Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins
Identifieur interne : 001879 ( Istex/Corpus ); précédent : 001878; suivant : 001880Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins
Auteurs : Michèle Ernoult-Lange ; Valérie Arranz ; Maryvonne Le Coniat ; Roland Berger ; Michel KressSource :
- Journal of Molecular Evolution [ 0022-2844 ] ; 1995-12-01.
English descriptors
- KwdEn :
- Teeft :
- Acidic, Additional motifs, Amino, Amino acids, Bellefroid, Biol, Blot, Cdna, Cdna1, Cell lines, Chromosome, Clone, Coding, Coding region, Codon, Corresponding mouse sequence, Different lanes, Different reading frames, Different restriction endonucleases, Encodes, Exon, Finger region, First motif, Gene, Genome, Genomic, Ghsmokcll, Ghsmokcll genomic clone, Hela, High stringency, Homology, Hsmok2, Human chromosome, Human gene, Human genomic, Human genomic ghsmokcll clone, Human mok2 gene, Human mok2 protein, Human protein, Hybridization, Hybridized, Mok2, Mok2 cdna, Mok2 gene, Mok2 protein, Mok2 transcripts, Motif, Mouse mok2 gene, Mouse mok2 protein, Mrna, Murine, Murine genomic, Murine mok2 cdna, Murine mok2 gene, Murine mok2 protein, Murine protein, Murine sequence, Nonfinger, Nonfinger coding region, Nucleic acids, Nucleotide, Nucleotide sequence, Nucleotide sequences, Proc natl acad, Single copy, Southern analysis, Southern blot, Stringency, Strong identity, Structural features, Transcription, Untranslated, Untranslated exon, Untranslated sequence, Xenopus, Xenopus laevis.
Abstract
Abstract: We have isolated the human homologue of Mok2 gene encoding a Kriippel-like protein. The identification of three cDNAs and genomic clones reveals that the human protein shows substantial structural differences with the mouse MOK2 protein. The mouse MOK2 protein is composed of seven tandem zinc-finger motifs with five additional amino acids at the COOH-terminal. This structural feature is also present at the end of the human MOK2 protein. The seven zinc-finger motifs show 94% identity between the two proteins. In addition, the human protein contains three additional zinc-finger motifs in tandem with the others and a nonfinger acidic domain of 173 amino acids at the NH2-terminal. The Southern analysis indicates that a single copy of these two genes is present in the genome. The human gene has been localized on chromosome 19 on band q13.2–q13.3. The comparison of human and mouse cDNA sequences reveals a strong identity in the sequences localized outside the seven highly conserved zinc-finger motifs. The divergence from their common ancestor results in the loss of a potential transcription activator domain in mouse MOK2 protein.
Url:
DOI: 10.1007/BF00173158
Links to Exploration step
ISTEX:CE4CFD3539F638C3DCAAB09B6CAAA5B7EB564D41Le document en format XML
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The identification of three cDNAs and genomic clones reveals that the human protein shows substantial structural differences with the mouse MOK2 protein. The mouse MOK2 protein is composed of seven tandem zinc-finger motifs with five additional amino acids at the COOH-terminal. This structural feature is also present at the end of the human MOK2 protein. The seven zinc-finger motifs show 94% identity between the two proteins. In addition, the human protein contains three additional zinc-finger motifs in tandem with the others and a nonfinger acidic domain of 173 amino acids at the NH2-terminal. The Southern analysis indicates that a single copy of these two genes is present in the genome. The human gene has been localized on chromosome 19 on band q13.2–q13.3. The comparison of human and mouse cDNA sequences reveals a strong identity in the sequences localized outside the seven highly conserved zinc-finger motifs. The divergence from their common ancestor results in the loss of a potential transcription activator domain in mouse MOK2 protein.</abstract><qualityIndicators><refBibsNative>false</refBibsNative><abstractWordCount>179</abstractWordCount><abstractCharCount>1151</abstractCharCount><keywordCount>5</keywordCount><score>9.148</score><pdfWordCount>8409</pdfWordCount><pdfCharCount>42845</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>11</pdfPageCount><pdfPageSize>598 x 785 pts</pdfPageSize></qualityIndicators><title>Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins</title><pmid><json:string>8587123</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>Journal of Molecular Evolution</title><language><json:string>unknown</json:string></language><publicationDate>1995</publicationDate><copyrightDate>1995</copyrightDate><issn><json:string>0022-2844</json:string></issn><eissn><json:string>1432-1432</json:string></eissn><journalId><json:string>239</json:string></journalId><volume>41</volume><issue>6</issue><pages><first>784</first><last>794</last></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Cell Biology</value></json:item><json:item><value>Microbiology</value></json:item><json:item><value>Plant