A clearance test in mice using non-adapted viruses to determine the immunogenicity of influenza strains
Identifieur interne : 001165 ( Istex/Corpus ); précédent : 001164; suivant : 001166A clearance test in mice using non-adapted viruses to determine the immunogenicity of influenza strains
Auteurs : G. A. Tannock ; Margaret C. Wark ; Linda E. Smith ; Megan M. SutherlandSource :
- Archives of Virology [ 0304-8608 ] ; 1981-06-01.
English descriptors
- Teeft :
- Better immunogen, Cell line, Cent seroeonverting dose, Challenge virus, Challenge viruses, Chicken sera, Clearance, Clearance test, Complete clearance, Control group, Control mice, Dos, Human vaccines, Immunizing dose, Immunogenic response, Immunogenicity, Immunogenie response, Individual serum titers, Influenza, Influenza strain, Influenza strains, Influenza vaccines, Influenza virus, Influenza viruses, Intranasal route, Least times, Lung extracts, Matrix protein, Mouse, Other studies, Respiratory symptoms, Same manner, Same virus, Serial passage, Significant reduction, Tcids0, Unpublished observations, Vaccinated, Vaccinated group, Vaccination, Vaccine, Various influenza strains, Virus, Virus growth, Virus yields, Vivo clearance test.
Abstract
Summary: A test for the immunogenicity of influenza viruses is described, which is based upon the intranasal vaccinating dose required to induce inhibition of multiplication of unadapted influenza viruses in the lungs of mice. This test is more sensitive than an antigen extinction procedure, in which immunogenicity is measured according to the dose required to induce the formation of hemagglutination-inhibition antibody. The clearance test has been used to demonstrate that a) influenza A/Northern Territory/60/68 virus is a better imunogen than A/Victoria/3/75 and both are probably superior to A/U.S.S.R./92/77; b) for A/Northern Territory/60/68, vaccination by the intranasal route in 25 g mice is at least 43,600 times more efficient than by the intraperitoneal route and c) common immunogenic relationships exist between various H3N2 viruses and an H1N1 strain.
Url:
DOI: 10.1007/BF01315003
Links to Exploration step
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<Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Linda</GivenName>
<GivenName>E.</GivenName>
<FamilyName>Smith</FamilyName>
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<Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Megan</GivenName>
<GivenName>M.</GivenName>
<FamilyName>Sutherland</FamilyName>
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<Affiliation ID="Aff1"><OrgName>Commonwealth Serum Laboratories</OrgName>
<OrgAddress><City>Parkville</City>
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<Country>Australia</Country>
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<Affiliation ID="Aff2"><OrgDivision>Faculty of Medicine</OrgDivision>
<OrgName>The University of Newcastle</OrgName>
<OrgAddress><Postcode>2308</Postcode>
<City>Newcastle</City>
<State>New south Wales</State>
<Country>Australia</Country>
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<Abstract ID="Abs1" Language="En"><Heading>Summary</Heading>
<Para>A test for the immunogenicity of influenza viruses is described, which is based upon the intranasal vaccinating dose required to induce inhibition of multiplication of unadapted influenza viruses in the lungs of mice. This test is more sensitive than an antigen extinction procedure, in which immunogenicity is measured according to the dose required to induce the formation of hemagglutination-inhibition antibody. The clearance test has been used to demonstrate that a) influenza A/Northern Territory/60/68 virus is a better imunogen than A/Victoria/3/75 and both are probably superior to A/U.S.S.R./92/77; b) for A/Northern Territory/60/68, vaccination by the intranasal route in 25 g mice is at least 43,600 times more efficient than by the intraperitoneal route and c) common immunogenic relationships exist between various H3N2 viruses and an H1N1 strain.</Para>
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<name type="personal"><namePart type="given">G.</namePart>
<namePart type="given">A.</namePart>
<namePart type="family">Tannock</namePart>
<affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</affiliation>
<affiliation>Faculty of Medicine, The University of Newcastle, 2308, Newcastle, New south Wales, Australia</affiliation>
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<name type="personal"><namePart type="given">Margaret</namePart>
<namePart type="given">C.</namePart>
<namePart type="family">Wark</namePart>
<affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</affiliation>
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<name type="personal"><namePart type="given">Linda</namePart>
<namePart type="given">E.</namePart>
<namePart type="family">Smith</namePart>
<affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</affiliation>
<role><roleTerm type="text">author</roleTerm>
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<name type="personal"><namePart type="given">Megan</namePart>
<namePart type="given">M.</namePart>
<namePart type="family">Sutherland</namePart>
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<abstract lang="en">Summary: A test for the immunogenicity of influenza viruses is described, which is based upon the intranasal vaccinating dose required to induce inhibition of multiplication of unadapted influenza viruses in the lungs of mice. This test is more sensitive than an antigen extinction procedure, in which immunogenicity is measured according to the dose required to induce the formation of hemagglutination-inhibition antibody. The clearance test has been used to demonstrate that a) influenza A/Northern Territory/60/68 virus is a better imunogen than A/Victoria/3/75 and both are probably superior to A/U.S.S.R./92/77; b) for A/Northern Territory/60/68, vaccination by the intranasal route in 25 g mice is at least 43,600 times more efficient than by the intraperitoneal route and c) common immunogenic relationships exist between various H3N2 viruses and an H1N1 strain.</abstract>
<note>Original Papers</note>
<relatedItem type="host"><titleInfo><title>Archives of Virology</title>
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<subject><genre>Biomedicine</genre>
<topic>Medical Microbiology</topic>
<topic>Virology</topic>
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<identifier type="ISSN">0304-8608</identifier>
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