Role of CD46 in Measles Virus Infection in CD46 Transgenic Mice
Identifieur interne : 002003 ( Istex/Corpus ); précédent : 002002; suivant : 002004Role of CD46 in Measles Virus Infection in CD46 Transgenic Mice
Auteurs : Merete Blixenkrone-M Ller ; Arlette Bernard ; Anne Bencsik ; Nathalie Sixt ; Lisa E. Diamond ; John S. Logan ; T. Fabian WildSource :
- Virology [ 0042-6822 ] ; 1998.
English descriptors
- Teeft :
- Academic press, Animal model, Becton dickinson, Brain tissue, Canine distemper virus, Canine distempter virus, Cell culture supernatants, Cell cultures, Cell lines, Cell lysates, Cerebellum, Cerebral edema, Clinical symptoms, Cofactor, Cortex hippocampus cerebellum, Cryo sections, Culture supernatants, Cultured cells, Different structures, Edmonston, Edmonston inoculation, Edmonston strain, Edmonston strains, Experimental period, Facs buffer, Fetal calf serum, First week postinoculation, Frontal cortex, Glioma cell line, Halle, Halle strain, Hela cells, Hippocampus, Human membrane cofactor protein, Human origin, Infection, Infection studies, Infectious virus, Inoculated, Inoculated intraperitoneally, Inoculation, Intracerebral, Intracerebral inoculation, Intranasal infection, Lung cell cultures, Lung tissue, Lyon cedex, Mabs, Measles, Measles virus, Measles virus binding, Measles virus infection, Measles virus replication, Membrane cofactor protein, Mice inoculated, Microscope slides, Mouse, Mouse brains, Mouse cell cultures, Murine, Negative controls, Nontransgenic, Nontransgenic cells, Nontransgenic mice, Normal mouse, Normal rabbit serum, Pbmc, Peripheral blood, Permissive host cells, Positive controls, Postinoculation, Present study, Primary antibody, Primer pair, Receptor, Receptor interactions, Replication, Replicative cycles, Same pattern, Secondary antibody, Serum samples, Southern blot, Sspe, Supernatant, Syncytia formation, Syncytium, Tissue sections, Transgenic, Transgenic cells, Transgenic mice, Transgenic mice measles virus, Transgenic mouse, Transgenic mouse cells, Transgenic rats, Vaccine, Vero, Vero cell cultures, Vero cells, Viral, Viral antigen, Viral replication, Viral transcripts, Virol, Virus, Virus infection, Virus isolation, Yagamata sspe strain, Yamagata, Yamagata strain.
Abstract
Abstract: The susceptibility of CD46 (human membrane cofactor protein) transgenic mice to measles virus (MV) infection was investigated. Cell cultures (lung and kidney) established from transgenic and control mice showed that although both could be infected only those from the CD46+ mice gave fusion. A complete round of replication with the release of infectious virus was detected exclusively in the transgenic cell cultures whose permissiveness to MV was markedly less than that of Vero cells. The ability of MV to replicatein vivoin mice was studied using both vaccine and laboratory-adapted wild-type strains of virus. After intraperitoneal and intranasal inoculations of transgenic mice, virus replication could not be detected. In contrast intracerebral inoculation induced infection in both transgenic and nontransgenic mice. Our results fromin vitroinfection studies support the hypothesis that CD46 is a major host cell factor involved in the MV-induced fusion process and MV entry. The studies further indicate that MV tropism is not governed solely by the expression of the CD46 gene and that the high efficiency of the replicative cycles characteristic of fully permissive host cells requires additional factors, which are lacking in both transgenic and nontransgenic mice.
