A spatial view of the CD8+ T‐cell response: the case of HCV
Identifieur interne : 001C79 ( Istex/Corpus ); précédent : 001C78; suivant : 001C80A spatial view of the CD8+ T‐cell response: the case of HCV
Auteurs : Vito Racanelli ; Patrizia Leone ; Arash GrakouiSource :
- Reviews in Medical Virology [ 1052-9276 ] ; 2011-11.
English descriptors
- Teeft :
- Active infection, Acute hepatitis, Acute infections, Antigen elimination, Antigen stimulation, Antigenexperienced cell, Antiviral, Antiviral therapy, Bone marrow, Ccr7, Cell differentiation, Cell population, Cell populations, Cell responses, Cells display, Central memory, Chemokine, Chemokine receptor type, Chronic hepatitis, Chronic infection, Chronic infections, Clinical investigation, Clinical oncology, Cognate antigen, Copyright, Cytokine, Cytotoxic, Different compartments, Effective immunotherapies, Effector, Effector cells, Effector functions, Effector memory, Effector phenotype, Effector subpopulations, Emory university school, European journal, Functional restoration, Granzyme, Hepatitis, High expression, High levels, Human infection, Human virus, Immediate effector function, Immunological memory, Immunology, Infection, Infectious diseases, Internal medicine, Intrahepatic, John wiley sons, Killer cell receptor, Klrg1, Large number, Late differentiation, Latent infections, Lung epithelial cells, Lymph nodes, Lymphocyte, Lymphoid, Major role, Memory cells, Memory differentiation, Memory phase, Memory precursors, Memory response, Memory subsets, Mucin protein, Nature medicine, Nonlymphoid tissues, Ongoing infection, Pathway, Perforin, Perihepatic lymph nodes, Peripheral blood, Phenotype, Racanelli, Receptor, Respiratory syncytial virus, Secondary lymphoid organs, Selective accumulation, Spatial view, Subset, Tissue damage, Viral, Viral clearance, Viral infection, Viral infections, Viral replication, Virol, Virology, Virus, Virus infec, Virus infection, Virus persistence.
Abstract
In viral infections, a memory T‐cell population comprises multiple subtypes of cells, distributed in diverse anatomic compartments and possibly re‐circulating among them. Accordingly, memory T cells display distinct phenotypes and functions, depending on the nature of the infecting virus, the anatomic location of the infection, and the differences between the sites of active infection and T‐cell collection. This paper explores the body compartments where virus‐specific CD8+ T cells have been found during chronic hepatitis C virus infection, describes the cells' memory qualities, and discusses how they are spatially regulated, in comparison with other human viral infections. Understanding the role of compartmentalization and diversity of HCV‐specific memory T‐cell subsets may be the key to developing effective immunotherapies. Copyright © 2011 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/rmv.702
Links to Exploration step
ISTEX:1AF33FB18114FD4FDCC6A74B72891B9F9CB59D8CLe document en format XML
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Copyright © 2011 John Wiley & Sons, Ltd.</abstract><qualityIndicators><score>8.488</score><pdfWordCount>6995</pdfWordCount><pdfCharCount>44159</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>11</pdfPageCount><pdfPageSize>566.929 x 737.008 pts</pdfPageSize><pdfWordsPerPage>636</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>124</abstractWordCount><abstractCharCount>878</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>A spatial view of the CD8+ T‐cell response: the case of HCV</title><pmid><json:string>21732472</json:string></pmid><genre><json:string>review-article</json:string></genre><host><title>Reviews in Medical Virology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1099-1654</json:string></doi><issn><json:string>1052-9276</json:string></issn><eissn><json:string>1099-1654</json:string></eissn><publisherId><json:string>RMV</json:string></publisherId><volume>21</volume><issue>6</issue><pages><first>347</first><last>357</last><total>11</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Review</value></json:item><json:item><value>Reviews</value></json:item></subject></host><namedEntities><unitex><date><json:string>2011-06-18</json:string></date><geogName></geogName><orgName><json:string>University of Bari Medical School</json:string><json:string>Sons, Ltd.</json:string><json:string>Emory Vaccine Center</json:string><json:string>Sons, Ltd</json:string><json:string>Italy Department of Medicine, Microbiology and Immunology</json:string><json:string>Emory University</json:string><json:string>Department of Internal Medicine and Clinical Oncology</json:string><json:string>National Academy</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Viral Im</json:string><json:string>C. 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[71]</json:string><json:string>[8]</json:string><json:string>Sallusto et al. [9]</json:string><json:string>[39]</json:string><json:string>[14,15]</json:string><json:string>[11,43]</json:string><json:string>[70]</json:string><json:string>Remmerswaal et al.</json:string><json:string>[1]</json:string><json:string>[43]</json:string><json:string>[43,46]</json:string><json:string>[30,31]</json:string><json:string>[13,65]</json:string><json:string>[11,42,43]</json:string><json:string>[3]</json:string><json:string>[10,56]</json:string><json:string>[75]</json:string><json:string>[37]</json:string><json:string>[10,13,43,52,58,65,68,69]</json:string><json:string>[6,7]</json:string><json:string>[74]</json:string><json:string>[28,29]</json:string><json:string>Accapezzato et al. [44]</json:string><json:string>[34,35,39,40]</json:string><json:string>Appay et al.</json:string><json:string>[69]</json:string><json:string>[9]</json:string><json:string>[73]</json:string><json:string>[77,78]</json:string><json:string>[13,42]</json:string><json:string>[2]</json:string><json:string>[46]</json:string><json:string>[20,22]</json:string><json:string>[16,17]</json:string><json:string>V. Racanelli et al.</json:string><json:string>[4,5]</json:string><json:string>[45,59]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-23P8ZJNM-6</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - virology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - virology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Virology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. 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<lineatedText><line>V. Racanelli, MD, Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico—11, Piazza G. Cesare, 70124 Bari, Italy.</line><line>E‐mail: <email>v.racanelli@dimo.uniba.it</email></line></lineatedText>
<lineatedText><line>A. Grakoui, PhD, Emory University School of Medicine, 954 Gatewood Road, NE, Atlanta, GA 30329, USA.</line><line>E‐mail: <email>arash.grakoui@emory.edu</email></line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:RMV.RMV702.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">A spatial view of the CD8<sup>+</sup> T‐cell response: the case of HCV</title><title type="tocForm">A spatial view of the CD8<sup>+</sup> T‐cell response: the case of HCV</title><title type="short">T‐cell memory response to HCV</title><title type="shortAuthors">V. Racanelli <i>et al.</i></title></titleGroup><creators><creator creatorRole="author" xml:id="rmv702-cr-0001" affiliationRef="#rmv702-aff-0001" corresponding="yes"><personName><givenNames>Vito</givenNames><familyName>Racanelli</familyName></personName><contactDetails><email>v.racanelli@dimo.uniba.it</email></contactDetails></creator><creator creatorRole="author" xml:id="rmv702-cr-0002" affiliationRef="#rmv702-aff-0001"><personName><givenNames>Patrizia</givenNames><familyName>Leone</familyName></personName></creator><creator creatorRole="author" xml:id="rmv702-cr-0003" affiliationRef="#rmv702-aff-0002" corresponding="yes"><personName><givenNames>Arash</givenNames><familyName>Grakoui</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="rmv702-aff-0001" countryCode="IT" type="organization"><orgDiv>Department of Internal Medicine and Clinical Oncology</orgDiv><orgName>University of Bari Medical School</orgName><address><city>Bari</city><country>Italy</country></address></affiliation><affiliation xml:id="rmv702-aff-0002" countryCode="US" type="organization"><orgDiv>Department of Medicine, Microbiology and Immunology</orgDiv><orgName>Emory Vaccine Center, Emory University School of Medicine</orgName><address><city>Atlanta</city><countryPart>GA</countryPart><postCode>30329</postCode><country>USA</country></address></affiliation></affiliationGroup><fundingInfo><fundingAgency>Associazione Italiana per la Ricerca sul Cancro</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Fondazione Cassa di Risparmio di Puglia</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Public Health Service</fundingAgency><fundingNumber>AI070101</fundingNumber><fundingNumber>DK083356</fundingNumber></fundingInfo><abstractGroup><abstract type="main"><title type="main">SUMMARY</title><p>In viral infections, a memory T‐cell population comprises multiple subtypes of cells, distributed in diverse anatomic compartments and possibly re‐circulating among them. Accordingly, memory T cells display distinct phenotypes and functions, depending on the nature of the infecting virus, the anatomic location of the infection, and the differences between the sites of active infection and T‐cell collection. This paper explores the body compartments where virus‐specific CD8<sup>+</sup> T cells have been found during chronic hepatitis C virus infection, describes the cells' memory qualities, and discusses how they are spatially regulated, in comparison with other human viral infections. Understanding the role of compartmentalization and diversity of HCV‐specific memory T‐cell subsets may be the key to developing effective immunotherapies. Copyright © 2011 John Wiley & Sons, Ltd.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A spatial view of the CD8+ T‐cell response: the case of HCV</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>T‐cell memory response to HCV</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>A spatial view of the CD8+ T‐cell response: the case of HCV</title></titleInfo><name type="personal"><namePart type="given">Vito</namePart><namePart type="family">Racanelli</namePart><affiliation>Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy</affiliation><affiliation>E-mail: v.racanelli@dimo.uniba.it</affiliation><affiliation>V. Racanelli, MD, Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico—11, Piazza G. Cesare, 70124 Bari, Italy.E‐mail:</affiliation><affiliation>E-mail: v.racanelli@dimo.uniba.it</affiliation><affiliation>A. Grakoui, PhD, Emory University School of Medicine, 954 Gatewood Road, NE, Atlanta, GA 30329, USA.E‐mail:</affiliation><affiliation>E-mail: arash.grakoui@emory.