The dynamics of the RNA world: insights and challenges
Identifieur interne : 002791 ( Istex/Corpus ); précédent : 002790; suivant : 002792The dynamics of the RNA world: insights and challenges
Auteurs : Ádám Kun ; András Szilágyi ; Balázs Könny ; Gergely Boza ; István Zachar ; Eörs SzathmárySource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2015-04.
Abstract
The RNA world hypothesis of the origin of life, in which RNA emerged as both enzyme and information carrier, is receiving solid experimental support. The prebiotic synthesis of biomolecules, the catalytic aid offered by mineral surfaces, and the vast enzymatic repertoire of ribozymes are only pieces of the origin of life puzzle; the full picture can only emerge if the pieces fit together by either following from one another or coexisting with each other. Here, we review the theory of the origin, maintenance, and enhancement of the RNA world as an evolving population of dynamical systems. The dynamical view of the origin of life allows us to pinpoint the missing and the not fitting pieces: (1) How can the first self‐replicating ribozyme emerge in the absence of template‐directed information replication? (2) How can nucleotide replicators avoid competitive exclusion despite utilizing the very same resources (nucleobases)? (3) How can the information catastrophe be avoided? (4) How can enough genes integrate into a cohesive system in order to transition to a cellular stage? (5) How can the way information is stored and metabolic complexity coevolve to pave to road leading out of the RNA world to the present protein–DNA world?
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DOI: 10.1111/nyas.12700
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Sci.</title></titleGroup></publicationMeta><publicationMeta level="part" position="04101"><doi>10.1111/nyas.2015.1341.issue-1</doi><titleGroup><title type="main">DNA Habitats and Their RNA Inhabitants</title></titleGroup><copyright ownership="thirdParty">© 2015 The New York Academy of Sciences</copyright><numberingGroup><numbering type="journalVolume" number="13411">1341</numbering><numbering type="journalIssue">1</numbering></numberingGroup><creators><creator xml:id="sped1" creatorRole="guestEditor" affiliationRef="#spref1"><personName><givenNames>Guenther</givenNames><familyName>Witzany</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="spref1"><orgName>Telos‐Philosophische Praxis, Bürmoos, Austria</orgName></affiliation></affiliationGroup><coverDate startDate="2015-04">April 2015</coverDate></publicationMeta><publicationMeta level="unit" position="90" type="article" status="forIssue"><doi origin="wiley">10.1111/nyas.12700</doi><idGroup><id type="unit" value="NYAS12700"></id></idGroup><countGroup><count type="pageTotal" number="21"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="thirdParty">© 2015 New York Academy of Sciences.</copyright><eventGroup><event type="xmlCreated" agent="Aptara" date="2015-01-07"></event><event type="publishedOnlineEarlyUnpaginated" date="2015-03-03"></event><event type="firstOnline" date="2015-03-03"></event><event type="publishedOnlineFinalForm" date="2015-04-03"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.7.2 mode:FullText" date="2016-01-05"></event></eventGroup><numberingGroup><numbering type="pageFirst">75</numbering><numbering type="pageLast">95</numbering></numberingGroup><correspondenceTo>Address for correspondence: Eörs Szathmáry, Parmenides Center for the Conceptual Foundations of Science, Kirchplatz 1, 82049 Munich/Pullach, Germany. <email>szathmary.eors@gmail.com</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:NYAS.NYAS12700.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">The dynamics of the RNA world: insights and challenges</title><title type="shortAuthors">Kun <i>et al</i>.