Uncaria tomentosa (Willd.) DC.—Ethnomedicinal use and new pharmacological, toxicological and botanical results
Identifieur interne : 001F17 ( Istex/Corpus ); précédent : 001F16; suivant : 001F18Uncaria tomentosa (Willd.) DC.—Ethnomedicinal use and new pharmacological, toxicological and botanical results
Auteurs : Klaus Keplinger ; Gerhard Laus ; Martin Wurm ; Manfred P. Dierich ; Herwig TeppnerSource :
- Journal of Ethnopharmacology [ 0378-8741 ] ; 1999.
English descriptors
- KwdEn :
- Teeft :
- Alkaloid, American species, Aquino, Ashaninka, Ashaninka indians, Ashaninka priests, Crude drug, Daily dose, Different concentrations, Elsevier science ireland, Endothelial, Endothelial cell cultures, Endothelial cells, Ethnopharmacology, Gato, Glycoside, Good spirits, Guianensis, Immunological methods, Individual plants, Isomer, Jurkat, Jurkat cells, Keplinger, Laus, Lymphocyte, Lymphocyte proliferation, Major alkaloids, Medical disorders, Medicinal system, Mitragyna, Mitragyna par6ifolia, Mitragyna species, Mitraphylline, Mitraphylline isomers, Mortality ratio, Natural products, Opera botanica belgica, Other hand, Outer side, Oxindole, Oxindole alkaloids, Pentacyclic, Pentacyclic oxindole alkaloids, Peru, Plant metabolites, Planta, Planta medica, Polyhydroxylated triterpenes, Pteropodine, Quality control, Quinovic, Quinovic acid glycosides, Raji, Relative kidney weight, Root bark, Rubiaceae, Secondary pollen presentation, Sodium chloride, Supernatant, Test persons, Tetracyclic, Tetracyclic alkaloids, Tetracyclic oxindole alkaloids, Tomentosa, Tomentosa root, Total pentacyclic oxindole alkaloids, Toxicity, Traditional medicine, Tropical america, Uncaria, Uncaria guianensis, Uncaria tomentosa, Vivo test.
Abstract
Abstract: The medicinal system of the Asháninka Indians in Perú is portrayed. Three categories of medical disorders and healers are recognized. A human is viewed to consist of a physical and a spiritual being who communicate with each other by means of a regulating element. The significance of Uncaria tomentosa (Willd.) DC. (Rubiaceae), locally known as uña de gato, in traditional medicine is emphasized by its exclusive use by priests to influence this regulation. Pharmacological and toxicological results obtained with extracts or isolated compounds are summarized. Pentacyclic oxindole alkaloids stimulate endothelial cells in vitro to produce a lymphocyte-proliferation-regulating factor. Tetracyclic oxindole alkaloids act as antagonists. A significant normalization of lymphocyte percentage was observed in vivo although total leucocyte numbers did not change.
