Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change
Identifieur interne : 002642 ( Istex/Corpus ); précédent : 002641; suivant : 002643Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change
Auteurs : Dusan Bartsch ; Mirella Ghirardi ; Paul A. Skehel ; Kevin A. Karl ; Susan P. Herder ; Mary Chen ; Craig H. Bailey ; Eric R. KandelSource :
- Cell [ 0092-8674 ] ; 1995.
English descriptors
- Teeft :
- Activator, Amino, Amino acids, Antiserum, Apclebp, Apcreb2, Apcreb2 antiserum, Apcreb2 antiserum injection, Apcreb2 protein, Apcrebl, Apcrebp, Apcrebp antiserum, Apcrfbp mrna, Aplysia, Assay, Atf4, Bailey, Bzlp, Bzlp domain, Castellucci, Catalytic subunit, Cdna, Cell culture, Cocultures, Control cells, Control cultures, Cotransfected, Crebl, Crebp, Drosophila, Epsp, Epsp amplitude, Facilitation, Flashbulb memories, Fusion protein, Fusion proteins, Ghirardi, Glanzman, Human crebp, Immune, Immune serum, Independent clones, Inhibitor, Injection, Kandel, Kinase, Leucine, Luciferase, Luciferase activity, Messenger pathways, Montarolo, Motor cell, Motor neuron, Mouse atf4, Mrna, Multiple bands, Neuron, Normal rabbit serum, Pathway, Percent change, Percentage change, Phosphatase, Photographic memory, Plasmid, Preimmune, Preimmune serum, Promoter, Protein synthesis, Protein synthesis inhibitor anisomycin, Pulse, Recombinant, Recombinant apcreb2, Recombinant apcrebp, Relative activation, Reporter gene, Represses, Repressor, Sensitization, Sensory neuron, Sensory neuron varicosities, Sensory neurons, Significant facilitation, Single pulse, Structural changes, Synaptic, Synaptic connections, Time course, Training trials, Transactivation, Transcription, Transcription factor, Transcription factors, Transcriptional, Varicosity, Western blot, Western blots, Zipper.
Abstract
Abstract: The switch from short- to long-term facilitation induced by behavioral sensitization in Aplysia involves CREB-like proteins, as well as the immediate-early gene ApC/EBP. Using the bZIP domain of ApC/EBP in a two-hybrid system, we have cloned ApCREB2, a transcription factor constitutively expressed in sensory neurons that resembles human CREB2 and mouse ATF4. ApCREB2 represses ApCREB1-mediated transcription in F9 cells. Injection of anti-ApCREB2 antibodies into Aplysia sensory neurons causes a single pulse of serotonin (5-HT), which induces only short-term facilitation lasting minutes, to evoke facilitation lasting more than 1 day. This facilitation has the properties of long-term facilitation: it requires transcription and translation, induces the growth of new synaptic connections, and occludes further facilitation by five pulses of 5-HT.