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Patrizia</namePart><namePart type="family">Leone</namePart><affiliation>Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Arash</namePart><namePart type="family">Grakoui</namePart><affiliation>Department of Medicine, Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, GA, 30329, Atlanta, USA</affiliation><affiliation>V. Racanelli, MD, Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico—11, Piazza G. Cesare, 70124 Bari, Italy.E‐mail:</affiliation><affiliation>E-mail: v.racanelli@dimo.uniba.it</affiliation><affiliation>A. Grakoui, PhD, Emory University School of Medicine, 954 Gatewood Road, NE, Atlanta, GA 30329, USA.E‐mail:</affiliation><affiliation>E-mail: arash.grakoui@emory.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>John Wiley & Sons, Ltd</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2011-11</dateIssued><dateCreated encoding="w3cdtf">2011-06-18</dateCreated><dateCaptured encoding="w3cdtf">2011-02-18</dateCaptured><dateValid encoding="w3cdtf">2011-05-27</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>In viral infections, a memory T‐cell population comprises multiple subtypes of cells, distributed in diverse anatomic compartments and possibly re‐circulating among them. Accordingly, memory T cells display distinct phenotypes and functions, depending on the nature of the infecting virus, the anatomic location of the infection, and the differences between the sites of active infection and T‐cell collection. This paper explores the body compartments where virus‐specific CD8+ T cells have been found during chronic hepatitis C virus infection, describes the cells' memory qualities, and discusses how they are spatially regulated, in comparison with other human viral infections. Understanding the role of compartmentalization and diversity of HCV‐specific memory T‐cell subsets may be the key to developing effective immunotherapies. Copyright © 2011 John Wiley & Sons, Ltd.</abstract><note type="funding">Associazione Italiana per la Ricerca sul Cancro</note><note type="funding">Fondazione Cassa di Risparmio di Puglia</note><note type="funding">Public Health Service - No. AI070101; No. DK083356; </note><relatedItem type="host"><titleInfo><title>Reviews in Medical Virology</title></titleInfo><titleInfo type="abbreviated"><title>Rev. Med. Virol.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Review</topic><topic>Reviews</topic></subject><identifier type="ISSN">1052-9276</identifier><identifier type="eISSN">1099-1654</identifier><identifier type="DOI">10.1002/(ISSN)1099-1654</identifier><identifier type="PublisherID">RMV</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>347</start><end>357</end><total>11</total></extent></part></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0001"><titleInfo><title>Response of naive and memory CD8+ T cells to antigen stimulation in vivo</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Veiga‐Fernandes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U</namePart><namePart type="family">Walter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Bourgeois</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Veiga‐Fernandes H, Walter U, Bourgeois C, et al. Response of naive and memory CD8+ T cells to antigen stimulation in vivo. Nature Immunology 2000; 1: 47–53.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>47</start><end>53</end></extent></part><relatedItem type="host"><titleInfo><title>Nature Immunology</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>47</start><end>53</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0002"><titleInfo><title>Human virus‐specific CD8+ T cells: diversity specialists</title></titleInfo><name type="personal"><namePart type="given">EM</namePart><namePart type="family">van Leeuwen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GJ</namePart><namePart type="family">de Bree</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IJ</namePart><namePart type="family">ten Berge</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">van Leeuwen EM, de Bree GJ, ten Berge IJ, et al. Human virus‐specific CD8+ T cells: diversity specialists. Immunological Reviews 2006; 211: 225–235.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>211</number></detail><extent unit="pages"><start>225</start><end>235</end></extent></part><relatedItem type="host"><titleInfo><title>Immunological Reviews</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>211</number></detail><extent unit="pages"><start>225</start><end>235</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0003"><titleInfo><title>The Tower of Babel of CD8+ T‐cell memory: known facts, deserted roads, muddy waters, and possible dead ends</title></titleInfo><name type="personal"><namePart type="given">B</namePart><namePart type="family">Rocha</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Tanchot</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rocha B, Tanchot C. The Tower of Babel of CD8+ T‐cell memory: known facts, deserted roads, muddy waters, and possible dead ends. Immunological Reviews 2006; 211: 182–196.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>211</number></detail><extent unit="pages"><start>182</start><end>196</end></extent></part><relatedItem type="host"><titleInfo><title>Immunological Reviews</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>211</number></detail><extent unit="pages"><start>182</start><end>196</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0004"><titleInfo><title>Immunological memory and protective immunity: understanding their relation</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Ahmed</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Gray</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ahmed R, Gray D. Immunological memory and protective immunity: understanding their relation. Science 1996; 272: 54–60.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>272</number></detail><extent unit="pages"><start>54</start><end>60</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>272</number></detail><extent unit="pages"><start>54</start><end>60</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0005"><titleInfo><title>Signaling and the generation of memory T cells</title></titleInfo><name type="personal"><namePart type="given">DL</namePart><namePart type="family">Farber</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TCR</namePart><namePart type="family">Differential</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Farber DL. Differential TCR Signaling and the generation of memory T cells. Journal of Immunology 1998; 160: 535–539.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>160</number></detail><extent unit="pages"><start>535</start><end>539</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>160</number></detail><extent unit="pages"><start>535</start><end>539</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0006"><titleInfo><title>Heterogeneity and cell‐fate decisions in effector and memory CD8+ T cell differentiation during viral infection</title></titleInfo><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Kaech</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EJ</namePart><namePart type="family">Wherry</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kaech SM, Wherry EJ. Heterogeneity and cell‐fate decisions in effector and memory CD8+ T cell differentiation during viral infection. Immunity 2007; 27: 393–405.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>393</start><end>405</end></extent></part><relatedItem type="host"><titleInfo><title>Immunity</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>393</start><end>405</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0007"><titleInfo><title>Progressive differentiation and selection of the fittest in the immune response</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Lanzavecchia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Sallusto</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lanzavecchia A, Sallusto F. Progressive differentiation and selection of the fittest in the immune response. Nature Reviews Immunology 2002; 2: 982–987.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>982</start><end>987</end></extent></part><relatedItem type="host"><titleInfo><title>Nature Reviews Immunology</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>982</start><end>987</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0008"><titleInfo><title>Direct ex vivo analysis reveals distinct phenotypic patterns of HIV‐specific CD8(+) T lymphocyte activation in response to therapeutic manipulation of virus load</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Oxenius</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HF</namePart><namePart type="family">Gunthard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Hirschel</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Oxenius A, Gunthard HF, Hirschel B, et al. Direct ex vivo analysis reveals distinct phenotypic patterns of HIV‐specific CD8(+) T lymphocyte activation in response to therapeutic manipulation of virus load. European Journal of Immunology 2001; 31: 1115–1121.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>1115</start><end>1121</end></extent></part><relatedItem type="host"><titleInfo><title>European Journal of Immunology</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>1115</start><end>1121</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0009"><titleInfo><title>Two subsets of memory T lymphocytes with distinct homing potentials and effector functions</title></titleInfo><name type="personal"><namePart type="given">F</namePart><namePart type="family">Sallusto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Lenig</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Forster</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sallusto F, Lenig D, Forster R, et al. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401: 708–712.