RNA Interference: From Basic Research to Therapeutic Applications
Identifieur interne : 000F80 ( Istex/Corpus ); précédent : 000F79; suivant : 000F81RNA Interference: From Basic Research to Therapeutic Applications
Auteurs : Jens KurreckSource :
- Angewandte Chemie International Edition [ 1433-7851 ] ; 2009-02-09.
Abstract
An efficient mechanism for the sequence‐specific inhibition of gene expression is RNA interference. In this process, double‐stranded RNA molecules induce cleavage of a selected target RNA (see picture). This technique has in recent years developed into a standard method of molecular biology. Successful applications in animal models have already led to the initiation of RNAi‐based clinical trials as a new therapeutic option. Only ten years ago Andrew Fire and Craig Mello were able to show that double‐stranded RNA molecules could inhibit the expression of homologous genes in eukaryotes. This process, termed RNA interference, has developed into a standard method of molecular biology. This Review provides an overview of the molecular processes involved, with a particular focus on the posttranscriptional inhibition of gene expression in mammalian cells, the possible applications in research, and the results of the first clinical studies.
An efficient mechanism for the sequence‐specific inhibition of gene expression is RNA interference. In this process, double‐stranded RNA molecules induce cleavage of a selected target RNA (see picture). This technique has in recent years developed into a standard method of molecular biology. Successful applications in animal models have already led to the initiation of RNAi‐based clinical trials as a new therapeutic option.
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DOI: 10.1002/anie.200802092
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De Vry</json:string><json:string>A. Yalcin</json:string><json:string>M. B. Laursen</json:string><json:string>I. M. Verma</json:string><json:string>J. Martinez</json:string><json:string>F. Sigaux</json:string><json:string>R. W. Serra</json:string><json:string>C. A. Sledz</json:string><json:string>R. Sorensen</json:string><json:string>J. Weiler</json:string><json:string>R. Jorgensen</json:string><json:string>D. Semizarov</json:string><json:string>J. Warner</json:string><json:string>T. Nguyen</json:string><json:string>I. Wolter</json:string><json:string>M. Centlivre</json:string><json:string>Q. Xu</json:string><json:string>J. Schelter</json:string><json:string>M. Lindholm</json:string><json:string>M. Labow</json:string><json:string>M. A. Behlke</json:string><json:string>S. K. Lee</json:string><json:string>B. Meloon</json:string><json:string>L. Nechev</json:string><json:string>C. H. Lee</json:string><json:string>S. Shanmugam</json:string><json:string>K. Kaseda</json:string><json:string>J. 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Frost</json:string><json:string>H. F. Hansen</json:string><json:string>S. Weger</json:string><json:string>E. A. Komarova</json:string><json:string>M. Overhoff</json:string><json:string>J. Li</json:string><json:string>G. Lavine</json:string><json:string>P. D. Patel</json:string><json:string>G. Sczakiel</json:string><json:string>A. D. Judge</json:string><json:string>J. Invest</json:string><json:string>A. A. Caudy</json:string><json:string>I. J. MacRae</json:string><json:string>F. Czauderna</json:string><json:string>H. Hasuwa</json:string><json:string>G. Wang</json:string><json:string>V. Jadhav</json:string><json:string>E. Yaworski</json:string><json:string>A. Z. Fire</json:string><json:string>S. Hacein-Bey</json:string><json:string>C. Schmedt</json:string><json:string>S. Weitzer</json:string><json:string>S. Kauppinen</json:string><json:string>S. Scaringe</json:string><json:string>L. A. Martinez</json:string><json:string>O. T. Brake</json:string><json:string>H. 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Artz-Oppitz</json:string><json:string>T. C. Chu</json:string><json:string>C. Prinz</json:string><json:string>T. Bergauer</json:string><json:string>G. Fisch</json:string><json:string>M. Donoghue</json:string><json:string>B. Kuter-Luks</json:string><json:string>N. Vaish</json:string><json:string>Y. Liu</json:string><json:string>Y. Sakaki</json:string><json:string>M. Okabe</json:string><json:string>M. Wissler</json:string><json:string>J. Kurreck</json:string><json:string>Z. Zhao</json:string><json:string>J. A. Doudna</json:string><json:string>K. McClintock</json:string><json:string>M. Frech</json:string><json:string>V. Chandrasekaran</json:string><json:string>L. Gitlin</json:string><json:string>K. Loffler</json:string><json:string>M. Lawrence</json:string><json:string>L. Tucker</json:string><json:string>I. S. Seo</json:string><json:string>B. Li</json:string><json:string>T. Racie</json:string></persName><placeName><json:string>Frebourg</json:string><json:string>Vandenburgh</json:string><json:string>Birmingham</json:string><json:string>Germany</json:string><json:string>US</json:string><json:string>Albuquerque</json:string><json:string>Europe</json:string><json:string>Chiba</json:string><json:string>Cambridge</json:string><json:string>Saint Basile</json:string><json:string>Goldberg</json:string></placeName><ref_url><json:string>http://microrna.sanger.ac.uk</json:string><json:string>http://www.uni-stuttgart.de/iig/institut/staff/kurreck/ index.html</json:string></ref_url><ref_bibl><json:string>Summary and Outlook 1395</json:string><json:string>[151]</json:string><json:string>[23]</json:string><json:string>[18]</json:string><json:string>[156]</json:string><json:string>[110]</json:string><json:string>[77]</json:string><json:string>January 2008</json:string><json:string>[81]</json:string><json:string>Medarova et al.</json:string><json:string>[1]</json:string><json:string>[76]</json:string><json:string>[158]</json:string><json:string>[131]</json:string><json:string>Kleinmann et al.[105]</json:string><json:string>[106]</json:string><json:string>[152]</json:string><json:string>July 2007</json:string><json:string>[51]</json:string><json:string>[6, 16]</json:string><json:string>May 2008</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-4WC0FXHR-7</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - chemistry, multidisciplinary</json:string></wos><scienceMetrix><json:string>1 - natural sciences</json:string><json:string>2 - chemistry</json:string><json:string>3 - organic chemistry</json:string></scienceMetrix><scopus><json:string>1 - Physical Sciences</json:string><json:string>2 - Chemistry</json:string><json:string>3 - General Chemistry</json:string><json:string>1 - Physical Sciences</json:string><json:string>2 - Chemical Engineering</json:string><json:string>3 - Catalysis</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string></inist></categories><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/anie.200802092</json:string></doi><id>6658B554E5216527EDB4F6F6F8029DE4471EEA0B</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-4WC0FXHR-7/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-4WC0FXHR-7/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-4WC0FXHR-7/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">RNA Interference: From Basic Research to Therapeutic Applications</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><availability><licence>Copyright © 2009 WILEY‐VCH Verlag GmbH & Co. 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In this process, double‐stranded RNA molecules induce cleavage of a selected target RNA (see picture). This technique has in recent years developed into a standard method of molecular biology. 