Sciences</value></json:item></subject></host><namedEntities><unitex><date></date><geogName></geogName><orgName></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName></persName><placeName></placeName><ref_url></ref_url><ref_bibl></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/1BB-D3HLQ475-S</json:string></ark><categories><wos><json:string>1 - 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The identification of three cDNAs and genomic clones reveals that the human protein shows substantial structural differences with the mouse MOK2 protein. The mouse MOK2 protein is composed of seven tandem zinc-finger motifs with five additional amino acids at the COOH-terminal. This structural feature is also present at the end of the human MOK2 protein. The seven zinc-finger motifs show 94% identity between the two proteins. In addition, the human protein contains three additional zinc-finger motifs in tandem with the others and a nonfinger acidic domain of 173 amino acids at the NH2-terminal. The Southern analysis indicates that a single copy of these two genes is present in the genome. The human gene has been localized on chromosome 19 on band q13.2–q13.3. The comparison of human and mouse cDNA sequences reveals a strong identity in the sequences localized outside the seven highly conserved zinc-finger motifs. The divergence from their common ancestor results in the loss of a potential transcription activator domain in mouse MOK2 protein.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>Zinc-finger protein</term></item><item><term>Human</term></item><item><term>Mouse</term></item><item><term>Chromosome location</term></item><item><term>Divergent evolution</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Life Sciences</head><item><term>Cell Biology</term></item><item><term>Microbiology</term></item><item><term>Plant Sciences</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1995-03-24">Created</change><change 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Evolution</JournalTitle><JournalAbbreviatedTitle>J Mol Evol</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Life Sciences</JournalSubject><JournalSubject Type="Secondary">Cell Biology</JournalSubject><JournalSubject Type="Secondary">Microbiology</JournalSubject><JournalSubject Type="Secondary">Plant Sciences</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>41</VolumeIDStart><VolumeIDEnd>41</VolumeIDEnd><VolumeIssueCount>6</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>6</IssueIDStart><IssueIDEnd>6</IssueIDEnd><IssueArticleCount>58</IssueArticleCount><IssueHistory><CoverDate><Year>1995</Year><Month>12</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1995</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art16"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF00173158</ArticleID><ArticleDOI>10.1007/BF00173158</ArticleDOI><ArticleSequenceNumber>16</ArticleSequenceNumber><ArticleTitle Language="En">Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins</ArticleTitle><ArticleCategory>Articles</ArticleCategory><ArticleFirstPage>784</ArticleFirstPage><ArticleLastPage>794</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>7</Month><Day>3</Day></RegistrationDate><Received><Year>1995</Year><Month>3</Month><Day>24</Day></Received><Accepted><Year>1995</Year><Month>7</Month><Day>17</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag New York Inc</CopyrightHolderName><CopyrightYear>1995</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>239</JournalID><VolumeIDStart>41</VolumeIDStart><VolumeIDEnd>41</VolumeIDEnd><IssueIDStart>6</IssueIDStart><IssueIDEnd>6</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Michèle</GivenName><FamilyName>Ernoult-Lange</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Valérie</GivenName><FamilyName>Arranz</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>Maryvonne</GivenName><Particle>Le</Particle><FamilyName>Coniat</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>Roland</GivenName><FamilyName>Berger</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Michel</GivenName><FamilyName>Kress</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Institut de Recherche sur le Cancer</OrgDivision><OrgName>GMIFC CNRS-UPR 9044</OrgName><OrgAddress><Street>7 rue Guy Moquet</Street><Postcode>94801</Postcode><City>Villejuif Cedex</City><Country>France</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Institut de Génétique Moléculaire</OrgDivision><OrgName>INSERM U-301</OrgName><OrgAddress><Street>27 rue Juliette Dodu</Street><Postcode>75010</Postcode><City>Paris</City><Country>France</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>We have isolated the human homologue of <Emphasis Type="Italic">Mok2</Emphasis> gene encoding a Kriippel-like protein. The identification of three cDNAs and genomic clones reveals that the human protein shows substantial structural differences with the mouse MOK2 protein. The mouse MOK2 protein is composed of seven tandem zinc-finger motifs with five additional amino acids at the COOH-terminal. This structural feature is also present at the end of the human MOK2 protein. The seven zinc-finger motifs show 94% identity between the two proteins. In addition, the human protein contains three additional zinc-finger motifs in tandem with the others and a nonfinger acidic domain of 173 amino acids at the NH<Subscript>2</Subscript>-terminal. The Southern analysis indicates that a single copy of these two genes is present in the genome. The human gene has been localized on chromosome 19 on band q13.2–q13.3. The comparison of human and mouse cDNA sequences reveals a strong identity in the sequences localized outside the seven highly conserved zinc-finger motifs. The divergence from their common ancestor results in the loss of a potential transcription activator domain in mouse MOK2 protein.