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>401</number></detail><extent unit="pages"><start>708</start><end>712</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>401</number></detail><extent unit="pages"><start>708</start><end>712</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0010"><titleInfo><title>Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections</title></titleInfo><name type="personal"><namePart type="given">V</namePart><namePart type="family">Appay</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PR</namePart><namePart type="family">Dunbar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Callan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Appay V, Dunbar PR, Callan M, et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nature Medicine 2002; 8: 379–385.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>379</start><end>385</end></extent></part><relatedItem type="host"><titleInfo><title>Nature Medicine</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>379</start><end>385</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0011"><titleInfo><title>Liver‐infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD‐1 and low levels of CD127 expression</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Radziewicz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Ibegbu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ML</namePart><namePart type="family">Fernandez</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Radziewicz H, Ibegbu CC, Fernandez ML, et al. Liver‐infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD‐1 and low levels of CD127 expression. Journal of Virology 2007; 81: 2545–2553.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>81</number></detail><extent unit="pages"><start>2545</start><end>2553</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Virology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>81</number></detail><extent unit="pages"><start>2545</start><end>2553</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0012"><titleInfo><title>Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long‐lived memory cells</title></titleInfo><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Kaech</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JT</namePart><namePart type="family">Tan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EJ</namePart><namePart type="family">Wherry</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kaech SM, Tan JT, Wherry EJ, et al. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long‐lived memory cells. Nature Immunology 2003; 4: 1191–1198.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>1191</start><end>1198</end></extent></part><relatedItem type="host"><titleInfo><title>Nature Immunology</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>1191</start><end>1198</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0013"><titleInfo><title>Expression of killer cell lectin‐like receptor G1 on antigen‐specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57</title></titleInfo><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Ibegbu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YX</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Harris</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ibegbu CC, Xu YX, Harris W, et al. Expression of killer cell lectin‐like receptor G1 on antigen‐specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57. Journal of Immunology 2005; 174: 6088–6094.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>174</number></detail><extent unit="pages"><start>6088</start><end>6094</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>174</number></detail><extent unit="pages"><start>6088</start><end>6094</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0014"><titleInfo><title>Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Bratke</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Kuepper</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Bade</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bratke K, Kuepper M, Bade B, et al. Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood. European Journal of Immunology 2005; 35: 2608–2616.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>2608</start><end>2616</end></extent></part><relatedItem type="host"><titleInfo><title>European Journal of Immunology</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>2608</start><end>2616</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0015"><titleInfo><title>Three memory subsets of human CD8+ T cells differently expressing three cytolytic effector molecules</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Takata</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Takiguchi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Takata H, Takiguchi M. Three memory subsets of human CD8+ T cells differently expressing three cytolytic effector molecules. Journal of Immunology 2006; 177: 4330–4340.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>177</number></detail><extent unit="pages"><start>4330</start><end>4340</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>177</number></detail><extent unit="pages"><start>4330</start><end>4340</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0016"><titleInfo><title>Immediate early effector functions of virus‐specific CD8+CCR7+ memory cells in humans defined by HLA and CC chemokine ligand 19 tetramers</title></titleInfo><name type="personal"><namePart type="given">EV</namePart><namePart type="family">Ravkov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CM</namePart><namePart type="family">Myrick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JD</namePart><namePart type="family">Altman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ravkov EV, Myrick CM, Altman JD. Immediate early effector functions of virus‐specific CD8+CCR7+ memory cells in humans defined by HLA and CC chemokine ligand 19 tetramers. Journal of Immunology 2003; 170: 2461–2468.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>170</number></detail><extent unit="pages"><start>2461</start><end>2468</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>170</number></detail><extent unit="pages"><start>2461</start><end>2468</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0017"><titleInfo><title>Cutting edge: CCR7+ and CCR7− memory T cells do not differ in immediate effector cell function</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Unsoeld</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Krautwald</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Voehringer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Unsoeld H, Krautwald S, Voehringer D, et al. Cutting edge: CCR7+ and CCR7− memory T cells do not differ in immediate effector cell function. Journal of Immunology 2002; 169: 638–641.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>169</number></detail><extent unit="pages"><start>638</start><end>641</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>169</number></detail><extent unit="pages"><start>638</start><end>641</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0018"><titleInfo><title>Viral persistence alters CD8 T‐cell immunodominance and tissue distribution and results in distinct stages of functional impairment</title></titleInfo><name type="personal"><namePart type="given">EJ</namePart><namePart type="family">Wherry</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JN</namePart><namePart type="family">Blattman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Murali‐Krishna</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wherry EJ, Blattman JN, Murali‐Krishna K, et al. Viral persistence alters CD8 T‐cell immunodominance and tissue distribution and results in distinct stages of functional impairment. Journal of Virology 2003; 77: 4911–4927.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>77</number></detail><extent unit="pages"><start>4911</start><end>4927</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Virology</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>77</number></detail><extent unit="pages"><start>4911</start><end>4927</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0019"><titleInfo><title>Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines</title></titleInfo><name type="personal"><namePart type="given">JD</namePart><namePart type="family">Miller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RG</namePart><namePart type="family">van der Most</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RS</namePart><namePart type="family">Akondy</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Miller JD, van der Most RG, Akondy RS, et al. Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines. Immunity 2008; 28: 710–722.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>710</start><end>722</end></extent></part><relatedItem type="host"><titleInfo><title>Immunity</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>710</start><end>722</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0020"><titleInfo><title>T cell immunity in lymphoid and non‐lymphoid tissues</title></titleInfo><name type="personal"><namePart type="given">L</namePart><namePart type="family">Lefrancois</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Masopust</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lefrancois L, Masopust D. T cell immunity in lymphoid and non‐lymphoid tissues. Current Opinion in Immunology 2002; 14: 503–508.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>503</start><end>508</end></extent></part><relatedItem type="host"><titleInfo><title>Current Opinion in Immunology</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>503</start><end>508</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0021"><titleInfo><title>Heterogeneous memory T cells in antiviral immunity and immunopathology</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Verhoeven</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JR</namePart><namePart type="family">Teijaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DL</namePart><namePart type="family">Farber</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Verhoeven D, Teijaro JR, Farber DL. Heterogeneous memory T cells in antiviral immunity and immunopathology. Viral Immunology 2008; 21: 99–113.