A clearance test in mice using non-adapted viruses to determine the immunogenicity of influenza strains
Identifieur interne : 001165 ( Istex/Corpus ); précédent : 001164; suivant : 001166A clearance test in mice using non-adapted viruses to determine the immunogenicity of influenza strains
Auteurs : G. A. Tannock ; Margaret C. Wark ; Linda E. Smith ; Megan M. SutherlandSource :
- Archives of Virology [ 0304-8608 ] ; 1981-06-01.
English descriptors
- Teeft :
- Better immunogen, Cell line, Cent seroeonverting dose, Challenge virus, Challenge viruses, Chicken sera, Clearance, Clearance test, Complete clearance, Control group, Control mice, Dos, Human vaccines, Immunizing dose, Immunogenic response, Immunogenicity, Immunogenie response, Individual serum titers, Influenza, Influenza strain, Influenza strains, Influenza vaccines, Influenza virus, Influenza viruses, Intranasal route, Least times, Lung extracts, Matrix protein, Mouse, Other studies, Respiratory symptoms, Same manner, Same virus, Serial passage, Significant reduction, Tcids0, Unpublished observations, Vaccinated, Vaccinated group, Vaccination, Vaccine, Various influenza strains, Virus, Virus growth, Virus yields, Vivo clearance test.
Abstract
Summary: A test for the immunogenicity of influenza viruses is described, which is based upon the intranasal vaccinating dose required to induce inhibition of multiplication of unadapted influenza viruses in the lungs of mice. This test is more sensitive than an antigen extinction procedure, in which immunogenicity is measured according to the dose required to induce the formation of hemagglutination-inhibition antibody. The clearance test has been used to demonstrate that a) influenza A/Northern Territory/60/68 virus is a better imunogen than A/Victoria/3/75 and both are probably superior to A/U.S.S.R./92/77; b) for A/Northern Territory/60/68, vaccination by the intranasal route in 25 g mice is at least 43,600 times more efficient than by the intraperitoneal route and c) common immunogenic relationships exist between various H3N2 viruses and an H1N1 strain.
Url:
DOI: 10.1007/BF01315003
Links to Exploration step
ISTEX:F0D4D1DC0DFA2504515C853FF0A973A8E78C2A37Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A clearance test in mice using non-adapted viruses to determine the immunogenicity of influenza strains</title><author><name sortKey="Tannock, G A" sort="Tannock, G A" uniqKey="Tannock G" first="G. A." last="Tannock">G. A. Tannock</name><affiliation><mods:affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Faculty of Medicine, The University of Newcastle, 2308, Newcastle, New south Wales, Australia</mods:affiliation></affiliation></author><author><name sortKey="Wark, Margaret C" sort="Wark, Margaret C" uniqKey="Wark M" first="Margaret C." last="Wark">Margaret C. Wark</name><affiliation><mods:affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</mods:affiliation></affiliation></author><author><name sortKey="Smith, Linda E" sort="Smith, Linda E" uniqKey="Smith L" first="Linda E." last="Smith">Linda E. Smith</name><affiliation><mods:affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</mods:affiliation></affiliation></author><author><name sortKey="Sutherland, Megan M" sort="Sutherland, Megan M" uniqKey="Sutherland M" first="Megan M." last="Sutherland">Megan M. Sutherland</name><affiliation><mods:affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F0D4D1DC0DFA2504515C853FF0A973A8E78C2A37</idno><date when="1981" year="1981">1981</date><idno type="doi">10.1007/BF01315003</idno><idno type="url">https://api.istex.fr/ark:/67375/1BB-6S8MFSNZ-K/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001165</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001165</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A clearance test in mice using non-adapted viruses to determine the immunogenicity of influenza strains</title><author><name sortKey="Tannock, G A" sort="Tannock, G A" uniqKey="Tannock G" first="G. A." last="Tannock">G. A. Tannock</name><affiliation><mods:affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Faculty of Medicine, The University of Newcastle, 2308, Newcastle, New south Wales, Australia</mods:affiliation></affiliation></author><author><name sortKey="Wark, Margaret C" sort="Wark, Margaret C" uniqKey="Wark M" first="Margaret C." last="Wark">Margaret C. Wark</name><affiliation><mods:affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</mods:affiliation></affiliation></author><author><name sortKey="Smith, Linda E" sort="Smith, Linda E" uniqKey="Smith L" first="Linda E." last="Smith">Linda E. Smith</name><affiliation><mods:affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</mods:affiliation></affiliation></author><author><name sortKey="Sutherland, Megan M" sort="Sutherland, Megan M" uniqKey="Sutherland M" first="Megan M." last="Sutherland">Megan M. Sutherland</name><affiliation><mods:affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Virology</title><title