Url:
DOI: 10.1006/viro.1998.9301
Links to Exploration step
ISTEX:ADD3A80DD31C377FD53D6EFD78492CBBC7C94BB6Le document en format XML
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Diamond</name><affiliation><mods:affiliation>Nextran, Inc. 303B College Road East, Princeton Forrestral Center, Princeton, New Jersey, 08540</mods:affiliation></affiliation></author><author><name sortKey="Logan, John S" sort="Logan, John S" uniqKey="Logan J" first="John S." last="Logan">John S. Logan</name><affiliation><mods:affiliation>Nextran, Inc. 303B College Road East, Princeton Forrestral Center, Princeton, New Jersey, 08540</mods:affiliation></affiliation></author><author><name sortKey="Wild, T Fabian" sort="Wild, T Fabian" uniqKey="Wild T" first="T. Fabian" last="Wild">T. Fabian Wild</name><affiliation><mods:affiliation>Inserm U 404, Immunité et Vaccination, Ex-Bâtiment Institut Pasteur de Lyon, Avenue Tony Garnier, 69365, Lyon Cedex 07, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Virology</title><title level="j" type="abbrev">YVIRO</title><idno type="ISSN">0042-6822</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">249</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="238">238</biblScope><biblScope unit="page" to="248">248</biblScope></imprint><idno type="ISSN">0042-6822</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0042-6822</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Academic press</term><term>Animal model</term><term>Becton dickinson</term><term>Brain tissue</term><term>Canine distemper virus</term><term>Canine distempter virus</term><term>Cell culture supernatants</term><term>Cell cultures</term><term>Cell lines</term><term>Cell lysates</term><term>Cerebellum</term><term>Cerebral edema</term><term>Clinical symptoms</term><term>Cofactor</term><term>Cortex hippocampus cerebellum</term><term>Cryo sections</term><term>Culture supernatants</term><term>Cultured cells</term><term>Different structures</term><term>Edmonston</term><term>Edmonston inoculation</term><term>Edmonston strain</term><term>Edmonston strains</term><term>Experimental period</term><term>Facs buffer</term><term>Fetal calf serum</term><term>First week postinoculation</term><term>Frontal cortex</term><term>Glioma cell line</term><term>Halle</term><term>Halle strain</term><term>Hela cells</term><term>Hippocampus</term><term>Human membrane cofactor protein</term><term>Human origin</term><term>Infection</term><term>Infection studies</term><term>Infectious virus</term><term>Inoculated</term><term>Inoculated intraperitoneally</term><term>Inoculation</term><term>Intracerebral</term><term>Intracerebral inoculation</term><term>Intranasal infection</term><term>Lung cell cultures</term><term>Lung tissue</term><term>Lyon cedex</term><term>Mabs</term><term>Measles</term><term>Measles virus</term><term>Measles virus binding</term><term>Measles virus infection</term><term>Measles virus replication</term><term>Membrane cofactor protein</term><term>Mice inoculated</term><term>Microscope slides</term><term>Mouse</term><term>Mouse brains</term><term>Mouse cell cultures</term><term>Murine</term><term>Negative controls</term><term>Nontransgenic</term><term>Nontransgenic cells</term><term>Nontransgenic mice</term><term>Normal mouse</term><term>Normal rabbit serum</term><term>Pbmc</term><term>Peripheral blood</term><term>Permissive host cells</term><term>Positive controls</term><term>Postinoculation</term><term>Present study</term><term>Primary antibody</term><term>Primer pair</term><term>Receptor</term><term>Receptor interactions</term><term>Replication</term><term>Replicative cycles</term><term>Same pattern</term><term>Secondary antibody</term><term>Serum samples</term><term>Southern blot</term><term>Sspe</term><term>Supernatant</term><term>Syncytia formation</term><term>Syncytium</term><term>Tissue sections</term><term>Transgenic</term><term>Transgenic cells</term><term>Transgenic mice</term><term>Transgenic mice measles virus</term><term>Transgenic mouse</term><term>Transgenic mouse cells</term><term>Transgenic rats</term><term>Vaccine</term><term>Vero</term><term>Vero cell cultures</term><term>Vero cells</term><term>Viral</term><term>Viral antigen</term><term>Viral replication</term><term>Viral transcripts</term><term>Virol</term><term>Virus</term><term>Virus infection</term><term>Virus isolation</term><term>Yagamata sspe strain</term><term>Yamagata</term><term>Yamagata strain</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The susceptibility of CD46 (human membrane cofactor protein) transgenic mice to measles virus (MV) infection was investigated. Cell cultures (lung and kidney) established from transgenic and control mice showed that although both could be infected only those from the CD46+ mice gave