Stereoselective Synthesis of trans‐threo‐trans‐Oligopyrrolidines: Potential Agents for RNA Cleavage
Identifieur interne : 002248 ( Istex/Corpus ); précédent : 002247; suivant : 002249Stereoselective Synthesis of trans‐threo‐trans‐Oligopyrrolidines: Potential Agents for RNA Cleavage
Auteurs : Hans-Dieter Arndt ; Rüdiger Welz ; Sabine Müller ; Burkhart Ziemer ; Ulrich KoertSource :
- Chemistry – A European Journal [ 0947-6539 ] ; 2004-08-20.
Abstract
The 2,5‐trans‐substituted oligopyrrolidines constitute a promising class of novel RNA‐binding agents as well as potential building blocks for artificial anion channels. A convergent synthesis of terpyrrolidine 1 and pyrrolidino‐THF‐pyrrolidine 2 is reported, relying upon convergent coupling of 2,5‐trans‐pyrrolidinecarboxaldehydes through bridging alkyne units under Felkin–Anh control and subsequent closure of the central ring. After complete deprotection, the free polyamine products were isolated in excellent yield and purity. Crystal structure analyses of a terpyrrolidine and a pyrrolidino‐THF‐pyrrolidine documented their helical privileged conformations. The compounds were then screened for RNA cleavage activity. Unlike the only weakly active simple polyamines, p‐nitrosulfonamide 33 was found to induce cleavage at mM concentrations under physiologically relevant conditions.
A promising class of novel RNA‐binding agents has been developed by using bis‐ and terpyrrolidines with 2,5′‐threo‐trans configurations. The compounds such as depicted were synthesized stereoselectively and tested for RNA cleavage.
Url:
DOI: 10.1002/chem.200400181
Links to Exploration step
ISTEX:6D4386B68FCD3EA7A029DDCFF647D72FD02A73FFLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Stereoselective Synthesis of trans‐threo‐trans‐Oligopyrrolidines: Potential Agents for RNA Cleavage</title><author><name sortKey="Arndt, Hans Ieter" sort="Arndt, Hans Ieter" uniqKey="Arndt H" first="Hans-Dieter" last="Arndt">Hans-Dieter Arndt</name><affiliation><mods:affiliation>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>New Address: Max‐Planck Institut fur Molekulare Physiologie, Abteilung IV—Chemische Biologie, Otto‐Hahn‐Strasse 11, 44227 Dortmund, Germany</mods:affiliation></affiliation></author><author><name sortKey="Welz, Rudiger" sort="Welz, Rudiger" uniqKey="Welz R" first="Rüdiger" last="Welz">Rüdiger Welz</name><affiliation><mods:affiliation>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</mods:affiliation></affiliation></author><author><name sortKey="Muller, Sabine" sort="Muller, Sabine" uniqKey="Muller S" first="Sabine" last="Müller">Sabine Müller</name><affiliation><mods:affiliation>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>New Address: Fakultät für Chemie, NC 3/171, Universitätsstrasse 150, 44780 Bochum, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: sabine.mueller@orch.ruhr‐uni‐bochum.de</mods:affiliation></affiliation></author><author><name sortKey="Ziemer, Burkhart" sort="Ziemer, Burkhart" uniqKey="Ziemer B" first="Burkhart" last="Ziemer">Burkhart Ziemer</name><affiliation><mods:affiliation>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: burkhard.ziemer@chemie.hu‐berlin.de</mods:affiliation></affiliation></author><author><name sortKey="Koert, Ulrich" sort="Koert, Ulrich" uniqKey="Koert U" first="Ulrich" last="Koert">Ulrich Koert</name><affiliation><mods:affiliation>Fachbereich Chemie der Philipps‐Universität Marburg, Hans‐Meerwein‐Strasse 35032 Marburg/Lahn, Germany, Fax: (+49) 6421‐28‐25677</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: koert@chemie.uni‐marburg.de</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6D4386B68FCD3EA7A029DDCFF647D72FD02A73FF</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1002/chem.200400181</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-MGP6WWS0-9/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002248</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002248</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Stereoselective Synthesis of trans‐threo‐trans‐Oligopyrrolidines: Potential Agents for RNA Cleavage</title><author><name sortKey="Arndt, Hans Ieter" sort="Arndt, Hans Ieter" uniqKey="Arndt H" first="Hans-Dieter" last="Arndt">Hans-Dieter Arndt</name><affiliation><mods:affiliation>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>New Address: Max‐Planck Institut fur Molekulare Physiologie, Abteilung IV—Chemische Biologie, Otto‐Hahn‐Strasse 11, 44227 Dortmund, Germany</mods:affiliation></affiliation></author><author><name sortKey="Welz, Rudiger" sort="Welz, Rudiger" uniqKey="Welz R" first="Rüdiger" last="Welz">Rüdiger Welz</name><affiliation><mods:affiliation>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</mods:affiliation></affiliation></author><author><name sortKey="Muller, Sabine" sort="Muller, Sabine" uniqKey="Muller S" first="Sabine" last="Müller">Sabine Müller</name><affiliation><mods:affiliation>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>New Address: Fakultät für Chemie, NC 3/171, Universitätsstrasse 150, 44780 Bochum, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: sabine.mueller@orch.ruhr‐uni‐bochum.de</mods:affiliation></affiliation></author><author><name sortKey="Ziemer, Burkhart" sort="Ziemer, Burkhart" uniqKey="Ziemer B" first="Burkhart" last="Ziemer">Burkhart Ziemer</name><affiliation><mods:affiliation>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: burkhard.ziemer@chemie.hu‐berlin.de</mods:affiliation></affiliation></author><author><name sortKey="Koert, Ulrich" sort="Koert, Ulrich" uniqKey="Koert U" first="Ulrich" last="Koert">Ulrich Koert</name><affiliation><mods:affiliation>Fachbereich Chemie der Philipps‐Universität Marburg, Hans‐Meerwein‐Strasse 35032 Marburg/Lahn, Germany, Fax: (+49) 6421‐28‐25677</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: koert@chemie.uni‐marburg.de</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Chemistry – A European Journal</title><idno type="ISSN">0947-6539</idno><idno type="eISSN">1521-3765</idno><imprint><biblScope unit="vol">10</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="3945">3945</biblScope><biblScope unit="page" to="3962">3962</biblScope><biblScope unit="page-count">18</biblScope><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2004-08-20">2004-08-20</date></imprint><idno type="ISSN">0947-6539</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0947-6539</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The 2,5‐trans‐substituted oligopyrrolidines constitute a promising class of novel RNA‐binding agents as well as potential building blocks for artificial anion channels. A convergent synthesis of terpyrrolidine 1 and pyrrolidino‐THF‐pyrrolidine 2 is reported, relying upon convergent coupling of 2,5‐trans‐pyrrolidinecarboxaldehydes through bridging alkyne units under Felkin–Anh control and subsequent closure of the central ring. After complete deprotection, the free polyamine products were isolated in excellent yield and purity. Crystal structure analyses of a terpyrrolidine and a pyrrolidino‐THF‐pyrrolidine documented their helical privileged conformations. The compounds were then screened for RNA cleavage activity. Unlike the only weakly active simple polyamines, p‐nitrosulfonamide 33 was found to induce cleavage at mM concentrations under physiologically relevant conditions.</div><div type="abstract" xml:lang="en">A promising class of novel RNA‐binding agents has been developed by using bis‐ and terpyrrolidines with 2,5′‐threo‐trans configurations. The compounds such as depicted were synthesized stereoselectively and tested for RNA cleavage.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>mmol</json:string><json:string>arom</json:string><json:string>cdcl3</json:string><json:string>equiv</json:string><json:string>chem</json:string><json:string>calcd</json:string><json:string>colourless</json:string><json:string>brine</json:string><json:string>mtbe</json:string><json:string>organic layer</json:string><json:string>hrms</json:string><json:string>aqueous layer</json:string><json:string>elemental analysis calcd</json:string><json:string>mgso4</json:string><json:string>chcl3</json:string><json:string>et2o</json:string><json:string>aldehyde</json:string><json:string>terpyrrolidine</json:string><json:string>dropwise</json:string><json:string>meoh</json:string><json:string>ribozyme</json:string><json:string>oligopyrrolidines</json:string><json:string>gmbh</json:string><json:string>verlag gmbh</json:string><json:string>kgaa</json:string><json:string>verlag</json:string><json:string>weinheim</json:string><json:string>alkyne</json:string><json:string>angew</json:string><json:string>net3</json:string><json:string>koert</json:string><json:string>cyclic</json:string><json:string>diol</json:string><json:string>etoac</json:string><json:string>rotamers</json:string><json:string>tetrahedron</json:string><json:string>pyrrolidine</json:string><json:string>nahco3</json:string><json:string>vacuo</json:string><json:string>toluene</json:string><json:string>polyamines</json:string><json:string>bispyrrolidine</json:string><json:string>hexane</json:string><json:string>lett</json:string><json:string>approx</json:string><json:string>cleavage</json:string><json:string>tetrahedron lett</json:string><json:string>helical</json:string><json:string>deprotected</json:string><json:string>tmsotf</json:string><json:string>celite</json:string><json:string>weinheim chem</json:string><json:string>conc</json:string><json:string>nbuli</json:string><json:string>coevaporated</json:string><json:string>sulfonamide</json:string><json:string>nh4cl</json:string><json:string>ch2osi</json:string><json:string>boc2o</json:string><json:string>colourless solid</json:string><json:string>hairpin ribozyme</json:string><json:string>nahco3 solution</json:string><json:string>colourless foam</json:string><json:string>hairpin</json:string><json:string>crystal structure</json:string><json:string>phosphate buffer</json:string><json:string>nucleic acid</json:string><json:string>full paper</json:string><json:string>stereochemical assignment</json:string></teeft></keywords><author><json:item><name>Hans‐Dieter Arndt Dr.