Differential expression of mRNA aromatase in ejaculated spermatozoa from infertile men in relation to either asthenozoospermia or teratozoospermia
Identifieur interne : 001C81 ( Istex/Corpus ); précédent : 001C80; suivant : 001C82Differential expression of mRNA aromatase in ejaculated spermatozoa from infertile men in relation to either asthenozoospermia or teratozoospermia
Auteurs : L. Said ; A. Saad ; S. CarreauSource :
- Andrologia [ 0303-4569 ] ; 2014-03.
Abstract
Oestrogen biosynthesis in ejaculated spermatozoa is an autonomous process, which may influence sperm functions. The purpose of this study was to evaluate the relationship between the expression of aromatase, sperm quality and seminal neutral α–glucosidase marker in semen of Tunisian infertile men: asthenozoospermia (A; n = 16), teratozoospermia (T; n = 12) and asthenoteratozoospermia (AT; n = 11) in comparison with 18 normozoospermic ones. Aromatase mRNA levels estimated by real‐time PCR were reduced in groups T (52%) and AT (67%) compared to controls and inversely correlated with the percentage of normal forms. A higher coefficient of correlation was noted in presence of microcephaly or acrosome malformations (r = −0.64). The asthenozoospermic group was divided into two subgroups according to the relative amount of aromatase. The subgroup (A2) with higher aromatase transcript level was associated with an increased seminal pH, a decreased sperm viability, low sperm percentage motility and low neutral α‐glucosidase semen levels. Our data highlight the involvement of aromatase in motility and morphology of spermatozoa. Thus, this enzyme could bring new insights about quality and fertilising capacity of human spermatozoa.
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DOI: 10.1111/and.12058
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ISTEX:6CC4CD60C6CB25BF2CEEE8A78BF00954A84A9206Le document en format XML
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Said, Laboratoire de Cytogénétique et de Biologie de la Reproduction, Hôpital Farhat Hached, 4002 Sousse, Tunisia.Tel.: +216 73 219 488;Fax: +216 73 219 488/216 73 465 404;E‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: lamia_said2001@yahoo.fr</mods:affiliation></affiliation></author><author><name sortKey="Saad, A" sort="Saad, A" uniqKey="Saad A" first="A." last="Saad">A. Saad</name><affiliation><mods:affiliation>Laboratory of Cytogenetics and Reproductive Biology, Hospital Farhat Hached, University of Sousse, Sousse, Tunisia</mods:affiliation></affiliation></author><author><name sortKey="Carreau, S" sort="Carreau, S" uniqKey="Carreau S" first="S." last="Carreau">S. 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The purpose of this study was to evaluate the relationship between the expression of aromatase, sperm quality and seminal neutral α–glucosidase marker in semen of Tunisian infertile men: asthenozoospermia (A; n = 16), teratozoospermia (T; n = 12) and asthenoteratozoospermia (AT; n = 11) in comparison with 18 normozoospermic ones. Aromatase mRNA levels estimated by real‐time PCR were reduced in groups T (52%) and AT (67%) compared to controls and inversely correlated with the percentage of normal forms. A higher coefficient of correlation was noted in presence of microcephaly or acrosome malformations (r = −0.64). The asthenozoospermic group was divided into two subgroups according to the relative amount of aromatase. The subgroup (A2) with higher aromatase transcript level was associated with an increased seminal pH, a decreased sperm viability, low sperm percentage motility and low neutral α‐glucosidase semen levels. 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Said, Laboratoire de Cytogénétique et de Biologie de la Reproduction, Hôpital Farhat Hached, 4002 Sousse, Tunisia.</line><line>Tel.: +216 73 219 488;</line><line>Fax: +216 73 219 488/216 73 465 404;</line><line>E‐mail: <email>lamia_said2001@yahoo.fr</email></line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:AND.AND12058.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Differential expression of <fc>mRNA</fc> aromatase in ejaculated spermatozoa from infertile men in relation to either asthenozoospermia or teratozoospermia</title><title type="shortAuthors">L. Said <i>et al</i>.</title></titleGroup><creators><creator affiliationRef="#and12058-aff-0001 #and12058-aff-0002" corresponding="yes" creatorRole="author" xml:id="and12058-cr-0001"><personName><givenNames>L.</givenNames> <familyName>Said</familyName></personName></creator><creator affiliationRef="#and12058-aff-0002" creatorRole="author" xml:id="and12058-cr-0002"><personName><givenNames>A.</givenNames> <familyName>Saad</familyName></personName></creator><creator affiliationRef="#and12058-aff-0001" creatorRole="author" xml:id="and12058-cr-0003"><personName><givenNames>S.