Url:
DOI: 10.1016/S0378-8741(98)00096-8
Links to Exploration step
ISTEX:428B0E7BAB2FE5001640959B356B913A8BD64D91Le document en format XML
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DC.—Ethnomedicinal use and new pharmacological, toxicological and botanical results</title><author><name sortKey="Keplinger, Klaus" sort="Keplinger, Klaus" uniqKey="Keplinger K" first="Klaus" last="Keplinger">Klaus Keplinger</name><affiliation><mods:affiliation>Immodal Pharmaka GmbH, Bundesstrasse 44, A-6111 Volders, Austria</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author.</mods:affiliation></affiliation></author><author><name sortKey="Laus, Gerhard" sort="Laus, Gerhard" uniqKey="Laus G" first="Gerhard" last="Laus">Gerhard Laus</name><affiliation><mods:affiliation>Immodal Pharmaka GmbH, Bundesstrasse 44, A-6111 Volders, Austria</mods:affiliation></affiliation></author><author><name sortKey="Wurm, Martin" sort="Wurm, Martin" uniqKey="Wurm M" first="Martin" last="Wurm">Martin Wurm</name><affiliation><mods:affiliation>Institut für Hygiene und Ludwig Boltzmann-Institut für AIDS-Forschung, University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Dierich, Manfred P" sort="Dierich, Manfred P" uniqKey="Dierich M" first="Manfred P" last="Dierich">Manfred P. 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DC.—Ethnomedicinal use and new pharmacological, toxicological and botanical results</title><author><name sortKey="Keplinger, Klaus" sort="Keplinger, Klaus" uniqKey="Keplinger K" first="Klaus" last="Keplinger">Klaus Keplinger</name><affiliation><mods:affiliation>Immodal Pharmaka GmbH, Bundesstrasse 44, A-6111 Volders, Austria</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author.</mods:affiliation></affiliation></author><author><name sortKey="Laus, Gerhard" sort="Laus, Gerhard" uniqKey="Laus G" first="Gerhard" last="Laus">Gerhard Laus</name><affiliation><mods:affiliation>Immodal Pharmaka GmbH, Bundesstrasse 44, A-6111 Volders, Austria</mods:affiliation></affiliation></author><author><name sortKey="Wurm, Martin" sort="Wurm, Martin" uniqKey="Wurm M" first="Martin" last="Wurm">Martin Wurm</name><affiliation><mods:affiliation>Institut für Hygiene und Ludwig Boltzmann-Institut für AIDS-Forschung, University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Dierich, Manfred P" sort="Dierich, Manfred P" uniqKey="Dierich M" first="Manfred P" last="Dierich">Manfred P. Dierich</name><affiliation><mods:affiliation>Institut für Hygiene und Ludwig Boltzmann-Institut für AIDS-Forschung, University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Teppner, Herwig" sort="Teppner, Herwig" uniqKey="Teppner H" first="Herwig" last="Teppner">Herwig Teppner</name><affiliation><mods:affiliation>Institut für Botanik, University of Graz, Holteigasse 6, A-8010 Graz, Austria</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Ethnopharmacology</title><title level="j" type="abbrev">JEP</title><idno type="ISSN">0378-8741</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">64</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="23">23</biblScope><biblScope unit="page" to="34">34</biblScope></imprint><idno type="ISSN">0378-8741</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0378-8741</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Asháninka</term><term>Lymphocyte proliferation</term><term>Oxindole alkaloids</term><term>Perú</term><term>Uncaria tomentosa</term><term>Uña de gato</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Alkaloid</term><term>American species</term><term>Aquino</term><term>Ashaninka</term><term>Ashaninka indians</term><term>Ashaninka priests</term><term>Crude drug</term><term>Daily dose</term><term>Different concentrations</term><term>Elsevier science ireland</term><term>Endothelial</term><term>Endothelial cell cultures</term><term>Endothelial cells</term><term>Ethnopharmacology</term><term>Gato</term><term>Glycoside</term><term>Good spirits</term><term>Guianensis</term><term>Immunological methods</term><term>Individual plants</term><term>Isomer</term><term>Jurkat</term><term>Jurkat cells</term><term>Keplinger</term><term>Laus</term><term>Lymphocyte</term><term>Lymphocyte proliferation</term><term>Major alkaloids</term><term>Medical disorders</term><term>Medicinal system</term><term>Mitragyna</term><term>Mitragyna par6ifolia</term><term>Mitragyna species</term><term>Mitraphylline</term><term>Mitraphylline isomers</term><term>Mortality ratio</term><term>Natural products</term><term>Opera botanica belgica</term><term>Other