Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia‐related syndrome
Identifieur interne : 001427 ( Istex/Corpus ); précédent : 001426; suivant : 001428Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia‐related syndrome
Auteurs : M. Willems ; L. Sheng ; T. Roskams ; B. Ramdani ; J. M. Doutrelepont ; F. Nevens ; P. Durez ; S. Treille ; M. Adler ; V. Desmet ; J. Fevery ; S. H. YapSource :
- Journal of Medical Virology [ 0146-6615 ] ; 1994-11.
English descriptors
- Teeft :
- Assay, Biopsy, Biopsy specimens, Chronic hepatitis, Clinical evidence, Clinical features, Clinical manifestations, Clinical practice, Concomitant infection, Consecutive patients, Cryoglobulinemia, Cryoglobulinemia type, Cryoglobulins, Diffuse glomerulonephritis, England journal, Genotype, Genotype prevalence, Genotyping, Glomerulonephritis, Hepatitis, Hepatocellular carcinoma, High prevalence, Infection, Interferon, Interferon therapy, Internal medicine, Kallestad diagnostics, Kidney biopsy, Liver biopsy, Liver disease, Membranoproliferative glomerulonephritis, Membranous glomerulonephritis, National academy, Negative patients, Noncoding region, Pancreatic diseases, Positive hbsag, Positive patients, Possible association, Progressive glomerulonephritis, Rheumatoid arthritis, Rheumatoid factor, Room temperature, Second generation, Serologic reactivities, Synovial biopsy, University hospital gasthuisberg, Urinary protein, Virology, Virus infection.
Abstract
Recently, evidence has been presented for a possible association between hepatitis C virus (HCV) infection and essential mixed cryoglobulinemia (EMC). Eleven consecutive patients with EMC and two with cryoglobulinemia type I were examined for the presence of markers of HCV infection. Eleven of 13 patients (10 with EMC and 1 with type I cryoglobulinemia) had anti‐HCV antibodies (as determined by a second generation anti‐HCV assay) and HCV‐RNA in plasma or serum. HCV‐RNA was also detected in liver biopsies of five patients. Genotyping showed that HCV genotype 1 was found in 10 of 11 patients with HCV‐RNA (9 genotype 1b and 1 genotype 1a) and only one patient had HCV genotype 2. However, a similar high prevalence of genotype 1b (100%) was found in a group of 14 consecutive patients with chronic hepatitis C, who had no clinical evidence of cryoglobulinemia. Concomitant infection was present in three patients with genotypes 2, 3 and 4, respectively. These findings stress the high prevalence of HCV infection in patients with EMC and further study shows that a difference in genotype prevalence was not found between HCV‐related EMC and chronic hepatitis C without clinical manifestations of EMC. © 1994 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.1890440310
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ISTEX:E1557BE6BC164A1B315C6914FFD82E7028F9056ALe document en format XML
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Sheng</name><affiliation><mods:affiliation>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Division of Liver and Pancreatic Diseases, Department of Internal Medicine, University Hospital Gasthuisberg, B‐3000 Leuven, Belgium===</mods:affiliation></affiliation></author><author><name sortKey="Roskams, T" sort="Roskams, T" uniqKey="Roskams T" first="T." last="Roskams">T. Roskams</name><affiliation><mods:affiliation>Department of Pathology, University Hospital Sint‐Rafaël, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Ramdani, B" sort="Ramdani, B" uniqKey="Ramdani B" first="B." last="Ramdani">B. Ramdani</name><affiliation><mods:affiliation>Hǒspital Civil de Jumet, Charleroi, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Doutrelepont, J M" sort="Doutrelepont, J M" uniqKey="Doutrelepont J" first="J. 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Adler</name><affiliation><mods:affiliation>Hǒpital Universitaire Erasme, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Desmet, V" sort="Desmet, V" uniqKey="Desmet V" first="V." last="Desmet">V. Desmet</name><affiliation><mods:affiliation>Department of Pathology, University Hospital Sint‐Rafaël, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Fevery, J" sort="Fevery, J" uniqKey="Fevery J" first="J." last="Fevery">J. Fevery</name><affiliation><mods:affiliation>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Yap, S H" sort="Yap, S H" uniqKey="Yap S" first="S. H." last="Yap">S. H. Yap</name><affiliation><mods:affiliation>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Division of Liver and Pancreatic Diseases, Department of Internal Medicine, University Hospital Gasthuisberg, B‐3000 Leuven, Belgium===</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E1557BE6BC164A1B315C6914FFD82E7028F9056A</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1002/jmv.1890440310</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-Z9JNH21Q-R/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001427</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001427</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia‐related