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In this process, double‐stranded RNA molecules induce cleavage of a selected target RNA (see picture). This technique has in recent years developed into a standard method of molecular biology. Successful applications in animal models have already led to the initiation of RNAi‐based clinical trials as a new therapeutic option. Only ten years ago Andrew Fire and Craig Mello were able to show that double‐stranded RNA molecules could inhibit the expression of homologous genes in eukaryotes. This process, termed RNA interference, has developed into a standard method of molecular biology. This Review provides an overview of the molecular processes involved, with a particular focus on the posttranscriptional inhibition of gene expression in mammalian cells, the possible applications in research, and the results of the first clinical studies.</abstract><abstract type="graphical" lang="en">An efficient mechanism for the sequence‐specific inhibition of gene expression is RNA interference. In this process, double‐stranded RNA molecules induce cleavage of a selected target RNA (see picture). This technique has in recent years developed into a standard method of molecular biology. Successful applications in animal models have already led to the initiation of RNAi‐based clinical trials as a new therapeutic option.</abstract><note type="funding">DFG - No. Ku‐1436/1; </note><note type="funding">BMBF/RNA Netzwerk</note><note type="funding">Fonds der Chemische Industrie</note><subject lang="en"><genre>keywords</genre><topic>gene expression</topic><topic>molecular biology</topic><topic>RNA interference</topic><topic>RNA</topic></subject><relatedItem type="host"><titleInfo><title>Angewandte Chemie International Edition</title></titleInfo><titleInfo type="abbreviated"><title>Angewandte Chemie International Edition</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Review</topic><topic>Review</topic><topic>Molecular Medicine</topic></subject><identifier type="ISSN">1433-7851</identifier><identifier type="eISSN">1521-3773</identifier><identifier type="DOI">10.1002/(ISSN)1521-3773</identifier><identifier type="PublisherID">ANIE</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>1378</start><end>1398</end><total>21</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Plant Cell</title></titleInfo><genre>journal-article</genre><note type="citation/reference">C. Napoli, C. Lemieux, R. Jorgensen, Plant Cell 1990, 2, 279–289.</note><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Napoli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Lemieux</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Jorgensen</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>279</start><end>289</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. Fire, S. Xu, M. K. Montgomery, S. A. Kostas, S. E. Driver, C. C. Mello, Nature 1998, 391, 806–811.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Fire</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. K.</namePart><namePart type="family">Montgomery</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. A.</namePart><namePart type="family">Kostas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. E.</namePart><namePart type="family">Driver</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. C.</namePart><namePart type="family">Mello</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>391</number></detail><extent unit="pages"><start>806</start><end>811</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>Angew. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">C. C. Mello, Angew. Chem. 2007, 119, 7114–7124;</note><name type="personal"><namePart type="given">C. C.</namePart><namePart type="family">Mello</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>119</number></detail><extent unit="pages"><start>7114</start><end>7124</end></extent></part><titleInfo><title>Angew. Chem. Int. Ed.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Angew. Chem. Int. Ed. 2007, 46, 6985–6994.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>6985</start><end>6994</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>Angew. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. Z. Fire, Angew. Chem. 2007, 119, 7094–7113;</note><name type="personal"><namePart type="given">A. Z.</namePart><namePart type="family">Fire</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>119</number></detail><extent unit="pages"><start>7094</start><end>7113</end></extent></part><titleInfo><title>Angew. Chem. Int. Ed.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Angew. Chem. Int. Ed. 2007, 46, 6966–6984.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>6966</start><end>6984</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>Nat. Biotechnol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">G. Taroncher‐Oldenburg, A. Marshall, Nat. Biotechnol. 2007, 25, 961.</note><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Taroncher‐Oldenburg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Marshall</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>961</start></extent></part></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Genes Dev.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. M. Elbashir, W. Lendeckel, T. Tuschl, Genes Dev. 2001, 15, 188–200.</note><name type="personal"><namePart type="given">S. M.</namePart><namePart type="family">Elbashir</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Lendeckel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Tuschl</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>188</start><end>200</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Science</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. Liu, M. A. Carmell, F. V. Rivas, C. G. Marsden, J. M. Thomson, J. J. Song, S. M. Hammond, L. Joshua‐Tor, G. J. Hannon, Science 2004, 305, 1437–1441.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Carmell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. V.</namePart><namePart type="family">Rivas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. G.</namePart><namePart type="family">Marsden</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. M.</namePart><namePart type="family">Thomson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">Song</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. M.</namePart><namePart type="family">Hammond</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Joshua‐Tor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. J.</namePart><namePart type="family">Hannon</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>305</number></detail><extent unit="pages"><start>1437</start><end>1441</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>Science</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. J. Song, S. K. Smith, G. J. Hannon, L. Joshua‐Tor, Science 2004, 305, 1434–1437.</note><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">Song</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. K.</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. J.</namePart><namePart type="family">Hannon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Joshua‐Tor</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>305</number></detail><extent unit="pages"><start>1434</start><end>1437</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>J. Neurochem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. Röhl, J. Kurreck, J. Neurochem. 2006, 99, 371–380.</note><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Röhl</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kurreck</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>99</number></detail><extent unit="pages"><start>371</start><end>380</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Cell</title></titleInfo><genre>journal-article</genre><note type="citation/reference">C. Matranga, Y. Tomari, C. Shin, D. P. Bartel, P. D. Zamore, Cell 2005, 123, 607–620.