hand</term><term>Outer side</term><term>Oxindole</term><term>Oxindole alkaloids</term><term>Pentacyclic</term><term>Pentacyclic oxindole alkaloids</term><term>Peru</term><term>Plant metabolites</term><term>Planta</term><term>Planta medica</term><term>Polyhydroxylated triterpenes</term><term>Pteropodine</term><term>Quality control</term><term>Quinovic</term><term>Quinovic acid glycosides</term><term>Raji</term><term>Relative kidney weight</term><term>Root bark</term><term>Rubiaceae</term><term>Secondary pollen presentation</term><term>Sodium chloride</term><term>Supernatant</term><term>Test persons</term><term>Tetracyclic</term><term>Tetracyclic alkaloids</term><term>Tetracyclic oxindole alkaloids</term><term>Tomentosa</term><term>Tomentosa root</term><term>Total pentacyclic oxindole alkaloids</term><term>Toxicity</term><term>Traditional medicine</term><term>Tropical america</term><term>Uncaria</term><term>Uncaria guianensis</term><term>Uncaria tomentosa</term><term>Vivo test</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The medicinal system of the Asháninka Indians in Perú is portrayed. Three categories of medical disorders and healers are recognized. A human is viewed to consist of a physical and a spiritual being who communicate with each other by means of a regulating element. The significance of Uncaria tomentosa (Willd.) DC. (Rubiaceae), locally known as uña de gato, in traditional medicine is emphasized by its exclusive use by priests to influence this regulation. Pharmacological and toxicological results obtained with extracts or isolated compounds are summarized. Pentacyclic oxindole alkaloids stimulate endothelial cells in vitro to produce a lymphocyte-proliferation-regulating factor. Tetracyclic oxindole alkaloids act as antagonists. 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alkaloids</json:string><json:string>mitraphylline isomers</json:string><json:string>relative kidney weight</json:string><json:string>ashaninka priests</json:string><json:string>medical disorders</json:string><json:string>plant metabolites</json:string><json:string>traditional medicine</json:string><json:string>immunological methods</json:string><json:string>elsevier science ireland</json:string><json:string>opera botanica belgica</json:string><json:string>mitragyna par6ifolia</json:string></teeft></keywords><author><json:item><name>Klaus Keplinger</name><affiliations><json:string>Immodal Pharmaka GmbH, Bundesstrasse 44, A-6111 Volders, Austria</json:string><json:string>Corresponding author.</json:string></affiliations></json:item><json:item><name>Gerhard Laus</name><affiliations><json:string>Immodal Pharmaka GmbH, Bundesstrasse 44, A-6111 Volders, Austria</json:string></affiliations></json:item><json:item><name>Martin Wurm</name><affiliations><json:string>Institut für Hygiene und Ludwig Boltzmann-Institut für AIDS-Forschung, University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Manfred P Dierich</name><affiliations><json:string>Institut für Hygiene und Ludwig Boltzmann-Institut für AIDS-Forschung, University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Herwig Teppner</name><affiliations><json:string>Institut für Botanik, University of Graz, Holteigasse 6, A-8010 Graz, Austria</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Uncaria tomentosa</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Uña de gato</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Oxindole alkaloids</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Lymphocyte proliferation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Asháninka</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Perú</value></json:item></subject><arkIstex>ark:/67375/6H6-20X2CF1F-Z</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: The medicinal system of the Asháninka Indians in Perú is portrayed. Three categories of medical disorders and healers are recognized. A human is viewed to consist of a physical and a spiritual being who communicate with each other by means of a regulating element. The significance of Uncaria tomentosa (Willd.) DC. (Rubiaceae), locally known as uña de gato, in traditional medicine is emphasized by its exclusive use by priests to influence this regulation. Pharmacological and toxicological results obtained with extracts or isolated compounds are summarized. Pentacyclic oxindole alkaloids stimulate endothelial cells in vitro to produce a lymphocyte-proliferation-regulating factor. Tetracyclic oxindole alkaloids act as antagonists. A significant normalization of lymphocyte percentage was observed in vivo although total leucocyte numbers did not change.