Mo-MuLV nucleotide sequence exhibits three levels of oligomeric repetitions, suggesting a stepwise molecular evolution
Identifieur interne : 000051 ( Istex/Curation ); précédent : 000050; suivant : 000052Mo-MuLV nucleotide sequence exhibits three levels of oligomeric repetitions, suggesting a stepwise molecular evolution
Auteurs : Ivan Laprevotte [France]Source :
- Journal of Molecular Evolution [ 0022-2844 ] ; 1992-11-01.
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- topic : ADN.
English descriptors
- KwdEn :
- Teeft :
- Actual compositions, Chain analysis, Coding, Coding part, Coding sectorsb, Codon, Codon usage, Complementary strands, Consensus ccagacc, Consensus sequence, Construction principle, Core consensus, Doublet frequencies, Eukaryotic viruses, Feline leukemia virus, Further investigation, Gene conversion, Genetic variation, Genome, High number, Hsrv, Human genes, Human spumaretrovirus, Intermediary stage, Intragenic duplications, Laprevotte, Local duplications, Local repetitions, Major source, Markov, Markov chain, Markov chain analysis, Molecular evolution, Noncoding, Noncoding part, Noncoding sectorsb, Nonoverlapping positions, Nucleic acids, Nucleotide, Nucleotide sequence, Ohno, Oligomeric, Oligomeric repetitions, Oligomers, Original tandemly, Overrepeated, Overrepresented, Overrepresented oligomers, Proc natl acad, Purine, Putative tandem repetitions, Pyrimidine, Relative frequencies, Relative frequency, Repetitive, Residual, Residual value, Residual values, Same length, Slippagelike mechanisms, Successive values, Tandem, Tandem repetitions, Threshold value, Total number, Trimeric distribution, Unequal crossover, Universal rule, Whole sequence.
Abstract
Summary: An exhaustive computer-assisted analysis of the Moloney murine leukemia virus nucleotide sequence shows numerous deviations in the oligomeric distribution, suggesting three overlapping levels of a stepwise duplicative evolution. (1) The sequence fits the universal rule of TG/CT excess which has been proposed as the construction principle of all sequences, and maintains some degree of symmetry between the two complementary strands. (2) Oligomeric repeating units share a core consensus regularly scattered throughout the sequence. This consensus is not merely predictable from the doublet frequencies and codon usage, but could correspond to an intermediary stage in a so-called periodic-to-chaotic transition. (3) Probable stepwise local duplications could be accounted for by slippagelike mechanisms. Comparison with the human spumaretrovirus (HSRV) shows similar segments in the overrepresented oligomers of the two sequences. The intermediary stage of transition oligomeric repeating units is not so clearly suggested in HSRV, perhaps because of numerous stepwise local duplications. In any case, a common evolutionary origin for the two viruses is not ruled out.
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DOI: 10.1007/BF00171820
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mo-MuLV nucleotide sequence exhibits three levels of oligomeric repetitions, suggesting a stepwise molecular evolution</title><author><name sortKey="Laprevotte, Ivan" sort="Laprevotte, Ivan" uniqKey="Laprevotte I" first="Ivan" last="Laprevotte">Ivan Laprevotte</name><affiliation wicri:level="1"><mods:affiliation>UPR 41 CNRS “Recombinaisons Génétiques,”, Centre Hayem Hôpital Saint-Louis, 75475, Paris cedex 10, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UPR 41 CNRS “Recombinaisons Génétiques,”, Centre Hayem Hôpital Saint-Louis, 75475, Paris cedex 10</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E293A76D253FD6A367EAB60BE64C82FFB0510DE2</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1007/BF00171820</idno><idno 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10</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Molecular Evolution</title><title level="j" type="abbrev">J Mol Evol</title><idno type="ISSN">0022-2844</idno><idno type="eISSN">1432-1432</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>New York</pubPlace><date type="published" when="1992-11-01">1992-11-01</date><biblScope unit="volume">35</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="420">420</biblScope><biblScope unit="page" to="428">428</biblScope></imprint><idno type="ISSN">0022-2844</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-2844</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Computer-assisted analysis</term><term>Core consensus</term><term>DNA</term><term>HSRV</term><term>Markov analysis</term><term>Mo-MuIV</term><term>Symmetry</term><term>TG/CT excess</term></keywords><keywords scheme="Teeft" 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sectorsb</term><term>Nonoverlapping positions</term><term>Nucleic acids</term><term>Nucleotide</term><term>Nucleotide sequence</term><term>Ohno</term><term>Oligomeric</term><term>Oligomeric repetitions</term><term>Oligomers</term><term>Original tandemly</term><term>Overrepeated</term><term>Overrepresented</term><term>Overrepresented oligomers</term><term>Proc natl acad</term><term>Purine</term><term>Putative tandem repetitions</term><term>Pyrimidine</term><term>Relative frequencies</term><term>Relative frequency</term><term>Repetitive</term><term>Residual</term><term>Residual value</term><term>Residual values</term><term>Same length</term><term>Slippagelike mechanisms</term><term>Successive values</term><term>Tandem</term><term>Tandem repetitions</term><term>Threshold value</term><term>Total number</term><term>Trimeric distribution</term><term>Unequal crossover</term><term>Universal rule</term><term>Whole sequence</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>ADN</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: An exhaustive computer-assisted analysis of the Moloney murine leukemia virus nucleotide sequence shows numerous deviations in the oligomeric distribution, suggesting three overlapping levels of a stepwise duplicative evolution. (1) The sequence fits the universal rule of TG/CT excess which has been proposed as the construction principle of all sequences, and maintains some degree of symmetry between the two complementary strands. (2) Oligomeric repeating units share a core consensus regularly scattered throughout the sequence. This consensus is not merely predictable from the doublet frequencies and codon usage, but could correspond to an intermediary stage in a so-called periodic-to-chaotic transition. (3) Probable stepwise local duplications could be accounted for by slippagelike mechanisms. Comparison with the human spumaretrovirus (HSRV) shows similar segments in the overrepresented oligomers of the two sequences. The intermediary stage of transition oligomeric repeating units is not so clearly suggested in HSRV, perhaps because of numerous stepwise local duplications. In any case, a common evolutionary origin for the two viruses is not ruled out.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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