</name><affiliations><json:string>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</json:string><json:string>New Address: Max‐Planck Institut fur Molekulare Physiologie, Abteilung IV—Chemische Biologie, Otto‐Hahn‐Strasse 11, 44227 Dortmund, Germany</json:string></affiliations></json:item><json:item><name>Rüdiger Welz Dr.</name><affiliations><json:string>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</json:string></affiliations></json:item><json:item><name>Sabine Müller Prof. Dr.</name><affiliations><json:string>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</json:string><json:string>New Address: Fakultät für Chemie, NC 3/171, Universitätsstrasse 150, 44780 Bochum, Germany</json:string><json:string>E-mail: sabine.mueller@orch.ruhr‐uni‐bochum.de</json:string></affiliations></json:item><json:item><name>Burkhart Ziemer Dr.</name><affiliations><json:string>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</json:string><json:string>E-mail: burkhard.ziemer@chemie.hu‐berlin.de</json:string></affiliations></json:item><json:item><name>Ulrich Koert Prof. Dr.</name><affiliations><json:string>Fachbereich Chemie der Philipps‐Universität Marburg, Hans‐Meerwein‐Strasse 35032 Marburg/Lahn, Germany, Fax: (+49) 6421‐28‐25677</json:string><json:string>E-mail: koert@chemie.uni‐marburg.de</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>helical structures</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>polyamines</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pyrrolidines</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>RNA binding</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>synthesis design</value></json:item></subject><articleId><json:string>CHEM200400181</json:string></articleId><arkIstex>ark:/67375/WNG-MGP6WWS0-9</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The 2,5‐trans‐substituted oligopyrrolidines constitute a promising class of novel RNA‐binding agents as well as potential building blocks for artificial anion channels. A convergent synthesis of terpyrrolidine 1 and pyrrolidino‐THF‐pyrrolidine 2 is reported, relying upon convergent coupling of 2,5‐trans‐pyrrolidinecarboxaldehydes through bridging alkyne units under Felkin–Anh control and subsequent closure of the central ring. After complete deprotection, the free polyamine products were isolated in excellent yield and purity. Crystal structure analyses of a terpyrrolidine and a pyrrolidino‐THF‐pyrrolidine documented their helical privileged conformations. The compounds were then screened for RNA cleavage activity. Unlike the only weakly active simple polyamines, p‐nitrosulfonamide 33 was found to induce cleavage at mM concentrations under physiologically relevant conditions.</abstract><qualityIndicators><score>8.32</score><pdfWordCount>19794</pdfWordCount><pdfCharCount>108686</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>18</pdfPageCount><pdfPageSize>595 x 842 pts (A4)</pdfPageSize><pdfWordsPerPage>1100</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>110</abstractWordCount><abstractCharCount>888</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Stereoselective Synthesis of trans‐threo‐trans‐Oligopyrrolidines: Potential Agents for RNA Cleavage</title><pmid><json:string>15317060</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Chemistry – A European Journal</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1521-3765</json:string></doi><issn><json:string>0947-6539</json:string></issn><eissn><json:string>1521-3765</json:string></eissn><publisherId><json:string>CHEM</json:string></publisherId><volume>10</volume><issue>16</issue><pages><first>3945</first><last>3962</last><total>18</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Full Paper</value></json:item></subject></host><namedEntities><unitex><date><json:string>18/8/4</json:string><json:string>2004</json:string></date><geogName></geogName><orgName><json:string>Biotech</json:string><json:string>Biochem</json:string><json:string>Fonds</json:string><json:string>Deutsche Forschungsgemeinschaft</json:string></orgName><orgName_funder><json:string>Fonds</json:string><json:string>Deutsche Forschungsgemeinschaft</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>A. Alexakis</json:string><json:string>A. V. Fraser</json:string><json:string>T. Yamada</json:string><json:string>M. Cheung</json:string><json:string>D. J. Earnshaw</json:string><json:string>Y. Ohfune</json:string><json:string>M. G. Gait</json:string><json:string>L. Marzocchi</json:string><json:string>H. E. Radunz</json:string><json:string>T. Thomas</json:string><json:string>J. Volker</json:string><json:string>C. Chouillet</json:string><json:string>D. Arndt</json:string><json:string>Y. Sugiura</json:string><json:string>M. T. Reetz</json:string><json:string>K. Kashiwagi</json:string><json:string>Y. G. Gololobov</json:string><json:string>J. Biol</json:string><json:string>S. Muller</json:string><json:string>G. Stucky</json:string><json:string>A. C. Forster</json:string><json:string>F. Schuber</json:string><json:string>W. B. Schweizer</json:string><json:string>H. Geneste</json:string><json:string>J. J. Irwin</json:string><json:string>I. S. Haworth</json:string><json:string>R. E. Zelle</json:string><json:string>J. Escalante</json:string><json:string>T. Antony</json:string><json:string>Ulrich Koert</json:string><json:string>M. Ochi</json:string><json:string>Z. Anorg</json:string><json:string>K. B. Sharpless</json:string><json:string>D. Papaioannou</json:string><json:string>D. Seebach</json:string><json:string>L. Battistini</json:string><json:string>E. S. Priestley</json:string><json:string>M. Hendrix</json:string><json:string>S. Roelens</json:string><json:string>H. Klump</json:string><json:string>H. Wagner</json:string><json:string>L. F. Kasukhin</json:string><json:string>W. Lipshitz</json:string><json:string>J. L. Gleason</json:string><json:string>V. Eiermann</json:string><json:string>W. Petter</json:string><json:string>T. Mukaiyama</json:string><json:string>S. Stern</json:string><json:string>T. Gohda</json:string><json:string>R. Bittman</json:string><json:string>T. Iamamoto</json:string><json:string>T. Maetzke</json:string><json:string>L. Pinna</json:string><json:string>V. Kotlyar</json:string><json:string>T. Inokawa</json:string><json:string>M. Heneghan</json:string><json:string>H. C. Arndt</json:string><json:string>E. Fischer</json:string><json:string>P. A. Grieco</json:string><json:string>B. Lamatsch</json:string><json:string>H. Felkin</json:string><json:string>T. Oishi</json:string><json:string>K. Yoshinari</json:string><json:string>B. Lamm</json:string><json:string>L. Auzzas</json:string><json:string>K. Yamazaki</json:string><json:string>A. Brandstroem</json:string><json:string>G. Weinig</json:string><json:string>A. Nudelman</json:string><json:string>G. Boheim</json:string><json:string>S. Bradamante</json:string><json:string>T. M. Jovin</json:string><json:string>W. Hoyer</json:string><json:string>C. Schmidt</json:string><json:string>M. Sakaitani</json:string><json:string>W. G. Kofron</json:string><json:string>A. Cavÿ</json:string><json:string>B. M. Trost</json:string><json:string>M. Maestro</json:string><json:string>G. Casiraghi</json:string><json:string>I. N. Zhmurova</json:string><json:string>P. B. Alper</json:string><json:string>T. J. Thomas</json:string><json:string>W. L. Gerlach</json:string><json:string>D. Nagamani</json:string><json:string>G. Pyl</json:string><json:string>C. Schickli</json:string><json:string>J. Org</json:string><json:string>F. Tabusa</json:string><json:string>MeLi BuLi</json:string><json:string>R. Locher</json:string><json:string>H. Kotsuki</json:string><json:string>P. Herold</json:string><json:string>J. Mol</json:string><json:string>G. Rassu</json:string><json:string>R. Amstutz</json:string><json:string>M. Hirama</json:string><json:string>K. Michaelis</json:string><json:string>A. R. Ferre</json:string><json:string>T. K. Highsmith</json:string><json:string>W. Hoth</json:string><json:string>M. Kalesse</json:string><json:string>K. Suzuki</json:string><json:string>K. Jow</json:string><json:string>I. Amarantos</json:string><json:string>D. Esposito</json:string><json:string>T. Hermann</json:string><json:string>M. Dobler</json:string><json:string>A. Rodger</json:string><json:string>A. K. Beck</json:string><json:string>I. K. Zarkadis</json:string><json:string>W. N. Speckamp</json:string><json:string>P. Puruhit</json:string><json:string>H. E. Gottlieb</json:string><json:string>U. Koert</json:string><json:string>M. Pichon</json:string><json:string>M. Komiyama</json:string><json:string>R. Kierzek</json:string><json:string>M. Gautschi</json:string><json:string>E. Yeheskiely</json:string><json:string>M. Egli</json:string><json:string>H. Kuzume</json:string><json:string>A. Vescovi</json:string><json:string>T. R. Verhoeven</json:string><json:string>N. T. Ahn</json:string><json:string>D. Quintana</json:string><json:string>Dr</json:string><json:string>K. Michael</json:string><json:string>I. Palmertz</json:string><json:string>S. Schlabbach</json:string><json:string>H. M. Wallace</json:string><json:string>L. M. Baclawski</json:string><json:string>J. Haseloff</json:string><json:string>G. Bernardinelli</json:string><json:string>K. Harms</json:string><json:string>E. Molins</json:string><json:string>B. A. L. M. Deiman</json:string><json:string>R. M. Devant</json:string><json:string>P. E. Strege</json:string><json:string>J. H. van Boom</json:string><json:string>A. Tomassini</json:string><json:string>M. Fukuhara</json:string><json:string>K. Igarashi</json:string><json:string>D. Acquotti</json:string><json:string>M. J. Fedor</json:string><json:string>N. Takiyama</json:string><json:string>G. A. van der