</abstract><qualityIndicators><score>8.464</score><pdfWordCount>5912</pdfWordCount><pdfCharCount>38472</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>12</pdfPageCount><pdfPageSize>535 x 675 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>122</abstractWordCount><abstractCharCount>870</abstractCharCount><keywordCount>6</keywordCount></qualityIndicators><title>Uncaria tomentosa (Willd.) DC.—Ethnomedicinal use and new pharmacological, toxicological and botanical results</title><pmid><json:string>10075119</json:string></pmid><pii><json:string>S0378-8741(98)00096-8</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Journal of Ethnopharmacology</title><language><json:string>unknown</json:string></language><publicationDate>1999</publicationDate><issn><json:string>0378-8741</json:string></issn><pii><json:string>S0378-8741(00)X0051-7</json:string></pii><volume>64</volume><issue>1</issue><pages><first>23</first><last>34</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1999</json:string></date><geogName></geogName><orgName><json:string>South American Uncaria</json:string><json:string>Belize and Guatemala</json:string><json:string>Huntingdon Research Centre</json:string><json:string>Elsevier Science Ireland Ltd</json:string><json:string>Calbiochem</json:string><json:string>Peru, Venezuela</json:string><json:string>Forschungsforderungsfond</json:string></orgName><orgName_funder><json:string>Forschungsforderungsfond</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Month</json:string><json:string>Viktor La Nazca</json:string><json:string>J. 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Selectivity</json:string><json:string>Taking</json:string><json:string>La Merced</json:string></persName><placeName><json:string>Germany</json:string><json:string>United States</json:string><json:string>Peru</json:string><json:string>Innsbruck</json:string><json:string>Austria</json:string><json:string>Suriname</json:string><json:string>Canberra</json:string><json:string>Graz</json:string><json:string>America</json:string><json:string>Ostendorf</json:string><json:string>Denmark</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Wurm, 1997</json:string><json:string>Laus and Keplinger, 1994</json:string><json:string>Keplinger, 1993a,b</json:string><json:string>Aquino et al., 1989, 1990</json:string><json:string>Reinhard, 1997</json:string><json:string>Phillipson et al., 1978</json:string><json:string>Rizzi et al., 1993</json:string><json:string>Stuppner et al., 1993</json:string><json:string>Edgell et al., 1983</json:string><json:string>Indiveri et al., 1980</json:string><json:string>isolated according to Freundlich and Avdalovic, 1983</json:string><json:string>Obregon-Vilches, 1994</json:string><json:string>Ridsdale, 1978</json:string><json:string>Phillipson et al. (1978)</json:string><json:string>Laus and Keplinger, 1997</json:string><json:string>Montenegro de Matta et al., 1976</json:string><json:string>Ellenberg, 1985</json:string><json:string>Dwyer (1980)</json:string><json:string>Lock de Ugaz and Callo, 1991</json:string><json:string>Jones, 1995</json:string><json:string>Andersson and Taylor (1994)</json:string><json:string>Lavault et al., 1983</json:string><json:string>Ridsdale (1978)</json:string><json:string>Kynoch and Lloyd, 1975</json:string><json:string>Andersson and Persson (1991)</json:string><json:string>Shellard and Houghton, 1972</json:string><json:string>Teppner et al., 1984</json:string><json:string>Cabieses, 1994</json:string><json:string>Standley and Williams (1975)</json:string><json:string>Laus et al., 1997</json:string><json:string>Senatore et al., 1989</json:string><json:string>Schauss, 1996</json:string><json:string>Svendsen and Skydsgaard, 1986</json:string><json:string>Cerri et al., 1988</json:string><json:string>van Ginkel, 1996</json:string><json:string>Kindberg, 1980</json:string><json:string>Shellard and Houghton, 1971</json:string><json:string>Stuppner et al., 1992a,b</json:string><json:string>Payne, 1980</json:string><json:string>K. Keplinger et al.