</note><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Matranga</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Tomari</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Shin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. P.</namePart><namePart type="family">Bartel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. D.</namePart><namePart type="family">Zamore</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>123</number></detail><extent unit="pages"><start>607</start><end>620</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>Cell</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. A. Rand, S. Petersen, F. Du, X. Wang, Cell 2005, 123, 621–629.</note><name type="personal"><namePart type="given">T. A.</namePart><namePart type="family">Rand</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Petersen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Du</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>123</number></detail><extent unit="pages"><start>621</start><end>629</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit14"><titleInfo><title>Proc. Natl. Acad. Sci. USA</title></titleInfo><genre>journal-article</genre><note type="citation/reference">I. J. MacRae, E. Ma, M. Zhou, C. V. Robinson, J. A. Doudna, Proc. Natl. Acad. Sci. USA 2008, 105, 512–517.</note><name type="personal"><namePart type="given">I. J.</namePart><namePart type="family">MacRae</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Zhou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. V.</namePart><namePart type="family">Robinson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. A.</namePart><namePart type="family">Doudna</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>105</number></detail><extent unit="pages"><start>512</start><end>517</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit15"><titleInfo><title>J. Interferon Cytokine Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. J. Clemens, A. Elia, J. Interferon Cytokine Res. 1997, 17, 503–524.</note><name type="personal"><namePart type="given">M. J.</namePart><namePart type="family">Clemens</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Elia</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>503</start><end>524</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit16"><titleInfo><title>Pharmacol. Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. R. Player, P. F. Torrence, Pharmacol. Ther. 1998, 78, 55–113.</note><name type="personal"><namePart type="given">M. R.</namePart><namePart type="family">Player</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. F.</namePart><namePart type="family">Torrence</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><extent unit="pages"><start>55</start><end>113</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>Mol. Cell. Biol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">L. Manche, S. R. Green, C. Schmedt, M. B. Mathews, Mol. Cell. Biol. 1992, 12, 5238–5248.</note><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Manche</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. R.</namePart><namePart type="family">Green</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Schmedt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. B.</namePart><namePart type="family">Mathews</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>5238</start><end>5248</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit18"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">E. Bernstein, A. A. Caudy, S. M. Hammond, G. J. Hannon, Nature 2001, 409, 363–366.</note><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Bernstein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. A.</namePart><namePart type="family">Caudy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. M.</namePart><namePart type="family">Hammond</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. J.</namePart><namePart type="family">Hannon</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>409</number></detail><extent unit="pages"><start>363</start><end>366</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit19"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. M. Elbashir, J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, T. Tuschl, Nature 2001, 411, 494–498.</note><name type="personal"><namePart type="given">S. M.</namePart><namePart type="family">Elbashir</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Harborth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Lendeckel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Yalcin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Weber</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Tuschl</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>411</number></detail><extent unit="pages"><start>494</start><end>498</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit20"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. Weitzer, J. Martinez, Nature 2007, 447, 222–226.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Weitzer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Martinez</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>447</number></detail><extent unit="pages"><start>222</start><end>226</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit21"><titleInfo><title>Nat. Chem. Biol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. R. Corey, Nat. Chem. Biol. 2007, 3, 8–11.</note><name type="personal"><namePart type="given">D. R.</namePart><namePart type="family">Corey</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>8</start><end>11</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit22"><titleInfo><title>Nat. Cell Biol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">G. L. Sen, H. M. Blau, Nat. Cell Biol. 2005, 7, 633–636.</note><name type="personal"><namePart type="given">G. L.</namePart><namePart type="family">Sen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. M.</namePart><namePart type="family">Blau</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>633</start><end>636</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit23"><titleInfo><title>Biochem. Biophys. Res. Commun.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. R. Bertrand, M. Pottier, A. Vekris, P. Opolon, A. Maksimenko, C. Malvy, Biochem. Biophys. Res. Commun. 2002, 296, 1000–1004.</note><name type="personal"><namePart type="given">J. R.</namePart><namePart type="family">Bertrand</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Pottier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Vekris</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Opolon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Maksimenko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Malvy</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>296</number></detail><extent unit="pages"><start>1000</start><end>1004</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit24"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. Grunweller, E. Wyszko, B. Bieber, R. Jahnel, V. A. Erdmann, J. Kurreck, Nucleic Acids Res. 2003, 31, 3185–3193.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Grunweller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Wyszko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Bieber</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Jahnel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. A.</namePart><namePart type="family">Erdmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kurreck</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>3185</start><end>3193</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit25"><titleInfo><title>J. Mol. Cell. Cardiol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. Watanabe, M. Arai, M. Yamazaki, N. Koitabashi, F. Wuytack, M. Kurabayashi, J. Mol. Cell. Cardiol. 2004, 37, 691–698.