Url:
DOI: 10.1016/0092-8674(95)90213-9
Links to Exploration step
ISTEX:1B9A2EDCCEA15ED7DAF1E25EB0D039C18F1635CCLe document en format XML
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Herder</name><affiliation><mods:affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</mods:affiliation></affiliation></author><author><name sortKey="Chen, Mary" sort="Chen, Mary" uniqKey="Chen M" first="Mary" last="Chen">Mary Chen</name><affiliation><mods:affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</mods:affiliation></affiliation></author><author><name sortKey="Bailey, Craig H" sort="Bailey, Craig H" uniqKey="Bailey C" first="Craig H." last="Bailey">Craig H. 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Skehel</name><affiliation><mods:affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</mods:affiliation></affiliation></author><author><name sortKey="Karl, Kevin A" sort="Karl, Kevin A" uniqKey="Karl K" first="Kevin A." last="Karl">Kevin A. Karl</name><affiliation><mods:affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</mods:affiliation></affiliation></author><author><name sortKey="Herder, Susan P" sort="Herder, Susan P" uniqKey="Herder S" first="Susan P." last="Herder">Susan P. Herder</name><affiliation><mods:affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</mods:affiliation></affiliation></author><author><name sortKey="Chen, Mary" sort="Chen, Mary" uniqKey="Chen M" first="Mary" last="Chen">Mary Chen</name><affiliation><mods:affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</mods:affiliation></affiliation></author><author><name sortKey="Bailey, Craig H" sort="Bailey, Craig H" uniqKey="Bailey C" first="Craig H." last="Bailey">Craig H. Bailey</name><affiliation><mods:affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</mods:affiliation></affiliation></author><author><name sortKey="Kandel, Eric R" sort="Kandel, Eric R" uniqKey="Kandel E" first="Eric R." last="Kandel">Eric R. Kandel</name><affiliation><mods:affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Cell</title><title level="j" type="abbrev">CELL</title><idno type="ISSN">0092-8674</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">83</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="979">979</biblScope><biblScope unit="page" to="992">992</biblScope></imprint><idno type="ISSN">0092-8674</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0092-8674</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Activator</term><term>Amino</term><term>Amino acids</term><term>Antiserum</term><term>Apclebp</term><term>Apcreb2</term><term>Apcreb2 antiserum</term><term>Apcreb2 antiserum injection</term><term>Apcreb2 protein</term><term>Apcrebl</term><term>Apcrebp</term><term>Apcrebp antiserum</term><term>Apcrfbp mrna</term><term>Aplysia</term><term>Assay</term><term>Atf4</term><term>Bailey</term><term>Bzlp</term><term>Bzlp domain</term><term>Castellucci</term><term>Catalytic subunit</term><term>Cdna</term><term>Cell culture</term><term>Cocultures</term><term>Control cells</term><term>Control cultures</term><term>Cotransfected</term><term>Crebl</term><term>Crebp</term><term>Drosophila</term><term>Epsp</term><term>Epsp amplitude</term><term>Facilitation</term><term>Flashbulb memories</term><term>Fusion protein</term><term>Fusion proteins</term><term>Ghirardi</term><term>Glanzman</term><term>Human crebp</term><term>Immune</term><term>Immune serum</term><term>Independent clones</term><term>Inhibitor</term><term>Injection</term><term>Kandel</term><term>Kinase</term><term>Leucine</term><term>Luciferase</term><term>Luciferase activity</term><term>Messenger pathways</term><term>Montarolo</term><term>Motor cell</term><term>Motor neuron</term><term>Mouse atf4</term><term>Mrna</term><term>Multiple bands</term><term>Neuron</term><term>Normal rabbit serum</term><term>Pathway</term><term>Percent change</term><term>Percentage change</term><term>Phosphatase</term><term>Photographic memory</term><term>Plasmid</term><term>Preimmune</term><term>Preimmune serum</term><term>Promoter</term><term>Protein synthesis</term><term>Protein synthesis inhibitor anisomycin</term><term>Pulse</term><term>Recombinant</term><term>Recombinant apcreb2</term><term>Recombinant apcrebp</term><term>Relative activation</term><term>Reporter gene</term><term>Represses</term><term>Repressor</term><term>Sensitization</term><term>Sensory neuron</term><term>Sensory neuron varicosities</term><term>Sensory neurons</term><term>Significant facilitation</term><term>Single pulse</term><term>Structural changes</term><term>Synaptic</term><term>Synaptic connections</term><term>Time course</term><term>Training trials</term><term>Transactivation</term><term>Transcription</term><term>Transcription factor</term><term>Transcription factors</term><term>Transcriptional</term><term>Varicosity</term><term>Western blot</term><term>Western blots</term><term>Zipper</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The switch from short- to