</json:string><json:string>Laus et al., 1996</json:string><json:string>Puff et al., 1996</json:string><json:string>Hemingway and Phillipson, 1974</json:string><json:string>Lopez-Avila et al., 1997</json:string><json:string>Aquino et al., 1989</json:string><json:string>Steyermark (1974)</json:string><json:string>Laus and Teppner, 1996</json:string><json:string>Salmi et al., 1995</json:string><json:string>Wagner et al., 1985</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-20X2CF1F-Z</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - plant sciences</json:string><json:string>2 - pharmacology & pharmacy</json:string><json:string>2 - integrative & complementary medicine</json:string><json:string>2 - chemistry, medicinal</json:string></wos><scienceMetrix><json:string>1 - natural sciences</json:string><json:string>2 - chemistry</json:string><json:string>3 - medicinal & biomolecular chemistry</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Drug Discovery</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Pharmacology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string><json:string>4 - physiologie vegetale et developpement</json:string></inist></categories><publicationDate>1999</publicationDate><copyrightDate>1999</copyrightDate><doi><json:string>10.1016/S0378-8741(98)00096-8</json:string></doi><id>428B0E7BAB2FE5001640959B356B913A8BD64D91</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-20X2CF1F-Z/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-20X2CF1F-Z/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-20X2CF1F-Z/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Uncaria tomentosa (Willd.) DC.—Ethnomedicinal use and new pharmacological, toxicological and botanical results</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>©1999 Elsevier Science Ireland Ltd</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</p></availability><date>1999</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note type="content">Table 1: Alkaloids of Uncaria tomentosa (Wild.) DC.</note><note type="content">Table 2: Mortality ratio and group mean bodyweight of mice dosed orally with an aqueous extract of U. tomentosa root</note><note type="content">Table 3: Leucocyte values and relative kidney weight in rats (group mean values±S.D.)</note><note type="content">Table 4: Effect on proliferation of different human cells and cell lines by treatment with pentacyclic oxindole alkaloids (POA)-incubated EA.hy936 endothelial cell culture supernatants (SN) (% of control±S.D.)</note><note type="content">Table 5: Proliferation of lymphoblastoid cell lines after treatment with culture supernatants (SN) of EA.hy936 endothelial cells incubated with pentacyclic oxindole alkaloids (POA), tetracyclic oxindole alkaloids (TOA) and mixtures thereof (% of control±S.D.)</note><note type="content">Table 6: Total leucocytes and percentage of lymphocytes in humans</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Uncaria tomentosa (Willd.) DC.—Ethnomedicinal use and new pharmacological, toxicological and botanical results</title><author xml:id="author-0000"><persName><forename type="first">Klaus</forename><surname>Keplinger</surname></persName><affiliation>Immodal Pharmaka GmbH, Bundesstrasse 44, A-6111 Volders, Austria</affiliation><affiliation>Corresponding author.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Gerhard</forename><surname>Laus</surname></persName><affiliation>Immodal Pharmaka GmbH, Bundesstrasse 44, A-6111 Volders, Austria</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Martin</forename><surname>Wurm</surname></persName><affiliation>Institut für Hygiene und Ludwig Boltzmann-Institut für AIDS-Forschung, University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Manfred P</forename><surname>Dierich</surname></persName><affiliation>Institut für Hygiene und Ludwig Boltzmann-Institut für AIDS-Forschung, University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Herwig</forename><surname>Teppner</surname></persName><affiliation>Institut für Botanik, University of Graz, Holteigasse 6, A-8010 Graz, Austria</affiliation></author><idno type="istex">428B0E7BAB2FE5001640959B356B913A8BD64D91</idno><idno type="ark">ark:/67375/6H6-20X2CF1F-Z</idno><idno type="DOI">10.1016/S0378-8741(98)00096-8</idno><idno type="PII">S0378-8741(98)00096-8</idno></analytic><monogr><title level="j">Journal of Ethnopharmacology</title><title level="j" type="abbrev">JEP</title><idno type="pISSN">0378-8741</idno><idno type="PII">S0378-8741(00)X0051-7</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">64</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="23">23</biblScope><biblScope unit="page" to="34">34</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The medicinal system of the Asháninka Indians in Perú is portrayed. Three categories of medical disorders and