fusion. A complete round of replication with the release of infectious virus was detected exclusively in the transgenic cell cultures whose permissiveness to MV was markedly less than that of Vero cells. The ability of MV to replicatein vivoin mice was studied using both vaccine and laboratory-adapted wild-type strains of virus. After intraperitoneal and intranasal inoculations of transgenic mice, virus replication could not be detected. In contrast intracerebral inoculation induced infection in both transgenic and nontransgenic mice. Our results fromin vitroinfection studies support the hypothesis that CD46 is a major host cell factor involved in the MV-induced fusion process and MV entry. The studies further indicate that MV tropism is not governed solely by the expression of the CD46 gene and that the high efficiency of the replicative cycles characteristic of fully permissive host cells requires additional factors, which are lacking in both transgenic and nontransgenic mice.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>transgenic</json:string><json:string>nontransgenic</json:string><json:string>viral</json:string><json:string>transgenic mice</json:string><json:string>postinoculation</json:string><json:string>edmonston</json:string><json:string>nontransgenic mice</json:string><json:string>vero cells</json:string><json:string>receptor</json:string><json:string>halle</json:string><json:string>virol</json:string><json:string>pbmc</json:string><json:string>measles 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interactions</json:string><json:string>measles virus binding</json:string><json:string>lung tissue</json:string><json:string>secondary antibody</json:string></teeft></keywords><author><json:item><name>Merete Blixenkrone-Møller</name><affiliations><json:string>Inserm U 404, Immunité et Vaccination, Ex-Bâtiment Institut Pasteur de Lyon, Avenue Tony Garnier, 69365, Lyon Cedex 07, France</json:string></affiliations></json:item><json:item><name>Arlette Bernard</name><affiliations><json:string>Inserm U 433, Neurobiologie Expérimentale et Physiopathologie, Faculté de Médicine Laënnec, Rue Guillaume Paradin, 69372, Lyon Cedex 08, France</json:string></affiliations></json:item><json:item><name>Anne Bencsik</name><affiliations><json:string>Inserm U 433, Neurobiologie Expérimentale et Physiopathologie, Faculté de Médicine Laënnec, Rue Guillaume Paradin, 69372, Lyon Cedex 08, France</json:string></affiliations></json:item><json:item><name>Nathalie Sixt</name><affiliations><json:string>Inserm U 404, Immunité et Vaccination, Ex-Bâtiment Institut Pasteur de Lyon, Avenue Tony Garnier, 69365, Lyon Cedex 07, France</json:string></affiliations></json:item><json:item><name>Lisa E. Diamond</name><affiliations><json:string>Nextran, Inc. 303B College Road East, Princeton Forrestral Center, Princeton, New Jersey, 08540</json:string></affiliations></json:item><json:item><name>John S. Logan</name><affiliations><json:string>Nextran, Inc. 303B College Road East, Princeton Forrestral Center, Princeton, New Jersey, 08540</json:string></affiliations></json:item><json:item><name>T.Fabian Wild</name><affiliations><json:string>Inserm U 404, Immunité et Vaccination, Ex-Bâtiment Institut Pasteur de Lyon, Avenue Tony Garnier, 69365, Lyon Cedex 07, France</json:string></affiliations></json:item></author><arkIstex>ark:/67375/6H6-Z0L59BRW-S</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: The susceptibility of CD46 (human membrane cofactor protein) transgenic mice to measles virus (MV) infection was investigated. Cell cultures (lung and kidney) established from transgenic and control mice showed that although both could be infected only those from the CD46+ mice gave fusion. A complete round of replication with the release of infectious virus was detected exclusively in the transgenic cell cultures whose permissiveness to MV was markedly less than that of Vero cells. The ability of MV to replicatein vivoin mice was studied using both vaccine and laboratory-adapted wild-type strains of virus. After intraperitoneal and intranasal inoculations of transgenic mice, virus replication could not be detected. In contrast intracerebral inoculation induced infection in both transgenic and nontransgenic mice. Our results fromin vitroinfection studies support the hypothesis that CD46 is a major host cell factor involved in the MV-induced fusion process and MV entry. The studies further indicate that MV tropism is not governed solely by the expression of the CD46 gene and that the high efficiency of the replicative cycles characteristic of fully permissive host cells requires additional factors, which are lacking in both transgenic and nontransgenic mice.