Reactive oligonucleotide derivatives as gene-targeted biologically active compounds and affinity probes
Identifieur interne : 001160 ( Istex/Corpus ); précédent : 001159; suivant : 001161Reactive oligonucleotide derivatives as gene-targeted biologically active compounds and affinity probes
Auteurs : D. G. Knorre ; V. V. VlassovSource :
- Genetica [ 0016-6707 ] ; 1991-01-01.
English descriptors
- KwdEn :
- Teeft :
- Acid, Active compounds, Active oxygen species, Affinity modification, Alkylating, Alkylating derivatives, Alkylating oligonucleotide derivatives, Analog, Antisense, Antisense inhibitors, Antisense oligonucleotides, Antiviral, Antiviral activity, Cell culture, Coding region, Derivative, Dervan, Encephalitis virus, Feb, Febs lett, Gene expression, Helene, Helene toulme, Infectious agents, Inhibitor, Ivanova, Knorre, Lett, Macmillan, Macmillan press, Mamaev, Modification, Mrna, Nucleic, Nucleic acid, Nucleic acid polymerases, Nucleic acids, Nucleotide, Oligonucleotide, Oligonucleotide derivatives, Oligonucleotides, Polymerase, Reactive, Reactive groups, Reactive oligonucleotide derivatives, Reagent, Ribosome, Toulme, Vlassov, Zarytova.
Abstract
Abstract: Development of efficient methods for synthesis of oligonucleotides and oligonucleotide analogs has opened up the possibility of designing a broad spectrum of affinity reagents for specific modification of nucleic acids and proteins. These affinity reagents are used for investigation of the topology of ribosomes and nucleic acid polymerases. Oligonucleotides and their analogs are already used for suppression of specific gene expression and for elucidation of the physiological role of their products. Oligonucleotide derivatives appear to offer considerable promise as potential gene-targeted drugs such as antivirals and specific inhibitors of oncogene expression.
Url:
DOI: 10.1007/BF00056106
Links to Exploration step
ISTEX:B5AE926DF7540913CFB30F185B6F3D19574C5FD7Le document en format XML
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Knorre</name><affiliation><mods:affiliation>Siberian Division of the USSR Academy of Sciences, Institute of Bioorganic Chemistry, 630090, Novosibirsk, USSR</mods:affiliation></affiliation></author><author><name sortKey="Vlassov, V V" sort="Vlassov, V V" uniqKey="Vlassov V" first="V. V." last="Vlassov">V. V. 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These affinity reagents are used for investigation of the topology of ribosomes and nucleic acid polymerases. Oligonucleotides and their analogs are already used for suppression of specific gene expression and for elucidation of the physiological role of their products. Oligonucleotide derivatives appear to offer considerable promise as potential gene-targeted drugs such as antivirals and specific inhibitors of oncogene expression.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>Antisense oligonucleotides</term></item><item><term>affinity modification</term></item><item><term>DNA</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head><item><term>Human Genetics</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1991-08-30">Created</change><change when="1991-01-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-G43F5WTQ-R/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Kluwer Academic Publishers</PublisherName><PublisherLocation>Dordrecht</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>10709</JournalID><JournalPrintISSN>0016-6707</JournalPrintISSN><JournalElectronicISSN>1573-6857</JournalElectronicISSN><JournalTitle>Genetica</JournalTitle><JournalSubTitle>An International Journal of Genetics and Evolution</JournalSubTitle><JournalAbbreviatedTitle>Genetica</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Biomedicine</JournalSubject><JournalSubject Type="Secondary">Human Genetics</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>85</VolumeIDStart><VolumeIDEnd>85</VolumeIDEnd><VolumeIssueCount>3</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd><IssueArticleCount>11</IssueArticleCount><IssueHistory><CoverDate><DateString>1991</DateString><Year>1991</Year><Month>1</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Kluwer Academic Publishers</CopyrightHolderName><CopyrightYear>1991</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art7"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF00056106</ArticleID><ArticleDOI>10.1007/BF00056106</ArticleDOI><ArticleSequenceNumber>7</ArticleSequenceNumber><ArticleTitle Language="En">Reactive oligonucleotide derivatives as gene-targeted biologically active compounds and affinity probes</ArticleTitle><ArticleFirstPage>53</ArticleFirstPage><ArticleLastPage>63</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>5</Month><Day>11</Day></RegistrationDate><Received><Year>1991</Year><Month>8</Month><Day>30</Day></Received><Accepted><Year>1991</Year><Month>8</Month><Day>30</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Kluwer Academic Publishers</CopyrightHolderName><CopyrightYear>1991</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>10709</JournalID><VolumeIDStart>85</VolumeIDStart><VolumeIDEnd>85</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>D.