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>99</start><end>113</end></extent></part><relatedItem type="host"><titleInfo><title>Viral Immunology</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>99</start><end>113</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0022"><titleInfo><title>Preferential localization of effector memory cells in nonlymphoid tissue</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Masopust</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Vezys</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Marzo</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Masopust D, Vezys V, Marzo AL, et al. Preferential localization of effector memory cells in nonlymphoid tissue. Science 2001; 291: 2413–2417.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>291</number></detail><extent unit="pages"><start>2413</start><end>2417</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>291</number></detail><extent unit="pages"><start>2413</start><end>2417</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0023"><titleInfo><title>Complex memory T‐cell phenotypes revealed by coexpression of CD62L and CCR7</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Unsoeld</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Pircher</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Unsoeld H, Pircher H. Complex memory T‐cell phenotypes revealed by coexpression of CD62L and CCR7. Journal of Virology 2005; 79: 4510–4513.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>4510</start><end>4513</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Virology</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>4510</start><end>4513</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0024"><titleInfo><title>Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Masopust</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Vezys</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EJ</namePart><namePart type="family">Wherry</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Masopust D, Vezys V, Wherry EJ, et al. Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population. Journal of Immunology 2006; 176: 2079–2083.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>176</number></detail><extent unit="pages"><start>2079</start><end>2083</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>176</number></detail><extent unit="pages"><start>2079</start><end>2083</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0025"><titleInfo><title>Cutting edge: migration to nonlymphoid tissues results in functional conversion of central to effector memory CD8 T cells</title></titleInfo><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Marzo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Yagita</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Lefrancois</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Marzo AL, Yagita H, Lefrancois L. Cutting edge: migration to nonlymphoid tissues results in functional conversion of central to effector memory CD8 T cells. Journal of Immunology 2007; 179: 36–40.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>36</start><end>40</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>36</start><end>40</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0026"><titleInfo><title>Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Sarkar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Teichgraber</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Kalia</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sarkar S, Teichgraber V, Kalia V, et al. Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation. Journal of Immunology 2007; 179: 6704–6714.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>6704</start><end>6714</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>6704</start><end>6714</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0027"><titleInfo><title>virus versus innate and adaptive immune responses: a tale of coevolution and coexistence</title></titleInfo><name type="personal"><namePart type="given">B</namePart><namePart type="family">Rehermann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Hepatitis</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rehermann B. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. The Journal of Clinical Investigation 2009; 119: 1745–1754.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>119</number></detail><extent unit="pages"><start>1745</start><end>1754</end></extent></part><relatedItem type="host"><titleInfo><title>The Journal of Clinical Investigation</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>119</number></detail><extent unit="pages"><start>1745</start><end>1754</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0028"><titleInfo><title>Accelerated CD8+ T‐cell memory and prime‐boost response after dendritic‐cell vaccination</title></titleInfo><name type="personal"><namePart type="given">VP</namePart><namePart type="family">Badovinac</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KA</namePart><namePart type="family">Messingham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Jabbari</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Badovinac VP, Messingham KA, Jabbari A, et al. Accelerated CD8+ T‐cell memory and prime‐boost response after dendritic‐cell vaccination. Nature Medicine 2005; 11: 748–756.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>748</start><end>756</end></extent></part><relatedItem type="host"><titleInfo><title>Nature Medicine</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>748</start><end>756</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0029"><titleInfo><title>Inflammation directs memory precursor and short‐lived effector CD8(+) T cell fates via the graded expression of T‐bet transcription factor</title></titleInfo><name type="personal"><namePart type="given">NS</namePart><namePart type="family">Joshi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Cui</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Chandele</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Joshi NS, Cui W, Chandele A, et al. Inflammation directs memory precursor and short‐lived effector CD8(+) T cell fates via the graded expression of T‐bet transcription factor. Immunity 2007; 27: 281–295.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>281</start><end>295</end></extent></part><relatedItem type="host"><titleInfo><title>Immunity</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>281</start><end>295</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0030"><titleInfo><title>Generation of CD8 T cell memory is regulated by IL‐12</title></titleInfo><name type="personal"><namePart type="given">EL</namePart><namePart type="family">Pearce</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Shen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Pearce EL, Shen H. Generation of CD8 T cell memory is regulated by IL‐12. Journal of Immunology 2007; 179: 2074–2081.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>2074</start><end>2081</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>2074</start><end>2081</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0031"><titleInfo><title>IL‐12 signaling drives CD8+ T cell IFN‐gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection</title></titleInfo><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Wilson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Matthews</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GS</namePart><namePart type="family">Yap</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wilson DC, Matthews S, Yap GS. IL‐12 signaling drives CD8+ T cell IFN‐gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection. Journal of Immunology 2008; 180: 5935–5945.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>180</number></detail><extent unit="pages"><start>5935</start><end>5945</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>180</number></detail><extent unit="pages"><start>5935</start><end>5945</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0032"><titleInfo><title>Polymorphisms in the IL‐12B gene and outcome of HCV infection</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Houldsworth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Metzner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Rossol</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Houldsworth A, Metzner M, Rossol S, et al. Polymorphisms in the IL‐12B gene and outcome of HCV infection. Journal of Interferon & Cytokine Research 2005; 25: 271–276.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>271</start><end>276</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Interferon & Cytokine Research</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>271</start><end>276</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0033"><titleInfo><title>Discordant role of CD4 T‐cell response relative to neutralizing antibody and CD8 T‐cell responses in acute hepatitis C</title></titleInfo><name type="personal"><namePart type="given">DE</namePart><namePart type="family">Kaplan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Sugimoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Newton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kaplan DE, Sugimoto K, Newton K, et al. Discordant role of CD4 T‐cell response relative to neutralizing antibody and CD8 T‐cell responses in acute hepatitis C. Gastroenterology 2007; 132: 654–666.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>132</number></detail><extent unit="pages"><start>654</start><end>666</end></extent></part><relatedItem type="host"><titleInfo><title>Gastroenterology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>132</number></detail><extent unit="pages"><start>654</start><end>666</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0034"><titleInfo><title>Analysis of successful immune responses in persons infected with hepatitis C virus</title></titleInfo><name type="personal"><namePart type="given">F</namePart><namePart type="family">Lechner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DK</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PR</namePart><namePart type="family">Dunbar</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lechner F, Wong DK, Dunbar PR, et al. Analysis of successful immune responses in persons infected with hepatitis C virus. The Journal of Experimental Medicine 2000; 191: 1499–1512.