Nucleotide sequence analysis of the LTRs and env genes of SM-FeSV and GA-FeSV
Identifieur interne : 001731 ( Istex/Corpus ); précédent : 001730; suivant : 001732Nucleotide sequence analysis of the LTRs and env genes of SM-FeSV and GA-FeSV
Auteurs : Stéphane Guilhot ; Annie Hampe ; Luc D'Auriol ; Francis GalibertSource :
- Virology [ 0042-6822 ] ; 1987.
English descriptors
- Teeft :
- Academic press, Acceptor, Amino acids, Dideoxy method, Feline, Frameshift mutations, Gilbert method, Homology, Major differences, Mutation, Nonproducer transformants, Nucleotide, Nucleotide sequence, Nucleotide sequences, Other viruses, Perfect homology, Point mutations, Reading frame, Recombinational events, Sherr, Short communications, Splice, Subgroup, Viral.
Abstract
Abstract: The nucleotide sequences of the env genes and the LTRs of SM- and GA-FeSV λ recombinants have been determined by the Maxam and Gilbert method and/or the dideoxy method with specific sequencing primers. Comparison of the two sequences reveals a homology of 93%, the differences being randomly distributed. Two frameshift mutations are observed in the GA-FeSV isolate which close the reading frame and would prevent the synthesis of the env protein. Comparison of these two FeSV sequences with the env sequences of each antigenic subgroup of FeLV (A, B, C) reveals that these two viruses can be assigned to the A/C subgroups.
Url:
DOI: 10.1016/0042-6822(87)90194-2
Links to Exploration step
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<abstract xml:lang="en"><p>Abstract: The nucleotide sequences of the env genes and the LTRs of SM- and GA-FeSV λ recombinants have been determined by the Maxam and Gilbert method and/or the dideoxy method with specific sequencing primers. Comparison of the two sequences reveals a homology of 93%, the differences being randomly distributed. Two frameshift mutations are observed in the GA-FeSV isolate which close the reading frame and would prevent the synthesis of the env protein. Comparison of these two FeSV sequences with the env sequences of each antigenic subgroup of FeLV (A, B, C) reveals that these two viruses can be assigned to the A/C subgroups.</p>
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