Marel</json:string><json:string>T. Fukuyama</json:string><json:string>S. Meder</json:string><json:string>M. Shiro</json:string><json:string>A. Hughes</json:string><json:string>J. Prakt</json:string><json:string>P. Mangeney</json:string><json:string>G. Karigiannis</json:string><json:string>E. M. Carreira</json:string><json:string>E. Pfammatter</json:string><json:string>D. A. Plattner</json:string><json:string>G. Procter</json:string><json:string>R. Hocquemiller</json:string><json:string>P. B. Rupert</json:string><json:string>Y. Gao</json:string><json:string>D. L. Kalpaxis</json:string><json:string>H. S. Byun</json:string><json:string>J. C. Verheijen</json:string><json:string>G. Barone</json:string><json:string>R. Fitzi</json:string><json:string>A. Mourino</json:string><json:string>B. Herradon</json:string><json:string>Y. Tor</json:string><json:string>M. J. Moolenaar</json:string><json:string>K. N. Ganesh</json:string><json:string>R. H. Symons</json:string><json:string>B. Figadõre</json:string><json:string>H. Wong</json:string><json:string>D. E. Frantz</json:string><json:string>London Ser</json:string><json:string>M. Stein</json:string></persName><placeName><json:string>Dortmund</json:string><json:string>Pagani</json:string><json:string>Bochum</json:string><json:string>Berlin</json:string><json:string>Marburg</json:string><json:string>Germany</json:string><json:string>Colombo</json:string><json:string>UK</json:string><json:string>Eppendorf</json:string><json:string>Ireland</json:string><json:string>Cambridge</json:string></placeName><ref_url><json:string>http://www.chemeurj.org/</json:string></ref_url><ref_bibl><json:string>[4]</json:string><json:string>[45]</json:string><json:string>[8]</json:string><json:string>[28]</json:string><json:string>[1]</json:string><json:string>[54]</json:string><json:string>[27]</json:string><json:string>[3]</json:string><json:string>U. Koert et al.</json:string><json:string>[64]</json:string><json:string>[26]</json:string><json:string>[63]</json:string><json:string>[47]</json:string><json:string>Carreira et al.</json:string><json:string>[40]</json:string><json:string>[46]</json:string><json:string>[54, 59, 60]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-MGP6WWS0-9</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - chemistry, multidisciplinary</json:string></wos><scienceMetrix><json:string>1 - natural sciences</json:string><json:string>2 - chemistry</json:string><json:string>3 - general chemistry</json:string></scienceMetrix><scopus><json:string>1 - Physical Sciences</json:string><json:string>2 - Chemistry</json:string><json:string>3 - General Chemistry</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2004</publicationDate><copyrightDate>2004</copyrightDate><doi><json:string>10.1002/chem.200400181</json:string></doi><id>6D4386B68FCD3EA7A029DDCFF647D72FD02A73FF</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-MGP6WWS0-9/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-MGP6WWS0-9/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-MGP6WWS0-9/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Stereoselective Synthesis of trans‐threo‐trans‐Oligopyrrolidines: Potential Agents for RNA Cleavage</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><availability><licence>Copyright © 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</licence></availability><date type="published" when="2004-08-20"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Stereoselective Synthesis of trans‐threo‐trans‐Oligopyrrolidines: Potential Agents for RNA Cleavage</title><author xml:id="author-0000"><persName><forename type="first">Hans‐Dieter</forename><surname>Arndt</surname><roleName type="degree">Dr.</roleName></persName><affiliation><orgName type="institution">Institut für Chemie der Humboldt‐Universität zu Berlin</orgName><address><addrLine>Brook‐Taylor‐Strasse 2</addrLine><addrLine>12489 Berlin, Germany</addrLine><country key="DE" xml:lang="en">GERMANY</country></address></affiliation><affiliation><orgName type="institution">New Address: Max‐Planck Institut fur Molekulare Physiologie</orgName><orgName type="laboratory">Abteilung IV—Chemische Biologie</orgName><address><addrLine>Otto‐Hahn‐Strasse 11</addrLine><addrLine>44227 Dortmund, Germany</addrLine><country key="DE" xml:lang="en">GERMANY</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Rüdiger</forename><surname>Welz</surname><roleName type="degree">Dr.</roleName></persName><affiliation><orgName type="institution">Institut für Chemie der Humboldt‐Universität zu Berlin</orgName><address><addrLine>Brook‐Taylor‐Strasse 2</addrLine><addrLine>12489 Berlin, Germany</addrLine><country key="DE" xml:lang="en">GERMANY</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Sabine</forename><surname>Müller</surname><roleName type="degree">Prof. Dr.</roleName></persName><email>sabine.mueller@orch.ruhr‐uni‐bochum.de</email><affiliation><orgName type="institution">Institut für Chemie der Humboldt‐Universität zu Berlin</orgName><address><addrLine>Brook‐Taylor‐Strasse 2</addrLine><addrLine>12489 Berlin, Germany</addrLine><country key="DE" xml:lang="en">GERMANY</country></address></affiliation><affiliation><orgName type="institution">New Address: Fakultät für Chemie</orgName><address><addrLine>NC 3/171</addrLine><addrLine>Universitätsstrasse 150, 44780 Bochum, Germany</addrLine><country key="DE" xml:lang="en">GERMANY</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Burkhart</forename><surname>Ziemer</surname><roleName type="degree">Dr.</roleName></persName><email>burkhard.ziemer@chemie.hu‐berlin.de</email><affiliation><orgName type="institution">Institut für Chemie der Humboldt‐Universität zu Berlin</orgName><address><addrLine>Brook‐Taylor‐Strasse 2</addrLine><addrLine>12489 Berlin, Germany</addrLine><country key="DE" xml:lang="en">GERMANY</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Ulrich</forename><surname>Koert</surname><roleName type="degree">Prof. Dr.</roleName></persName><email>koert@chemie.uni‐marburg.de</email><affiliation><orgName type="institution">Fachbereich Chemie der Philipps‐Universität Marburg</orgName><address><addrLine>Hans‐Meerwein‐Strasse 35032 Marburg/Lahn</addrLine><addrLine>Germany, Fax: (+49) 6421‐28‐25677</addrLine><country key="DE" xml:lang="en">GERMANY</country></address></affiliation></author><idno type="istex">6D4386B68FCD3EA7A029DDCFF647D72FD02A73FF</idno><idno type="ark">ark:/67375/WNG-MGP6WWS0-9</idno><idno type="DOI">10.1002/chem.200400181</idno><idno type="unit">CHEM200400181</idno><idno type="toTypesetVersion">file:CHEM.CHEM200400181.pdf</idno></analytic><monogr><title level="j" type="main">Chemistry – A European Journal</title><idno type="pISSN">0947-6539</idno><idno type="eISSN">1521-3765</idno><idno type="book-DOI">10.1002/(ISSN)1521-3765</idno><idno type="book-part-DOI">10.1002/chem.v10:16</idno><idno type="product">CHEM</idno><imprint><biblScope unit="vol">10</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="3945">3945</biblScope><biblScope unit="page" to="3962">3962</biblScope><biblScope unit="page-count">18</biblScope><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2004-08-20"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>The 2,5‐<hi rend="italic">trans</hi>‐substituted oligopyrrolidines constitute a promising class of novel RNA‐binding agents as well as potential building blocks for artificial anion channels. A convergent synthesis of terpyrrolidine <hi rend="bold">1</hi> and pyrrolidino‐THF‐pyrrolidine <hi rend="bold">2</hi> is reported, relying upon convergent coupling of 2,5‐<hi rend="italic">trans</hi>‐pyrrolidinecarboxaldehydes through bridging alkyne units under Felkin–Anh control and subsequent closure of the central ring. After complete deprotection, the free polyamine products were isolated in excellent yield and purity. Crystal structure analyses of a terpyrrolidine and a pyrrolidino‐THF‐pyrrolidine documented their helical privileged conformations. The compounds were then screened for RNA cleavage activity. Unlike the only weakly active simple polyamines, <hi rend="italic">p</hi>‐nitrosulfonamide <hi rend="bold">33</hi> was found to induce cleavage at m<hi rend="smallCaps">M</hi> concentrations under physiologically relevant conditions.</p></abstract><abstract xml:lang="en" style="graphical"><p><hi rend="bold">A promising class of novel RNA‐binding agents</hi> has been developed by using bis‐ and terpyrrolidines with 2,5′‐<hi rend="italic">threo‐trans</hi> configurations. The compounds such as depicted were synthesized stereoselectively and tested for RNA cleavage.<figure type="box"><media mimeType="image" url="urn:x-wiley:09476539:media:CHEM200400181:content"></media><media mimeType="image/gif" url="" rendition="webLoRes"></media><media mimeType="image/gif" url="" rendition="webOriginal"></media><media mimeType="image/gif" url="" rendition="webHiRes"></media></figure></p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">helical structures</term><term xml:id="kwd2">polyamines</term><term xml:id="kwd3">pyrrolidines</term><term xml:id="kwd4">RNA binding</term><term xml:id="kwd5">synthesis design</term></keywords><keywords rend="articleCategory"><term>Full Paper</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-MGP6WWS0-9/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>WILEY‐VCH Verlag</publisherName><publisherLoc>Weinheim</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1521-3765</doi><issn type="print">0947-6539</issn><issn type="electronic">1521-3765</issn><idGroup><id type="product" value="CHEM"></id></idGroup><titleGroup><title type="main" xml:lang="en">Chemistry – A European Journal</title><title type="short">Chemistry – A European Journal</title></titleGroup></publicationMeta><publicationMeta level="part" position="160"><doi origin="wiley" registered="yes">10.1002/chem.v10:16</doi><numberingGroup><numbering type="journalVolume" number="10">10</numbering><numbering type="journalIssue">16</numbering></numberingGroup><coverDate startDate="2004-08-20">August 20, 2004</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="14" status="forIssue"><doi origin="wiley" registered="yes">10.1002/chem.200400181</doi><idGroup><id type="unit" value="CHEM200400181"></id></idGroup><countGroup><count type="pageTotal" number="18"></count></countGroup><titleGroup><title type="articleCategory">Full Paper</title></titleGroup><copyright ownership="publisher">Copyright © 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</copyright><eventGroup><event type="firstOnline" date="2004-06-28"></event><event type="publishedOnlineFinalForm" date="2004-08-12"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.6 mode:FullText source:FullText result:FullText mathml2tex" date="2010-05-18"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-09"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-15"></event></eventGroup><numberingGroup><numbering type="pageFirst">3945</numbering><numbering type="pageLast">3962</numbering></numberingGroup><objectNameGroup><objectName elementName="figure">Scheme</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file:CHEM.CHEM200400181.