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>191</number></detail><extent unit="pages"><start>1499</start><end>1512</end></extent></part><relatedItem type="host"><titleInfo><title>The Journal of Experimental Medicine</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>191</number></detail><extent unit="pages"><start>1499</start><end>1512</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0035"><titleInfo><title>Determinants of viral clearance and persistence during acute hepatitis C virus infection</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Thimme</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Oldach</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KM</namePart><namePart type="family">Chang</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Thimme R, Oldach D, Chang KM, et al. Determinants of viral clearance and persistence during acute hepatitis C virus infection. The Journal of Experimental Medicine 2001; 194: 1395–1406.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>194</number></detail><extent unit="pages"><start>1395</start><end>1406</end></extent></part><relatedItem type="host"><titleInfo><title>The Journal of Experimental Medicine</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>194</number></detail><extent unit="pages"><start>1395</start><end>1406</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0036"><titleInfo><title>Virus‐specific CD8+ lymphocytes share the same effector‐memory phenotype but exhibit functional differences in acute hepatitis B and C</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Urbani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Boni</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Missale</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Urbani S, Boni C, Missale G, et al. Virus‐specific CD8+ lymphocytes share the same effector‐memory phenotype but exhibit functional differences in acute hepatitis B and C. Journal of Virology 2002; 76: 12423–12434.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>76</number></detail><extent unit="pages"><start>12423</start><end>12434</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Virology</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>76</number></detail><extent unit="pages"><start>12423</start><end>12434</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0037"><titleInfo><title>High level of PD‐1 expression on hepatitis C virus (HCV)‐specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome</title></titleInfo><name type="personal"><namePart type="given">V</namePart><namePart type="family">Kasprowicz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Schulze Zur Wiesch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Kuntzen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kasprowicz V, Schulze Zur Wiesch J, Kuntzen T, et al. High level of PD‐1 expression on hepatitis C virus (HCV)‐specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. Journal of Virology 2008; 82: 3154–3160.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>82</number></detail><extent unit="pages"><start>3154</start><end>3160</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Virology</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>82</number></detail><extent unit="pages"><start>3154</start><end>3160</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0038"><titleInfo><title>Effects of antiviral therapy on the cellular immune response in acute hepatitis C</title></titleInfo><name type="personal"><namePart type="given">F</namePart><namePart type="family">Rahman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Heller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Sobao</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rahman F, Heller T, Sobao Y, et al. Effects of antiviral therapy on the cellular immune response in acute hepatitis C. Hepatology 2004; 40: 87–97.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>87</start><end>97</end></extent></part><relatedItem type="host"><titleInfo><title>Hepatology</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>87</start><end>97</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0039"><titleInfo><title>CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained</title></titleInfo><name type="personal"><namePart type="given">F</namePart><namePart type="family">Lechner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NH</namePart><namePart type="family">Gruener</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Urbani</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lechner F, Gruener NH, Urbani S, et al. CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained. European Journal of Immunology 2000; 30: 2479–2487.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><extent unit="pages"><start>2479</start><end>2487</end></extent></part><relatedItem type="host"><titleInfo><title>European Journal of Immunology</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><extent unit="pages"><start>2479</start><end>2487</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0040"><titleInfo><title>Outcome of acute hepatitis C is related to virus‐specific CD4 function and maturation of antiviral memory CD8 responses</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Urbani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Amadei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Fisicaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Urbani S, Amadei B, Fisicaro P, et al. Outcome of acute hepatitis C is related to virus‐specific CD4 function and maturation of antiviral memory CD8 responses. Hepatology 2006; 44: 126–139.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>126</start><end>139</end></extent></part><relatedItem type="host"><titleInfo><title>Hepatology</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>126</start><end>139</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0041"><titleInfo><title>PD‐1 expression in acute hepatitis C virus (HCV) infection is associated with HCV‐specific CD8 exhaustion</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Urbani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Amadei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Tola</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Urbani S, Amadei B, Tola D, et al. PD‐1 expression in acute hepatitis C virus (HCV) infection is associated with HCV‐specific CD8 exhaustion. Journal of Virology 2006; 80: 11398–11403.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>80</number></detail><extent unit="pages"><start>11398</start><end>11403</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Virology</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>80</number></detail><extent unit="pages"><start>11398</start><end>11403</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0042"><titleInfo><title>Analysis of CD127 and KLRG1 expression on hepatitis C virus‐specific CD8+ T cells reveals the existence of different memory T‐cell subsets in the peripheral blood and liver</title></titleInfo><name type="personal"><namePart type="given">B</namePart><namePart type="family">Bengsch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HC</namePart><namePart type="family">Spangenberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Kersting</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bengsch B, Spangenberg HC, Kersting N, et al. Analysis of CD127 and KLRG1 expression on hepatitis C virus‐specific CD8+ T cells reveals the existence of different memory T‐cell subsets in the peripheral blood and liver. Journal of Virology 2007; 81: 945–953.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>81</number></detail><extent unit="pages"><start>945</start><end>953</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Virology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>81</number></detail><extent unit="pages"><start>945</start><end>953</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0043"><titleInfo><title>Functional restoration of HCV‐specific CD8 T cells by PD‐1 blockade is defined by PD‐1 expression and compartmentalization</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Nakamoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DE</namePart><namePart type="family">Kaplan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Coleclough</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nakamoto N, Kaplan DE, Coleclough J, et al. Functional restoration of HCV‐specific CD8 T cells by PD‐1 blockade is defined by PD‐1 expression and compartmentalization. Gastroenterology 2008; 134: 1927–1937.e2.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>134</number></detail><extent unit="pages"><start>1927</start><end>1937.e2</end></extent></part><relatedItem type="host"><titleInfo><title>Gastroenterology</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>134</number></detail><extent unit="pages"><start>1927</start><end>1937.e2</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0044"><titleInfo><title>Hepatic expansion of a virus‐specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Accapezzato</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Francavilla</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Paroli</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Accapezzato D, Francavilla V, Paroli M, et al. Hepatic expansion of a virus‐specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection. The Journal of Clinical Investigation 2004; 113: 963–972.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>113</number></detail><extent unit="pages"><start>963</start><end>972</end></extent></part><relatedItem type="host"><titleInfo><title>The Journal of Clinical Investigation</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>113</number></detail><extent unit="pages"><start>963</start><end>972</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0045"><titleInfo><title>Bone marrow of persistently hepatitis C virus‐infected individuals accumulates memory CD8+ T cells specific for current and historical viral antigens: a study in patients with benign hematological disorders</title></titleInfo><name type="personal"><namePart type="given">V</namePart><namePart type="family">Racanelli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Frassanito</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Leone</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Racanelli V, Frassanito MA, Leone P, et al. Bone marrow of persistently hepatitis C virus‐infected individuals accumulates memory CD8+ T cells specific for current and historical viral antigens: a study in patients with benign hematological disorders. Journal of Immunology 2007; 179: 5387–5398.