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Watanabe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Arai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Yamazaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Koitabashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Wuytack</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Kurabayashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>691</start><end>698</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit26"><titleInfo><title>Biochem. Biophys. Res. Commun.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. Christoph, A. Grunweller, J. Mika, M. K. Schafer, E. J. Wade, E. Weihe, V. A. Erdmann, R. Frank, C. Gillen, J. Kurreck, Biochem. Biophys. Res. Commun. 2006, 350, 238–243.</note><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Christoph</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Grunweller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Mika</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. K.</namePart><namePart type="family">Schafer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. J.</namePart><namePart type="family">Wade</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Weihe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. A.</namePart><namePart type="family">Erdmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Frank</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Gillen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kurreck</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>350</number></detail><extent unit="pages"><start>238</start><end>243</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit27"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. S. Zimmermann, A. C. Lee, A. Akinc, B. Bramlage, D. Bumcrot, M. N. Fedoruk, J. Harborth, J. A. Heyes, L. B. Jeffs, M. John, A. D. Judge, K. Lam, K. McClintock, L. V. Nechev, L. R. Palmer, T. Racie, I. Rohl, S. Seiffert, S. Shanmugam, V. Sood, J. Soutschek, I. Toudjarska, A. J. Wheat, E. Yaworski, W. Zedalis, V. Koteliansky, M. Manoharan, H. P. Vornlocher, I. MacLachlan, Nature 2006, 441, 111–114.</note><name type="personal"><namePart type="given">T. S.</namePart><namePart type="family">Zimmermann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. C.</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Akinc</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Bramlage</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Bumcrot</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. N.</namePart><namePart type="family">Fedoruk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Harborth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. A.</namePart><namePart type="family">Heyes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. B.</namePart><namePart type="family">Jeffs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">John</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. D.</namePart><namePart type="family">Judge</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Lam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">McClintock</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. V.</namePart><namePart type="family">Nechev</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. R.</namePart><namePart type="family">Palmer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Racie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Rohl</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Seiffert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Shanmugam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Sood</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Soutschek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Toudjarska</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. J.</namePart><namePart type="family">Wheat</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Yaworski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Zedalis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Koteliansky</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Manoharan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. P.</namePart><namePart type="family">Vornlocher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">MacLachlan</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>441</number></detail><extent unit="pages"><start>111</start><end>114</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit28"><titleInfo><title>Nat. Struct. Mol. Biol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. Bühler, D. Moazed, Nat. Struct. Mol. Biol. 2007, 14, 1041–1048.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Bühler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Moazed</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>1041</start><end>1048</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit29"><titleInfo><title>Nat. Rev. Genet.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Review: W. Filipowicz, S. N. Bhattacharyya, N. Sonenberg, Nat. Rev. Genet. 2008, 9, 102–114.</note><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Filipowicz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. N.</namePart><namePart type="family">Bhattacharyya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Sonenberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>102</start><end>114</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit30"><titleInfo><title>Curr. Med. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. L. Yeung, Y. Bennasser, K. T. Jeang, Curr. Med. Chem. 2007, 14, 191–197.</note><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Yeung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Bennasser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. T.</namePart><namePart type="family">Jeang</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>191</start><end>197</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit31"><titleInfo><title>FEBS Lett.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">B. Berkhout, J. Haasnoot, FEBS Lett. 2006, 580, 2896–2902.</note><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Berkhout</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Haasnoot</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>580</number></detail><extent unit="pages"><start>2896</start><end>2902</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit32"><titleInfo><title>Nat. Cell Biol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">P. Jin, R. S. Alisch, S. T. Warren, Nat. Cell Biol. 2004, 6, 1048–1053.</note><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Jin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. S.</namePart><namePart type="family">Alisch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. T.</namePart><namePart type="family">Warren</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>1048</start><end>1053</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit33"><titleInfo><title>Annu. Rev. Cell Dev. Biol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">N. Bushati, S. M. Cohen, Annu. Rev. Cell Dev. Biol. 2007, 23, 175–205.</note><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Bushati</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. M.</namePart><namePart type="family">Cohen</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>175</start><end>205</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit34"><titleInfo><title>Science</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. A. Aravin, G. J. Hannon, J. Brennecke, Science 2007, 318, 761–764.</note><name type="personal"><namePart type="given">A. A.</namePart><namePart type="family">Aravin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. J.