level="j" type="abbrev">Archives of Virology</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1981-06-01">1981-06-01</date><biblScope unit="volume">70</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="91">91</biblScope><biblScope unit="page" to="101">101</biblScope></imprint><idno type="ISSN">0304-8608</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-8608</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Better immunogen</term><term>Cell line</term><term>Cent seroeonverting dose</term><term>Challenge virus</term><term>Challenge viruses</term><term>Chicken sera</term><term>Clearance</term><term>Clearance test</term><term>Complete clearance</term><term>Control group</term><term>Control mice</term><term>Dos</term><term>Human vaccines</term><term>Immunizing dose</term><term>Immunogenic response</term><term>Immunogenicity</term><term>Immunogenie response</term><term>Individual serum titers</term><term>Influenza</term><term>Influenza strain</term><term>Influenza strains</term><term>Influenza vaccines</term><term>Influenza virus</term><term>Influenza viruses</term><term>Intranasal route</term><term>Least times</term><term>Lung extracts</term><term>Matrix protein</term><term>Mouse</term><term>Other studies</term><term>Respiratory symptoms</term><term>Same manner</term><term>Same virus</term><term>Serial passage</term><term>Significant reduction</term><term>Tcids0</term><term>Unpublished observations</term><term>Vaccinated</term><term>Vaccinated group</term><term>Vaccination</term><term>Vaccine</term><term>Various influenza strains</term><term>Virus</term><term>Virus growth</term><term>Virus yields</term><term>Vivo clearance test</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: A test for the immunogenicity of influenza viruses is described, which is based upon the intranasal vaccinating dose required to induce inhibition of multiplication of unadapted influenza viruses in the lungs of mice. This test is more sensitive than an antigen extinction procedure, in which immunogenicity is measured according to the dose required to induce the formation of hemagglutination-inhibition antibody. The clearance test has been used to demonstrate that a) influenza A/Northern Territory/60/68 virus is a better imunogen than A/Victoria/3/75 and both are probably superior to A/U.S.S.R./92/77; b) for A/Northern Territory/60/68, vaccination by the intranasal route in 25 g mice is at least 43,600 times more efficient than by the intraperitoneal route and c) common immunogenic relationships exist between various H3N2 viruses and an H1N1 strain.</div></front></TEI><istex><corpusName>springer-journals</corpusName><keywords><teeft><json:string>influenza</json:string><json:string>immunogenicity</json:string><json:string>tcids0</json:string><json:string>vaccinated</json:string><json:string>influenza viruses</json:string><json:string>influenza strains</json:string><json:string>clearance test</json:string><json:string>vaccine</json:string><json:string>influenza strain</json:string><json:string>vivo clearance test</json:string><json:string>complete clearance</json:string><json:string>influenza virus</json:string><json:string>respiratory symptoms</json:string><json:string>challenge virus</json:string><json:string>immunogenie response</json:string><json:string>dos</json:string><json:string>immunizing dose</json:string><json:string>unpublished observations</json:string><json:string>control mice</json:string><json:string>influenza vaccines</json:string><json:string>mouse</json:string><json:string>virus</json:string><json:string>clearance</json:string><json:string>vaccination</json:string><json:string>better immunogen</json:string><json:string>individual serum titers</json:string><json:string>cent seroeonverting dose</json:string><json:string>same virus</json:string><json:string>lung extracts</json:string><json:string>control group</json:string><json:string>other studies</json:string><json:string>same manner</json:string><json:string>least times</json:string><json:string>intranasal route</json:string><json:string>virus yields</json:string><json:string>serial passage</json:string><json:string>immunogenic response</json:string><json:string>various influenza strains</json:string><json:string>challenge viruses</json:string><json:string>vaccinated group</json:string><json:string>significant reduction</json:string><json:string>virus growth</json:string><json:string>chicken sera</json:string><json:string>cell line</json:string><json:string>human vaccines</json:string><json:string>matrix protein</json:string></teeft></keywords><author><json:item><name>G. A. Tannock</name><affiliations><json:string>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</json:string><json:string>Faculty of Medicine, The University of Newcastle, 2308, Newcastle, New south Wales, Australia</json:string></affiliations></json:item><json:item><name>Margaret