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>5387</start><end>5398</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>5387</start><end>5398</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0046"><titleInfo><title>Quantitative analysis of hepatitis C virus‐specific CD8(+) T cells in peripheral blood and liver using peptide‐MHC tetramers</title></titleInfo><name type="personal"><namePart type="given">XS</namePart><namePart type="family">He</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Rehermann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FX</namePart><namePart type="family">Lopez‐Labrador</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">He XS, Rehermann B, Lopez‐Labrador FX, et al. Quantitative analysis of hepatitis C virus‐specific CD8(+) T cells in peripheral blood and liver using peptide‐MHC tetramers. Proceedings of the National Academy of Sciences of the United States of America 1999; 96: 5692–5697.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>96</number></detail><extent unit="pages"><start>5692</start><end>5697</end></extent></part><relatedItem type="host"><titleInfo><title>Proceedings of the National Academy of Sciences of the United States of America</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>96</number></detail><extent unit="pages"><start>5692</start><end>5697</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0047"><titleInfo><title>Intrahepatic CD8+ T‐cell failure during chronic hepatitis C virus infection</title></titleInfo><name type="personal"><namePart type="given">HC</namePart><namePart type="family">Spangenberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Viazov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Kersting</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Spangenberg HC, Viazov S, Kersting N, et al. Intrahepatic CD8+ T‐cell failure during chronic hepatitis C virus infection. Hepatology 2005; 42: 828–837.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>828</start><end>837</end></extent></part><relatedItem type="host"><titleInfo><title>Hepatology</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>828</start><end>837</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0048"><titleInfo><title>Upregulation of PD‐1 expression on circulating and intrahepatic hepatitis C virus‐specific CD8+ T cells associated with reversible immune dysfunction</title></titleInfo><name type="personal"><namePart type="given">L</namePart><namePart type="family">Golden‐Mason</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Palmer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Klarquist</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Golden‐Mason L, Palmer B, Klarquist J, et al. Upregulation of PD‐1 expression on circulating and intrahepatic hepatitis C virus‐specific CD8+ T cells associated with reversible immune dysfunction. Journal of Virology 2007; 81: 9249–9258.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>81</number></detail><extent unit="pages"><start>9249</start><end>9258</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Virology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>81</number></detail><extent unit="pages"><start>9249</start><end>9258</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0049"><titleInfo><title>Dysfunction and functional restoration of HCV‐specific CD8 responses in chronic hepatitis C virus infection</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Penna</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Pilli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Zerbini</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Penna A, Pilli M, Zerbini A, et al. Dysfunction and functional restoration of HCV‐specific CD8 responses in chronic hepatitis C virus infection. Hepatology 2007; 45: 588–601.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>588</start><end>601</end></extent></part><relatedItem type="host"><titleInfo><title>Hepatology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>588</start><end>601</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0050"><titleInfo><title>Synergistic reversal of intrahepatic HCV‐specific CD8 T cell exhaustion by combined PD‐1/CTLA‐4 blockade</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Nakamoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Cho</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Shaked</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nakamoto N, Cho H, Shaked A, et al. Synergistic reversal of intrahepatic HCV‐specific CD8 T cell exhaustion by combined PD‐1/CTLA‐4 blockade. PLoS Pathogens 2009; 5: e1000313.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>e1000313</start></extent></part><relatedItem type="host"><titleInfo><title>PLoS Pathogens</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>e1000313</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0051"><titleInfo><title>Negative immune regulator Tim‐3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells</title></titleInfo><name type="personal"><namePart type="given">L</namePart><namePart type="family">Golden‐Mason</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BE</namePart><namePart type="family">Palmer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Kassam</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Golden‐Mason L, Palmer BE, Kassam N, et al. Negative immune regulator Tim‐3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. Journal of Virology 2009; 83: 9122–9130.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>9122</start><end>9130</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Virology</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>9122</start><end>9130</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0052"><titleInfo><title>Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung</title></titleInfo><name type="personal"><namePart type="given">GJ</namePart><namePart type="family">de Bree</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EM</namePart><namePart type="family">van Leeuwen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TA</namePart><namePart type="family">Out</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">de Bree GJ, van Leeuwen EM, Out TA, et al. Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung. The Journal of Experimental Medicine 2005; 202: 1433–1442.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>202</number></detail><extent unit="pages"><start>1433</start><end>1442</end></extent></part><relatedItem type="host"><titleInfo><title>The Journal of Experimental Medicine</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>202</number></detail><extent unit="pages"><start>1433</start><end>1442</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0053"><titleInfo><title>The size and phenotype of virus‐specific T cell populations is determined by repetitive antigenic stimulation and environmental cytokines</title></titleInfo><name type="personal"><namePart type="given">LE</namePart><namePart type="family">Gamadia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EM</namePart><namePart type="family">van Leeuwen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EB</namePart><namePart type="family">Remmerswaal</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gamadia LE, van Leeuwen EM, Remmerswaal EB, et al. The size and phenotype of virus‐specific T cell populations is determined by repetitive antigenic stimulation and environmental cytokines. Journal of Immunology 2004; 172: 6107–6114.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>172</number></detail><extent unit="pages"><start>6107</start><end>6114</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>172</number></detail><extent unit="pages"><start>6107</start><end>6114</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0054"><titleInfo><title>High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection</title></titleInfo><name type="personal"><namePart type="given">GM</namePart><namePart type="family">Lauer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Barnes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Lucas</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lauer GM, Barnes E, Lucas M, et al. High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology 2004; 127: 924–936.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>127</number></detail><extent unit="pages"><start>924</start><end>936</end></extent></part><relatedItem type="host"><titleInfo><title>Gastroenterology</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>127</number></detail><extent unit="pages"><start>924</start><end>936</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0055"><titleInfo><title>Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+ T cells</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Lucas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Vargas‐Cuero</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GM</namePart><namePart type="family">Lauer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lucas M, Vargas‐Cuero AL, Lauer GM, et al. Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+ T cells. Journal of Immunology 2004; 172: 1744–1753.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>172</number></detail><extent unit="pages"><start>1744</start><end>1753</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>172</number></detail><extent unit="pages"><start>1744</start><end>1753</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0056"><titleInfo><title>Impaired effector function of hepatitis C virus‐specific CD8+ T cells in chronic hepatitis C virus infection</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Wedemeyer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">XS</namePart><namePart type="family">He</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Nascimbeni</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wedemeyer H, He XS, Nascimbeni M, et al. Impaired effector function of hepatitis C virus‐specific CD8+ T cells in chronic hepatitis C virus infection. Journal of Immunology 2002; 169: 3447–3458.