</namePart><namePart type="family">Hannon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Brennecke</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>318</number></detail><extent unit="pages"><start>761</start><end>764</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit35"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. Watanabe, Y. Totoki, A. Toyoda, M. Kaneda, S. Kuramochi‐Miyagawa, Y. Obata, H. Chiba, Y. Kohara, T. Kono, T. Nakano, M. A. Surani, Y. Sakaki, H. Sasaki, Nature 2008, 453, 539–543.</note><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Watanabe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Totoki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Toyoda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Kaneda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kuramochi‐Miyagawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Obata</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Chiba</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Kohara</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Kono</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Nakano</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Surani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Sakaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Sasaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>453</number></detail><extent unit="pages"><start>539</start><end>543</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit36"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">O. H. Tam, A. A. Aravin, P. Stein, A. Girard, E. P. Murchison, S. Cheloufi, E. Hodges, M. Anger, R. Sachidanandam, R. M. Schultz, G. J. Hannon, Nature 2008, 453, 534–538.</note><name type="personal"><namePart type="given">O. H.</namePart><namePart type="family">Tam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. A.</namePart><namePart type="family">Aravin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Stein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Girard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. P.</namePart><namePart type="family">Murchison</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Cheloufi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Hodges</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Anger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Sachidanandam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. M.</namePart><namePart type="family">Schultz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. J.</namePart><namePart type="family">Hannon</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>453</number></detail><extent unit="pages"><start>534</start><end>538</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit37"><titleInfo><title>Nat. Biotechnol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">C. A. Stein, Nat. Biotechnol. 2001, 19, 737–738.</note><name type="personal"><namePart type="given">C. A.</namePart><namePart type="family">Stein</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>737</start><end>738</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit38"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. Holen, M. Amarzguioui, M. T. Wiiger, E. Babaie, H. Prydz, Nucleic Acids Res. 2002, 30, 1757–1766.</note><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Holen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Amarzguioui</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. T.</namePart><namePart type="family">Wiiger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Babaie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Prydz</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><extent unit="pages"><start>1757</start><end>1766</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit39"><titleInfo><title>J. Biomed. Biotechnol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Review: J. Kurreck, J. Biomed. Biotechnol. 2006, 83757.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kurreck</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><extent unit="pages"><start>83757</start></extent></part></relatedItem><relatedItem type="references" displayLabel="cit40"><titleInfo><title>Cell</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. Khvorova, A. Reynolds, S. D. Jayasena, Cell 2003, 115, 209–216.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Khvorova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Reynolds</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. D.</namePart><namePart type="family">Jayasena</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>115</number></detail><extent unit="pages"><start>209</start><end>216</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit41"><titleInfo><title>Cell</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. S. Schwarz, G. Hutvagner, T. Du, Z. Xu, N. Aronin, P. D. Zamore, Cell 2003, 115, 199–208.</note><name type="personal"><namePart type="given">D. S.</namePart><namePart type="family">Schwarz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Hutvagner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Du</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Aronin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. D.</namePart><namePart type="family">Zamore</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>115</number></detail><extent unit="pages"><start>199</start><end>208</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit42"><titleInfo><title>Science</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Y. Tomari, C. Matranga, B. Haley, N. Martinez, P. D. Zamore, Science 2004, 306, 1377–1380.</note><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Tomari</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Matranga</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Haley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Martinez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. D.</namePart><namePart type="family">Zamore</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>306</number></detail><extent unit="pages"><start>1377</start><end>1380</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit43"><titleInfo><title>Nat. Biotechnol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. Reynolds, D. Leake, Q. Boese, S. Scaringe, W. S. Marshall, A. Khvorova, Nat. Biotechnol. 2004, 22, 326–330.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Reynolds</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Leake</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Q.</namePart><namePart type="family">Boese</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Scaringe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. S.</namePart><namePart type="family">Marshall</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Khvorova</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>326</start><end>330</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit44"><titleInfo><title>Nat. Biotechnol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. Huesken, J. Lange, C. Mickanin, J. Weiler, F. Asselbergs, J. Warner, B. Meloon, S. Engel, A. Rosenberg, D. Cohen, M. Labow, M. Reinhardt, F. Natt, J. Hall, Nat. Biotechnol. 2005, 23, 995–1001.</note><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Huesken</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Lange</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Mickanin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Weiler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Asselbergs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Warner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Meloon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Engel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Rosenberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Cohen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Labow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Reinhardt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Natt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Hall</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>995</start><end>1001</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit45"><titleInfo><title>Biochem. Biophys. Res. Commun.