long-term facilitation induced by behavioral sensitization in Aplysia involves CREB-like proteins, as well as the immediate-early gene ApC/EBP. Using the bZIP domain of ApC/EBP in a two-hybrid system, we have cloned ApCREB2, a transcription factor constitutively expressed in sensory neurons that resembles human CREB2 and mouse ATF4. ApCREB2 represses ApCREB1-mediated transcription in F9 cells. Injection of anti-ApCREB2 antibodies into Aplysia sensory neurons causes a single pulse of serotonin (5-HT), which induces only short-term facilitation lasting minutes, to evoke facilitation lasting more than 1 day. This facilitation has the properties of long-term facilitation: it requires transcription and translation, induces the growth of new synaptic connections, and occludes further facilitation by five pulses of 5-HT.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>apcreb2</json:string><json:string>facilitation</json:string><json:string>aplysia</json:string><json:string>apcrebp</json:string><json:string>apcrebl</json:string><json:string>neuron</json:string><json:string>repressor</json:string><json:string>epsp</json:string><json:string>activator</json:string><json:string>kandel</json:string><json:string>sensory neurons</json:string><json:string>apcreb2 antiserum</json:string><json:string>transcriptional</json:string><json:string>crebl</json:string><json:string>cdna</json:string><json:string>synaptic</json:string><json:string>apclebp</json:string><json:string>varicosity</json:string><json:string>mrna</json:string><json:string>amino acids</json:string><json:string>epsp amplitude</json:string><json:string>bzlp</json:string><json:string>recombinant</json:string><json:string>single pulse</json:string><json:string>crebp</json:string><json:string>cocultures</json:string><json:string>apcrebp antiserum</json:string><json:string>pathway</json:string><json:string>immune</json:string><json:string>montarolo</json:string><json:string>transactivation</json:string><json:string>sensitization</json:string><json:string>kinase</json:string><json:string>phosphatase</json:string><json:string>drosophila</json:string><json:string>leucine</json:string><json:string>castellucci</json:string><json:string>plasmid</json:string><json:string>amino</json:string><json:string>ghirardi</json:string><json:string>luciferase</json:string><json:string>motor neuron</json:string><json:string>structural changes</json:string><json:string>preimmune</json:string><json:string>transcription</json:string><json:string>represses</json:string><json:string>atf4</json:string><json:string>cotransfected</json:string><json:string>protein synthesis</json:string><json:string>glanzman</json:string><json:string>antiserum</json:string><json:string>bzlp domain</json:string><json:string>transcription factors</json:string><json:string>percentage change</json:string><json:string>sensory neuron varicosities</json:string><json:string>relative activation</json:string><json:string>human crebp</json:string><json:string>recombinant apcrebp</json:string><json:string>time course</json:string><json:string>cell culture</json:string><json:string>mouse atf4</json:string><json:string>apcreb2 protein</json:string><json:string>pulse</json:string><json:string>preimmune serum</json:string><json:string>sensory neuron</json:string><json:string>western blots</json:string><json:string>control cells</json:string><json:string>synaptic connections</json:string><json:string>multiple bands</json:string><json:string>fusion proteins</json:string><json:string>control cultures</json:string><json:string>assay</json:string><json:string>zipper</json:string><json:string>promoter</json:string><json:string>injection</json:string><json:string>motor cell</json:string><json:string>apcrfbp mrna</json:string><json:string>recombinant apcreb2</json:string><json:string>catalytic subunit</json:string><json:string>protein synthesis inhibitor anisomycin</json:string><json:string>percent change</json:string><json:string>immune serum</json:string><json:string>luciferase activity</json:string><json:string>independent clones</json:string><json:string>significant facilitation</json:string><json:string>transcription factor</json:string><json:string>western blot</json:string><json:string>apcreb2 antiserum injection</json:string><json:string>normal rabbit serum</json:string><json:string>reporter gene</json:string><json:string>photographic memory</json:string><json:string>messenger pathways</json:string><json:string>training trials</json:string><json:string>flashbulb memories</json:string><json:string>fusion protein</json:string><json:string>bailey</json:string><json:string>inhibitor</json:string></teeft></keywords><author><json:item><name>Dusan Bartsch</name><affiliations><json:string>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</json:string></affiliations></json:item><json:item><name>Mirella Ghirardi</name><affiliations><json:string>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</json:string></affiliations></json:item><json:item><name>Paul