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="13"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="69"></count></countGroup><titleGroup><title type="main" xml:lang="en">Stereoselective Synthesis of <i>trans</i>‐<i>threo</i>‐<i>trans</i>‐Oligopyrrolidines: Potential Agents for RNA Cleavage</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#ab #ac"><personName><givenNames>Hans‐Dieter</givenNames><familyName>Arndt</familyName><degrees>Dr.</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#ab"><personName><givenNames>Rüdiger</givenNames><familyName>Welz</familyName><degrees>Dr.</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#ab #ad"><personName><givenNames>Sabine</givenNames><familyName>Müller</familyName><degrees>Prof. Dr.</degrees></personName><contactDetails><email normalForm="sabine.mueller@orch.ruhr-uni-bochum.de">sabine.mueller@orch.ruhr‐uni‐bochum.de</email></contactDetails></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#ab"><personName><givenNames>Burkhart</givenNames><familyName>Ziemer</familyName><degrees>Dr.</degrees></personName><contactDetails><email normalForm="burkhard.ziemer@chemie.hu-berlin.de">burkhard.ziemer@chemie.hu‐berlin.de</email></contactDetails></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#aa"><personName><givenNames>Ulrich</givenNames><familyName>Koert</familyName><degrees>Prof. Dr.</degrees></personName><contactDetails><email normalForm="koert@chemie.uni-marburg.de">koert@chemie.uni‐marburg.de</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="aa" countryCode="DE" type="organization"><unparsedAffiliation>Fachbereich Chemie der Philipps‐Universität Marburg, Hans‐Meerwein‐Strasse 35032 Marburg/Lahn, Germany, Fax: (+49) 6421‐28‐25677</unparsedAffiliation></affiliation><affiliation xml:id="ab" countryCode="DE" type="organization"><unparsedAffiliation>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</unparsedAffiliation></affiliation><affiliation xml:id="ac" countryCode="DE" type="organization"><unparsedAffiliation>New Address: Max‐Planck Institut fur Molekulare Physiologie, Abteilung IV—Chemische Biologie, Otto‐Hahn‐Strasse 11, 44227 Dortmund, Germany</unparsedAffiliation></affiliation><affiliation xml:id="ad" countryCode="DE" type="organization"><unparsedAffiliation>New Address: Fakultät für Chemie, NC 3/171, Universitätsstrasse 150, 44780 Bochum, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">helical structures</keyword><keyword xml:id="kwd2">polyamines</keyword><keyword xml:id="kwd3">pyrrolidines</keyword><keyword xml:id="kwd4">RNA binding</keyword><keyword xml:id="kwd5">synthesis design</keyword></keywordGroup><supportingInformation><p>Supporting information for this article is available on the WWW under <url href="http://www.wiley-vch.de/contents/jc_2111/2004/f400181_s.pdf">http://www.wiley‐vch.de/contents/jc_2111/2004/f400181_s.pdf</url> or from the author.</p></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The 2,5‐<i>trans</i>‐substituted oligopyrrolidines constitute a promising class of novel RNA‐binding agents as well as potential building blocks for artificial anion channels. A convergent synthesis of terpyrrolidine <b>1</b> and pyrrolidino‐THF‐pyrrolidine <b>2</b> is reported, relying upon convergent coupling of 2,5‐<i>trans</i>‐pyrrolidinecarboxaldehydes through bridging alkyne units under Felkin–Anh control and subsequent closure of the central ring. After complete deprotection, the free polyamine products were isolated in excellent yield and purity. Crystal structure analyses of a terpyrrolidine and a pyrrolidino‐THF‐pyrrolidine documented their helical privileged conformations. The compounds were then screened for RNA cleavage activity. Unlike the only weakly active simple polyamines, <i>p</i>‐nitrosulfonamide <b>33</b> was found to induce cleavage at m<sc>M</sc> concentrations under physiologically relevant conditions.</p></abstract><abstract type="graphical" xml:lang="en"><p><b>A promising class of novel RNA‐binding agents</b> has been developed by using bis‐ and terpyrrolidines with 2,5′‐<i>threo‐trans</i> configurations. The compounds such as depicted were synthesized stereoselectively and tested for RNA cleavage.<blockFixed type="graphic"><mediaResourceGroup><mediaResource alt="image" eRights="yes" copyright="WILEY-VCH" href="urn:x-wiley:09476539:media:CHEM200400181:content"></mediaResource><mediaResource alt="thumbnail image" rendition="webLoRes" mimeType="image/gif" href=""></mediaResource><mediaResource alt="original image" rendition="webOriginal" mimeType="image/gif" href=""></mediaResource><mediaResource alt="magnified image" rendition="webHiRes" mimeType="image/gif" href=""></mediaResource></mediaResourceGroup></blockFixed></p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Stereoselective Synthesis of trans‐threo‐trans‐Oligopyrrolidines: Potential Agents for RNA Cleavage</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Stereoselective Synthesis of trans‐threo‐trans‐Oligopyrrolidines: Potential Agents for RNA Cleavage</title></titleInfo><name type="personal"><namePart type="given">Hans‐Dieter</namePart><namePart type="family">Arndt</namePart><namePart type="termsOfAddress">Dr.</namePart><affiliation>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</affiliation><affiliation>New Address: Max‐Planck Institut fur Molekulare Physiologie, Abteilung IV—Chemische Biologie, Otto‐Hahn‐Strasse 11, 44227 Dortmund, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rüdiger</namePart><namePart type="family">Welz</namePart><namePart type="termsOfAddress">Dr.</namePart><affiliation>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sabine</namePart><namePart type="family">Müller</namePart><namePart type="termsOfAddress">Prof. Dr.</namePart><affiliation>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</affiliation><affiliation>New Address: Fakultät für Chemie, NC 3/171, Universitätsstrasse 150, 44780 Bochum, Germany</affiliation><affiliation>E-mail: sabine.mueller@orch.ruhr‐uni‐bochum.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Burkhart</namePart><namePart type="family">Ziemer</namePart><namePart type="termsOfAddress">Dr.</namePart><affiliation>Institut für Chemie der Humboldt‐Universität zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin, Germany</affiliation><affiliation>E-mail: burkhard.ziemer@chemie.hu‐berlin.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ulrich</namePart><namePart type="family">Koert</namePart><namePart type="termsOfAddress">Prof. Dr.</namePart><affiliation>Fachbereich Chemie der Philipps‐Universität Marburg, Hans‐Meerwein‐Strasse 35032 Marburg/Lahn, Germany, Fax: (+49) 6421‐28‐25677</affiliation><affiliation>E-mail: koert@chemie.uni‐marburg.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>WILEY‐VCH Verlag</publisher><place><placeTerm type="text">Weinheim</placeTerm></place><dateIssued encoding="w3cdtf">2004-08-20</dateIssued><copyrightDate encoding="w3cdtf">2004</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">13</extent><extent unit="tables">1</extent><extent unit="references">69</extent></physicalDescription><abstract lang="en">The 2,5‐trans‐substituted oligopyrrolidines constitute a promising class of novel RNA‐binding agents as well as potential building blocks for artificial anion channels. A convergent synthesis of terpyrrolidine 1 and pyrrolidino‐THF‐pyrrolidine 2 is reported, relying upon convergent coupling of 2,5‐trans‐pyrrolidinecarboxaldehydes through bridging alkyne units under Felkin–Anh control and subsequent closure of the central ring. After complete deprotection, the free polyamine products were isolated in excellent yield and purity. Crystal structure analyses of a terpyrrolidine and a pyrrolidino‐THF‐pyrrolidine documented their helical privileged conformations. The compounds were then screened for RNA cleavage activity. Unlike the only weakly active simple polyamines, p‐nitrosulfonamide 33 was found to induce cleavage at mM concentrations under physiologically relevant conditions.</abstract><abstract type="graphical" lang="en">A promising class of novel RNA‐binding agents has been developed by using bis‐ and terpyrrolidines with 2,5′‐threo‐trans configurations. The compounds such as depicted were synthesized stereoselectively and tested for RNA cleavage.</abstract><subject lang="en"><genre>keywords</genre><topic>helical structures</topic><topic>polyamines</topic><topic>pyrrolidines</topic><topic>RNA binding</topic><topic>synthesis design</topic></subject><relatedItem type="host"><titleInfo><title>Chemistry – A European Journal</title></titleInfo><titleInfo type="abbreviated"><title>Chemistry – A European Journal</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><note type="content"> Supporting information for this article is available on the WWW under http://www.wiley‐vch.de/contents/jc_2111/2004/f400181_s.pdf or from the author.</note><subject><genre>article-category</genre><topic>Full Paper</topic></subject><identifier type="ISSN">0947-6539</identifier><identifier type="eISSN">1521-3765</identifier><identifier type="DOI">10.1002/(ISSN)1521-3765</identifier><identifier type="PublisherID">CHEM</identifier><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><detail type="issue"><caption>no.