</title><title type="short">The dynamics of the RNA world</title></titleGroup><creators><creator xml:id="nyas12700-cr-0001" creatorRole="author" affiliationRef="#nyas12700-aff-0001 #nyas12700-aff-0002"><personName><givenNames>Ádám</givenNames><familyName>Kun</familyName></personName></creator><creator xml:id="nyas12700-cr-0002" creatorRole="author" affiliationRef="#nyas12700-aff-0001 #nyas12700-aff-0004"><personName><givenNames>András</givenNames><familyName>Szilágyi</familyName></personName></creator><creator xml:id="nyas12700-cr-0003" creatorRole="author" affiliationRef="#nyas12700-aff-0003"><personName><givenNames>Balázs</givenNames><familyName>Könnyű</familyName></personName></creator><creator xml:id="nyas12700-cr-0004" creatorRole="author" affiliationRef="#nyas12700-aff-0003"><personName><givenNames>Gergely</givenNames><familyName>Boza</familyName></personName></creator><creator xml:id="nyas12700-cr-0005" creatorRole="author" affiliationRef="#nyas12700-aff-0001"><personName><givenNames>István</givenNames><familyName>Zachar</familyName></personName></creator><creator xml:id="nyas12700-cr-0006" creatorRole="author" affiliationRef="#nyas12700-aff-0001 #nyas12700-aff-0003 #nyas12700-aff-0004" corresponding="yes"><personName><givenNames>Eörs</givenNames><familyName>Szathmáry</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="nyas12700-aff-0001" countryCode="DE"><orgName>Parmenides Center for the Conceptual Foundations of Science</orgName><address><city>Munich/Pullach</city><country>Germany</country></address></affiliation><affiliation xml:id="nyas12700-aff-0002" countryCode="HU"><orgName>MTA‐ELTE‐MTMT Ecology Research Group</orgName><address><city>Budapest</city><country>Hungary</country></address></affiliation><affiliation xml:id="nyas12700-aff-0003" countryCode="HU"><orgDiv>Department of Plant Systematics, Ecology and Theoretical Biology</orgDiv><orgDiv>Institute of Biology</orgDiv><orgName>Eötvös University</orgName><address><city>Budapest</city><country>Hungary</country></address></affiliation><affiliation xml:id="nyas12700-aff-0004" countryCode="HU"><orgDiv>MTA‐ELTE Theoretical Biology and Evolutionary Ecology Research Group</orgDiv><orgDiv>Department of Plant Systematics</orgDiv><orgName>Ecology and Theoretical Biology</orgName><address><city>Budapest</city><country>Hungary</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="nyas12700-kwd-0001">RNA world</keyword><keyword xml:id="nyas12700-kwd-0002">origin of life</keyword><keyword xml:id="nyas12700-kwd-0003">error threshold</keyword><keyword xml:id="nyas12700-kwd-0004">hypercycle</keyword><keyword xml:id="nyas12700-kwd-0005">metabolism</keyword><keyword xml:id="nyas12700-kwd-0006">ribozyme</keyword></keywordGroup><fundingInfo><fundingAgency>European Research Council under the European Community's Seventh Framework Programme</fundingAgency><fundingNumber>294332</fundingNumber></fundingInfo><fundingInfo><fundingAgency>European Union cofinanced by the European Social Fund</fundingAgency><fundingNumber>TAMOP 4.2.1/B‐09/1/KMR‐2010‐0003</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Hungarian Research Foundation</fundingAgency><fundingNumber>K100806</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Hungarian Research</fundingAgency><fundingNumber>OTKA K100299</fundingNumber></fundingInfo><abstractGroup><abstract type="main"><p>The RNA world hypothesis of the origin of life, in which RNA emerged as both enzyme and information carrier, is receiving solid experimental support. The prebiotic synthesis of biomolecules, the catalytic aid offered by mineral surfaces, and the vast enzymatic repertoire of ribozymes are only pieces of the origin of life puzzle; the full picture can only emerge if the pieces fit together by either following from one another or coexisting with each other. Here, we review the theory of the origin, maintenance, and enhancement of the RNA world as an evolving population of dynamical systems. The dynamical view of the origin of life allows us to pinpoint the missing and the not fitting pieces: (1) How can the first self‐replicating ribozyme emerge in the absence of template‐directed information replication? (2) How can nucleotide replicators avoid competitive exclusion despite utilizing the very same resources (nucleobases)? (3) How can the information catastrophe be avoided? (4) How can enough genes integrate into a cohesive system in order to transition to a cellular stage? (5) How can the way information is stored and metabolic complexity coevolve to pave to road leading out of the RNA world to the present protein–DNA world?