Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen
Identifieur interne : 002501 ( Istex/Corpus ); précédent : 002500; suivant : 002502Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen
Auteurs : Carla J. Aldrich ; Amy Decloux ; Amina S. Woods ; Robert J. Cotter ; Mark J. Soloski ; James FormanSource :
- Cell [ 0092-8674 ] ; 1994.
English descriptors
- Teeft :
- Acad, Acid extraction, Acid extracts, Active fraction, Active fractions, Active peptide, Aldrich, Allele, Alloreactive, Alloreactive ctls, Alloreactive cytotoxic, Amaprtlll, Amino, Amino acid, Amino acids, Antigen, Antigen presentation, Bevan, Blmin gradient, Cell clones, Cell contact residue, Cell hybridomas, Cell lines, Cell receptor, Cell receptors, Cell recognition, Clone, Consensus peptide, Ctls, Cytotoxic, Determinant, Determinant modifier, Dmso, Dmso effect, Epitope, Fischer, Fischer lindahl, Forman, High determinant density, Histocompatibility, Hplc, Hplc fractions, Immune system, Immunol, Individual hplc fractions, Kind gift, Large array, Large number, Leader peptide, Leader sequence, Lindahl, Lymphoblast, Lymphocyte, Lysis, Major histocompatibility, Mass spectrometer, Mass spectrometry, Mass spectrum, Medical center, Molecular weight, Molecular weight peptides, Molecule, Mouse histocompatibility antigen, Mouse strains, Murine, Murine class, Mutant cell line, National institutes, Natl, Nonamer, Nonamer amaprtlll, Nonamer peptide, Open circles, Open diamonds, Open squares, Open triangles, Other class, Other peptides, Peptide, Peptide species, Polymorphism, Proc, Receptor, Room temperature, Same peptide, Sample site, Second gene, Sequence fragment, Shallow gradients, Signal recognition particle, Single peptide, Specialized role, Specific ctls, Stroynowski, Synthetic peptides, Target cell recognition, Target cells, Transporter, Wide array.
Abstract
Abstract: Recognition of the class Ib antigen Qa-1 by a portion of alloreactive cytotoxic T lymphocyte (CTL) clones requires that the target cell express a second gene, termed Qa-1 determinant modifier (Qdm). We show that Qdm is identical to most D allele genes, excepting Dk, and that a nonamer peptide derived from D alloantigens restores CTL recognition on cells that lack the Qdm-encoded determinant. The equivalent Dk peptide has an Ala→Val interchange at P3 and requires ∼4 logs more peptide than the AlaP3 peptide for target cell lysis. Two of five CTL clones, not dependent on Qdm for target cell recognition, also recognize the Qdm peptide as well as the ValP3 variant. Although the Qdm peptide spans residues 3–11 from the leader, it requires the Tap transporters for its expression. Thus, the response against this class Ib molecule provides a tool for dissecting alloreactivity as well as pathways for antigen presentation.
