The renaturation of deoxyribonucleic acids. I. Rates of bimolecular reactions of complementary and noncomplementary Gaussian chains
Identifieur interne : 001316 ( Istex/Corpus ); précédent : 001315; suivant : 001317The renaturation of deoxyribonucleic acids. I. Rates of bimolecular reactions of complementary and noncomplementary Gaussian chains
Auteurs : Akiyoshi Wada ; Hiroko YamagamiSource :
- Biopolymers [ 0006-3525 ] ; 1964-10.
Abstract
The mechanism of the renaturation of DNA molecules is examined on the basis of the bimolecular interaction of Gaussian chain polymers. In the nucleus formation by hydrogen bonding in segment–segment interaction, two types of interchain interaction, that is, one between complementary chains and one between noncomplementary chains, and one noncomplementary intrachain interaction are considered to be, in competition. Several previously observed characteristics of the renaturation process are displayed by this simple model. In particular it accounts for the dependence of the extent of renaturation on the heterogeneity, molecular weight, and radius of gyration of DNA, and of the ratios of the reaction rates between complementary and noncomplementary segments. Among these variables the ratio of reaction rates has shown to have a quite specific value, as high as the order of 104, which favors the complementary‐strand interaction. This very great bias in favor of complementary strand interaction emphasizes that the renaturation phenomena displays the same character of biological specificity that is associated with enzyme–substrate interaction or antigen–antibody interaction. Moreover, since DNA is a good example of a one‐dimensional system, it seems to provide a suitable clue for pursuing the analysis of pattern recognition at the macromolecular level.
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DOI: 10.1002/bip.1964.360020504
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This very great bias in favor of complementary strand interaction emphasizes that the renaturation phenomena displays the same character of biological specificity that is associated with enzyme–substrate interaction or antigen–antibody interaction. 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Rates of bimolecular reactions of complementary and noncomplementary Gaussian chains</title><title type="short" xml:lang="en">RENATURATION OF DEOXYRIBONUCLEIC ACIDS</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Akiyoshi</givenNames><familyName>Wada</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Hiroko</givenNames><familyName>Yamagami</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="JP" type="organization"><unparsedAffiliation>Department of Physics, Faculty of Science, The University of Tokyo, Bunkyo‐ku, Tokyo</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="JP" type="organization"><unparsedAffiliation>National Institute of Radiological Science, Kurosuna, Chiba, Japan</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The mechanism of the renaturation of DNA molecules is examined on the basis of the bimolecular interaction of Gaussian chain polymers. In the nucleus formation by hydrogen bonding in segment–segment interaction, two types of interchain interaction, that is, one between complementary chains and one between noncomplementary chains, and one noncomplementary intrachain interaction are considered to be, in competition. Several previously observed characteristics of the renaturation process are displayed by this simple model. In particular it accounts for the dependence of the extent of renaturation on the heterogeneity, molecular weight, and radius of gyration of DNA, and of the ratios of the reaction rates between complementary and noncomplementary segments. Among these variables the ratio of reaction rates has shown to have a quite specific value, as high as the order of 10<sup>4</sup>, which favors the complementary‐strand interaction. This very great bias in favor of complementary strand interaction emphasizes that the renaturation phenomena displays the same character of biological specificity that is associated with enzyme–substrate interaction or antigen–antibody interaction. Moreover, since DNA is a good example of a one‐dimensional system, it seems to provide a suitable clue for pursuing the analysis of <i>pattern recognition</i> at the macromolecular level.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The renaturation of deoxyribonucleic acids. I. Rates of bimolecular reactions of complementary and noncomplementary Gaussian chains</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>RENATURATION OF DEOXYRIBONUCLEIC ACIDS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The renaturation of deoxyribonucleic acids. I. Rates of bimolecular reactions of complementary and noncomplementary Gaussian chains</title></titleInfo><name type="personal"><namePart type="given">Akiyoshi</namePart><namePart type="family">Wada</namePart><affiliation>Department of Physics, Faculty of Science, The University of Tokyo, Bunkyo‐ku, Tokyo</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hiroko</namePart><namePart type="family">Yamagami</namePart><affiliation>National Institute of Radiological Science, Kurosuna, Chiba, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1964-10</dateIssued><dateCaptured encoding="w3cdtf">1964-07-22</dateCaptured><copyrightDate encoding="w3cdtf">1964</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">8</extent><extent unit="tables">0</extent><extent unit="references">17</extent></physicalDescription><abstract lang="en">The mechanism of the renaturation of DNA molecules is examined on the basis of the bimolecular interaction of Gaussian chain polymers. In the nucleus formation by hydrogen bonding in segment–segment interaction, two types of interchain interaction, that is, one between complementary chains and one between noncomplementary chains, and one noncomplementary intrachain interaction are considered to be, in competition. Several previously observed characteristics of the renaturation process are displayed by this simple model. In particular it accounts for the dependence of the extent of renaturation on the heterogeneity, molecular weight, and radius of gyration of DNA, and of the ratios of the reaction rates between complementary and noncomplementary segments. Among these variables the ratio of reaction rates has shown to have a quite specific value, as high as the order of 104, which favors the complementary‐strand interaction. This very great bias in favor of complementary strand interaction emphasizes that the renaturation phenomena displays the same character of biological specificity that is associated with enzyme–substrate interaction or antigen–antibody interaction. Moreover, since DNA is a good example of a one‐dimensional system, it seems to provide a suitable clue for pursuing the analysis of pattern recognition at the macromolecular level.</abstract><relatedItem type="host"><titleInfo><title>Biopolymers</title><subTitle>Original Research on Biomolecules</subTitle></titleInfo><titleInfo type="abbreviated"><title>Biopolymers</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Article</topic><topic>Articles</topic></subject><identifier type="ISSN">0006-3525</identifier><identifier type="eISSN">1097-0282</identifier><identifier type="DOI">10.1002/(ISSN)1097-0282</identifier><identifier type="PublisherID">BIP</identifier><part><date>1964</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>445</start><end>462</end><total>18</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>See the comprehensive review written byJ. 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|texte= The renaturation of deoxyribonucleic acids. I. Rates of bimolecular reactions of complementary and noncomplementary Gaussian chains
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