MersV1, Istex, Corpus, bibRecord, 001521

Self-stabilized antisense oligodeoxynucleotide phosphorothioates: properties and anti-HIV activity

Identifieur interne : 001521 ( Istex/Corpus ); précédent : 001520; suivant : 001522

Self-stabilized antisense oligodeoxynucleotide phosphorothioates: properties and anti-HIV activity

Auteurs : Jin Yan Tang ; Jamal Temsamani ; Sudhir Agrawal

Source :

Nucleic Acids Research [ 0305-1048 ] ; 1993.

RBID : ISTEX:584B1518CC098D3590881D7BBD6FF9D94DC70D17

Abstract

A new class of oligodeoxyribonucleotides has been designed, referred to here as ‘self-stabilized’ oligonucleotides. These oligonucleotides have hairpin loop structures at their 3′ ends, and show increased resistance to degradation by snake venom phosphodiesterase, DNA polymerase I and fetal bovine serum. The self-stabilized region of the oligonucleotide does not interfere in hybridization with complementary nucleic acids as shown by melting temperature, mobility-shift and RNase H cleavage studies. Various self-stabilized oligonucleotides containing increasingly stable hairpin loop regions were studied for their anti-HIV activity. Pharmacokinetic and stability studies in mice showed increased In vivo persistence of self-stabilized oligonucleotides with respect to their linear counterparts.

Url:

https://api.istex.fr/ark:/67375/HXZ-2V4BBJSX-G/fulltext.pdf

DOI: 10.1093/nar/21.11.2729

Links to Exploration step

ISTEX:584B1518CC098D3590881D7BBD6FF9D94DC70D17

Le document en format XML

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	Serveur d'exploration MERS
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Serveur d'exploration MERS

Self-stabilized antisense oligodeoxynucleotide phosphorothioates: properties and anti-HIV activity

Self-stabilized antisense oligodeoxynucleotide phosphorothioates: properties and anti-HIV activity

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