Boolean Algebraic Structures of the Genetic Code: Possibilities of Applications
Identifieur interne : 000424 ( Istex/Curation ); précédent : 000423; suivant : 000425Boolean Algebraic Structures of the Genetic Code: Possibilities of Applications
Auteurs : Ricardo Grau [Cuba] ; Maria Del C. Chavez [Cuba] ; Robersy Sanchez [Cuba] ; Eberto Morgado [Cuba] ; Gladys Casas [Cuba] ; Isis Bonet [Cuba]Source :
- Lecture Notes in Computer Science [ 0302-9743 ]
Abstract
Abstract: Authors had reported before two dual Boolean algebras to understand the underlying logic of the genetic code structure. In such Boolean structures, deductions have physico-chemical meaning. We summarize here that these algebraic structures can help us to describe the gene evolution process. Particularly in the experimental confrontation, it was found that most of the mutations of several proteins correspond to deductions in these algebras and they have a small Hamming distance related to their respective wild type. Two applications of the corresponding codification system in bioinformatics problems are also shown. The first one is the classification of mutations in a protein. The other one is related with the problem of detecting donors and acceptors in DNA sequences. Besides, pure mathematical models, Statistical techniques (Decision Trees) and Artificial Intelligence techniques (Bayesian Networks) were used in order to show how to accomplish them to solve these knowledge-discovery practical problems.
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DOI: 10.1007/978-3-540-71037-0_2
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Chavez">Maria Del C. Chavez</name><affiliation wicri:level="1"><mods:affiliation>Center of Studies on Informatics, Central University of Las Villas, Santa Clara, CP 54830, Cuba</mods:affiliation><country xml:lang="fr">Cuba</country><wicri:regionArea>Center of Studies on Informatics, Central University of Las Villas, Santa Clara, CP 54830</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: MChavez@uclv.edu.cu</mods:affiliation><country wicri:rule="url">Cuba</country></affiliation></author><author><name sortKey="Sanchez, Robersy" sort="Sanchez, Robersy" uniqKey="Sanchez R" first="Robersy" last="Sanchez">Robersy Sanchez</name><affiliation wicri:level="1"><mods:affiliation>Research Institute of Tropical Roots, Tuber Crops and Banana (INIVIT), Biotechnology Group, Santo Domingo, Cuba</mods:affiliation><country xml:lang="fr">Cuba</country><wicri:regionArea>Research Institute of Tropical Roots, Tuber Crops and Banana (INIVIT), Biotechnology Group, Santo Domingo</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: Robersy@uclv.edu.cu</mods:affiliation><country wicri:rule="url">Cuba</country></affiliation></author><author><name sortKey="Morgado, Eberto" sort="Morgado, Eberto" uniqKey="Morgado E" first="Eberto" last="Morgado">Eberto Morgado</name><affiliation wicri:level="1"><mods:affiliation>Center of Studies on Informatics, Central University of Las Villas, Santa Clara, CP 54830, Cuba</mods:affiliation><country xml:lang="fr">Cuba</country><wicri:regionArea>Center of Studies on Informatics, Central University of Las Villas, Santa Clara, CP 54830</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: Morgado@uclv.edu.cu</mods:affiliation><country wicri:rule="url">Cuba</country></affiliation></author><author><name sortKey="Casas, Gladys" sort="Casas, Gladys" uniqKey="Casas G" first="Gladys" last="Casas">Gladys Casas</name><affiliation wicri:level="1"><mods:affiliation>Center of Studies on Informatics, Central University of Las Villas, Santa Clara, CP 54830, Cuba</mods:affiliation><country xml:lang="fr">Cuba</country><wicri:regionArea>Center of Studies on Informatics, Central University of Las Villas, Santa Clara, CP 54830</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: Gladita@uclv.edu.cu</mods:affiliation><country wicri:rule="url">Cuba</country></affiliation></author><author><name sortKey="Bonet, Isis" sort="Bonet, Isis" uniqKey="Bonet I" first="Isis" last="Bonet">Isis Bonet</name><affiliation wicri:level="1"><mods:affiliation>Center of Studies on Informatics, Central University of Las Villas, Santa Clara, CP 54830, Cuba</mods:affiliation><country xml:lang="fr">Cuba</country><wicri:regionArea>Center of Studies on Informatics, Central University of Las Villas, Santa Clara, CP 54830</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: Ibonet@uclv.edu.cu</mods:affiliation><country wicri:rule="url">Cuba</country></affiliation></author></analytic><monogr></monogr><series><title level="s" type="main" xml:lang="en">Lecture Notes in Computer Science</title><title level="s" type="abbrev">LNCS</title><idno type="ISSN">0302-9743</idno><idno type="eISSN">1611-3349</idno><idno type="ISSN">0302-9743</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0302-9743</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Authors had reported before two dual Boolean algebras to understand the underlying logic of the genetic code structure. In such Boolean structures, deductions have physico-chemical meaning. We summarize here that these algebraic structures can help us to describe the gene evolution process. Particularly in the experimental confrontation, it was found that most of the mutations of several proteins correspond to deductions in these algebras and they have a small Hamming distance related to their respective wild type. Two applications of the corresponding codification system in bioinformatics problems are also shown. The first one is the classification of mutations in a protein. The other one is related with the problem of detecting donors and acceptors in DNA sequences. Besides, pure mathematical models, Statistical techniques (Decision Trees) and Artificial Intelligence techniques (Bayesian Networks) were used in order to show how to accomplish them to solve these knowledge-discovery practical problems.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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