A. Skehel</name><affiliations><json:string>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</json:string></affiliations></json:item><json:item><name>Kevin A. Karl</name><affiliations><json:string>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</json:string></affiliations></json:item><json:item><name>Susan P. Herder</name><affiliations><json:string>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</json:string></affiliations></json:item><json:item><name>Mary Chen</name><affiliations><json:string>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</json:string></affiliations></json:item><json:item><name>Craig H. Bailey</name><affiliations><json:string>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</json:string></affiliations></json:item><json:item><name>Eric R. Kandel</name><affiliations><json:string>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</json:string></affiliations></json:item></author><arkIstex>ark:/67375/6H6-4WBGHNJ1-V</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: The switch from short- to long-term facilitation induced by behavioral sensitization in Aplysia involves CREB-like proteins, as well as the immediate-early gene ApC/EBP. Using the bZIP domain of ApC/EBP in a two-hybrid system, we have cloned ApCREB2, a transcription factor constitutively expressed in sensory neurons that resembles human CREB2 and mouse ATF4. ApCREB2 represses ApCREB1-mediated transcription in F9 cells. Injection of anti-ApCREB2 antibodies into Aplysia sensory neurons causes a single pulse of serotonin (5-HT), which induces only short-term facilitation lasting minutes, to evoke facilitation lasting more than 1 day. This facilitation has the properties of long-term facilitation: it requires transcription and translation, induces the growth of new synaptic connections, and occludes further facilitation by five pulses of 5-HT.</abstract><qualityIndicators><score>8.428</score><pdfWordCount>9048</pdfWordCount><pdfCharCount>68646</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>14</pdfPageCount><pdfPageSize>539.96 x 828.12 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>119</abstractWordCount><abstractCharCount>861</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change</title><pmid><json:string>8521521</json:string></pmid><pii><json:string>0092-8674(95)90213-9</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>Proc. Natl. Aced. Sci. USA</title><language><json:string>unknown</json:string></language><volume>85</volume><pages><first>2373</first><last>2377</last></pages></serie><host><title>Cell</title><language><json:string>unknown</json:string></language><publicationDate>1995</publicationDate><issn><json:string>0092-8674</json:string></issn><pii><json:string>S0092-8674(00)X0440-0</json:string></pii><volume>83</volume><issue>6</issue><pages><first>979</first><last>992</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>35S</json:string><json:string>1995</json:string><json:string>1134</json:string></date><geogName></geogName><orgName><json:string>Surgeons Columbia University</json:string><json:string>Bethesda Research Laboratories</json:string><json:string>Upstate Biotechnology</json:string><json:string>National Institutes of Health</json:string><json:string>Howard Hughes Medical Institute</json:string></orgName><orgName_funder><json:string>National Institutes of Health</json:string><json:string>Howard Hughes Medical Institute</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Hui Xiang</json:string><json:string>Thomas Jessell</json:string><json:string>Time Course</json:string><json:string>Craig H. Bailey</json:string><json:string>Richard Goodman</json:string><json:string>Paul A. Skehel</json:string><json:string>Mark Barad</json:string><json:string>Tom Rooney</json:string><json:string>Ted Abel</json:string><json:string>Paul Bartels</json:string><json:string>Richard Axel</json:string><json:string>A. R. Luria</json:string><json:string>Kevin A. Karl</json:string><json:string>Stanley Fields</json:string><json:string>Kennedy</json:string><json:string>Harriet Ayers</json:string><json:string>Susan P. Herder</json:string><json:string>The</json:string><json:string>Mark Mayford</json:string><json:string>Gene</json:string><json:string>S. Elledge</json:string><json:string>R. Goodman</json:string><json:string>Mary Chen</json:string><json:string>O.Ol</json:string><json:string>Ke Huang</json:string><json:string>D. C. Shershevski</json:string><json:string>P. Bartels</json:string><json:string>Stephen Elledge</json:string><json:string>Michael Kiebler</json:string><json:string>Andrew Krawetz</json:string></persName><placeName><json:string>Poland</json:string><json:string>Harlow</json:string><json:string>Specificity</json:string><json:string>New Synaptic</json:string><json:string>York</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Ma and Ptashne, 1987</json:string><json:string>Tsujimoto et al., 19911</json:string><json:string>Pinsker et al., 1973</json:string><json:string>Mielnicki and Pruitt, 1991</json:string><json:string>Alberini et al., 1994</json:string><json:string>Ellis et al.