C. Wark</name><affiliations><json:string>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</json:string></affiliations></json:item><json:item><name>Linda E. Smith</name><affiliations><json:string>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</json:string></affiliations></json:item><json:item><name>Megan M. Sutherland</name><affiliations><json:string>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</json:string></affiliations></json:item></author><articleId><json:string>BF01315003</json:string><json:string>Art2</json:string></articleId><arkIstex>ark:/67375/1BB-6S8MFSNZ-K</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Summary: A test for the immunogenicity of influenza viruses is described, which is based upon the intranasal vaccinating dose required to induce inhibition of multiplication of unadapted influenza viruses in the lungs of mice. This test is more sensitive than an antigen extinction procedure, in which immunogenicity is measured according to the dose required to induce the formation of hemagglutination-inhibition antibody. The clearance test has been used to demonstrate that a) influenza A/Northern Territory/60/68 virus is a better imunogen than A/Victoria/3/75 and both are probably superior to A/U.S.S.R./92/77; b) for A/Northern Territory/60/68, vaccination by the intranasal route in 25 g mice is at least 43,600 times more efficient than by the intraperitoneal route and c) common immunogenic relationships exist between various H3N2 viruses and an H1N1 strain.</abstract><qualityIndicators><score>8.524</score><pdfWordCount>5161</pdfWordCount><pdfCharCount>23666</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>11</pdfPageCount><pdfPageSize>476 x 677 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>127</abstractWordCount><abstractCharCount>870</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>A clearance test in mice using non-adapted viruses to determine the immunogenicity of influenza strains</title><pmid><json:string>7036956</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>Archives of Virology</title><language><json:string>unknown</json:string></language><publicationDate>1981</publicationDate><copyrightDate>1981</copyrightDate><issn><json:string>0304-8608</json:string></issn><eissn><json:string>1432-8798</json:string></eissn><journalId><json:string>705</json:string></journalId><volume>70</volume><issue>2</issue><pages><first>91</first><last>101</last></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Medical Microbiology</value></json:item><json:item><value>Virology</value></json:item><json:item><value>Infectious Diseases</value></json:item></subject></host><namedEntities><unitex><date></date><geogName></geogName><orgName></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName></persName><placeName></placeName><ref_url></ref_url><ref_bibl></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/1BB-6S8MFSNZ-K</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - virology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - virology</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Virology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - General Medicine</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1981</publicationDate><copyrightDate>1981</copyrightDate><doi><json:string>10.1007/BF01315003</json:string></doi><id>F0D4D1DC0DFA2504515C853FF0A973A8E78C2A37</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-6S8MFSNZ-K/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-6S8MFSNZ-K/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/1BB-6S8MFSNZ-K/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">A clearance test in mice using non-adapted viruses to determine the immunogenicity of influenza strains</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><availability><licence><p>Springer-Verlag, 1981</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</p></availability><date>1981-05-25</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>Original Papers</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">A clearance test in mice using non-adapted viruses to determine the immunogenicity of influenza strains</title><author xml:id="author-0000"><persName><forename type="first">G.