Url:
DOI: 10.1016/0092-8674(94)90550-9
Links to Exploration step
ISTEX:A588A2C4064E8E20E50D98BCF273319FF127F8BBLe document en format XML
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Aldrich</name><affiliation><mods:affiliation>Department of Microbiology University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9048, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>† Present address: Evansville Center, Indiana University School of Medicine, Evansville, Indiana 47712.</mods:affiliation></affiliation></author><author><name sortKey="Decloux, Amy" sort="Decloux, Amy" uniqKey="Decloux A" first="Amy" last="Decloux">Amy Decloux</name><affiliation><mods:affiliation>Department of Medicine Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</mods:affiliation></affiliation></author><author><name sortKey="Woods, Amina S" sort="Woods, Amina S" uniqKey="Woods A" first="Amina S." last="Woods">Amina S. Woods</name><affiliation><mods:affiliation>Department of Pharmacology and Molecular Sciences Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</mods:affiliation></affiliation></author><author><name sortKey="Cotter, Robert J" sort="Cotter, Robert J" uniqKey="Cotter R" first="Robert J." last="Cotter">Robert J. Cotter</name><affiliation><mods:affiliation>Department of Pharmacology and Molecular Sciences Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</mods:affiliation></affiliation></author><author><name sortKey="Soloski, Mark J" sort="Soloski, Mark J" uniqKey="Soloski M" first="Mark J." last="Soloski">Mark J. Soloski</name><affiliation><mods:affiliation>Department of Medicine Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</mods:affiliation></affiliation></author><author><name sortKey="Forman, James" sort="Forman, James" uniqKey="Forman J" first="James" last="Forman">James Forman</name><affiliation><mods:affiliation>Department of Microbiology University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9048, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A588A2C4064E8E20E50D98BCF273319FF127F8BB</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1016/0092-8674(94)90550-9</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-JCSVJP65-3/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002501</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002501</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen</title><author><name sortKey="Aldrich, Carla J" sort="Aldrich, Carla J" uniqKey="Aldrich C" first="Carla J." last="Aldrich">Carla J. Aldrich</name><affiliation><mods:affiliation>Department of Microbiology University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9048, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>† Present address: Evansville Center, Indiana University School of Medicine, Evansville, Indiana 47712.</mods:affiliation></affiliation></author><author><name sortKey="Decloux, Amy" sort="Decloux, Amy" uniqKey="Decloux A" first="Amy" last="Decloux">Amy Decloux</name><affiliation><mods:affiliation>Department of Medicine Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</mods:affiliation></affiliation></author><author><name sortKey="Woods, Amina S" sort="Woods, Amina S" uniqKey="Woods A" first="Amina S." last="Woods">Amina S. Woods</name><affiliation><mods:affiliation>Department of Pharmacology and Molecular Sciences Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</mods:affiliation></affiliation></author><author><name sortKey="Cotter, Robert J" sort="Cotter, Robert J" uniqKey="Cotter R" first="Robert J." last="Cotter">Robert J. Cotter</name><affiliation><mods:affiliation>Department of Pharmacology and Molecular Sciences Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</mods:affiliation></affiliation></author><author><name sortKey="Soloski, Mark J" sort="Soloski, Mark J" uniqKey="Soloski M" first="Mark J." last="Soloski">Mark J. 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We show that Qdm is identical to most D allele genes, excepting Dk, and that a nonamer peptide derived from D alloantigens restores CTL recognition on cells that lack the Qdm-encoded determinant. The equivalent Dk peptide has an Ala→Val interchange at P3 and requires ∼4 logs more peptide than the AlaP3 peptide for target cell lysis. Two of five CTL clones, not dependent on Qdm for target cell recognition, also recognize the Qdm peptide as well as the ValP3 variant. Although the Qdm peptide spans residues 3–11 from the leader, it requires the Tap transporters for its expression. Thus, the response against this class Ib molecule provides a tool for dissecting alloreactivity as well as pathways for antigen presentation.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>peptide</json:string><json:string>clone</json:string><json:string>ctls</json:string><json:string>lymphoblast</json:string><json:string>immunol</json:string><json:string>hplc</json:string><json:string>nonamer</json:string><json:string>target cells</json:string><json:string>lymphocyte</json:string><json:string>allele</json:string><json:string>aldrich</json:string><json:string>lysis</json:string><json:string>alloreactive</json:string><json:string>histocompatibility</json:string><json:string>cytotoxic</json:string><json:string>dmso</json:string><json:string>epitope</json:string><json:string>amaprtlll</json:string><json:string>amino acids</json:string><json:string>receptor</json:string><json:string>polymorphism</json:string><json:string>stroynowski</json:string><json:string>forman</json:string><json:string>transporter</json:string><json:string>proc</json:string><json:string>murine</json:string><json:string>natl</json:string><json:string>acad</json:string><json:string>bevan</json:string><json:string>fischer</json:string><json:string>lindahl</json:string><json:string>fischer lindahl</json:string><json:string>amino</json:string><json:string>other class</json:string><json:string>molecule</json:string><json:string>antigen presentation</json:string><json:string>room temperature</json:string><json:string>determinant</json:string><json:string>leader sequence</json:string><json:string>kind gift</json:string><json:string>medical center</json:string><json:string>leader peptide</json:string><json:string>major histocompatibility</json:string><json:string>alloreactive ctls</json:string><json:string>molecular weight peptides</json:string><json:string>acid extracts</json:string><json:string>blmin gradient</json:string><json:string>murine class</json:string><json:string>cell receptor</json:string><json:string>cell recognition</json:string><json:string>nonamer amaprtlll</json:string><json:string>alloreactive cytotoxic</json:string><json:string>mass spectrometer</json:string><json:string>same peptide</json:string><json:string>synthetic peptides</json:string><json:string>mass spectrometry</json:string><json:string>other peptides</json:string><json:string>sample site</json:string><json:string>hplc fractions</json:string><json:string>peptide species</json:string><json:string>molecular weight</json:string><json:string>cell clones</json:string><json:string>antigen</json:string><json:string>signal recognition particle</json:string><json:string>open circles</json:string><json:string>mass spectrum</json:string><json:string>sequence fragment</json:string><json:string>active fractions</json:string><json:string>shallow gradients</json:string><json:string>active fraction</json:string><json:string>open diamonds</json:string><json:string>open squares</json:string><json:string>active peptide</json:string><json:string>consensus peptide</json:string><json:string>mouse strains</json:string><json:string>dmso effect</json:string><json:string>cell contact residue</json:string><json:string>amino acid</json:string><json:string>specific ctls</json:string><json:string>open triangles</json:string><json:string>acid extraction</json:string><json:string>large number</json:string><json:string>cell receptors</json:string><json:string>large array</json:string><json:string>single peptide</json:string><json:string>high determinant density</json:string><json:string>cell hybridomas</json:string><json:string>cell lines</json:string><json:string>wide array</json:string><json:string>specialized role</json:string><json:string>immune system</json:string><json:string>national institutes</json:string><json:string>target cell recognition</json:string><json:string>nonamer peptide</json:string><json:string>mouse histocompatibility antigen</json:string><json:string>determinant modifier</json:string><json:string>second gene</json:string><json:string>individual hplc fractions</json:string><json:string>mutant cell line</json:string></teeft></keywords><author><json:item><name>Carla J. Aldrich</name><affiliations><json:string>Department of Microbiology University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9048, USA</json:string><json:string>† Present address: Evansville Center, Indiana University School of Medicine, Evansville, Indiana 47712.</json:string></affiliations></json:item><json:item><name>Amy DeCloux</name><affiliations><json:string>Department of Medicine Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</json:string></affiliations></json:item><json:item><name>Amina S. Woods</name><affiliations><json:string>Department of Pharmacology and Molecular Sciences Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</json:string></affiliations></json:item><json:item><name>Robert J. Cotter</name><affiliations><json:string>Department of Pharmacology and Molecular Sciences Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</json:string></affiliations></json:item><json:item><name>Mark J. Soloski</name><affiliations><json:string>Department of Medicine Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</json:string></affiliations></json:item><json:item><name>James Forman</name><affiliations><json:string>Department of Microbiology University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9048, USA</json:string></affiliations></json:item></author><arkIstex>ark:/67375/6H6-JCSVJP65-3</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Recognition of the class Ib antigen Qa-1 by a portion of alloreactive cytotoxic T lymphocyte (CTL) clones requires that the target cell express a second gene, termed Qa-1 determinant modifier (Qdm). We show that Qdm is identical to most D allele genes, excepting Dk, and that a nonamer peptide derived from D alloantigens restores CTL recognition on cells that lack the Qdm-encoded determinant. The equivalent Dk peptide has an Ala→Val interchange at P3 and requires ∼4 logs more peptide than the AlaP3 peptide for target cell lysis. Two of five CTL clones, not dependent on Qdm for target cell recognition, also recognize the Qdm peptide as well as the ValP3 variant. Although the Qdm peptide spans residues 3–11 from the leader, it requires the Tap transporters for its expression. Thus, the response against this class Ib molecule provides a tool for dissecting alloreactivity as well as pathways for antigen presentation.</abstract><qualityIndicators><score>8.812</score><pdfWordCount>7932</pdfWordCount><pdfCharCount>49775</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>576 x 785 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>151</abstractWordCount><abstractCharCount>935</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen</title><pmid><json:string>7525079</json:string></pmid><pii><json:string>0092-8674(94)90550-9</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>in press</title><language><json:string>unknown</json:string></language><volume>91</volume></serie><host><title>Cell</title><language><json:string>unknown</json:string></language><publicationDate>1994</publicationDate><issn><json:string>0092-8674</json:string></issn><pii><json:string>S0092-8674(00)X0412-6</json:string></pii><volume>79</volume><issue>4</issue><pages><first>649</first><last>658</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>4000</json:string><json:string>1994</json:string></date><geogName></geogName><orgName><json:string>Molecular Sciences Johns Hopkins University</json:string><json:string>Stanford University</json:string><json:string>Vanderbilt University</json:string><json:string>Indiana University</json:string><json:string>University of Texas Southwestern Medical Center</json:string><json:string>National Science Foundation Regional Instrumentation Facility</json:string><json:string>and National Science Foundation</json:string><json:string>Mannheim</json:string><json:string>Department of Medicine</json:string><json:string>National Institutes of Health</json:string><json:string>Middle Atlantic Mass Spectrometry Center</json:string><json:string>Calbiochem</json:string><json:string>Department of Biochemistry, University of Texas Southwestern Medical Center</json:string><json:string>Indiana Center</json:string><json:string>National Institutes of Health</json:string></orgName><orgName_funder><json:string>National Institutes of Health</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Peter Parham</json:string><json:string>Klas Karre</json:string><json:string>Clive Slaughter</json:string><json:string>Amy DeCloux</json:string><json:string>Luc Van Kaer</json:string><json:string>BlO</json:string><json:string>H.La</json:string><json:string>H.Ld</json:string><json:string>Charlie Hasemann</json:string><json:string>Vinay Kumar</json:string><json:string>Jonathan Sheehan</json:string><json:string>The</json:string><json:string>Mark J. Soloski</json:string><json:string>Washington Class</json:string><json:string>Robert J. Cotter</json:string><json:string>Identification</json:string><json:string>To</json:string><json:string>D. Alloreactivity</json:string><json:string>Helena Ong</json:string><json:string>C. Kuyler</json:string><json:string>H.Lo</json:string></persName><placeName><json:string>Cytotoxicity</json:string><json:string>Dallas</json:string><json:string>IN</json:string><json:string>Baltimore</json:string><json:string>Manchester</json:string><json:string>Indianapolis</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Connolly, 1994</json:string><json:string>Esquivel et al., 1992</json:string><json:string>Pease et al. 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sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string><json:string>4 - immunologie fondamentale</json:string></inist></categories><publicationDate>1994</publicationDate><copyrightDate>1994</copyrightDate><doi><json:string>10.1016/0092-8674(94)90550-9</json:string></doi><id>A588A2C4064E8E20E50D98BCF273319FF127F8BB</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-JCSVJP65-3/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-JCSVJP65-3/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-JCSVJP65-3/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1994</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note type="content">Section title: Article</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen</title><author xml:id="author-0000"><persName><forename type="first">Carla J.</forename><surname>Aldrich</surname></persName><affiliation>Department of Microbiology University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9048, USA</affiliation><affiliation>† Present address: Evansville Center, Indiana University School of Medicine, Evansville, Indiana 47712.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Amy</forename><surname>DeCloux</surname></persName><affiliation>Department of Medicine Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Amina S.</forename><surname>Woods</surname></persName><affiliation>Department of Pharmacology and Molecular Sciences Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Robert J.</forename><surname>Cotter</surname></persName><affiliation>Department of Pharmacology and Molecular Sciences Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Mark J.</forename><surname>Soloski</surname></persName><affiliation>Department of Medicine Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</affiliation></author><author xml:id="author-0005"><persName><forename type="first">James</forename><surname>Forman</surname></persName><affiliation>Department of Microbiology University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9048, USA</affiliation></author><idno type="istex">A588A2C4064E8E20E50D98BCF273319FF127F8BB</idno><idno type="ark">ark:/67375/6H6-JCSVJP65-3</idno><idno type="DOI">10.1016/0092-8674(94)90550-9</idno><idno type="PII">0092-8674(94)90550-9</idno></analytic><monogr><title level="j">Cell</title><title level="j" type="abbrev">CELL</title><idno type="pISSN">0092-8674</idno><idno type="PII">S0092-8674(00)X0412-6</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994"></date><biblScope unit="volume">79</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="649">649</biblScope><biblScope unit="page" to="658">658</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1994</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Recognition of the class Ib antigen Qa-1 by a portion of alloreactive cytotoxic T lymphocyte (CTL) clones requires that the target cell express a second gene, termed Qa-1 determinant modifier (Qdm). We show that Qdm is identical to most D allele genes, excepting Dk, and that a nonamer peptide derived from D alloantigens restores CTL recognition on cells that lack the Qdm-encoded determinant. The equivalent Dk peptide has an Ala→Val interchange at P3 and requires ∼4 logs more peptide than the AlaP3 peptide for target cell lysis. Two of five CTL clones, not dependent on Qdm for target cell recognition, also recognize the Qdm peptide as well as the ValP3 variant. Although the Qdm peptide spans residues 3–11 from the leader, it requires the Tap transporters for its expression. Thus, the response against this class Ib molecule provides a tool for dissecting alloreactivity as well as pathways for antigen presentation.</p></abstract></profileDesc><revisionDesc><change when="1994-08-30">Modified</change><change when="1994">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-JCSVJP65-3/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>CELL</jid><aid>94905509</aid><ce:pii>0092-8674(94)90550-9</ce:pii><ce:doi>10.1016/0092-8674(94)90550-9</ce:doi><ce:copyright type="unknown" year="1994"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Article</ce:textfn></ce:dochead><ce:title>Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen</ce:title><ce:author-group><ce:author><ce:given-name>Carla J.</ce:given-name><ce:surname>Aldrich</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup>†</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Amy</ce:given-name><ce:surname>DeCloux</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>‡</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Amina S.</ce:given-name><ce:surname>Woods</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>§</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Robert J.</ce:given-name><ce:surname>Cotter</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>§</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Mark J.</ce:given-name><ce:surname>Soloski</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>‡</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>James</ce:given-name><ce:surname>Forman</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>∗</ce:label><ce:textfn>Department of Microbiology University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9048, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>‡</ce:label><ce:textfn>Department of Medicine Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>§</ce:label><ce:textfn>Department of Pharmacology and Molecular Sciences Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</ce:textfn></ce:affiliation><ce:footnote id="FN1"><ce:label>†</ce:label><ce:note-para>Present address: Evansville Center, Indiana University School of Medicine, Evansville, Indiana 47712.