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>169</number></detail><extent unit="pages"><start>3447</start><end>3458</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>169</number></detail><extent unit="pages"><start>3447</start><end>3458</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0057"><titleInfo><title>Analysis of the frequencies and of the memory T cell phenotypes of human CD8+ T cells specific for influenza A viruses</title></titleInfo><name type="personal"><namePart type="given">XS</namePart><namePart type="family">He</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Mahmood</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HT</namePart><namePart type="family">Maecker</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">He XS, Mahmood K, Maecker HT, et al. Analysis of the frequencies and of the memory T cell phenotypes of human CD8+ T cells specific for influenza A viruses. Journal of Infectious Diseases 2003; 187: 1075–1084.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>187</number></detail><extent unit="pages"><start>1075</start><end>1084</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Infectious Diseases</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>187</number></detail><extent unit="pages"><start>1075</start><end>1084</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0058"><titleInfo><title>IL‐7R alpha versus CCR7 and CD45 as markers of virus‐specific CD8+ T cell differentiation: contrasting pictures in blood and tonsillar lymphoid tissue</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Sauce</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Larsen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Leese</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sauce D, Larsen M, Leese AM, et al. IL‐7R alpha versus CCR7 and CD45 as markers of virus‐specific CD8+ T cell differentiation: contrasting pictures in blood and tonsillar lymphoid tissue. Journal of Infectious Diseases 2007; 195: 268–278.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>195</number></detail><extent unit="pages"><start>268</start><end>278</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Infectious Diseases</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>195</number></detail><extent unit="pages"><start>268</start><end>278</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0059"><titleInfo><title>Respiratory syncytial virus‐specific CD8+ memory T cell responses in elderly persons</title></titleInfo><name type="personal"><namePart type="given">GJ</namePart><namePart type="family">de Bree</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Heidema</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EM</namePart><namePart type="family">van Leeuwen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">de Bree GJ, Heidema J, van Leeuwen EM, et al. Respiratory syncytial virus‐specific CD8+ memory T cell responses in elderly persons. Journal of Infectious Diseases 2005; 191: 1710–1718.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>191</number></detail><extent unit="pages"><start>1710</start><end>1718</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Infectious Diseases</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>191</number></detail><extent unit="pages"><start>1710</start><end>1718</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0060"><titleInfo><title>Hepatitis C virus (HCV) sequence variation induces an HCV‐specific T‐cell phenotype analogous to spontaneous resolution</title></titleInfo><name type="personal"><namePart type="given">V</namePart><namePart type="family">Kasprowicz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YH</namePart><namePart type="family">Kang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Lucas</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kasprowicz V, Kang YH, Lucas M, et al. Hepatitis C virus (HCV) sequence variation induces an HCV‐specific T‐cell phenotype analogous to spontaneous resolution. Journal of Virology 84: 1656–1663.</note><part><detail type="volume"><caption>vol.</caption><number>84</number></detail><extent unit="pages"><start>1656</start><end>1663</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Virology</title></titleInfo><part><detail type="volume"><caption>vol.</caption><number>84</number></detail><extent unit="pages"><start>1656</start><end>1663</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0061"><titleInfo><title>Coexpression of PD‐1, 2B4, CD160 and KLRG1 on exhausted HCV‐specific CD8+ T cells is linked to antigen recognition and T cell differentiation</title></titleInfo><name type="personal"><namePart type="given">B</namePart><namePart type="family">Bengsch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Seigel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ruhl</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bengsch B, Seigel B, Ruhl M, et al. Coexpression of PD‐1, 2B4, CD160 and KLRG1 on exhausted HCV‐specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathogens 6: e1000947.</note><part><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>e1000947</start></extent></part><relatedItem type="host"><titleInfo><title>PLoS Pathogens</title></titleInfo><part><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>e1000947</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0062"><titleInfo><title>High‐programmed death‐1 levels on hepatitis C virus‐specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Rutebemberwa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SC</namePart><namePart type="family">Ray</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Astemborski</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rutebemberwa A, Ray SC, Astemborski J, et al. High‐programmed death‐1 levels on hepatitis C virus‐specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection. Journal of Immunology 2008; 181: 8215–8225.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>181</number></detail><extent unit="pages"><start>8215</start><end>8225</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>181</number></detail><extent unit="pages"><start>8215</start><end>8225</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0063"><titleInfo><title>Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV‐infected individuals</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Paiardini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Cervasi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Albrecht</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Paiardini M, Cervasi B, Albrecht H, et al. Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV‐infected individuals. Journal of Immunology 2005; 174: 2900–2909.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>174</number></detail><extent unit="pages"><start>2900</start><end>2909</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>174</number></detail><extent unit="pages"><start>2900</start><end>2909</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0064"><titleInfo><title>IL‐7 receptor alpha chain expression distinguishes functional subsets of virus‐specific human CD8+ T cells</title></titleInfo><name type="personal"><namePart type="given">EM</namePart><namePart type="family">van Leeuwen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GJ</namePart><namePart type="family">de Bree</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EB</namePart><namePart type="family">Remmerswaal</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">van Leeuwen EM, de Bree GJ, Remmerswaal EB, et al. IL‐7 receptor alpha chain expression distinguishes functional subsets of virus‐specific human CD8+ T cells. Blood 2005; 106: 2091–2098.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>106</number></detail><extent unit="pages"><start>2091</start><end>2098</end></extent></part><relatedItem type="host"><titleInfo><title>Blood</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>106</number></detail><extent unit="pages"><start>2091</start><end>2098</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0065"><titleInfo><title>Increased expression of the NK cell receptor KLRG1 by virus‐specific CD8 T cells during persistent antigen stimulation</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Thimme</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Appay</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Koschella</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Thimme R, Appay V, Koschella M, et al. Increased expression of the NK cell receptor KLRG1 by virus‐specific CD8 T cells during persistent antigen stimulation. Journal of Virology 2005; 79: 12112–12116.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>12112</start><end>12116</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Virology</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>12112</start><end>12116</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0066"><titleInfo><title>HIV‐specific cytotoxic cell frequencies measured directly ex vivo by the Lysispot assay can be higher or lower than the frequencies of IFN‐gamma‐secreting cells: anti‐HIV cytotoxicity is not generally impaired relative to other chronic virus responses</title></titleInfo><name type="personal"><namePart type="given">JE</namePart><namePart type="family">Snyder‐Cappione</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AA</namePart><namePart type="family">Divekar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GM</namePart><namePart type="family">Maupin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Snyder‐Cappione JE, Divekar AA, Maupin GM, et al. HIV‐specific cytotoxic cell frequencies measured directly ex vivo by the Lysispot assay can be higher or lower than the frequencies of IFN‐gamma‐secreting cells: anti‐HIV cytotoxicity is not generally impaired relative to other chronic virus responses. Journal of Immunology 2006; 176: 2662–2668.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>176</number></detail><extent unit="pages"><start>2662</start><end>2668</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>176</number></detail><extent unit="pages"><start>2662</start><end>2668</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0067"><titleInfo><title>Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV‐1 infection</title></titleInfo><name type="personal"><namePart type="given">BL</namePart><namePart type="family">Shacklett</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CA</namePart><namePart type="family">Cox</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MF</namePart><namePart type="family">Quigley</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Shacklett BL, Cox CA, Quigley MF, et al. Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV‐1 infection. Journal of Immunology 2004; 173: 641–648.