healers are recognized. A human is viewed to consist of a physical and a spiritual being who communicate with each other by means of a regulating element. The significance of Uncaria tomentosa (Willd.) DC. (Rubiaceae), locally known as uña de gato, in traditional medicine is emphasized by its exclusive use by priests to influence this regulation. Pharmacological and toxicological results obtained with extracts or isolated compounds are summarized. Pentacyclic oxindole alkaloids stimulate endothelial cells in vitro to produce a lymphocyte-proliferation-regulating factor. Tetracyclic oxindole alkaloids act as antagonists. A significant normalization of lymphocyte percentage was observed in vivo although total leucocyte numbers did not change.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Uncaria tomentosa</term></item><item><term>Uña de gato</term></item><item><term>Oxindole alkaloids</term></item><item><term>Lymphocyte proliferation</term></item><item><term>Asháninka</term></item><item><term>Perú</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1998-04-28">Modified</change><change when="1999">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-20X2CF1F-Z/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>JEP</jid><aid>1757</aid><ce:pii>S0378-8741(98)00096-8</ce:pii><ce:doi>10.1016/S0378-8741(98)00096-8</ce:doi><ce:copyright year="1999" type="full-transfer">Elsevier Science Ireland Ltd</ce:copyright></item-info><head><ce:title><ce:italic>Uncaria tomentosa</ce:italic> (Willd.) DC.—Ethnomedicinal use and new pharmacological, toxicological and botanical results</ce:title><ce:author-group><ce:author><ce:given-name>Klaus</ce:given-name><ce:surname>Keplinger</ce:surname><ce:cross-ref refid="AFF1">a</ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref></ce:author><ce:author><ce:given-name>Gerhard</ce:given-name><ce:surname>Laus</ce:surname><ce:cross-ref refid="AFF1">a</ce:cross-ref></ce:author><ce:author><ce:given-name>Martin</ce:given-name><ce:surname>Wurm</ce:surname><ce:cross-ref refid="AFF2">b</ce:cross-ref></ce:author><ce:author><ce:given-name>Manfred P</ce:given-name><ce:surname>Dierich</ce:surname><ce:cross-ref refid="AFF2">b</ce:cross-ref></ce:author><ce:author><ce:given-name>Herwig</ce:given-name><ce:surname>Teppner</ce:surname><ce:cross-ref refid="AFF3">c</ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Immodal Pharmaka GmbH, Bundesstrasse 44, A-6111 Volders, Austria</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Institut für Hygiene und Ludwig Boltzmann-Institut für AIDS-Forschung, University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Institut für Botanik, University of Graz, Holteigasse 6, A-8010 Graz, Austria</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Corresponding author.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="3" month="1" year="1998"></ce:date-received><ce:date-revised day="28" month="4" year="1998"></ce:date-revised><ce:date-accepted day="16" month="5" year="1998"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The medicinal system of the Asháninka Indians in Perú is portrayed. Three categories of medical disorders and healers are recognized. A human is viewed to consist of a physical and a spiritual being who communicate with each other by means of a regulating element. The significance of <ce:italic>Uncaria tomentosa</ce:italic> (Willd.) DC. (Rubiaceae), locally known as uña de gato, in traditional medicine is emphasized by its exclusive use by priests to influence this regulation. Pharmacological and toxicological results obtained with extracts or isolated compounds are summarized. Pentacyclic oxindole alkaloids stimulate endothelial cells in vitro to produce a lymphocyte-proliferation-regulating factor. Tetracyclic oxindole alkaloids act as antagonists. A significant normalization of lymphocyte percentage was observed in vivo although total leucocyte numbers did not change.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text><ce:italic>Uncaria tomentosa</ce:italic></ce:text></ce:keyword><ce:keyword><ce:text>Uña de gato</ce:text></ce:keyword><ce:keyword><ce:text>Oxindole alkaloids</ce:text></ce:keyword><ce:keyword><ce:text>Lymphocyte proliferation</ce:text></ce:keyword><ce:keyword><ce:text>Asháninka</ce:text></ce:keyword><ce:keyword><ce:text>Perú</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Uncaria tomentosa (Willd.) DC.—Ethnomedicinal use and new pharmacological, toxicological and botanical results</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>(Willd.) DC.