</abstract><qualityIndicators><score>9.28</score><pdfWordCount>6093</pdfWordCount><pdfCharCount>38045</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>11</pdfPageCount><pdfPageSize>537 x 722 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>190</abstractWordCount><abstractCharCount>1287</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Role of CD46 in Measles Virus Infection in CD46 Transgenic Mice</title><pmid><json:string>9791016</json:string></pmid><pii><json:string>S0042-6822(98)99301-1</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Virology</title><language><json:string>unknown</json:string></language><publicationDate>1998</publicationDate><issn><json:string>0042-6822</json:string></issn><pii><json:string>S0042-6822(00)X0084-0</json:string></pii><volume>249</volume><issue>2</issue><pages><first>238</first><last>248</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>200 or 1/500</json:string><json:string>1998</json:string></date><geogName></geogName><orgName><json:string>Genosys</json:string><json:string>Princeton Forrestral Center</json:string><json:string>Nextran, Inc.</json:string><json:string>Institute of Veterinary Microbiology, The Royal Veterinary and Agricultural University</json:string><json:string>Lilly Research Laboratories, Indianapolis, IN</json:string><json:string>Danish Agricultural and Veterinary Research Council</json:string></orgName><orgName_funder><json:string>Danish Agricultural and Veterinary Research Council</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Chantal Bella</json:string><json:string>Cyril Devignes</json:string><json:string>Joel Fayolle</json:string><json:string>Nathalie Sixt</json:string><json:string>de Lyon</json:string><json:string>Nathalie Etchart</json:string><json:string>Valerie Lecouturier</json:string><json:string>J. Fayolle</json:string><json:string>Bernadette Maret</json:string><json:string>Farida Henry</json:string><json:string>Danish Vet</json:string><json:string>A. Glasebrook</json:string><json:string>Chantal Lagresle</json:string><json:string>Jurgen Schneider-Schaulies</json:string><json:string>Guillaume Paradin</json:string><json:string>J. Schneider-Schaulies</json:string><json:string>Society</json:string><json:string>Lisa E. Diamond</json:string><json:string>Danish Pasteur</json:string><json:string>Dominique Kaiserlian</json:string><json:string>Glenn Rall</json:string><json:string>E. Malvoisin</json:string><json:string>John S. Logan</json:string><json:string>Alicia Cardoso</json:string><json:string>Isabelle Grosjean</json:string><json:string>Etienne Malvoisin</json:string><json:string>Anne Bencsik</json:string><json:string>Tony Garnier</json:string></persName><placeName><json:string>Germany</json:string><json:string>Halle</json:string><json:string>UK</json:string><json:string>Madison</json:string><json:string>San Jose</json:string><json:string>Denmark</json:string><json:string>CA</json:string><json:string>France</json:string><json:string>WI</json:string><json:string>Cambridge</json:string><json:string>Lyon</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Wild et al., 1992</json:string><json:string>Giraudon et al., 1988</json:string><json:string>Blixenkrone-Mùller et al., 1991</json:string><json:string>Bloom, 1989</json:string><json:string>Manchester et al., 1995</json:string><json:string>MéLLER ET AL.</json:string><json:string>Dorig et al., 1993</json:string><json:string>Allen et al., 1996</json:string><json:string>Lublin et al., 1988</json:string><json:string>Iwata et al., 1995</json:string><json:string>Schroeder, 1986</json:string><json:string>Schneider-Schaulies et al., 1995</json:string><json:string>Baczko et al., 1993</json:string><json:string>Manchester et al., 1994, 1995</json:string><json:string>Chomzynski and Sacchi (1987)</json:string><json:string>de Vries et al., 1988</json:string><json:string>Hsu et al., 1998</json:string><json:string>Rima et al., 1995</json:string><json:string>Bencsik et al., 1996</json:string><json:string>Johnstone et al., 1993</json:string><json:string>Harrowe et al., 1990, 1992</json:string><json:string>Karp et al., 1996</json:string><json:string>Horvat et al., 1996</json:string><json:string>Homma et al., 1982</json:string><json:string>Summers and Appel, 1994</json:string><json:string>Rall et al., (1997)</json:string><json:string>Esolen et al., 1993</json:string><json:string>Barbosa et al., 1971</json:string><json:string>Drillien et al., 1988</json:string><json:string>Blixenkrone-Mùller et al., 1992</json:string><json:string>Liebert and Finke, 1995</json:string><json:string>Niewiesk et al., 1997</json:string><json:string>Naniche et al., 1993</json:string><json:string>Auwaerter et al., 1996</json:string><json:string>Yanagi et al., 