</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The dynamics of the RNA world: insights and challenges</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>The dynamics of the RNA world</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The dynamics of the RNA world: insights and challenges</title></titleInfo><name type="personal"><namePart type="given">Ádám</namePart><namePart type="family">Kun</namePart><affiliation>Parmenides Center for the Conceptual Foundations of Science, Munich/Pullach, Germany</affiliation><affiliation>MTA‐ELTE‐MTMT Ecology Research Group, Budapest, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">András</namePart><namePart type="family">Szilágyi</namePart><affiliation>Parmenides Center for the Conceptual Foundations of Science, Munich/Pullach, Germany</affiliation><affiliation>MTA‐ELTE Theoretical Biology and Evolutionary Ecology Research Group, Department of Plant Systematics, Ecology and Theoretical Biology, Budapest, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Balázs</namePart><namePart type="family">Könnyű</namePart><affiliation>Department of Plant Systematics, Ecology and Theoretical Biology, Institute of Biology, Eötvös University, Budapest, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gergely</namePart><namePart type="family">Boza</namePart><affiliation>Department of Plant Systematics, Ecology and Theoretical Biology, Institute of Biology, Eötvös University, Budapest, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">István</namePart><namePart type="family">Zachar</namePart><affiliation>Parmenides Center for the Conceptual Foundations of Science, Munich/Pullach, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eörs</namePart><namePart type="family">Szathmáry</namePart><affiliation>Parmenides Center for the Conceptual Foundations of Science, Munich/Pullach, Germany</affiliation><affiliation>Department of Plant Systematics, Ecology and Theoretical Biology, Institute of Biology, Eötvös University, Budapest, Hungary</affiliation><affiliation>MTA‐ELTE Theoretical Biology and Evolutionary Ecology Research Group, Department of Plant Systematics, Ecology and Theoretical Biology, Budapest, Hungary</affiliation><affiliation>E-mail: szathmary.eors@gmail.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2015-04</dateIssued><dateCreated encoding="w3cdtf">2015-01-07</dateCreated><copyrightDate encoding="w3cdtf">2015</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>The RNA world hypothesis of the origin of life, in which RNA emerged as both enzyme and information carrier, is receiving solid experimental support. The prebiotic synthesis of biomolecules, the catalytic aid offered by mineral surfaces, and the vast enzymatic repertoire of ribozymes are only pieces of the origin of life puzzle; the full picture can only emerge if the pieces fit together by either following from one another or coexisting with each other. Here, we review the theory of the origin, maintenance, and enhancement of the RNA world as an evolving population of dynamical systems. The dynamical view of the origin of life allows us to pinpoint the missing and the not fitting pieces: (1) How can the first self‐replicating ribozyme emerge in the absence of template‐directed information replication? (2) How can nucleotide replicators avoid competitive exclusion despite utilizing the very same resources (nucleobases)? (3) How can the information catastrophe be avoided? (4) How can enough genes integrate into a cohesive system in order to transition to a cellular stage? (5) How can the way information is stored and metabolic complexity coevolve to pave to road leading out of the RNA world to the present protein–DNA world?</abstract><note type="funding">European Research Council under the European Community's Seventh Framework Programme - No. 294332; </note><note type="funding">European Union cofinanced by the European Social Fund - No. TAMOP 4.2.1/B‐09/1/KMR‐2010‐0003; </note><note type="funding">Hungarian Research Foundation - No. K100806; </note><note type="funding">Hungarian Research - No. OTKA K100299; </note><subject><genre>keywords</genre><topic>RNA world</topic><topic>origin of life</topic><topic>error threshold</topic><topic>hypercycle</topic><topic>metabolism</topic><topic>ribozyme</topic></subject><relatedItem type="host"><titleInfo><title>Annals of the New York Academy of Sciences</title></titleInfo><titleInfo type="abbreviated"><title>Ann. N.Y. Acad. 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