—Ethnomedicinal use and new pharmacological, toxicological and botanical results</title></titleInfo><name type="personal"><namePart type="given">Klaus</namePart><namePart type="family">Keplinger</namePart><affiliation>Immodal Pharmaka GmbH, Bundesstrasse 44, A-6111 Volders, Austria</affiliation><affiliation>Corresponding author.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gerhard</namePart><namePart type="family">Laus</namePart><affiliation>Immodal Pharmaka GmbH, Bundesstrasse 44, A-6111 Volders, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Martin</namePart><namePart type="family">Wurm</namePart><affiliation>Institut für Hygiene und Ludwig Boltzmann-Institut für AIDS-Forschung, University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Manfred P</namePart><namePart type="family">Dierich</namePart><affiliation>Institut für Hygiene und Ludwig Boltzmann-Institut für AIDS-Forschung, University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Herwig</namePart><namePart type="family">Teppner</namePart><affiliation>Institut für Botanik, University of Graz, Holteigasse 6, A-8010 Graz, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><dateModified encoding="w3cdtf">1998-04-28</dateModified><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The medicinal system of the Asháninka Indians in Perú is portrayed. Three categories of medical disorders and healers are recognized. A human is viewed to consist of a physical and a spiritual being who communicate with each other by means of a regulating element. The significance of Uncaria tomentosa (Willd.) DC. (Rubiaceae), locally known as uña de gato, in traditional medicine is emphasized by its exclusive use by priests to influence this regulation. Pharmacological and toxicological results obtained with extracts or isolated compounds are summarized. Pentacyclic oxindole alkaloids stimulate endothelial cells in vitro to produce a lymphocyte-proliferation-regulating factor. Tetracyclic oxindole alkaloids act as antagonists. A significant normalization of lymphocyte percentage was observed in vivo although total leucocyte numbers did not change.</abstract><note type="content">Table 1: Alkaloids of Uncaria tomentosa (Wild.) DC.</note><note type="content">Table 2: Mortality ratio and group mean bodyweight of mice dosed orally with an aqueous extract of U. tomentosa root</note><note type="content">Table 3: Leucocyte values and relative kidney weight in rats (group mean values±S.D.)</note><note type="content">Table 4: Effect on proliferation of different human cells and cell lines by treatment with pentacyclic oxindole alkaloids (POA)-incubated EA.hy936 endothelial cell culture supernatants (SN) (% of control±S.D.)</note><note type="content">Table 5: Proliferation of lymphoblastoid cell lines after treatment with culture supernatants (SN) of EA.hy936 endothelial cells incubated with pentacyclic oxindole alkaloids (POA), tetracyclic oxindole alkaloids (TOA) and mixtures thereof (% of control±S.D.)</note><note type="content">Table 6: Total leucocytes and percentage of lymphocytes in humans</note><subject lang="en"><genre>Keywords</genre><topic>Uncaria tomentosa</topic><topic>Uña de gato</topic><topic>Oxindole alkaloids</topic><topic>Lymphocyte proliferation</topic><topic>Asháninka</topic><topic>Perú</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Ethnopharmacology</title></titleInfo><titleInfo type="abbreviated"><title>JEP</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued></originInfo><identifier type="ISSN">0378-8741</identifier><identifier type="PII">S0378-8741(00)X0051-7</identifier><part><date>1999</date><detail type="volume"><number>64</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue-pages"><start>1</start><end>100</end></extent><extent unit="pages"><start>23</start><end>34</end></extent></part></relatedItem><identifier type="istex">428B0E7BAB2FE5001640959B356B913A8BD64D91</identifier><identifier type="ark">ark:/67375/6H6-20X2CF1F-Z</identifier><identifier type="DOI">10.1016/S0378-8741(98)00096-8</identifier><identifier type="PII">S0378-8741(98)00096-8</identifier><accessCondition type="use and reproduction" contentType="copyright">©1999 Elsevier Science Ireland Ltd</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource><recordOrigin>Elsevier Science Ireland Ltd, ©1999</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-20X2CF1F-Z/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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