</GivenName><GivenName>G.</GivenName><FamilyName>Knorre</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>V.</GivenName><GivenName>V.</GivenName><FamilyName>Vlassov</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Siberian Division of the USSR Academy of Sciences</OrgDivision><OrgName>Institute of Bioorganic Chemistry</OrgName><OrgAddress><Postcode>630090</Postcode><City>Novosibirsk</City><Country>USSR</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Development of efficient methods for synthesis of oligonucleotides and oligonucleotide analogs has opened up the possibility of designing a broad spectrum of affinity reagents for specific modification of nucleic acids and proteins. These affinity reagents are used for investigation of the topology of ribosomes and nucleic acid polymerases. Oligonucleotides and their analogs are already used for suppression of specific gene expression and for elucidation of the physiological role of their products. Oligonucleotide derivatives appear to offer considerable promise as potential gene-targeted drugs such as antivirals and specific inhibitors of oncogene expression.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Antisense oligonucleotides</Keyword><Keyword>affinity modification</Keyword><Keyword>DNA</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Reactive oligonucleotide derivatives as gene-targeted biologically active compounds and affinity probes</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Reactive oligonucleotide derivatives as gene-targeted biologically active compounds and affinity probes</title></titleInfo><name type="personal"><namePart type="given">D.</namePart><namePart type="given">G.</namePart><namePart type="family">Knorre</namePart><affiliation>Siberian Division of the USSR Academy of Sciences, Institute of Bioorganic Chemistry, 630090, Novosibirsk, USSR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="given">V.</namePart><namePart type="family">Vlassov</namePart><affiliation>Siberian Division of the USSR Academy of Sciences, Institute of Bioorganic Chemistry, 630090, Novosibirsk, USSR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Kluwer Academic Publishers</publisher><place><placeTerm type="text">Dordrecht</placeTerm></place><dateCreated encoding="w3cdtf">1991-08-30</dateCreated><dateIssued encoding="w3cdtf">1991-01-01</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Development of efficient methods for synthesis of oligonucleotides and oligonucleotide analogs has opened up the possibility of designing a broad spectrum of affinity reagents for specific modification of nucleic acids and proteins. These affinity reagents are used for investigation of the topology of ribosomes and nucleic acid polymerases. Oligonucleotides and their analogs are already used for suppression of specific gene expression and for elucidation of the physiological role of their products. Oligonucleotide derivatives appear to offer considerable promise as potential gene-targeted drugs such as antivirals and specific inhibitors of oncogene expression.</abstract><subject lang="en"><genre>Key words</genre><topic>Antisense oligonucleotides</topic><topic>affinity modification</topic><topic>DNA</topic></subject><relatedItem type="host"><titleInfo><title>Genetica</title><subTitle>An International Journal of Genetics and Evolution</subTitle></titleInfo><titleInfo type="abbreviated"><title>Genetica</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1991-01-01</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Human Genetics</topic></subject><identifier type="ISSN">0016-6707</identifier><identifier type="eISSN">1573-6857</identifier><identifier type="JournalID">10709</identifier><identifier type="IssueArticleCount">11</identifier><identifier type="VolumeIssueCount">3</identifier><part><date>1991</date><detail type="volume"><number>85</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="pages"><start>53</start><end>63</end></extent></part><recordInfo><recordOrigin>Kluwer Academic Publishers, 1991</recordOrigin></recordInfo></relatedItem><identifier type="istex">B5AE926DF7540913CFB30F185B6F3D19574C5FD7</identifier><identifier type="ark">ark:/67375/1BB-G43F5WTQ-R</identifier><identifier type="DOI">10.1007/BF00056106</identifier><identifier type="ArticleID">BF00056106</identifier><identifier type="ArticleID">Art7</identifier><accessCondition type="use and reproduction" contentType="copyright">Kluwer Academic Publishers, 1991</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Kluwer Academic Publishers, 1991</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-G43F5WTQ-R/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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