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. Hong, N. Wei, A. Chalk, J. Wang, Y. Song, F. Yi, R. P. Qiao, E. L. Sonnhammer, C. Wahlestedt, Z. Liang, Q. Du, Biochem. Biophys. Res. Commun. 2008, 368, 703–708.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Hong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Wei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Chalk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Song</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Yi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. P.</namePart><namePart type="family">Qiao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. L.</namePart><namePart type="family">Sonnhammer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Wahlestedt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Liang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Q.</namePart><namePart type="family">Du</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>368</number></detail><extent unit="pages"><start>703</start><end>708</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit46"><titleInfo><title>Nat. Biotechnol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">V. Patzel, S. Rutz, I. Dietrich, C. Koberle, A. Scheffold, S. H. Kaufmann, Nat. Biotechnol. 2005, 23, 1440–1444.</note><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Patzel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Rutz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Dietrich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Koberle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Scheffold</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. H.</namePart><namePart type="family">Kaufmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>1440</start><end>1444</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit47"><titleInfo><title>Oligonucleotides</title></titleInfo><genre>journal-article</genre><note type="citation/reference">U. Krueger, T. Bergauer, B. Kaufmann, I. Wolter, S. Pilk, M. Heider‐Fabian, S. Kirch, C. Artz‐Oppitz, M. Isselhorst, J. Konrad, Oligonucleotides 2007, 17, 237–250.</note><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Krueger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Bergauer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Kaufmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Wolter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Pilk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Heider‐Fabian</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kirch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Artz‐Oppitz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Isselhorst</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Konrad</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>237</start><end>250</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit48"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">R. Kretschmer‐Kazemi Far, G. Sczakiel, Nucleic Acids Res. 2003, 31, 4417–4424.</note><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Kretschmer‐Kazemi Far</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Sczakiel</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>4417</start><end>4424</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit49"><titleInfo><title>J. Mol. Biol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. Overhoff, M. Alken, R. K. Far, M. Lemaitre, B. Lebleu, G. Sczakiel, I. Robbins, J. Mol. Biol. 2005, 348, 871–881.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Overhoff</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Alken</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. K.</namePart><namePart type="family">Far</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Lemaitre</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Lebleu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Sczakiel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Robbins</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>348</number></detail><extent unit="pages"><start>871</start><end>881</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit50"><titleInfo><title>J. Mol. Biol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. Schubert, A. Grunweller, V. A. Erdmann, J. Kurreck, J. Mol. Biol. 2005, 348, 883–893.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Schubert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Grunweller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. A.</namePart><namePart type="family">Erdmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kurreck</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>348</number></detail><extent unit="pages"><start>883</start><end>893</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit51"><titleInfo><title>RNA</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Y. Shao, C. Y. Chan, A. Maliyekkel, C. E. Lawrence, I. B. Roninson, Y. Ding, RNA 2007, 13, 1631–1640.</note><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Shao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. Y.</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Maliyekkel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. E.</namePart><namePart type="family">Lawrence</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. B.</namePart><namePart type="family">Roninson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Ding</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>1631</start><end>1640</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit52"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">E. M. Westerhout, B. Berkhout, Nucleic Acids Res. 2007, 35, 4322–4330.</note><name type="personal"><namePart type="given">E. M.</namePart><namePart type="family">Westerhout</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Berkhout</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>4322</start><end>4330</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit53"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Y. Ding, C. Y. Chan, C. E. Lawrence, Nucleic Acids Res. 2004, 32, W135–141.</note><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Ding</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. Y.</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. E.</namePart><namePart type="family">Lawrence</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>135</start><end>141</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit54"><titleInfo><title>Nat. Biotechnol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. H. Kim, M. A. Behlke, S. D. Rose, M. S. Chang, S. Choi, J. J. Rossi, Nat. Biotechnol. 2005, 23, 222–226.</note><name type="personal"><namePart type="given">D. H.</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Behlke</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. D.</namePart><namePart type="family">Rose</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. S.</namePart><namePart type="family">Chang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Choi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">Rossi</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>222</start><end>226</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit55"><titleInfo><title>Nat. Biotechnol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. Siolas, C. Lerner, J. Burchard, W. Ge, P. S. Linsley, P. J. Paddison, G. J. Hannon, M. A. Cleary, Nat. Biotechnol. 2005, 23, 227–231.</note><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Siolas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Lerner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Burchard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Ge</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. S.