1994</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-Z0L59BRW-S</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - virology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - virology</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Virology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string></inist></categories><publicationDate>1998</publicationDate><copyrightDate>1998</copyrightDate><doi><json:string>10.1006/viro.1998.9301</json:string></doi><id>ADD3A80DD31C377FD53D6EFD78492CBBC7C94BB6</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-Z0L59BRW-S/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-Z0L59BRW-S/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-Z0L59BRW-S/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Role of CD46 in Measles Virus Infection in CD46 Transgenic Mice</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>©1998 Academic Press</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</p></availability><date>1998</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note type="content">Section title: Regular Article</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Role of CD46 in Measles Virus Infection in CD46 Transgenic Mice</title><author xml:id="author-0000"><persName><forename type="first">Merete</forename><surname>Blixenkrone-Møller</surname></persName><note type="biography">To whom reprint requests should be addressed Fax: 45 35 28 27 42. E-mail:MBM@KVL.DK.</note><affiliation>To whom reprint requests should be addressed Fax: 45 35 28 27 42. E-mail:MBM@KVL.DK.</affiliation><affiliation>Inserm U 404, Immunité et Vaccination, Ex-Bâtiment Institut Pasteur de Lyon, Avenue Tony Garnier, 69365, Lyon Cedex 07, France</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Arlette</forename><surname>Bernard</surname></persName><affiliation>Inserm U 433, Neurobiologie Expérimentale et Physiopathologie, Faculté de Médicine Laënnec, Rue Guillaume Paradin, 69372, Lyon Cedex 08, France</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Anne</forename><surname>Bencsik</surname></persName><affiliation>Inserm U 433, Neurobiologie Expérimentale et Physiopathologie, Faculté de Médicine Laënnec, Rue Guillaume Paradin, 69372, Lyon Cedex 08, France</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Nathalie</forename><surname>Sixt</surname></persName><affiliation>Inserm U 404, Immunité et Vaccination, Ex-Bâtiment Institut Pasteur de Lyon, Avenue Tony Garnier, 69365, Lyon Cedex 07, France</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Lisa E.</forename><surname>Diamond</surname></persName><affiliation>Nextran, Inc. 303B College Road East, Princeton Forrestral Center, Princeton, New Jersey, 08540</affiliation></author><author xml:id="author-0005"><persName><forename type="first">John S.</forename><surname>Logan</surname></persName><affiliation>Nextran, Inc. 303B College Road East, Princeton Forrestral Center, Princeton, New Jersey, 08540</affiliation></author><author xml:id="author-0006"><persName><forename type="first">T.Fabian</forename><surname>Wild</surname></persName><affiliation>Inserm U 404, Immunité et Vaccination, Ex-Bâtiment Institut Pasteur de Lyon, Avenue Tony Garnier, 69365, Lyon Cedex 07, France</affiliation></author><idno type="istex">ADD3A80DD31C377FD53D6EFD78492CBBC7C94BB6</idno><idno type="ark">ark:/67375/6H6-Z0L59BRW-S</idno><idno type="DOI">10.1006/viro.1998.9301</idno><idno type="PII">S0042-6822(98)99301-1</idno></analytic><monogr><title level="j">Virology</title><title level="j" type="abbrev">YVIRO</title><idno type="pISSN">0042-6822</idno><idno type="PII">S0042-6822(00)X0084-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998"></date><biblScope unit="volume">249</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="238">238</biblScope><biblScope unit="page" to="248">248</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1998</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The susceptibility of CD46 (human membrane cofactor protein) transgenic mice to measles virus (MV) infection was investigated. Cell cultures (lung and kidney) established from transgenic and control mice showed that although both could be infected only those from the CD46+ mice gave fusion. A complete round of replication with the release of infectious virus was detected exclusively in the transgenic cell cultures whose permissiveness to MV was markedly less than that of Vero cells. The ability of MV to replicatein vivoin mice was studied using both vaccine and laboratory-adapted wild-type strains of virus. After intraperitoneal and intranasal inoculations of transgenic mice, virus replication could not be detected. In contrast intracerebral inoculation induced infection in both transgenic and nontransgenic mice. Our results fromin vitroinfection studies support the hypothesis that CD46 is a major host cell factor involved in the MV-induced fusion process and MV entry. The studies further indicate that MV tropism is not governed solely by the expression of the CD46 gene and that the high efficiency of the replicative cycles characteristic of fully permissive host cells requires additional factors, which are lacking in both transgenic and nontransgenic mice.