syndrome</title><author><name sortKey="Willems, M" sort="Willems, M" uniqKey="Willems M" first="M." last="Willems">M. Willems</name><affiliation><mods:affiliation>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Division of Liver and Pancreatic Diseases, Department of Internal Medicine, University Hospital Gasthuisberg, B‐3000 Leuven, Belgium===</mods:affiliation></affiliation></author><author><name sortKey="Sheng, L" sort="Sheng, L" uniqKey="Sheng L" first="L." last="Sheng">L. Sheng</name><affiliation><mods:affiliation>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Division of Liver and Pancreatic Diseases, Department of Internal Medicine, University Hospital Gasthuisberg, B‐3000 Leuven, Belgium===</mods:affiliation></affiliation></author><author><name sortKey="Roskams, T" sort="Roskams, T" uniqKey="Roskams T" first="T." last="Roskams">T. Roskams</name><affiliation><mods:affiliation>Department of Pathology, University Hospital Sint‐Rafaël, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Ramdani, B" sort="Ramdani, B" uniqKey="Ramdani B" first="B." last="Ramdani">B. Ramdani</name><affiliation><mods:affiliation>Hǒspital Civil de Jumet, Charleroi, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Doutrelepont, J M" sort="Doutrelepont, J M" uniqKey="Doutrelepont J" first="J. M." last="Doutrelepont">J. M. Doutrelepont</name><affiliation><mods:affiliation>Hǒpital Universitaire Erasme, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Nevens, F" sort="Nevens, F" uniqKey="Nevens F" first="F." last="Nevens">F. Nevens</name><affiliation><mods:affiliation>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Durez, P" sort="Durez, P" uniqKey="Durez P" first="P." last="Durez">P. Durez</name><affiliation><mods:affiliation>Hǒpital Universitaire Erasme, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Treille, S" sort="Treille, S" uniqKey="Treille S" first="S." last="Treille">S. Treille</name><affiliation><mods:affiliation>Hǒspital Civil de Jumet, Charleroi, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Adler, M" sort="Adler, M" uniqKey="Adler M" first="M." last="Adler">M. Adler</name><affiliation><mods:affiliation>Hǒpital Universitaire Erasme, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Desmet, V" sort="Desmet, V" uniqKey="Desmet V" first="V." last="Desmet">V. Desmet</name><affiliation><mods:affiliation>Department of Pathology, University Hospital Sint‐Rafaël, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Fevery, J" sort="Fevery, J" uniqKey="Fevery J" first="J." last="Fevery">J. Fevery</name><affiliation><mods:affiliation>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Yap, S H" sort="Yap, S H" uniqKey="Yap S" first="S. H." last="Yap">S. H. Yap</name><affiliation><mods:affiliation>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Division of Liver and Pancreatic Diseases, Department of Internal Medicine, University Hospital Gasthuisberg, B‐3000 Leuven, Belgium===</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">44</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="266">266</biblScope><biblScope unit="page" to="271">271</biblScope><biblScope unit="page-count">6</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1994-11">1994-11</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Assay</term><term>Biopsy</term><term>Biopsy specimens</term><term>Chronic hepatitis</term><term>Clinical evidence</term><term>Clinical features</term><term>Clinical manifestations</term><term>Clinical practice</term><term>Concomitant infection</term><term>Consecutive patients</term><term>Cryoglobulinemia</term><term>Cryoglobulinemia type</term><term>Cryoglobulins</term><term>Diffuse glomerulonephritis</term><term>England journal</term><term>Genotype</term><term>Genotype prevalence</term><term>Genotyping</term><term>Glomerulonephritis</term><term>Hepatitis</term><term>Hepatocellular carcinoma</term><term>High prevalence</term><term>Infection</term><term>Interferon</term><term>Interferon therapy</term><term>Internal medicine</term><term>Kallestad diagnostics</term><term>Kidney biopsy</term><term>Liver biopsy</term><term>Liver disease</term><term>Membranoproliferative glomerulonephritis</term><term>Membranous glomerulonephritis</term><term>National academy</term><term>Negative patients</term><term>Noncoding region</term><term>Pancreatic diseases</term><term>Positive hbsag</term><term>Positive patients</term><term>Possible association</term><term>Progressive glomerulonephritis</term><term>Rheumatoid arthritis</term><term>Rheumatoid factor</term><term>Room temperature</term><term>Second generation</term><term>Serologic reactivities</term><term>Synovial biopsy</term><term>University hospital gasthuisberg</term><term>Urinary protein</term><term>Virology</term><term>Virus infection</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recently, evidence has been presented for a possible association between hepatitis C virus (HCV) infection and essential mixed cryoglobulinemia (EMC). Eleven consecutive patients with EMC and