</caption><number>16</number></detail><extent unit="pages"><start>3945</start><end>3962</end><total>18</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Biochem. Biophys. Res. Commun.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">K. Igarashi, K. Kashiwagi, Biochem. Biophys. Res. Commun. 2000, 271, 559–564.</note><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Igarashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Kashiwagi</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>271</number></detail><extent unit="pages"><start>559</start><end>564</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Cell. Mol. Life Sci.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. Thomas, T. J. Thomas, Cell. Mol. Life Sci. 2001, 58, 244–258.</note><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Thomas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. J.</namePart><namePart type="family">Thomas</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>58</number></detail><extent unit="pages"><start>244</start><end>258</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>Biochem. J.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H. M. Wallace, A. V. Fraser, A. Hughes, Biochem. J. 2003, 376, 1–14.</note><name type="personal"><namePart type="given">H. M.</namePart><namePart type="family">Wallace</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. V.</namePart><namePart type="family">Fraser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Hughes</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>376</number></detail><extent unit="pages"><start>1</start><end>14</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>Biochem. J.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">F. Schuber, Biochem. J. 1989, 260, 1–10.</note><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Schuber</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>260</number></detail><extent unit="pages"><start>1</start><end>10</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>Chem. unserer Zeit</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H. Geneste, M. Hesse, Chem. unserer Zeit 1998, 32, 206–218.</note><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Geneste</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hesse</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>206</start><end>218</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>J. Am. Chem. Soc.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. Esposito, P. del Vecchio, G. Barone, J. Am. Chem. Soc. 1997, 119, 2606–2613.</note><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Esposito</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">del Vecchio</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Barone</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>119</number></detail><extent unit="pages"><start>2606</start><end>2613</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>Eur. J. Org. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">G. Karigiannis, D. Papaioannou, Eur. J. Org. Chem. 2000, 1841–1863.</note><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Karigiannis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Papaioannou</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2000</date><extent unit="pages"><start>1841</start><end>1863</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>J. Biol. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. Antony, W. Hoyer, D. Cherny, G. Heim, T. M. Jovin, V. Subramaniam, J. Biol. Chem. 2003, 278, 3235–3240.</note><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Antony</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Hoyer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Cherny</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Heim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. M.</namePart><namePart type="family">Jovin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Subramaniam</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>278</number></detail><extent unit="pages"><start>3235</start><end>3240</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Proc. R. Soc. London Ser. B</title></titleInfo><genre>journal-article</genre><note type="citation/reference">I. S. Haworth, A. Rodger, W. G. Richards, Proc. R. Soc. London Ser. B 1994, 255‐258, 107–116.</note><name type="personal"><namePart type="given">I. S.</namePart><namePart type="family">Haworth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Rodger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. G.</namePart><namePart type="family">Richards</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>255‐258</number></detail><extent unit="pages"><start>107</start><end>116</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>Biochemistry</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. Volker, H. Klump, Biochemistry 1994, 33, 13 502–13 508.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Volker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Klump</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><extent unit="pages"><start>13 502</start><end>13 508</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>Angew. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. Hermann, Angew. Chem. 2000, 112, 1962–1979;</note><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Hermann</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>112</number></detail><extent unit="pages"><start>1962</start><end>1979</end></extent></part><titleInfo><title>Angew. Chem. Int. Ed.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Angew. Chem. Int. Ed. 2000, 39, 1890–1904.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>1890</start><end>1904</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">I. Amarantos, I. K. Zarkadis, D. L. Kalpaxis, Nucleic Acids Res. 2002, 30, 2832–2843.</note><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Amarantos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. K.</namePart><namePart type="family">Zarkadis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. L.</namePart><namePart type="family">Kalpaxis</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><extent unit="pages"><start>2832</start><end>2843</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit14"><titleInfo><title>Angew. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. Hendrix, P. B. Alper, E. S. Priestley, C.‐H. Wong, Angew. Chem. 1997, 109, 119–122;</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hendrix</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. B.</namePart><namePart type="family">Alper</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. S.</namePart><namePart type="family">Priestley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.‐H.</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>109</number></detail><extent unit="pages"><start>119</start><end>122</end></extent></part><titleInfo><title>Angew. Chem. Int. Ed.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Angew. Chem. Int. Ed. 1997, 36, 95–98.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>95</start><end>98</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit16"><titleInfo><title>Chem. Eur. J.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">K. Michael, Y. Tor, Chem. Eur. J. 1998, 4, 2091–2098.</note><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Michael</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Tor</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>2091</start><end>2098</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">P. Puruhit, S. Stern, Nature 1994, 370, 659–662.</note><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Puruhit</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Stern</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>370</number></detail><extent unit="pages"><start>659</start><end>662</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit18"><titleInfo><title>Synthesis</title></titleInfo><genre>journal-article</genre><note type="citation/reference">U. Koert, Synthesis 1995, 115–132.</note><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Koert</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1995</date><extent unit="pages"><start>115</start><end>132</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit19"><titleInfo><title>Angew. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">U. Koert, M. Stein, K. Harms, Angew. Chem. 1994, 106, 1238–1240;</note><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Koert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Stein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Harms</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>106</number></detail><extent unit="pages"><start>1238</start><end>1240</end></extent></part><titleInfo><title>Angew. Chem. Int. Ed. Engl.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Angew. Chem. Int. Ed. Engl. 1994, 33, 1180–1182.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><extent unit="pages"><start>1180</start><end>1182</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit21"><titleInfo><title>Angew. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H. Wagner, K. Harms, U. Koert, S. Meder, G. Boheim, Angew. Chem. 1996, 108, 2836–2839;</note><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Wagner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Harms</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Koert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Meder</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Boheim</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>108</number></detail><extent unit="pages"><start>2836</start><end>2839</end></extent></part><titleInfo><title>Angew. Chem. Int. Ed.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Angew. Chem. Int. Ed. 1996, 35, 2643–2646.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>2643</start><end>2646</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit23"><titleInfo><title>J. Prakt. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">U. Koert, J. Prakt. Chem. 2000, 342, 325–333.</note><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Koert</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>342</number></detail><extent unit="pages"><start>325</start><end>333</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit24"><titleInfo><title>Angew. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. Schrey, A. Vescovi, A. Knoll, C. Rickert, U. Koert, Angew. Chem. 2000, 112, 928–931;</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Schrey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Vescovi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Knoll</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Rickert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Koert</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>112</number></detail><extent unit="pages"><start>928</start><end>931</end></extent></part><titleInfo><title>Angew. Chem. Int. Ed.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Angew. Chem. Int. Ed. 2000, 39, 900–902.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>900</start><end>902</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit26"><titleInfo><title>Tetrahedron: Asymmetry</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H. Kotsuki, H. Kuzume, T. Gohda, M. Fukuhara, M. Ochi, T. Oishi, M. Hirama, M. Shiro, Tetrahedron: Asymmetry 1995, 6, 2227–2236.</note><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Kotsuki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Kuzume</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Gohda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Fukuhara</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Ochi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Oishi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hirama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Shiro</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>2227</start><end>2236</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit27"><titleInfo><title>Angew. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. Alexakis, A. Tomassini, C. Chouillet, S. Roland, P. Mangeney, G. Bernardinelli, Angew. Chem. 2000, 112, 4259–4261;</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Alexakis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Tomassini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Chouillet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Roland</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Mangeney</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Bernardinelli</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>112</number></detail><extent unit="pages"><start>4259</start><end>4261</end></extent></part><titleInfo><title>Angew. Chem. Int. Ed.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Angew. Chem. Int. Ed. 2000, 39, 4093–4095.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>4093</start><end>4095</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit29"><titleInfo><title>Tetrahedron Lett.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. Pichon, B. Figadère, A. Cavé, Tetrahedron Lett. 1996, 37, 7963–7966.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Pichon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Figadère</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Cavé</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>7963</start><end>7966</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit30"><titleInfo><title>Tetrahedron Lett.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. Pichon, R. Hocquemiller, B. Figadère, Tetrahedron Lett. 1999, 40, 8567–8570.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Pichon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Hocquemiller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Figadère</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>8567</start><end>8570</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit31"><titleInfo><title>J. Org. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">F. Zanardi, L. Battistini, G. Rassu, L. Auzzas, L. Pinna, L. Marzocchi, D. Acquotti, G. Casiraghi, J. Org. Chem. 2000, 65, 2048–2064.</note><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Zanardi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Battistini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Rassu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Auzzas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Pinna</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Marzocchi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Acquotti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Casiraghi</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>2048</start><end>2064</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit32"><titleInfo><title>Tetrahedron Lett.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H.‐D. Arndt, K. Polborn, U. Koert, Tetrahedron Lett. 1997, 38, 3879–3882.</note><name type="personal"><namePart type="given">H.‐D.</namePart><namePart type="family">Arndt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Polborn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Koert</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><extent unit="pages"><start>3879</start><end>3882</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit33"><titleInfo><title>J. Org. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. L. Flynn, R. E. Zelle, P. A. Grieco, J. Org. Chem. 1983, 48, 2424.</note><name type="personal"><namePart type="given">D. L.</namePart><namePart type="family">Flynn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. E.</namePart><namePart type="family">Zelle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. A.</namePart><namePart type="family">Grieco</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>2424</start></extent></part></relatedItem><relatedItem type="references" displayLabel="cit34"><titleInfo><title>Tetrahedron</title></titleInfo><genre>journal-article</genre><note type="citation/reference">W. N. Speckamp, M. J. Moolenaar, Tetrahedron 2000, 56, 3817–3856.</note><name type="personal"><namePart type="given">W. N.</namePart><namePart type="family">Speckamp</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. J.</namePart><namePart type="family">Moolenaar</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>56</number></detail><extent unit="pages"><start>3817</start><end>3856</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit35"><titleInfo><title>Liebigs Ann. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H. E. Radunz, R. M. Devant, V. Eiermann, Liebigs Ann. Chem. 1988, 1103–1105.</note><name type="personal"><namePart type="given">H. E.</namePart><namePart type="family">Radunz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. M.</namePart><namePart type="family">Devant</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Eiermann</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1988</date><extent unit="pages"><start>1103</start><end>1105</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit36"><titleInfo><title>Helv. Chim. Acta</title></titleInfo><genre>journal-article</genre><note type="citation/reference">P. Herold, Helv. Chim. Acta 1988, 71, 354–362.</note><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Herold</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>71</number></detail><extent unit="pages"><start>354</start><end>362</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit37"><titleInfo><title>Tetrahedron Lett.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. Iamamoto, Y. Sugiura, N. Takiyama, Tetrahedron Lett. 1984, 25, 4233–4236.</note><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Iamamoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Sugiura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Takiyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>4233</start><end>4236</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit38"><titleInfo><title>Tetrahedron</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. Mukaiyama, K. Suzuki, T. Yamada, F. Tabusa, Tetrahedron 1990, 46, 265–276.</note><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Mukaiyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Suzuki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Yamada</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Tabusa</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>265</start><end>276</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit39"><titleInfo><title>J. Am. Chem. Soc.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. E. Frantz, R. Fässler, E. M. Carreira, J. Am. Chem. Soc. 2000, 122, 1806–1807.</note><name type="personal"><namePart type="given">D. E.</namePart><namePart type="family">Frantz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Fässler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. M.</namePart><namePart type="family">Carreira</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>122</number></detail><extent unit="pages"><start>1806</start><end>1807</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit40"><titleInfo><title>J. Am. Chem. Soc.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Y. Gao, K. B. Sharpless, J. Am. Chem. Soc. 1988, 110, 7538–7539.</note><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Gao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. B.</namePart><namePart type="family">Sharpless</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>110</number></detail><extent unit="pages"><start>7538</start><end>7539</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit41"><titleInfo><title>Tetrahedron</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H. S. Byun, L. L. He, R. Bittman, Tetrahedron 2000, 56, 7051–7091.</note><name type="personal"><namePart type="given">H. S.</namePart><namePart type="family">Byun</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. L.