</json:string><json:string>Karpinski et al., 1992</json:string><json:string>Tsujimoto et al., 1991</json:string><json:string>Frangioni and Neel, 1993</json:string><json:string>Stratton, 1917</json:string><json:string>Castellucci et al., 1989</json:string><json:string>Davis and Squire, 1984</json:string><json:string>Jungling et al., 1994</json:string><json:string>Montarolo et al., 1986</json:string><json:string>Chevray and Nathans, 1992</json:string><json:string>Hai et al., 1989</json:string><json:string>Schachar et al., 1988</json:string><json:string>Dash et al., 1990</json:string><json:string>Scholz and Byrne, 1988</json:string><json:string>Bailey and Kandel, 1993</json:string><json:string>Bourtchuladze et al., 1994</json:string><json:string>Fields and Song, 1989</json:string><json:string>Brown and Deffenbacher, 1995</json:string><json:string>Glanzman et al.</json:string><json:string>Yin et al. 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invertebres</json:string></inist></categories><publicationDate>1995</publicationDate><copyrightDate>1995</copyrightDate><doi><json:string>10.1016/0092-8674(95)90213-9</json:string></doi><id>1B9A2EDCCEA15ED7DAF1E25EB0D039C18F1635CC</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-4WBGHNJ1-V/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-4WBGHNJ1-V/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-4WBGHNJ1-V/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1995</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note type="content">Section title: Article</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change</title><author xml:id="author-0000"><persName><forename type="first">Dusan</forename><surname>Bartsch</surname></persName><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Mirella</forename><surname>Ghirardi</surname></persName><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Paul A.</forename><surname>Skehel</surname></persName><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Kevin A.</forename><surname>Karl</surname></persName><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Susan P.</forename><surname>Herder</surname></persName><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation></author><author xml:id="author-0005"><persName><forename type="first">Mary</forename><surname>Chen</surname></persName><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation></author><author xml:id="author-0006"><persName><forename type="first">Craig H.</forename><surname>Bailey</surname></persName><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation></author><author xml:id="author-0007"><persName><forename type="first">Eric R.</forename><surname>Kandel</surname></persName><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation></author><idno type="istex">1B9A2EDCCEA15ED7DAF1E25EB0D039C18F1635CC</idno><idno type="ark">ark:/67375/6H6-4WBGHNJ1-V</idno><idno type="DOI">10.1016/0092-8674(95)90213-9</idno><idno type="PII">0092-8674(95)90213-9</idno></analytic><monogr><title level="j">Cell</title><title level="j" type="abbrev">CELL</title><idno type="pISSN">0092-8674</idno><idno type="PII">S0092-8674(00)X0440-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995"></date><biblScope unit="volume">83</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="979">979</biblScope><biblScope unit="page" to="992">992</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1995</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The switch from short- to long-term facilitation induced by behavioral sensitization in Aplysia involves CREB-like proteins, as well as the immediate-early gene ApC/EBP. Using the bZIP domain of ApC/EBP in a two-hybrid system, we have cloned ApCREB2, a transcription factor constitutively expressed in sensory neurons that resembles human CREB2 and mouse ATF4. ApCREB2 represses ApCREB1-mediated transcription in F9 cells. Injection of anti-ApCREB2 antibodies into Aplysia sensory neurons causes a single pulse of serotonin (5-HT), which induces only short-term facilitation lasting minutes, to evoke facilitation lasting more than 1 day. This facilitation has the properties of long-term facilitation: it requires transcription and translation, induces the growth of new synaptic connections, and occludes further facilitation by five pulses of 5-HT.</p></abstract></profileDesc><revisionDesc><change when="1995">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-4WBGHNJ1-V/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>CELL</jid><aid>95902139</aid><ce:pii>0092-8674(95)90213-9</ce:pii><ce:doi>10.1016/0092-8674(95)90213-9</ce:doi><ce:copyright type="unknown" year="1995"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Article</ce:textfn></ce:dochead><ce:title>Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change</ce:title><ce:author-group><ce:author><ce:given-name>Dusan</ce:given-name><ce:surname>Bartsch</ce:surname></ce:author><ce:author><ce:given-name>Mirella</ce:given-name><ce:surname>Ghirardi</ce:surname></ce:author><ce:author><ce:given-name>Paul A.