</forename><surname>Tannock</surname></persName><affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</affiliation><affiliation>Faculty of Medicine, The University of Newcastle, 2308, Newcastle, New south Wales, Australia</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Margaret</forename><surname>Wark</surname></persName><affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Linda</forename><surname>Smith</surname></persName><affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Megan</forename><surname>Sutherland</surname></persName><affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</affiliation></author><idno type="istex">F0D4D1DC0DFA2504515C853FF0A973A8E78C2A37</idno><idno type="ark">ark:/67375/1BB-6S8MFSNZ-K</idno><idno type="DOI">10.1007/BF01315003</idno><idno type="article-id">BF01315003</idno><idno type="article-id">Art2</idno></analytic><monogr><title level="j">Archives of Virology</title><title level="j" type="abbrev">Archives of Virology</title><idno type="pISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><idno type="journal-ID">true</idno><idno type="issue-article-count">10</idno><idno type="volume-issue-count">4</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1981-06-01"></date><biblScope unit="volume">70</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="91">91</biblScope><biblScope unit="page" to="101">101</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1981-05-25</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Summary: A test for the immunogenicity of influenza viruses is described, which is based upon the intranasal vaccinating dose required to induce inhibition of multiplication of unadapted influenza viruses in the lungs of mice. This test is more sensitive than an antigen extinction procedure, in which immunogenicity is measured according to the dose required to induce the formation of hemagglutination-inhibition antibody. The clearance test has been used to demonstrate that a) influenza A/Northern Territory/60/68 virus is a better imunogen than A/Victoria/3/75 and both are probably superior to A/U.S.S.R./92/77; b) for A/Northern Territory/60/68, vaccination by the intranasal route in 25 g mice is at least 43,600 times more efficient than by the intraperitoneal route and c) common immunogenic relationships exist between various H3N2 viruses and an H1N1 strain.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head><item><term>Medical Microbiology</term></item><item><term>Virology</term></item><item><term>Infectious Diseases</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1981-05-25">Created</change><change when="1981-06-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-6S8MFSNZ-K/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Vienna</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>705</JournalID><JournalPrintISSN>0304-8608</JournalPrintISSN><JournalElectronicISSN>1432-8798</JournalElectronicISSN><JournalTitle>Archives of Virology</JournalTitle><JournalAbbreviatedTitle>Archives of Virology</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Biomedicine</JournalSubject><JournalSubject Type="Secondary">Medical Microbiology</JournalSubject><JournalSubject Type="Secondary">Virology</JournalSubject><JournalSubject Type="Secondary">Infectious Diseases</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>70</VolumeIDStart><VolumeIDEnd>70</VolumeIDEnd><VolumeIssueCount>4</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>2</IssueIDStart><IssueIDEnd>2</IssueIDEnd><IssueArticleCount>10</IssueArticleCount><IssueHistory><CoverDate><DateString>1981</DateString><Year>1981</Year><Month>6</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1981</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art2"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF01315003</ArticleID><ArticleDOI>10.1007/BF01315003</ArticleDOI><ArticleSequenceNumber>2</ArticleSequenceNumber><ArticleTitle Language="En">A clearance test in mice using non-adapted viruses to determine the immunogenicity of influenza strains</ArticleTitle><ArticleCategory>Original Papers</ArticleCategory><ArticleFirstPage>91</ArticleFirstPage><ArticleLastPage>101</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2005</Year><Month>3</Month><Day>1</Day></RegistrationDate><Received><Year>1981</Year><Month>5</Month><Day>25</Day></Received><Accepted><Year>1981</Year><Month>8</Month><Day>7</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1981</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>705</JournalID><VolumeIDStart>70</VolumeIDStart><VolumeIDEnd>70</VolumeIDEnd><IssueIDStart>2</IssueIDStart><IssueIDEnd>2</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1 Aff2"><AuthorName DisplayOrder="Western"><GivenName>G.</GivenName><GivenName>A.</GivenName><FamilyName>Tannock</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Margaret</GivenName><GivenName>C.</GivenName><FamilyName>Wark</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Linda</GivenName><GivenName>E.</GivenName><FamilyName>Smith</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Megan</GivenName><GivenName>M.