</givenNames> <familyName>Carreau</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="FR" type="organization" xml:id="and12058-aff-0001"><orgDiv>Department of Biochemistry</orgDiv> <orgName>University of Caen</orgName> <address><city>Caen</city> <country>France</country></address></affiliation><affiliation countryCode="TN" type="organization" xml:id="and12058-aff-0002"><orgDiv>Laboratory of Cytogenetics and Reproductive Biology</orgDiv> <orgName>Hospital Farhat Hached</orgName> <orgName>University of Sousse</orgName> <address><city>Sousse</city> <country>Tunisia</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="and12058-kwd-0001">Aromatase</keyword><keyword xml:id="and12058-kwd-0002">fertility</keyword><keyword xml:id="and12058-kwd-0003">morphology</keyword><keyword xml:id="and12058-kwd-0004">motility</keyword><keyword xml:id="and12058-kwd-0005">spermatozoa</keyword></keywordGroup><fundingInfo><fundingAgency>French Ministry of Education and Research</fundingAgency></fundingInfo><fundingInfo><fundingAgency>National Institute of Research in Agronomy</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Ministry of Higher Education and Scientific Research of Tunisia</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:id="and12058-abs-0001" xml:lang="en"><title type="main">Summary</title><p>Oestrogen biosynthesis in ejaculated spermatozoa is an autonomous process, which may influence sperm functions. The purpose of this study was to evaluate the relationship between the expression of aromatase, sperm quality and seminal neutral α–glucosidase marker in semen of Tunisian infertile men: asthenozoospermia (A; <i>n</i> = 16), teratozoospermia (T; <i>n</i> = 12) and asthenoteratozoospermia (AT; <i>n</i> = 11) in comparison with 18 normozoospermic ones. Aromatase <fc>mRNA</fc> levels estimated by real‐time PCR were reduced in groups T (52%) and AT (67%) compared to controls and inversely correlated with the percentage of normal forms. A higher coefficient of correlation was noted in presence of microcephaly or acrosome malformations (<i>r</i> = −0.64). The asthenozoospermic group was divided into two subgroups according to the relative amount of aromatase. The subgroup (A2) with higher aromatase transcript level was associated with an increased seminal <fc>pH</fc>, a decreased sperm viability, low sperm percentage motility and low neutral α‐glucosidase semen levels. Our data highlight the involvement of aromatase in motility and morphology of spermatozoa. Thus, this enzyme could bring new insights about quality and fertilising capacity of human spermatozoa.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Differential expression of mRNA aromatase in ejaculated spermatozoa from infertile men in relation to either asthenozoospermia or teratozoospermia</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Differential expression of mRNA aromatase in ejaculated spermatozoa from infertile men in relation to either asthenozoospermia or teratozoospermia</title></titleInfo><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Said</namePart><affiliation>Department of Biochemistry, University of Caen, Caen, France</affiliation><affiliation>Laboratory of Cytogenetics and Reproductive Biology, Hospital Farhat Hached, University of Sousse, Sousse, Tunisia</affiliation><affiliation>L. Said, Laboratoire de Cytogénétique et de Biologie de la Reproduction, Hôpital Farhat Hached, 4002 Sousse, Tunisia.Tel.: +216 73 219 488;Fax: +216 73 219 488/216 73 465 404;E‐mail:</affiliation><affiliation>E-mail: lamia_said2001@yahoo.fr</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Saad</namePart><affiliation>Laboratory of Cytogenetics and Reproductive Biology, Hospital Farhat Hached, University of Sousse, Sousse, Tunisia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Carreau</namePart><affiliation>Department of Biochemistry, University of Caen, Caen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-03</dateIssued><dateCreated encoding="w3cdtf">2012-12-05</dateCreated><dateValid encoding="w3cdtf">2012-10-24</dateValid><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Oestrogen biosynthesis in ejaculated spermatozoa is an autonomous process, which may influence sperm functions. The purpose of this study was to evaluate the relationship between the expression of aromatase, sperm quality and seminal neutral α–glucosidase marker in semen of Tunisian infertile men: asthenozoospermia (A; n = 16), teratozoospermia (T; n = 12) and asthenoteratozoospermia (AT; n = 11) in comparison with 18 normozoospermic ones. Aromatase mRNA levels estimated by real‐time PCR were reduced in groups T (52%) and AT (67%) compared to controls and inversely correlated with the percentage of normal forms. A higher coefficient of correlation was noted in presence of microcephaly or acrosome malformations (r = −0.64). The asthenozoospermic group was divided into two subgroups according to the relative amount of aromatase. The subgroup (A2) with higher aromatase transcript level was associated with an increased seminal pH, a decreased sperm viability, low sperm percentage motility and low neutral α‐glucosidase semen levels. Our data highlight the involvement of aromatase in motility and morphology of spermatozoa. 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