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Zinc-finger protein</Keyword><Keyword>Human</Keyword><Keyword>Mouse</Keyword><Keyword>Chromosome location</Keyword><Keyword>Divergent evolution</Keyword></KeywordGroup><ArticleNote Type="Misc"><SimplePara><Emphasis Type="Italic">Correspondence to:</Emphasis> M. Ernoult-Lange</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins</title></titleInfo><name type="personal"><namePart type="given">Michèle</namePart><namePart type="family">Ernoult-Lange</namePart><affiliation>Institut de Recherche sur le Cancer, GMIFC CNRS-UPR 9044, 7 rue Guy Moquet, 94801, Villejuif Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Valérie</namePart><namePart type="family">Arranz</namePart><affiliation>Institut de Recherche sur le Cancer, GMIFC CNRS-UPR 9044, 7 rue Guy Moquet, 94801, Villejuif Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maryvonne</namePart><namePart type="family">Le Coniat</namePart><affiliation>Institut de Génétique Moléculaire, INSERM U-301, 27 rue Juliette Dodu, 75010, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roland</namePart><namePart type="family">Berger</namePart><affiliation>Institut de Génétique Moléculaire, INSERM U-301, 27 rue Juliette Dodu, 75010, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michel</namePart><namePart type="family">Kress</namePart><affiliation>Institut de Recherche sur le Cancer, GMIFC CNRS-UPR 9044, 7 rue Guy Moquet, 94801, Villejuif Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">New York</placeTerm></place><dateCreated encoding="w3cdtf">1995-03-24</dateCreated><dateIssued encoding="w3cdtf">1995-12-01</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: We have isolated the human homologue of Mok2 gene encoding a Kriippel-like protein. The identification of three cDNAs and genomic clones reveals that the human protein shows substantial structural differences with the mouse MOK2 protein. The mouse MOK2 protein is composed of seven tandem zinc-finger motifs with five additional amino acids at the COOH-terminal. This structural feature is also present at the end of the human MOK2 protein. The seven zinc-finger motifs show 94% identity between the two proteins. In addition, the human protein contains three additional zinc-finger motifs in tandem with the others and a nonfinger acidic domain of 173 amino acids at the NH2-terminal. The Southern analysis indicates that a single copy of these two genes is present in the genome. The human gene has been localized on chromosome 19 on band q13.2–q13.3. The comparison of human and mouse cDNA sequences reveals a strong identity in the sequences localized outside the seven highly conserved zinc-finger motifs. The divergence from their common ancestor results in the loss of a potential transcription activator domain in mouse MOK2 protein.</abstract><note>Articles</note><subject lang="en"><genre>Key words</genre><topic>Zinc-finger protein</topic><topic>Human</topic><topic>Mouse</topic><topic>Chromosome location</topic><topic>Divergent evolution</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Molecular Evolution</title></titleInfo><titleInfo type="abbreviated"><title>J Mol Evol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1995-12-01</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><subject><genre>Life Sciences</genre><topic>Cell Biology</topic><topic>Microbiology</topic><topic>Plant Sciences</topic></subject><identifier type="ISSN">0022-2844</identifier><identifier type="eISSN">1432-1432</identifier><identifier type="JournalID">239</identifier><identifier type="IssueArticleCount">58</identifier><identifier type="VolumeIssueCount">6</identifier><part><date>1995</date><detail type="volume"><number>41</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="pages"><start>784</start><end>794</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1995</recordOrigin></recordInfo></relatedItem><identifier type="istex">CE4CFD3539F638C3DCAAB09B6CAAA5B7EB564D41</identifier><identifier type="ark">ark:/67375/1BB-D3HLQ475-S</identifier><identifier type="DOI">10.1007/BF00173158</identifier><identifier type="ArticleID">BF00173158</identifier><identifier type="ArticleID">Art16</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag New York Inc, 1995</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag New York Inc, 1995</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-D3HLQ475-S/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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