</namePart><namePart type="family">Linsley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. J.</namePart><namePart type="family">Paddison</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. J.</namePart><namePart type="family">Hannon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Cleary</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>227</start><end>231</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit56"><titleInfo><title>Nat. Methods</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Review: F. Buchholz, R. Kittler, M. Slabicki, M. Theis, Nat. Methods 2006, 3, 696–700.</note><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Buchholz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Kittler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Slabicki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Theis</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>696</start><end>700</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit57"><titleInfo><title>J. Clin. Invest.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. R. Corey, J. Clin. Invest. 2007, 117, 3615–3622.</note><name type="personal"><namePart type="given">D. R.</namePart><namePart type="family">Corey</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>117</number></detail><extent unit="pages"><start>3615</start><end>3622</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit58"><titleInfo><title>Curr. Top. Med. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H. Y. Zhang, Q. Du, C. Wahlestedt, Z. Liang, Curr. Top. Med. Chem. 2006, 6, 893–900.</note><name type="personal"><namePart type="given">H. Y.</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Q.</namePart><namePart type="family">Du</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Wahlestedt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Liang</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>893</start><end>900</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit59"><titleInfo><title>Curr. Opin. Chem. Biol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. Manoharan, Curr. Opin. Chem. Biol. 2004, 8, 570–579.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Manoharan</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>570</start><end>579</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit60"><titleInfo><title>Cell</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. Martinez, A. Patkaniowska, H. Urlaub, R. Luhrmann, T. Tuschl, Cell 2002, 110, 563–574.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Martinez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Patkaniowska</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Urlaub</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Luhrmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Tuschl</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>110</number></detail><extent unit="pages"><start>563</start><end>574</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit61"><titleInfo><title>Oligonucleotides</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. Grunweller, C. Gillen, V. A. Erdmann, J. Kurreck, Oligonucleotides 2003, 13, 345–352.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Grunweller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Gillen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. A.</namePart><namePart type="family">Erdmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kurreck</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>345</start><end>352</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit62"><titleInfo><title>Bioorg. Med. Chem. Lett.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">C. Lorenz, P. Hadwiger, M. John, H. P. Vornlocher, C. Unverzagt, Bioorg. Med. Chem. Lett. 2004, 14, 4975–4977.</note><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Lorenz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Hadwiger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">John</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. P.</namePart><namePart type="family">Vornlocher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Unverzagt</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>4975</start><end>4977</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit63"><titleInfo><title>Antisense Nucleic Acid Drug Dev.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. Harborth, S. M. Elbashir, K. Vandenburgh, H. Manninga, S. A. Scaringe, K. Weber, T. Tuschl, Antisense Nucleic Acid Drug Dev. 2003, 13, 83–105.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Harborth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. M.</namePart><namePart type="family">Elbashir</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Vandenburgh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Manninga</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. A.</namePart><namePart type="family">Scaringe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Weber</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Tuschl</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>83</start><end>105</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit64"><titleInfo><title>Biochemistry</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. A. Braasch, S. Jensen, Y. Liu, K. Kaur, K. Arar, M. A. White, D. R. Corey, Biochemistry 2003, 42, 7967–7975.</note><name type="personal"><namePart type="given">D. A.</namePart><namePart type="family">Braasch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Jensen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Kaur</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Arar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">White</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. R.</namePart><namePart type="family">Corey</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>7967</start><end>7975</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit65"><titleInfo><title>RNA</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Y. L. Chiu, T. M. Rana, RNA 2003, 9, 1034–1048.</note><name type="personal"><namePart type="given">Y. L.</namePart><namePart type="family">Chiu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. M.</namePart><namePart type="family">Rana</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>1034</start><end>1048</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit66"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">F. Czauderna, M. Fechtner, S. Dames, H. Aygun, A. Klippel, G. J. Pronk, K. Giese, J. Kaufmann, Nucleic Acids Res. 2003, 31, 2705–2716.</note><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Czauderna</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Fechtner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Dames</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Aygun</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Klippel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. J.</namePart><namePart type="family">Pronk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Giese</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kaufmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>2705</start><end>2716</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit67"><titleInfo><title>Gene Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. Santel, M. Aleku, O. Keil, J. Endruschat, V. Esche, G. Fisch, S. Dames, K. Loffler, M. Fechtner, W. Arnold, K. Giese, A. Klippel, J. Kaufmann, Gene Ther. 2006, 13, 1222–1234.