</GivenName><FamilyName>Sutherland</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgName>Commonwealth Serum Laboratories</OrgName><OrgAddress><City>Parkville</City><State>Victoria</State><Country>Australia</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Faculty of Medicine</OrgDivision><OrgName>The University of Newcastle</OrgName><OrgAddress><Postcode>2308</Postcode><City>Newcastle</City><State>New south Wales</State><Country>Australia</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>A test for the immunogenicity of influenza viruses is described, which is based upon the intranasal vaccinating dose required to induce inhibition of multiplication of unadapted influenza viruses in the lungs of mice. This test is more sensitive than an antigen extinction procedure, in which immunogenicity is measured according to the dose required to induce the formation of hemagglutination-inhibition antibody. The clearance test has been used to demonstrate that a) influenza A/Northern Territory/60/68 virus is a better imunogen than A/Victoria/3/75 and both are probably superior to A/U.S.S.R./92/77; b) for A/Northern Territory/60/68, vaccination by the intranasal route in 25 g mice is at least 43,600 times more efficient than by the intraperitoneal route and c) common immunogenic relationships exist between various H3N2 viruses and an H1N1 strain.</Para></Abstract><ArticleNote Type="Misc"><SimplePara>With 6 Figures</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A clearance test in mice using non-adapted viruses to determine the immunogenicity of influenza strains</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>A clearance test in mice using non-adapted viruses to determine the immunogenicity of influenza strains</title></titleInfo><name type="personal"><namePart type="given">G.</namePart><namePart type="given">A.</namePart><namePart type="family">Tannock</namePart><affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</affiliation><affiliation>Faculty of Medicine, The University of Newcastle, 2308, Newcastle, New south Wales, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Margaret</namePart><namePart type="given">C.</namePart><namePart type="family">Wark</namePart><affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Linda</namePart><namePart type="given">E.</namePart><namePart type="family">Smith</namePart><affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Megan</namePart><namePart type="given">M.</namePart><namePart type="family">Sutherland</namePart><affiliation>Commonwealth Serum Laboratories, Parkville, Victoria, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Vienna</placeTerm></place><dateCreated encoding="w3cdtf">1981-05-25</dateCreated><dateIssued encoding="w3cdtf">1981-06-01</dateIssued><copyrightDate encoding="w3cdtf">1981</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: A test for the immunogenicity of influenza viruses is described, which is based upon the intranasal vaccinating dose required to induce inhibition of multiplication of unadapted influenza viruses in the lungs of mice. This test is more sensitive than an antigen extinction procedure, in which immunogenicity is measured according to the dose required to induce the formation of hemagglutination-inhibition antibody. The clearance test has been used to demonstrate that a) influenza A/Northern Territory/60/68 virus is a better imunogen than A/Victoria/3/75 and both are probably superior to A/U.S.S.R./92/77; b) for A/Northern Territory/60/68, vaccination by the intranasal route in 25 g mice is at least 43,600 times more efficient than by the intraperitoneal route and c) common immunogenic relationships exist between various H3N2 viruses and an H1N1 strain.</abstract><note>Original Papers</note><relatedItem type="host"><titleInfo><title>Archives of Virology</title></titleInfo><titleInfo type="abbreviated"><title>Archives of Virology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1981-06-01</dateIssued><copyrightDate encoding="w3cdtf">1981</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Medical Microbiology</topic><topic>Virology</topic><topic>Infectious Diseases</topic></subject><identifier type="ISSN">0304-8608</identifier><identifier type="eISSN">1432-8798</identifier><identifier type="JournalID">705</identifier><identifier type="IssueArticleCount">10</identifier><identifier type="VolumeIssueCount">4</identifier><part><date>1981</date><detail type="volume"><number>70</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="pages"><start>91</start><end>101</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1981</recordOrigin></recordInfo></relatedItem><identifier type="istex">F0D4D1DC0DFA2504515C853FF0A973A8E78C2A37</identifier><identifier type="ark">ark:/67375/1BB-6S8MFSNZ-K</identifier><identifier type="DOI">10.1007/BF01315003</identifier><identifier type="ArticleID">BF01315003</identifier><identifier type="ArticleID">Art2</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1981</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 1981</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-6S8MFSNZ-K/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001165 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001165 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:F0D4D1DC0DFA2504515C853FF0A973A8E78C2A37
|texte= A clearance test in mice using non-adapted viruses to determine the immunogenicity of influenza strains
}}
| This area was generated with Dilib version V0.6.33. |  |