two with cryoglobulinemia type I were examined for the presence of markers of HCV infection. Eleven of 13 patients (10 with EMC and 1 with type I cryoglobulinemia) had anti‐HCV antibodies (as determined by a second generation anti‐HCV assay) and HCV‐RNA in plasma or serum. HCV‐RNA was also detected in liver biopsies of five patients. Genotyping showed that HCV genotype 1 was found in 10 of 11 patients with HCV‐RNA (9 genotype 1b and 1 genotype 1a) and only one patient had HCV genotype 2. However, a similar high prevalence of genotype 1b (100%) was found in a group of 14 consecutive patients with chronic hepatitis C, who had no clinical evidence of cryoglobulinemia. Concomitant infection was present in three patients with genotypes 2, 3 and 4, respectively. These findings stress the high prevalence of HCV infection in patients with EMC and further study shows that a difference in genotype prevalence was not found between HCV‐related EMC and chronic hepatitis C without clinical manifestations of EMC. © 1994 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>cryoglobulinemia</json:string><json:string>genotype</json:string><json:string>glomerulonephritis</json:string><json:string>chronic hepatitis</json:string><json:string>hepatitis</json:string><json:string>interferon</json:string><json:string>genotyping</json:string><json:string>cryoglobulins</json:string><json:string>virology</json:string><json:string>cryoglobulinemia type</json:string><json:string>assay</json:string><json:string>liver disease</json:string><json:string>virus infection</json:string><json:string>urinary protein</json:string><json:string>kidney biopsy</json:string><json:string>possible association</json:string><json:string>consecutive patients</json:string><json:string>liver biopsy</json:string><json:string>membranoproliferative glomerulonephritis</json:string><json:string>clinical evidence</json:string><json:string>clinical manifestations</json:string><json:string>biopsy</json:string><json:string>clinical features</json:string><json:string>interferon therapy</json:string><json:string>high prevalence</json:string><json:string>synovial biopsy</json:string><json:string>noncoding region</json:string><json:string>england journal</json:string><json:string>membranous glomerulonephritis</json:string><json:string>biopsy specimens</json:string><json:string>hepatocellular carcinoma</json:string><json:string>negative patients</json:string><json:string>positive hbsag</json:string><json:string>diffuse glomerulonephritis</json:string><json:string>clinical practice</json:string><json:string>national academy</json:string><json:string>kallestad diagnostics</json:string><json:string>second generation</json:string><json:string>serologic reactivities</json:string><json:string>university hospital gasthuisberg</json:string><json:string>genotype prevalence</json:string><json:string>internal medicine</json:string><json:string>rheumatoid arthritis</json:string><json:string>room temperature</json:string><json:string>rheumatoid factor</json:string><json:string>pancreatic diseases</json:string><json:string>concomitant infection</json:string><json:string>positive patients</json:string><json:string>progressive glomerulonephritis</json:string><json:string>infection</json:string></teeft></keywords><author><json:item><name>M. Willems</name><affiliations><json:string>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</json:string><json:string>Correspondence address: Division of Liver and Pancreatic Diseases, Department of Internal Medicine, University Hospital Gasthuisberg, B‐3000 Leuven, Belgium===</json:string></affiliations></json:item><json:item><name>L. Sheng</name><affiliations><json:string>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</json:string><json:string>Correspondence address: Division of Liver and Pancreatic Diseases, Department of Internal Medicine, University Hospital Gasthuisberg, B‐3000 Leuven, Belgium===</json:string></affiliations></json:item><json:item><name>T. Roskams</name><affiliations><json:string>Department of Pathology, University Hospital Sint‐Rafaël, Leuven, Belgium</json:string></affiliations></json:item><json:item><name>B. Ramdani</name><affiliations><json:string>Hǒspital Civil de Jumet, Charleroi, Belgium</json:string></affiliations></json:item><json:item><name>J. M. Doutrelepont</name><affiliations><json:string>Hǒpital Universitaire Erasme, Brussels, Belgium</json:string></affiliations></json:item><json:item><name>F. Nevens</name><affiliations><json:string>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</json:string></affiliations></json:item><json:item><name>P. Durez</name><affiliations><json:string>Hǒpital Universitaire Erasme, Brussels, Belgium</json:string></affiliations></json:item><json:item><name>S. Treille</name><affiliations><json:string>Hǒspital Civil de Jumet, Charleroi, Belgium</json:string></affiliations></json:item><json:item><name>M. Adler</name><affiliations><json:string>Hǒpital Universitaire Erasme, Brussels, Belgium</json:string></affiliations></json:item><json:item><name>V. Desmet</name><affiliations><json:string>Department of Pathology, University Hospital Sint‐Rafaël, Leuven, Belgium</json:string></affiliations></json:item><json:item><name>J. Fevery</name><affiliations><json:string>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</json:string></affiliations></json:item><json:item><name>Prof. Dr. S. H. Yap</name><affiliations><json:string>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</json:string><json:string>Correspondence address: Division of Liver and Pancreatic Diseases, Department of Internal Medicine, University Hospital Gasthuisberg, B‐3000 Leuven, Belgium===</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>glomerulonephritis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genotyping</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>non‐A</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>non‐B hepatitis</value></json:item></subject><articleId><json:string>JMV1890440310</json:string></articleId><arkIstex>ark:/67375/WNG-Z9JNH21Q-R</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Recently, evidence has been presented for a possible association between hepatitis C virus (HCV) infection and essential mixed cryoglobulinemia (EMC). Eleven consecutive patients with EMC and two with cryoglobulinemia type I were examined for the presence of markers of HCV infection. Eleven of 13 patients (10 with EMC and 1 with type I cryoglobulinemia) had anti‐HCV antibodies (as determined by a second generation anti‐HCV assay) and HCV‐RNA in plasma or serum. HCV‐RNA was also detected in liver biopsies of five patients. Genotyping showed that HCV genotype 1 was found in 10 of 11 patients with HCV‐RNA (9 genotype 1b and 1 genotype 1a) and only one patient had HCV genotype 2. However, a similar high prevalence of genotype 1b (100%) was found in a group of 14 consecutive patients with chronic hepatitis C, who had no clinical evidence of cryoglobulinemia. Concomitant infection was present in three patients with genotypes 2, 3 and 4, respectively. These findings stress the high prevalence of HCV infection in patients with EMC and further study shows that a difference in genotype prevalence was not found between HCV‐related EMC and chronic hepatitis C without clinical manifestations of EMC. © 1994 Wiley‐Liss, Inc.</abstract><qualityIndicators><score>8.491</score><pdfWordCount>4139</pdfWordCount><pdfCharCount>26217</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>576 x 791.759 pts</pdfPageSize><pdfWordsPerPage>690</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>196</abstractWordCount><abstractCharCount>1229</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia‐related syndrome</title><pmid><json:string>7531756</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Medical Virology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1096-9071</json:string></doi><issn><json:string>0146-6615</json:string></issn><eissn><json:string>1096-9071</json:string></eissn><publisherId><json:string>JMV</json:string></publisherId><volume>44</volume><issue>3</issue><pages><first>266</first><last>271</last><total>6</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Article</value></json:item><json:item><value>Articles</value></json:item></subject></host><namedEntities><unitex><date><json:string>between November 1991 and August 1993</json:string><json:string>1994</json:string></date><geogName></geogName><orgName><json:string>and Department of Pathology, University Hospital Sint-Rafael, Leuven</json:string><json:string>Department of Internal Medicine, University Hospital Gasthuisberg</json:string><json:string>Promega</json:string><json:string>Kallestad Diagnostics</json:string><json:string>Ortho Diagnostic Systems</json:string><json:string>Belgium Recently</json:string><json:string>Laboratory of Clinical Immunology, UZ St</json:string><json:string>Wiley-Liss, Inc</json:string><json:string>LISS, INC.</json:string><json:string>Laboratory Methods for Detection of Cryoglobulins</json:string><json:string>Department of Liver and Pancreatic Diseases</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>B. Ramdani</json:string><json:string>J. Fevery</json:string><json:string>Age</json:string><json:string>F. Nevens</json:string><json:string>Serum</json:string><json:string>M. Adler</json:string><json:string>J.M. Doutrelepont</json:string><json:string>T. Roskams</json:string><json:string>V. De Wilde</json:string><json:string>Jan Ziekenhuis</json:string><json:string>G. Marien</json:string><json:string>C. Van den Eynde</json:string><json:string>W. Van Steenbergen</json:string><json:string>Genotyping</json:string><json:string>L. Sheng</json:string><json:string>T. Crabbe</json:string><json:string>P. Durez</json:string><json:string>S.H. Yap</json:string><json:string>S. Treille</json:string><json:string>V. Desmet</json:string></persName><placeName><json:string>UK</json:string><json:string>Madison</json:string><json:string>Raritan</json:string><json:string>Brussels</json:string><json:string>Chaska</json:string><json:string>Leuven</json:string><json:string>NJ</json:string><json:string>WI</json:string><json:string>MN</json:string><json:string>Belgium</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Rollino et al. 119911</json:string><json:string>Willems et al.</json:string><json:string>Pozatto et al., 1991</json:string><json:string>Chan et al., 1991</json:string><json:string>Houghton et al., 19881</json:string><json:string>Misiani et al., 19921</json:string><json:string>Levo et al., 19771</json:string><json:string>Marson et al., 19911</json:string><json:string>Yoshioka et al., 19921</json:string><json:string>Takekoshi et al., 1991</json:string><json:string>Doutrelepont et al., 1993</json:string><json:string>Okamoto et al., 1991, 19921</json:string><json:string>Stuyver et al. 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[1976]</json:string><json:string>Newman and Frieman, 1992</json:string><json:string>Pozatto et al.</json:string><json:string>Lai and Lai, 19911</json:string><json:string>Bukh et al., 19931</json:string><json:string>Ferri et al., 1991b</json:string><json:string>Miller and Purcell, 19901</json:string><json:string>Ferri et al.</json:string><json:string>Misiani et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-Z9JNH21Q-R</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - virology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - virology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Virology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1994</publicationDate><copyrightDate>1994</copyrightDate><doi><json:string>10.1002/jmv.1890440310</json:string></doi><id>E1557BE6BC164A1B315C6914FFD82E7028F9056A</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-Z9JNH21Q-R/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-Z9JNH21Q-R/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-Z9JNH21Q-R/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia‐related syndrome</title><title level="a" type="short" xml:lang="en">HCV and Essential Mixed Cryoglobulinemia</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><availability><licence>Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company</licence></availability><date type="published" when="1994-11"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia‐related syndrome</title><title level="a" type="short" xml:lang="en">HCV and Essential Mixed Cryoglobulinemia</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">M.</forename><surname>Willems</surname></persName><affiliation><orgName type="division">Department of Internal Medicine</orgName><orgName type="institution">University Hospital Gasthuisberg</orgName><address><addrLine>Leuven</addrLine><addrLine>Belgium</addrLine><country key="BE" xml:lang="en">BELGIUM</country></address></affiliation></author><author xml:id="author-0001" role="corresp"><persName><forename type="first">L.</forename><surname>Sheng</surname></persName><affiliation><orgName type="division">Department of Internal Medicine</orgName><orgName type="institution">University Hospital Gasthuisberg</orgName><address><addrLine>Leuven</addrLine><addrLine>Belgium</addrLine><country key="BE" xml:lang="en">BELGIUM</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">T.</forename><surname>Roskams</surname></persName><affiliation><orgName type="department">Department of Pathology</orgName><orgName type="institution">University Hospital Sint‐Rafaël</orgName><address><addrLine>Leuven</addrLine><addrLine>Belgium</addrLine><country key="BE" xml:lang="en">BELGIUM</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">B.</forename><surname>Ramdani</surname></persName><affiliation><address><addrLine>Hǒspital Civil de Jumet</addrLine><addrLine>Charleroi, Belgium</addrLine><country key="BE" xml:lang="en">BELGIUM</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">J. 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Eleven consecutive patients with EMC and two with cryoglobulinemia type I were examined for the presence of markers of HCV infection. Eleven of 13 patients (10 with EMC and 1 with type I cryoglobulinemia) had anti‐HCV antibodies (as determined by a second generation anti‐HCV assay) and HCV‐RNA in plasma or serum. HCV‐RNA was also detected in liver biopsies of five patients.</p><p>Genotyping showed that HCV genotype 1 was found in 10 of 11 patients with HCV‐RNA (9 genotype 1b and 1 genotype 1a) and only one patient had HCV genotype 2. However, a similar high prevalence of genotype 1b (100%) was found in a group of 14 consecutive patients with chronic hepatitis C, who had no clinical evidence of cryoglobulinemia. Concomitant infection was present in three patients with genotypes 2, 3 and 4, respectively.</p><p>These findings stress the high prevalence of HCV infection in patients with EMC and further study shows that a difference in genotype prevalence was not found between HCV‐related EMC and chronic hepatitis C without clinical manifestations of EMC. © 1994 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia‐related syndrome</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>HCV and Essential Mixed Cryoglobulinemia</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia‐related syndrome</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Willems</namePart><affiliation>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</affiliation><affiliation>Correspondence address: Division of Liver and Pancreatic Diseases, Department of Internal Medicine, University Hospital Gasthuisberg, B‐3000 Leuven, Belgium===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Sheng</namePart><affiliation>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</affiliation><affiliation>Correspondence address: Division of Liver and Pancreatic Diseases, Department of Internal Medicine, University Hospital Gasthuisberg, B‐3000 Leuven, Belgium===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Roskams</namePart><affiliation>Department of Pathology, University Hospital Sint‐Rafaël, Leuven, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Ramdani</namePart><affiliation>Hǒspital Civil de Jumet, Charleroi, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. M.</namePart><namePart type="family">Doutrelepont</namePart><affiliation>Hǒpital Universitaire Erasme, Brussels, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Nevens</namePart><affiliation>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Durez</namePart><affiliation>Hǒpital Universitaire Erasme, Brussels, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Treille</namePart><affiliation>Hǒspital Civil de Jumet, Charleroi, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Adler</namePart><affiliation>Hǒpital Universitaire Erasme, Brussels, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Desmet</namePart><affiliation>Department of Pathology, University Hospital Sint‐Rafaël, Leuven, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Fevery</namePart><affiliation>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Prof. Dr.</namePart><namePart type="given">S. H.</namePart><namePart type="family">Yap</namePart><affiliation>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium</affiliation><affiliation>Correspondence address: Division of Liver and Pancreatic Diseases, Department of Internal Medicine, University Hospital Gasthuisberg, B‐3000 Leuven, Belgium===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">1994-11</dateIssued><dateValid encoding="w3cdtf">1994-03-01</dateValid><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">0</extent><extent unit="tables">4</extent><extent unit="references">39</extent></physicalDescription><abstract lang="en">Recently, evidence has been presented for a possible association between hepatitis C virus (HCV) infection and essential mixed cryoglobulinemia (EMC). Eleven consecutive patients with EMC and two with cryoglobulinemia type I were examined for the presence of markers of HCV infection. Eleven of 13 patients (10 with EMC and 1 with type I cryoglobulinemia) had anti‐HCV antibodies (as determined by a second generation anti‐HCV assay) and HCV‐RNA in plasma or serum. HCV‐RNA was also detected in liver biopsies of five patients. Genotyping showed that HCV genotype 1 was found in 10 of 11 patients with HCV‐RNA (9 genotype 1b and 1 genotype 1a) and only one patient had HCV genotype 2. However, a similar high prevalence of genotype 1b (100%) was found in a group of 14 consecutive patients with chronic hepatitis C, who had no clinical evidence of cryoglobulinemia. Concomitant infection was present in three patients with genotypes 2, 3 and 4, respectively. These findings stress the high prevalence of HCV infection in patients with EMC and further study shows that a difference in genotype prevalence was not found between HCV‐related EMC and chronic hepatitis C without clinical manifestations of EMC. © 1994 Wiley‐Liss, Inc.</abstract><note type="funding">Levenslijn</note><subject lang="en"><genre>keywords</genre><topic>glomerulonephritis</topic><topic>genotyping</topic><topic>non‐A</topic><topic>non‐B hepatitis</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Medical Virology</title></titleInfo><titleInfo type="abbreviated"><title>J. Med. 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Hepatology 16: 293–299.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>293</start><end>299</end></extent></part><relatedItem type="host"><titleInfo><title>Hepatology</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>293</start><end>299</end></extent></part></relatedItem></relatedItem><identifier type="istex">E1557BE6BC164A1B315C6914FFD82E7028F9056A</identifier><identifier type="ark">ark:/67375/WNG-Z9JNH21Q-R</identifier><identifier type="DOI">10.1002/jmv.1890440310</identifier><identifier type="ArticleID">JMV1890440310</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-15</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-Z9JNH21Q-R/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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