The influence of base sequence on the immunostimulatory properties of DNA
Auteurs : David S. Pisetsky [États-Unis]Source :
- Immunologic Research [ 0257-277X ] ; 1999-02-01.
Descripteurs français
- Wicri :
- topic : ADN.
English descriptors
- KwdEn :
Abstract
Abstract: DNA is a complex macromolecule whose immunological properties vary with base sequences. As shown with synthetic oligonucleotides, potent immune stimulation results from six base motifs called CpG motifs or immunostimulatory sequences (ISS). These sequences center on an unmethylated CpG dinucleotide and occur much more commonly in bacterial DNA than mammalian DNA. As such, CpG motifs may function as a danger signal to stimulate B cell activation and cytokine production. In addition to CpG motifs, runs of deoxyguanosine (dG) residues in DNA can induce B cell activation and promote macrophage cytokine expression by adjacent CpG motifs. The array of these sequences may determine the overall immune activity of a DNA molecule and affect such processes as host defense against infection as well as the use of plasmids and synthetic oligonucleotides to treat disease.
Url:
DOI: 10.1007/BF02786475
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001102
Links to Exploration step
ISTEX:851D18CABBDD15BCF7E6CA82E19A717712D71AD9Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The influence of base sequence on the immunostimulatory properties of DNA</title>
<author><name sortKey="Pisetsky, David S" sort="Pisetsky, David S" uniqKey="Pisetsky D" first="David S." last="Pisetsky">David S. Pisetsky</name>
<affiliation wicri:level="2"><mods:affiliation>Medical Service Durham VA Medical Center and Division of Rheumatology, Allergy and Clinical Immunology, Duke University Medical Center, Box 15IG, 508 Fulton St., 27705, Durham, NC</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Medical Service Durham VA Medical Center and Division of Rheumatology, Allergy and Clinical Immunology, Duke University Medical Center, Box 15IG, 508 Fulton St., 27705, Durham</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: dpiset@acpub.duke.edu</mods:affiliation>
<country wicri:rule="url">États-Unis</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:851D18CABBDD15BCF7E6CA82E19A717712D71AD9</idno>
<date when="1999" year="1999">1999</date>
<idno type="doi">10.1007/BF02786475</idno>
<idno type="url">https://api.istex.fr/ark:/67375/VQC-NPX7D9TB-9/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001102</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001102</idno>
<idno type="wicri:Area/Istex/Curation">001102</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The influence of base sequence on the immunostimulatory properties of DNA</title>
<author><name sortKey="Pisetsky, David S" sort="Pisetsky, David S" uniqKey="Pisetsky D" first="David S." last="Pisetsky">David S. Pisetsky</name>
<affiliation wicri:level="2"><mods:affiliation>Medical Service Durham VA Medical Center and Division of Rheumatology, Allergy and Clinical Immunology, Duke University Medical Center, Box 15IG, 508 Fulton St., 27705, Durham, NC</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Medical Service Durham VA Medical Center and Division of Rheumatology, Allergy and Clinical Immunology, Duke University Medical Center, Box 15IG, 508 Fulton St., 27705, Durham</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: dpiset@acpub.duke.edu</mods:affiliation>
<country wicri:rule="url">États-Unis</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Immunologic Research</title>
<title level="j" type="abbrev">Immunol Res</title>
<idno type="ISSN">0257-277X</idno>
<idno type="eISSN">1559-0755</idno>
<imprint><publisher>Humana Press</publisher>
<pubPlace>Totowa</pubPlace>
<date type="published" when="1999-02-01">1999-02-01</date>
<biblScope unit="volume">19</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="35">35</biblScope>
<biblScope unit="page" to="46">46</biblScope>
</imprint>
<idno type="ISSN">0257-277X</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0257-277X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antisense</term>
<term>Cytokines</term>
<term>DNA</term>
<term>Host defense</term>
<term>Immunostimulation</term>
<term>Phosphorothioates</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>ADN</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: DNA is a complex macromolecule whose immunological properties vary with base sequences. As shown with synthetic oligonucleotides, potent immune stimulation results from six base motifs called CpG motifs or immunostimulatory sequences (ISS). These sequences center on an unmethylated CpG dinucleotide and occur much more commonly in bacterial DNA than mammalian DNA. As such, CpG motifs may function as a danger signal to stimulate B cell activation and cytokine production. In addition to CpG motifs, runs of deoxyguanosine (dG) residues in DNA can induce B cell activation and promote macrophage cytokine expression by adjacent CpG motifs. The array of these sequences may determine the overall immune activity of a DNA molecule and affect such processes as host defense against infection as well as the use of plasmids and synthetic oligonucleotides to treat disease.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001102 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 001102 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:851D18CABBDD15BCF7E6CA82E19A717712D71AD9 |texte= The influence of base sequence on the immunostimulatory properties of DNA }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |