Nanosphere Lithography as a Versatile Method to Generate Surface‐Imprinted Polymer Films for Selective Protein Recognition
Identifieur interne : 001337 ( Istex/Corpus ); précédent : 001336; suivant : 001338Nanosphere Lithography as a Versatile Method to Generate Surface‐Imprinted Polymer Films for Selective Protein Recognition
Auteurs : Júlia Bognár ; Júlia Sz Cs ; Zsanett Dork ; Viola Horváth ; R Bert E. GyurcsányiSource :
- Advanced Functional Materials [ 1616-301X ] ; 2013-10-04.
English descriptors
- Teeft :
- Adsorption, Anal, Aqueous solution, Avidin, Bead, Bead conjugates, Beads, Binding isotherms, Binding sites, Bovine serum albumin, Carrier buffer, Carrier solution, Chem, Cleavable crosslinker, Compact layer, Electrical charge, Electropolymerization, Full paper, Funct, Gmbh, Heterobifunctional crosslinker, Imprinting, Imprinting factor, Kgaa, Lithography, Macromolecular template, Mater, Mips, Nanogravimetric measurements, Nanosphere, Nanosphere lithography, Polymer, Polymer surface, Polystyrene beads, Preferential growth, Protein imprinting, Protein target, Quartz, Quartz crystal resonator, Quartz crystals, Selective protein recognition, Sigma aldrich, Successive steps, Target molecule, Verlag, Verlag gmbh, Weinheim.
Abstract
A versatile approach based on nanosphere lithography is proposed to generate surface‐imprinted polymers for selective protein recognition. A layer of 750 nm diameter latex bead‐protein conjugate is deposited onto the surface of gold‐coated quartz crystals followed by the electrosynthesis of a poly(3,4‐ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) film with thicknesses on the order of the bead radius. The removal of the polymer bead‐protein conjugates, facilitated by using a cleavable protein‐nanosphere linkage is shown to result in 2D arrays of periodic complementary size cavities. Here it is demonstrated by nanogravimetric measurements that the imprinting proceeds further at molecular level and the protein (avidin) coating of the beads generates selective recognition sites for avidin on the surface of the PEDOT/PSS film. The binding capacity of such surface‐imprinted polymer films is ca. 6.5 times higher than that of films imprinted with unmodified beads. They also exhibit excellent selectivity against analogues of avidin, i.e., extravidin, streptavidin, and neutravidin, the latter being in fact undetectable. This methodology, if coupled with properly oriented conjugation of the macromolecular template to the nanoparticles, offers the possibility of site‐directed imprinting.
A versatile approach based on nanosphere lithography is proposed to generate surface‐imprinted polymers for selective protein recognition. Nanogravimetric measurements demonstrate that the protein (avidin) coating of the nanospheres generates selective recognition sites for avidin on the surface of the PEDOT/PSS film. This methodology coupled with oriented conjugation of the macromolecular template to the nanospheres offers the possibility of site‐directed imprinting.
Url:
DOI: 10.1002/adfm.201300113
Links to Exploration step
ISTEX:7C997DB092E3D292DBA571E8F3B4521C6DF234E9Le document en format XML
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Gellért tér 4, Budapest, H‐1111, Hungary.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Advanced Functional Materials</title><title level="j" type="alt">ADVANCED FUNCTIONAL MATERIALS</title><idno type="ISSN">1616-301X</idno><idno type="eISSN">1616-3028</idno><imprint><biblScope unit="vol">23</biblScope><biblScope unit="issue">37</biblScope><biblScope unit="page" from="4703">4703</biblScope><biblScope unit="page" to="4709">4709</biblScope><biblScope unit="page-count">7</biblScope><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2013-10-04">2013-10-04</date></imprint><idno type="ISSN">1616-301X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1616-301X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adsorption</term><term>Anal</term><term>Aqueous solution</term><term>Avidin</term><term>Bead</term><term>Bead conjugates</term><term>Beads</term><term>Binding isotherms</term><term>Binding sites</term><term>Bovine serum albumin</term><term>Carrier buffer</term><term>Carrier solution</term><term>Chem</term><term>Cleavable crosslinker</term><term>Compact layer</term><term>Electrical charge</term><term>Electropolymerization</term><term>Full paper</term><term>Funct</term><term>Gmbh</term><term>Heterobifunctional crosslinker</term><term>Imprinting</term><term>Imprinting factor</term><term>Kgaa</term><term>Lithography</term><term>Macromolecular template</term><term>Mater</term><term>Mips</term><term>Nanogravimetric measurements</term><term>Nanosphere</term><term>Nanosphere lithography</term><term>Polymer</term><term>Polymer surface</term><term>Polystyrene beads</term><term>Preferential growth</term><term>Protein imprinting</term><term>Protein target</term><term>Quartz</term><term>Quartz crystal resonator</term><term>Quartz crystals</term><term>Selective protein recognition</term><term>Sigma aldrich</term><term>Successive steps</term><term>Target molecule</term><term>Verlag</term><term>Verlag gmbh</term><term>Weinheim</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A versatile approach based on nanosphere lithography is proposed to generate surface‐imprinted polymers for selective protein recognition. A layer of 750 nm diameter latex bead‐protein conjugate is deposited onto the surface of gold‐coated quartz crystals followed by the electrosynthesis of a poly(3,4‐ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) film with thicknesses on the order of the bead radius. The removal of the polymer bead‐protein conjugates, facilitated by using a cleavable protein‐nanosphere linkage is shown to result in 2D arrays of periodic complementary size cavities. Here it is demonstrated by nanogravimetric measurements that the imprinting proceeds further at molecular level and the protein (avidin) coating of the beads generates selective recognition sites for avidin on the surface of the PEDOT/PSS film. The binding capacity of such surface‐imprinted polymer films is ca. 6.5 times higher than that of films imprinted with unmodified beads. They also exhibit excellent selectivity against analogues of avidin, i.e., extravidin, streptavidin, and neutravidin, the latter being in fact undetectable. This methodology, if coupled with properly oriented conjugation of the macromolecular template to the nanoparticles, offers the possibility of site‐directed imprinting.</div><div type="abstract" xml:lang="en">A versatile approach based on nanosphere lithography is proposed to generate surface‐imprinted polymers for selective protein recognition. Nanogravimetric measurements demonstrate that the protein (avidin) coating of the nanospheres generates selective recognition sites for avidin on the surface of the PEDOT/PSS film. 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Gellért tér 4, Budapest, H‐1111, Hungary</json:string></affiliations></json:item><json:item><name>Júlia Szűcs</name><affiliations><json:string>Research Group for Technical Analytical Chemistry, Hungarian Academy of Sciences, Szt. Gellért tér 4, Budapest, H‐1111, Hungary</json:string></affiliations></json:item><json:item><name>Zsanett Dorkó</name><affiliations><json:string>Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellért tér 4, Budapest, H‐1111, Hungary</json:string></affiliations></json:item><json:item><name>Viola Horváth</name><affiliations><json:string>Research Group for Technical Analytical Chemistry, Hungarian Academy of Sciences, Szt. Gellért tér 4, Budapest, H‐1111, Hungary</json:string></affiliations></json:item><json:item><name>Róbert E. Gyurcsányi</name><affiliations><json:string>Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellért tér 4, Budapest, H‐1111, Hungary</json:string><json:string>Research Group for Technical Analytical Chemistry, Hungarian Academy of Sciences, Szt. Gellért tér 4, Budapest, H‐1111, Hungary</json:string><json:string>E-mail: robertgy@mail.bme.hu</json:string><json:string>Correspondence address: Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. 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A layer of 750 nm diameter latex bead‐protein conjugate is deposited onto the surface of gold‐coated quartz crystals followed by the electrosynthesis of a poly(3,4‐ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) film with thicknesses on the order of the bead radius. The removal of the polymer bead‐protein conjugates, facilitated by using a cleavable protein‐nanosphere linkage is shown to result in 2D arrays of periodic complementary size cavities. Here it is demonstrated by nanogravimetric measurements that the imprinting proceeds further at molecular level and the protein (avidin) coating of the beads generates selective recognition sites for avidin on the surface of the PEDOT/PSS film. The binding capacity of such surface‐imprinted polymer films is ca. 6.5 times higher than that of films imprinted with unmodified beads. They also exhibit excellent selectivity against analogues of avidin, i.e., extravidin, streptavidin, and neutravidin, the latter being in fact undetectable. This methodology, if coupled with properly oriented conjugation of the macromolecular template to the nanoparticles, offers the possibility of site‐directed imprinting.</abstract><qualityIndicators><score>8.896</score><pdfWordCount>4772</pdfWordCount><pdfCharCount>29563</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>7</pdfPageCount><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><pdfWordsPerPage>682</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>177</abstractWordCount><abstractCharCount>1309</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Nanosphere Lithography as a Versatile Method to Generate Surface‐Imprinted Polymer Films for Selective Protein Recognition</title><genre><json:string>article</json:string></genre><host><title>Advanced Functional Materials</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1616-3028</json:string></doi><issn><json:string>1616-301X</json:string></issn><eissn><json:string>1616-3028</json:string></eissn><publisherId><json:string>ADFM</json:string></publisherId><volume>23</volume><issue>37</issue><pages><first>4703</first><last>4709</last><total>7</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Full Paper</value></json:item><json:item><value>Full Papers</value></json:item></subject></host><namedEntities><unitex><date><json:string>2013</json:string></date><geogName></geogName><orgName><json:string>Gamry Instruments</json:string><json:string>Millipore Corporation</json:string><json:string>Research Group for Technical Analytical Chemistry Hungarian Academy of Sciences Szt</json:string><json:string>Microchem</json:string><json:string>Als Co.</json:string><json:string>Budapest University</json:string><json:string>Hungary DOI</json:string><json:string>LightForm Inc.</json:string><json:string>Pierce Chemical Co</json:string><json:string>ROMIL</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>J. 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KGaA, Weinheim</licence></availability><date type="published" when="2013-10-04"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Nanosphere Lithography as a Versatile Method to Generate Surface‐Imprinted Polymer Films for Selective Protein Recognition</title><author xml:id="author-0000"><persName><forename type="first">Júlia</forename><surname>Bognár</surname></persName><affiliation><orgName type="division">Department of Inorganic and Analytical Chemistry</orgName><orgName type="institution">Budapest University of Technology and Economics</orgName><address><addrLine>Szt. 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<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>A versatile approach based on nanosphere lithography is proposed to generate surface‐imprinted polymers for selective protein recognition. A layer of 750 nm diameter latex bead‐protein conjugate is deposited onto the surface of gold‐coated quartz crystals followed by the electrosynthesis of a poly(3,4‐ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) film with thicknesses on the order of the bead radius. The removal of the polymer bead‐protein conjugates, facilitated by using a cleavable protein‐nanosphere linkage is shown to result in 2D arrays of periodic complementary size cavities. Here it is demonstrated by nanogravimetric measurements that the imprinting proceeds further at molecular level and the protein (avidin) coating of the beads generates selective recognition sites for avidin on the surface of the PEDOT/PSS film. The binding capacity of such surface‐imprinted polymer films is ca. 6.5 times higher than that of films imprinted with unmodified beads. They also exhibit excellent selectivity against analogues of avidin, i.e., extravidin, streptavidin, and neutravidin, the latter being in fact undetectable. This methodology, if coupled with properly oriented conjugation of the macromolecular template to the nanoparticles, offers the possibility of site‐directed imprinting.</p></abstract><abstract xml:lang="en" style="graphical"><p><hi rend="bold">A versatile approach based on nanosphere lithography</hi> is proposed to generate surface‐imprinted polymers for selective protein recognition. Nanogravimetric measurements demonstrate that the protein (avidin) coating of the nanospheres generates selective recognition sites for avidin on the surface of the PEDOT/PSS film. This methodology coupled with oriented conjugation of the macromolecular template to the nanospheres offers the possibility of site‐directed imprinting.
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KGaA, Weinheim</copyright><eventGroup><event type="manuscriptReceived" date="2013-01-10"></event><event type="manuscriptRevised" date="2013-02-15"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.2.5 mode:FullText" date="2013-10-01"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-04-11"></event><event type="firstOnline" date="2013-04-11"></event><event type="publishedOnlineFinalForm" date="2013-10-01"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2013-12-31"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-02"></event></eventGroup><numberingGroup><numbering type="pageFirst">4703</numbering><numbering type="pageLast">4709</numbering></numberingGroup><correspondenceTo>Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. 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</p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:1616301X:media:adfm201300113:adfm_201300113_sm_suppl"></mediaResource><caption>suppl</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>A versatile approach based on nanosphere lithography is proposed to generate surface‐imprinted polymers for selective protein recognition. A layer of 750 nm diameter latex bead‐protein conjugate is deposited onto the surface of gold‐coated quartz crystals followed by the electrosynthesis of a poly(3,4‐ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) film with thicknesses on the order of the bead radius. The removal of the polymer bead‐protein conjugates, facilitated by using a cleavable protein‐nanosphere linkage is shown to result in 2D arrays of periodic complementary size cavities. Here it is demonstrated by nanogravimetric measurements that the imprinting proceeds further at molecular level and the protein (avidin) coating of the beads generates selective recognition sites for avidin on the surface of the PEDOT/PSS film. The binding capacity of such surface‐imprinted polymer films is ca. 6.5 times higher than that of films imprinted with unmodified beads. They also exhibit excellent selectivity against analogues of avidin, i.e., extravidin, streptavidin, and neutravidin, the latter being in fact undetectable. This methodology, if coupled with properly oriented conjugation of the macromolecular template to the nanoparticles, offers the possibility of site‐directed imprinting.</p></abstract><abstract type="graphical" xml:lang="en"><p><b>A versatile approach based on nanosphere lithography</b> is proposed to generate surface‐imprinted polymers for selective protein recognition. Nanogravimetric measurements demonstrate that the protein (avidin) coating of the nanospheres generates selective recognition sites for avidin on the surface of the PEDOT/PSS film. This methodology coupled with oriented conjugation of the macromolecular template to the nanospheres offers the possibility of site‐directed imprinting.
<blockFixed type="graphic"><mediaResourceGroup><mediaResource alt="image" eRights="yes" copyright="WILEY-VCH" href="urn:x-wiley:1616301X:media:ADFM201300113:content"></mediaResource></mediaResourceGroup></blockFixed></p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Nanosphere Lithography as a Versatile Method to Generate Surface‐Imprinted Polymer Films for Selective Protein Recognition</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Nanosphere Lithography as a Versatile Method to Generate Surface‐Imprinted Polymer Films for Selective Protein Recognition</title></titleInfo><name type="personal"><namePart type="given">Júlia</namePart><namePart type="family">Bognár</namePart><affiliation>Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. 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Gellért tér 4, Budapest, H‐1111, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Róbert E.</namePart><namePart type="family">Gyurcsányi</namePart><affiliation>Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellért tér 4, Budapest, H‐1111, Hungary</affiliation><affiliation>Research Group for Technical Analytical Chemistry, Hungarian Academy of Sciences, Szt. Gellért tér 4, Budapest, H‐1111, Hungary</affiliation><affiliation>E-mail: robertgy@mail.bme.hu</affiliation><affiliation>Correspondence address: Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellért tér 4, Budapest, H‐1111, Hungary.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>WILEY‐VCH Verlag</publisher><place><placeTerm type="text">Weinheim</placeTerm></place><dateIssued encoding="w3cdtf">2013-10-04</dateIssued><dateCaptured encoding="w3cdtf">2013-01-10</dateCaptured><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">6</extent><extent unit="references">36</extent></physicalDescription><abstract lang="en">A versatile approach based on nanosphere lithography is proposed to generate surface‐imprinted polymers for selective protein recognition. A layer of 750 nm diameter latex bead‐protein conjugate is deposited onto the surface of gold‐coated quartz crystals followed by the electrosynthesis of a poly(3,4‐ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) film with thicknesses on the order of the bead radius. The removal of the polymer bead‐protein conjugates, facilitated by using a cleavable protein‐nanosphere linkage is shown to result in 2D arrays of periodic complementary size cavities. Here it is demonstrated by nanogravimetric measurements that the imprinting proceeds further at molecular level and the protein (avidin) coating of the beads generates selective recognition sites for avidin on the surface of the PEDOT/PSS film. The binding capacity of such surface‐imprinted polymer films is ca. 6.5 times higher than that of films imprinted with unmodified beads. They also exhibit excellent selectivity against analogues of avidin, i.e., extravidin, streptavidin, and neutravidin, the latter being in fact undetectable. This methodology, if coupled with properly oriented conjugation of the macromolecular template to the nanoparticles, offers the possibility of site‐directed imprinting.</abstract><abstract type="graphical" lang="en">A versatile approach based on nanosphere lithography is proposed to generate surface‐imprinted polymers for selective protein recognition. Nanogravimetric measurements demonstrate that the protein (avidin) coating of the nanospheres generates selective recognition sites for avidin on the surface of the PEDOT/PSS film. This methodology coupled with oriented conjugation of the macromolecular template to the nanospheres offers the possibility of site‐directed imprinting.</abstract><subject lang="en"><genre>keywords</genre><topic>molecularly imprinted polymers</topic><topic>surface imprinting</topic><topic>protein recognition</topic><topic>nanosphere lithography</topic><topic>PEDOT/PSS</topic></subject><relatedItem type="host"><titleInfo><title>Advanced Functional Materials</title></titleInfo><titleInfo type="abbreviated"><title>Adv. Funct. Mater.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><note type="content"> As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset. 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