</namePart><namePart type="family">He</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Bittman</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>56</number></detail><extent unit="pages"><start>7051</start><end>7091</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit42"><titleInfo><title>Helv. Chim. Acta</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. Seebach, B. Lamatsch, R. Amstutz, A. K. Beck, M. Dobler, M. Egli, R. Fitzi, M. Gautschi, B. Herradon, P. C. Hidber, J. J. Irwin, R. Locher, M. Maestro, T. Maetzke, A. Mourino, E. Pfammatter, D. A. Plattner, C. Schickli, W. B. Schweizer, P. Seiler, G. Stucky, W. Petter, J. Escalante, E. Juaristi, D. Quintana, C. Miravitelles, E. Molins, Helv. Chim. Acta 1992, 75, 913–934.</note><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Seebach</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Lamatsch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Amstutz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. K.</namePart><namePart type="family">Beck</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Dobler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Egli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Fitzi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Gautschi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Herradon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. C.</namePart><namePart type="family">Hidber</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">Irwin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Locher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Maestro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Maetzke</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Mourino</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Pfammatter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. A.</namePart><namePart type="family">Plattner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Schickli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. B.</namePart><namePart type="family">Schweizer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Seiler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Stucky</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Petter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Escalante</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Juaristi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Quintana</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Miravitelles</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Molins</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><extent unit="pages"><start>913</start><end>934</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit43"><titleInfo><title>J. Org. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. Sakaitani, Y. Ohfune, J. Org. Chem. 1990, 55, 870–876.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Sakaitani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Ohfune</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>55</number></detail><extent unit="pages"><start>870</start><end>876</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit44"><titleInfo><title>J. Org. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">R. E. Ireland, J. L. Gleason, L. D. Gegnas, T. K. Highsmith, J. Org. Chem. 1996, 61, 6856–6872.</note><name type="personal"><namePart type="given">R. E.</namePart><namePart type="family">Ireland</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. L.</namePart><namePart type="family">Gleason</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. D.</namePart><namePart type="family">Gegnas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. K.</namePart><namePart type="family">Highsmith</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>61</number></detail><extent unit="pages"><start>6856</start><end>6872</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit45"><titleInfo><title>Org. Biomol. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. Vescovi, A. Knoll, U. Koert, Org. Biomol. Chem. 2003, 1, 2983–2997.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Vescovi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Knoll</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Koert</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>2983</start><end>2997</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit46"><titleInfo><title>Tetrahedron Lett.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. Fukuyama, C.‐K. Jow, M. Cheung, Tetrahedron Lett. 1995, 36, 6373–6374.</note><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Fukuyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.‐K.</namePart><namePart type="family">Jow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Cheung</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>6373</start><end>6374</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit47"><titleInfo><title>Synlett</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. Heneghan, G. Procter, Synlett 1992, 489–490.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Heneghan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Procter</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1992</date><extent unit="pages"><start>489</start><end>490</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit48"><titleInfo><title>Tetrahedron Lett.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. Chérest, H. Felkin, Tetrahedron Lett. 1968, 2205–2208.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Chérest</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Felkin</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1968</date><extent unit="pages"><start>2205</start><end>2208</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit49"><titleInfo><title>Top. Curr. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">N. T. Ahn, Top. Curr. Chem. 1980, 88, 145–162.</note><name type="personal"><namePart type="given">N. T.</namePart><namePart type="family">Ahn</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1980</date><detail type="volume"><caption>vol.</caption><number>88</number></detail><extent unit="pages"><start>145</start><end>162</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit50"><titleInfo><title>Chem. Rev.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. T. Reetz, Chem. Rev. 1999, 99, 1121–1162.</note><name type="personal"><namePart type="given">M. T.</namePart><namePart type="family">Reetz</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>99</number></detail><extent unit="pages"><start>1121</start><end>1162</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit51"><titleInfo><title>Tetrahedron</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Y. G. Gololobov, I. N. Zhmurova, L. F. Kasukhin, Tetrahedron 1981, 37, 437–472.</note><name type="personal"><namePart type="given">Y. G.</namePart><namePart type="family">Gololobov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. N.</namePart><namePart type="family">Zhmurova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. F.</namePart><namePart type="family">Kasukhin</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>437</start><end>472</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit52"><titleInfo><title>Tetrahedron Lett.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">B. M. Trost, H. C. Arndt, P. E. Strege, T. R. Verhoeven, Tetrahedron Lett. 1976, 3477–3481.</note><name type="personal"><namePart type="given">B. M.</namePart><namePart type="family">Trost</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. C.</namePart><namePart type="family">Arndt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. E.</namePart><namePart type="family">Strege</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. R.</namePart><namePart type="family">Verhoeven</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1976</date><extent unit="pages"><start>3477</start><end>3481</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit53"><titleInfo><title>Helv. Chim. Acta</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. Bradamante, S. Colombo, G. A. Pagani, S. Roelens, Helv. Chim. Acta 1981, 64, 2524–2527.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Bradamante</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Colombo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. A.</namePart><namePart type="family">Pagani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Roelens</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>64</number></detail><extent unit="pages"><start>2524</start><end>2527</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit54"><titleInfo><title>J. Chem. Soc. Chem. Commun.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. Komiyama, T. Inokawa, K. Yoshinari, J. Chem. Soc. Chem. Commun. 1995, 77, 77–78.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Komiyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Inokawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Yoshinari</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>77</number></detail><extent unit="pages"><start>77</start><end>78</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit55"><titleInfo><title>Angew. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">K. Michaelis, M. Kalesse, Angew. Chem. 1999, 111, 2382–2385;</note><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Michaelis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Kalesse</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>111</number></detail><extent unit="pages"><start>2382</start><end>2385</end></extent></part><titleInfo><title>Angew. Chem. Int. Ed.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Angew. Chem. Int. Ed. 1999, 38, 2243–2245.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><extent unit="pages"><start>2243</start><end>2245</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit57"><titleInfo><title>ChemBioChem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">K. Michaelis, M. Kalesse, ChemBioChem 2001, 2, 79–83.