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>173</number></detail><extent unit="pages"><start>641</start><end>648</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>173</number></detail><extent unit="pages"><start>641</start><end>648</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0068"><titleInfo><title>Tonsillar homing of Epstein‐Barr virus‐specific CD8+ T cells and the virus‐host balance</title></titleInfo><name type="personal"><namePart type="given">AD</namePart><namePart type="family">Hislop</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Kuo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AB</namePart><namePart type="family">Drake‐Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hislop AD, Kuo M, Drake‐Lee AB, et al. Tonsillar homing of Epstein‐Barr virus‐specific CD8+ T cells and the virus‐host balance. The Journal of Clinical Investigation 2005; 115: 2546–2555.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>115</number></detail><extent unit="pages"><start>2546</start><end>2555</end></extent></part><relatedItem type="host"><titleInfo><title>The Journal of Clinical Investigation</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>115</number></detail><extent unit="pages"><start>2546</start><end>2555</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0069"><titleInfo><title>Selective accumulation of virus‐specific CD8+ T cells with unique homing phenotype within the human bone marrow</title></titleInfo><name type="personal"><namePart type="given">U</namePart><namePart type="family">Palendira</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Chinn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Raza</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Palendira U, Chinn R, Raza W, et al. Selective accumulation of virus‐specific CD8+ T cells with unique homing phenotype within the human bone marrow. Blood 2008; 112: 3293–3302.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>112</number></detail><extent unit="pages"><start>3293</start><end>3302</end></extent></part><relatedItem type="host"><titleInfo><title>Blood</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>112</number></detail><extent unit="pages"><start>3293</start><end>3302</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0070"><titleInfo><title>Hepatitis C virus‐specific T‐cell gamma interferon and proliferative responses are more common in perihepatic lymph nodes than in peripheral blood or liver</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Moonka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KA</namePart><namePart type="family">Milkovich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Rodriguez</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Moonka D, Milkovich KA, Rodriguez B, et al. Hepatitis C virus‐specific T‐cell gamma interferon and proliferative responses are more common in perihepatic lymph nodes than in peripheral blood or liver. Journal of Virology 2008; 82: 11742–11748.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>82</number></detail><extent unit="pages"><start>11742</start><end>11748</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Virology</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>82</number></detail><extent unit="pages"><start>11742</start><end>11748</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0071"><titleInfo><title>CMV‐specific central memory T cells reside in bone marrow</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Letsch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Knoedler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IK</namePart><namePart type="family">Na</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Letsch A, Knoedler M, Na IK, et al. CMV‐specific central memory T cells reside in bone marrow. European Journal of Immunology 2007; 37: 3063–3068.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>3063</start><end>3068</end></extent></part><relatedItem type="host"><titleInfo><title>European Journal of Immunology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>3063</start><end>3068</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0072"><titleInfo><title>The history of cytomegalovirus and its diseases</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ho</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ho M. The history of cytomegalovirus and its diseases. Medical Microbiology and Immunology 2008; 197: 65–73.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>197</number></detail><extent unit="pages"><start>65</start><end>73</end></extent></part><relatedItem type="host"><titleInfo><title>Medical Microbiology and Immunology</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>197</number></detail><extent unit="pages"><start>65</start><end>73</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0073"><titleInfo><title>Intraepithelial lymphocytes: exploring the Third Way in immunology</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hayday</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Theodoridis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Ramsburg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hayday A, Theodoridis E, Ramsburg E, et al. Intraepithelial lymphocytes: exploring the Third Way in immunology. Nature Immunology 2001; 2: 997–1003.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>997</start><end>1003</end></extent></part><relatedItem type="host"><titleInfo><title>Nature Immunology</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>997</start><end>1003</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0074"><titleInfo><title>Ontogeny and specificities of mucosal and blood human immunodeficiency virus type 1‐specific CD8(+) cytotoxic T lymphocytes</title></titleInfo><name type="personal"><namePart type="given">L</namePart><namePart type="family">Musey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Ding</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Cao</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Musey L, Ding Y, Cao J, et al. Ontogeny and specificities of mucosal and blood human immunodeficiency virus type 1‐specific CD8(+) cytotoxic T lymphocytes. Journal of Virology 2003; 77: 291–300.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>77</number></detail><extent unit="pages"><start>291</start><end>300</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Virology</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>77</number></detail><extent unit="pages"><start>291</start><end>300</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0075"><titleInfo><title>Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C‐infected liver</title></titleInfo><name type="personal"><namePart type="given">PL</namePart><namePart type="family">Shields</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CM</namePart><namePart type="family">Morland</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Salmon</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Shields PL, Morland CM, Salmon M, et al. Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C‐infected liver. Journal of Immunology 1999; 163: 6236–6243.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>163</number></detail><extent unit="pages"><start>6236</start><end>6243</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Immunology</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>163</number></detail><extent unit="pages"><start>6236</start><end>6243</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0076"><titleInfo><title>CD161 expression on hepatitis C virus‐specific CD8+ T cells suggests a distinct pathway of T cell differentiation</title></titleInfo><name type="personal"><namePart type="given">JW</namePart><namePart type="family">Northfield</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Kasprowicz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Lucas</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Northfield JW, Kasprowicz V, Lucas M, et al. CD161 expression on hepatitis C virus‐specific CD8+ T cells suggests a distinct pathway of T cell differentiation. Hepatology 2008; 47: 396–406.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>396</start><end>406</end></extent></part><relatedItem type="host"><titleInfo><title>Hepatology</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>396</start><end>406</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0077"><titleInfo><title>The liver as an immunological organ</title></titleInfo><name type="personal"><namePart type="given">V</namePart><namePart type="family">Racanelli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Rehermann</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Racanelli V, Rehermann B. The liver as an immunological organ. Hepatology 2006; 43: S54–S62.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>43</number></detail><extent unit="pages"><start>S54</start><end>S62</end></extent></part><relatedItem type="host"><titleInfo><title>Hepatology</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>43</number></detail><extent unit="pages"><start>S54</start><end>S62</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="rmv702-cit-0078"><titleInfo><title>Impaired hepatitis C virus (HCV)‐specific effector CD8+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Radziewicz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Ibegbu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Hon</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Radziewicz H, Ibegbu CC, Hon H, et al. Impaired hepatitis C virus (HCV)‐specific effector CD8+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection. Journal of Virology 2008; 82: 9808–9822.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>82</number></detail><extent unit="pages"><start>9808</start><end>9822</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Virology</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>82</number></detail><extent unit="pages"><start>9808</start><end>9822</end></extent></part></relatedItem></relatedItem><identifier type="istex">1AF33FB18114FD4FDCC6A74B72891B9F9CB59D8C</identifier><identifier type="ark">ark:/67375/WNG-23P8ZJNM-6</identifier><identifier type="DOI">10.1002/rmv.702</identifier><identifier type="ArticleID">RMV702</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 John Wiley & Sons, Ltd.Copyright © 2011 John Wiley & Sons, Ltd.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-16</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-23P8ZJNM-6/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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