</p></abstract></profileDesc><revisionDesc><change when="1998-02-23">Modified</change><change when="1998">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-Z0L59BRW-S/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>YVIRO</jid><aid>99301</aid><ce:pii>S0042-6822(98)99301-1</ce:pii><ce:doi>10.1006/viro.1998.9301</ce:doi><ce:copyright type="full-transfer" year="1998">Academic Press</ce:copyright></item-info><head><ce:dochead><ce:textfn>Regular Article</ce:textfn></ce:dochead><ce:title>Role of CD46 in Measles Virus Infection in CD46 Transgenic Mice</ce:title><ce:author-group><ce:author><ce:given-name>Merete</ce:given-name><ce:surname>Blixenkrone-Møller</ce:surname><ce:cross-ref refid="VY989301A1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="VY989301A2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="VY989301FN1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Arlette</ce:given-name><ce:surname>Bernard</ce:surname><ce:cross-ref refid="VY989301A3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Anne</ce:given-name><ce:surname>Bencsik</ce:surname><ce:cross-ref refid="VY989301A3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Nathalie</ce:given-name><ce:surname>Sixt</ce:surname><ce:cross-ref refid="VY989301A1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Lisa E.</ce:given-name><ce:surname>Diamond</ce:surname><ce:cross-ref refid="VY989301A4"><ce:sup>d</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>John S.</ce:given-name><ce:surname>Logan</ce:surname><ce:cross-ref refid="VY989301A4"><ce:sup>d</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>T.Fabian</ce:given-name><ce:surname>Wild</ce:surname><ce:cross-ref refid="VY989301A1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="VY989301A1"><ce:label>a</ce:label><ce:textfn>Inserm U 404, Immunité et Vaccination, Ex-Bâtiment Institut Pasteur de Lyon, Avenue Tony Garnier, 69365, Lyon Cedex 07, France</ce:textfn></ce:affiliation><ce:affiliation id="VY989301A2"><ce:label>b</ce:label><ce:textfn>Laboratory of Virology and Immunology, Institute of Veterinary Microbiology, The Royal Veterinary and Agricultural University, 13 Bülowsvej, 1870, Frederiksberg, Denmark</ce:textfn></ce:affiliation><ce:affiliation id="VY989301A3"><ce:label>c</ce:label><ce:textfn>Inserm U 433, Neurobiologie Expérimentale et Physiopathologie, Faculté de Médicine Laënnec, Rue Guillaume Paradin, 69372, Lyon Cedex 08, France</ce:textfn></ce:affiliation><ce:affiliation id="VY989301A4"><ce:label>d</ce:label><ce:textfn>Nextran, Inc. 303B College Road East, Princeton Forrestral Center, Princeton, New Jersey, 08540</ce:textfn></ce:affiliation><ce:footnote id="VY989301FN1"><ce:label>1</ce:label><ce:note-para>To whom reprint requests should be addressed Fax: 45 35 28 27 42. E-mail:MBM@KVL.DK.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="24" month="11" year="1997"></ce:date-received><ce:date-revised day="23" month="2" year="1998"></ce:date-revised><ce:date-accepted day="19" month="6" year="1998"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The susceptibility of CD46 (human membrane cofactor protein) transgenic mice to measles virus (MV) infection was investigated. Cell cultures (lung and kidney) established from transgenic and control mice showed that although both could be infected only those from the CD46+ mice gave fusion. A complete round of replication with the release of infectious virus was detected exclusively in the transgenic cell cultures whose permissiveness to MV was markedly less than that of Vero cells. The ability of MV to replicate<ce:italic>in vivo</ce:italic>in mice was studied using both vaccine and laboratory-adapted wild-type strains of virus. After intraperitoneal and intranasal inoculations of transgenic mice, virus replication could not be detected. In contrast intracerebral inoculation induced infection in both transgenic and nontransgenic mice. Our results from<ce:italic>in vitro</ce:italic>infection studies support the hypothesis that CD46 is a major host cell factor involved in the MV-induced fusion process and MV entry. The studies further indicate that MV tropism is not governed solely by the expression of the CD46 gene and that the high efficiency of the replicative cycles characteristic of fully permissive host cells requires additional factors, which are lacking in both transgenic and nontransgenic mice.