</note><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Michaelis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Kalesse</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>79</start><end>83</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit58"><titleInfo><title>Angew. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. C. Verheijen, B. A. L. M. Deiman, E. Yeheskiely, G. A. van der Marel, J. H. van Boom, Angew. Chem. 2000, 112, 377–380;</note><name type="personal"><namePart type="given">J. C.</namePart><namePart type="family">Verheijen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. A. L. M.</namePart><namePart type="family">Deiman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Yeheskiely</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. A.</namePart><namePart type="family">van der Marel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. H.</namePart><namePart type="family">van Boom</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>112</number></detail><extent unit="pages"><start>377</start><end>380</end></extent></part><titleInfo><title>Angew. Chem. Int. Ed.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Angew. Chem. Int. Ed. 2000, 39, 369–372.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>369</start><end>372</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit60"><titleInfo><title>J. Am. Chem. Soc.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">K. Yoshinari, K. Yamazaki, M. Komiyama, J. Am. Chem. Soc. 1991, 113, 5899–5901.</note><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Yoshinari</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Yamazaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Komiyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>113</number></detail><extent unit="pages"><start>5899</start><end>5901</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit61"><titleInfo><title> </title></titleInfo><genre>other</genre></relatedItem><relatedItem type="references" displayLabel="cit62"><titleInfo><title>J. Org. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. Komiyama, K. Yoshinari, J. Org. Chem. 1997, 62, 2155–2160;</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Komiyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Yoshinari</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>62</number></detail><extent unit="pages"><start>2155</start><end>2160</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit63"><titleInfo><title>Org. Lett.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. Nagamani, K. N. Ganesh, Org. Lett. 2001, 3, 103–106.</note><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Nagamani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. N.</namePart><namePart type="family">Ganesh</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>103</start><end>106</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit64"><titleInfo><title>Biochem. Biophys. Res. Commun.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">R. Welz, C. Schmidt, S. Muller, Biochem. Biophys. Res. Commun. 2001, 283, 648–654.</note><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Welz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Schmidt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Muller</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>283</number></detail><extent unit="pages"><start>648</start><end>654</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit65"><titleInfo><title>Cell</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. C. Forster, R. H. Symons, Cell 1987, 49, 211–220.</note><name type="personal"><namePart type="given">A. C.</namePart><namePart type="family">Forster</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. H.</namePart><namePart type="family">Symons</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>211</start><end>220</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit66"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. Haseloff, W. L. Gerlach, Nature 1988, 334, 585–591.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Haseloff</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. L.</namePart><namePart type="family">Gerlach</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>334</number></detail><extent unit="pages"><start>585</start><end>591</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit67"><titleInfo><title>J. Mol. Biol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. J. Fedor, J. Mol. Biol. 2000, 297, 269–291.</note><name type="personal"><namePart type="given">M. J.</namePart><namePart type="family">Fedor</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>297</number></detail><extent unit="pages"><start>269</start><end>291</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit68"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">P. B. Rupert, A. R. Ferre‐D'Amare, Nature 2001, 410, 780–786.</note><name type="personal"><namePart type="given">P. B.</namePart><namePart type="family">Rupert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. R.</namePart><namePart type="family">Ferre‐D'Amare</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>410</number></detail><extent unit="pages"><start>780</start><end>786</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit69"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. J. Earnshaw, M. G. Gait, Nucleic Acids Res. 1998, 26, 5551–5561.</note><name type="personal"><namePart type="given">D. J.</namePart><namePart type="family">Earnshaw</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. G.</namePart><namePart type="family">Gait</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><extent unit="pages"><start>5551</start><end>5561</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit70"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">C. Schmidt, R. Welz, S. Müller, Nucleic Acids Res. 2000, 28, 886–894.</note><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Schmidt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Welz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Müller</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>886</start><end>894</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit71"><titleInfo><title>J. Org. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">W. G. Kofron, L. M. Baclawski, J. Org. Chem. 1976, 41, 1879–1880.</note><name type="personal"><namePart type="given">W. G.</namePart><namePart type="family">Kofron</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. M.</namePart><namePart type="family">Baclawski</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>1879</start><end>1880</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit72"><titleInfo><title>Z. Anorg. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">W. Hoth, G. Pyl, Z. Anorg. Chem. 1929, 42, 888–891.</note><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Hoth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Pyl</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1929</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>888</start><end>891</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit73"><titleInfo><title>Acta Chem. Scand. Ser. B</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. Brandstroem, B. Lamm, I. Palmertz, Acta Chem. Scand. Ser. B 1974, 28, 699–701.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Brandstroem</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Lamm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Palmertz</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>699</start><end>701</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit74"><titleInfo><title>Chem. Ber.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">E. Fischer, W. Lipshitz, Chem. Ber. 1915, 48, 360–378.</note><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Fischer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Lipshitz</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1915</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>360</start><end>378</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit75"><titleInfo><title>J. Org. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H. E. Gottlieb, V. Kotlyar, A. Nudelman, J. Org. Chem. 1997, 62, 7512–7515.</note><name type="personal"><namePart type="given">H. E.</namePart><namePart type="family">Gottlieb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Kotlyar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Nudelman</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>62</number></detail><extent unit="pages"><start>7512</start><end>7515</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit76"><titleInfo><title>Tetrahedron Lett.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">R. Welz, S. Müller, Tetrahedron Lett. 2002, 43, 795–797.</note><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Welz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Müller</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>43</number></detail><extent unit="pages"><start>795</start><end>797</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit77"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">R. Kierzek, Nucleic Acids Res. 1992, 20, 5073–5077.</note><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Kierzek</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>5073</start><end>5077</end></extent></part></relatedItem><identifier type="istex">6D4386B68FCD3EA7A029DDCFF647D72FD02A73FF</identifier><identifier type="ark">ark:/67375/WNG-MGP6WWS0-9</identifier><identifier type="DOI">10.1002/chem.200400181</identifier><identifier type="ArticleID">CHEM200400181</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-14</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-MGP6WWS0-9/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002248 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 002248 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:6D4386B68FCD3EA7A029DDCFF647D72FD02A73FF
|texte= Stereoselective Synthesis of trans‐threo‐trans‐Oligopyrrolidines: Potential Agents for RNA Cleavage
}}
| This area was generated with Dilib version V0.6.33. |  |