</ce:given-name><ce:surname>Skehel</ce:surname></ce:author><ce:author><ce:given-name>Kevin A.</ce:given-name><ce:surname>Karl</ce:surname></ce:author><ce:author><ce:given-name>Susan P.</ce:given-name><ce:surname>Herder</ce:surname></ce:author><ce:author><ce:given-name>Mary</ce:given-name><ce:surname>Chen</ce:surname></ce:author><ce:author><ce:given-name>Craig H.</ce:given-name><ce:surname>Bailey</ce:surname></ce:author><ce:author><ce:given-name>Eric R.</ce:given-name><ce:surname>Kandel</ce:surname></ce:author><ce:affiliation><ce:textfn>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</ce:textfn></ce:affiliation></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The switch from short- to long-term facilitation induced by behavioral sensitization in Aplysia involves CREB-like proteins, as well as the immediate-early gene ApC/EBP. Using the bZIP domain of ApC/EBP in a two-hybrid system, we have cloned ApCREB2, a transcription factor constitutively expressed in sensory neurons that resembles human CREB2 and mouse ATF4. ApCREB2 represses ApCREB1-mediated transcription in F9 cells. Injection of anti-ApCREB2 antibodies into Aplysia sensory neurons causes a single pulse of serotonin (5-HT), which induces only short-term facilitation lasting minutes, to evoke facilitation lasting more than 1 day. This facilitation has the properties of long-term facilitation: it requires transcription and translation, induces the growth of new synaptic connections, and occludes further facilitation by five pulses of 5-HT.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change</title></titleInfo><name type="personal"><namePart type="given">Dusan</namePart><namePart type="family">Bartsch</namePart><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mirella</namePart><namePart type="family">Ghirardi</namePart><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul A.</namePart><namePart type="family">Skehel</namePart><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kevin A.</namePart><namePart type="family">Karl</namePart><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Susan P.</namePart><namePart type="family">Herder</namePart><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mary</namePart><namePart type="family">Chen</namePart><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Craig H.</namePart><namePart type="family">Bailey</namePart><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eric R.</namePart><namePart type="family">Kandel</namePart><affiliation>Howard Hughes Medical Institute and Center for Neurobiology and Behavior College of Physicians and Surgeons Columbia University New York, New York 10032, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1995</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The switch from short- to long-term facilitation induced by behavioral sensitization in Aplysia involves CREB-like proteins, as well as the immediate-early gene ApC/EBP. Using the bZIP domain of ApC/EBP in a two-hybrid system, we have cloned ApCREB2, a transcription factor constitutively expressed in sensory neurons that resembles human CREB2 and mouse ATF4. ApCREB2 represses ApCREB1-mediated transcription in F9 cells. Injection of anti-ApCREB2 antibodies into Aplysia sensory neurons causes a single pulse of serotonin (5-HT), which induces only short-term facilitation lasting minutes, to evoke facilitation lasting more than 1 day. This facilitation has the properties of long-term facilitation: it requires transcription and translation, induces the growth of new synaptic connections, and occludes further facilitation by five pulses of 5-HT.</abstract><note type="content">Section title: Article</note><relatedItem type="host"><titleInfo><title>Cell</title></titleInfo><titleInfo type="abbreviated"><title>CELL</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1995</dateIssued></originInfo><identifier type="ISSN">0092-8674</identifier><identifier type="PII">S0092-8674(00)X0440-0</identifier><part><date>1995</date><detail type="volume"><number>83</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="issue-pages"><start>831</start><end>1058</end></extent><extent unit="pages"><start>979</start><end>992</end></extent></part></relatedItem><identifier type="istex">1B9A2EDCCEA15ED7DAF1E25EB0D039C18F1635CC</identifier><identifier type="ark">ark:/67375/6H6-4WBGHNJ1-V</identifier><identifier type="DOI">10.1016/0092-8674(95)90213-9</identifier><identifier type="PII">0092-8674(95)90213-9</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-4WBGHNJ1-V/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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