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Role of CD46 in Measles Virus Infection in CD46 Transgenic Mice</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Role of CD46 in Measles Virus Infection in CD46 Transgenic Mice</title></titleInfo><name type="personal"><namePart type="given">Merete</namePart><namePart type="family">Blixenkrone-Møller</namePart><affiliation>Inserm U 404, Immunité et Vaccination, Ex-Bâtiment Institut Pasteur de Lyon, Avenue Tony Garnier, 69365, Lyon Cedex 07, France</affiliation><description>To whom reprint requests should be addressed Fax: 45 35 28 27 42. E-mail:MBM@KVL.DK.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Arlette</namePart><namePart type="family">Bernard</namePart><affiliation>Inserm U 433, Neurobiologie Expérimentale et Physiopathologie, Faculté de Médicine Laënnec, Rue Guillaume Paradin, 69372, Lyon Cedex 08, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anne</namePart><namePart type="family">Bencsik</namePart><affiliation>Inserm U 433, Neurobiologie Expérimentale et Physiopathologie, Faculté de Médicine Laënnec, Rue Guillaume Paradin, 69372, Lyon Cedex 08, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nathalie</namePart><namePart type="family">Sixt</namePart><affiliation>Inserm U 404, Immunité et Vaccination, Ex-Bâtiment Institut Pasteur de Lyon, Avenue Tony Garnier, 69365, Lyon Cedex 07, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lisa E.</namePart><namePart type="family">Diamond</namePart><affiliation>Nextran, Inc. 303B College Road East, Princeton Forrestral Center, Princeton, New Jersey, 08540</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John S.</namePart><namePart type="family">Logan</namePart><affiliation>Nextran, Inc. 303B College Road East, Princeton Forrestral Center, Princeton, New Jersey, 08540</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.Fabian</namePart><namePart type="family">Wild</namePart><affiliation>Inserm U 404, Immunité et Vaccination, Ex-Bâtiment Institut Pasteur de Lyon, Avenue Tony Garnier, 69365, Lyon Cedex 07, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1998</dateIssued><dateModified encoding="w3cdtf">1998-02-23</dateModified><copyrightDate encoding="w3cdtf">1998</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The susceptibility of CD46 (human membrane cofactor protein) transgenic mice to measles virus (MV) infection was investigated. Cell cultures (lung and kidney) established from transgenic and control mice showed that although both could be infected only those from the CD46+ mice gave fusion. A complete round of replication with the release of infectious virus was detected exclusively in the transgenic cell cultures whose permissiveness to MV was markedly less than that of Vero cells. The ability of MV to replicatein vivoin mice was studied using both vaccine and laboratory-adapted wild-type strains of virus. After intraperitoneal and intranasal inoculations of transgenic mice, virus replication could not be detected. In contrast intracerebral inoculation induced infection in both transgenic and nontransgenic mice. Our results fromin vitroinfection studies support the hypothesis that CD46 is a major host cell factor involved in the MV-induced fusion process and MV entry. The studies further indicate that MV tropism is not governed solely by the expression of the CD46 gene and that the high efficiency of the replicative cycles characteristic of fully permissive host cells requires additional factors, which are lacking in both transgenic and nontransgenic mice.</abstract><note type="content">Section title: Regular Article</note><relatedItem type="host"><titleInfo><title>Virology</title></titleInfo><titleInfo type="abbreviated"><title>YVIRO</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1998</dateIssued></originInfo><identifier type="ISSN">0042-6822</identifier><identifier type="PII">S0042-6822(00)X0084-0</identifier><part><date>1998</date><detail type="volume"><number>249</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue-pages"><start>203</start><end>472</end></extent><extent unit="pages"><start>238</start><end>248</end></extent></part></relatedItem><identifier type="istex">ADD3A80DD31C377FD53D6EFD78492CBBC7C94BB6</identifier><identifier type="ark">ark:/67375/6H6-Z0L59BRW-S</identifier><identifier type="DOI">10.1006/viro.1998.9301</identifier><identifier type="PII">S0042-6822(98)99301-1</identifier><accessCondition type="use and reproduction" contentType="copyright">©1998 Academic Press</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource><recordOrigin>Academic Press, ©1998</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-Z0L59BRW-S/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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