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="6" month="7" year="1994"></ce:date-received><ce:date-revised day="30" month="8" year="1994"></ce:date-revised><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Recognition of the class Ib antigen Qa-1 by a portion of alloreactive cytotoxic T lymphocyte (CTL) clones requires that the target cell express a second gene, termed Qa-1 determinant modifier (<ce:italic>Qdm</ce:italic>). We show that <ce:italic>Qdm</ce:italic> is identical to most <ce:italic>D</ce:italic> allele genes, excepting <ce:italic>D</ce:italic><ce:sup><ce:italic>k</ce:italic></ce:sup>, and that a nonamer peptide derived from D alloantigens restores CTL recognition on cells that lack the <ce:italic>Qdm</ce:italic>-encoded determinant. The equivalent D<ce:sup>k</ce:sup> peptide has an Ala→Val interchange at P3 and requires ∼4 logs more peptide than the Ala<ce:sup>P3</ce:sup> peptide for target cell lysis. Two of five CTL clones, not dependent on <ce:italic>Qdm</ce:italic> for target cell recognition, also recognize the Qdm peptide as well as the Val<ce:sup>P3</ce:sup> variant. Although the Qdm peptide spans residues 3–11 from the leader, it requires the Tap transporters for its expression. Thus, the response against this class Ib molecule provides a tool for dissecting alloreactivity as well as pathways for antigen presentation.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen</title></titleInfo><name type="personal"><namePart type="given">Carla J.</namePart><namePart type="family">Aldrich</namePart><affiliation>Department of Microbiology University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9048, USA</affiliation><affiliation>† Present address: Evansville Center, Indiana University School of Medicine, Evansville, Indiana 47712.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Amy</namePart><namePart type="family">DeCloux</namePart><affiliation>Department of Medicine Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Amina S.</namePart><namePart type="family">Woods</namePart><affiliation>Department of Pharmacology and Molecular Sciences Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert J.</namePart><namePart type="family">Cotter</namePart><affiliation>Department of Pharmacology and Molecular Sciences Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mark J.</namePart><namePart type="family">Soloski</namePart><affiliation>Department of Medicine Johns Hopkins University Medical School Baltimore, Maryland 21205, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">James</namePart><namePart type="family">Forman</namePart><affiliation>Department of Microbiology University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9048, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued><dateModified encoding="w3cdtf">1994-08-30</dateModified><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Recognition of the class Ib antigen Qa-1 by a portion of alloreactive cytotoxic T lymphocyte (CTL) clones requires that the target cell express a second gene, termed Qa-1 determinant modifier (Qdm). We show that Qdm is identical to most D allele genes, excepting Dk, and that a nonamer peptide derived from D alloantigens restores CTL recognition on cells that lack the Qdm-encoded determinant. The equivalent Dk peptide has an Ala→Val interchange at P3 and requires ∼4 logs more peptide than the AlaP3 peptide for target cell lysis. Two of five CTL clones, not dependent on Qdm for target cell recognition, also recognize the Qdm peptide as well as the ValP3 variant. Although the Qdm peptide spans residues 3–11 from the leader, it requires the Tap transporters for its expression. Thus, the response against this class Ib molecule provides a tool for dissecting alloreactivity as well as pathways for antigen presentation.</abstract><note type="content">Section title: Article</note><relatedItem type="host"><titleInfo><title>Cell</title></titleInfo><titleInfo type="abbreviated"><title>CELL</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued></originInfo><identifier type="ISSN">0092-8674</identifier><identifier type="PII">S0092-8674(00)X0412-6</identifier><part><date>1994</date><detail type="volume"><number>79</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="issue-pages"><start>547</start><end>743</end></extent><extent unit="pages"><start>649</start><end>658</end></extent></part></relatedItem><identifier type="istex">A588A2C4064E8E20E50D98BCF273319FF127F8BB</identifier><identifier type="ark">ark:/67375/6H6-JCSVJP65-3</identifier><identifier type="DOI">10.1016/0092-8674(94)90550-9</identifier><identifier type="PII">0092-8674(94)90550-9</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-JCSVJP65-3/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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