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Santel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Aleku</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Keil</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Endruschat</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Esche</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Fisch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Dames</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Loffler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Fechtner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Arnold</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Giese</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Klippel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kaufmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>1222</start><end>1234</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit68"><titleInfo><title>BioDrugs</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. Grünweller, R. K. Hartmann, BioDrugs 2007, 21, 235–243.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Grünweller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. K.</namePart><namePart type="family">Hartmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>235</start><end>243</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit69"><titleInfo><title>Handb. Exp. Pharmacol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. Kauppinen, B. Vester, J. Wengel, Handb. Exp. Pharmacol. 2006, 173, 405–422.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kauppinen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Vester</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wengel</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>173</number></detail><extent unit="pages"><start>405</start><end>422</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit70"><titleInfo><title>Chem. Rev.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H. Kaur, B. R. Babu, S. Maiti, Chem. Rev. 2007, 107, 4672–4697.</note><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Kaur</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. R.</namePart><namePart type="family">Babu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Maiti</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>107</number></detail><extent unit="pages"><start>4672</start><end>4697</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit71"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. Elmen, H. Thonberg, K. Ljungberg, M. Frieden, M. Westergaard, Y. Xu, B. Wahren, Z. Liang, H. Orum, T. Koch, C. Wahlestedt, Nucleic Acids Res. 2005, 33, 439–447.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Elmen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Thonberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Ljungberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Frieden</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Westergaard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Wahren</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Liang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Orum</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Koch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Wahlestedt</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><extent unit="pages"><start>439</start><end>447</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit72"><titleInfo><title>Mol. Cancer Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">O. R. Mook, F. Baas, M. B. de Wissel, K. Fluiter, Mol. Cancer Ther. 2007, 6, 833–843.</note><name type="personal"><namePart type="given">O. R.</namePart><namePart type="family">Mook</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Baas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. B.</namePart><namePart type="family">de Wissel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Fluiter</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>833</start><end>843</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit73"><titleInfo><title>Antiviral Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. Schubert, D. Rothe, D. Werk, H. P. Grunert, H. Zeichhardt, V. A. Erdmann, J. Kurreck, Antiviral Res. 2007, 73, 197–205.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Schubert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Rothe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Werk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. P.</namePart><namePart type="family">Grunert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Zeichhardt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. A.</namePart><namePart type="family">Erdmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kurreck</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>197</start><end>205</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit74"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. B. Bramsen, M. B. Laursen, C. K. Damgaard, S. W. Lena, B. R. Babu, J. Wengel, J. Kjems, Nucleic Acids Res. 2007, 35, 5886–5897.</note><name type="personal"><namePart type="given">J. B.</namePart><namePart type="family">Bramsen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. B.</namePart><namePart type="family">Laursen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. K.</namePart><namePart type="family">Damgaard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. W.</namePart><namePart type="family">Lena</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. R.</namePart><namePart type="family">Babu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wengel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kjems</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>5886</start><end>5897</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit75"><titleInfo><title>Hepatology</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. V. Morrissey, K. Blanchard, L. Shaw, K. Jensen, J. A. Lockridge, B. Dickinson, J. A. McSwiggen, C. Vargeese, K. Bowman, C. S. Shaffer, B. A. Polisky, S. Zinnen, Hepatology 2005, 41, 1349–1356.</note><name type="personal"><namePart type="given">D. V.</namePart><namePart type="family">Morrissey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Blanchard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Shaw</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Jensen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. A.</namePart><namePart type="family">Lockridge</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Dickinson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. A.</namePart><namePart type="family">McSwiggen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Vargeese</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Bowman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. S.</namePart><namePart type="family">Shaffer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. A.</namePart><namePart type="family">Polisky</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Zinnen</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>1349</start><end>1356</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit76"><titleInfo><title>Trends Genet.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Review: Y. Shi, Trends Genet. 2003, 19, 9–12.</note><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Shi</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>9</start><end>12</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit77"><titleInfo><title>Science</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. R. Brummelkamp, R. Bernards, R. Agami, Science 2002, 296, 550–553.</note><name type="personal"><namePart type="given">T. R.</namePart><namePart type="family">Brummelkamp</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Bernards</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Agami</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>296</number></detail><extent unit="pages"><start>550</start><end>553</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit78"><titleInfo><title>Nat. Struct. Biol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. A. Carmell, L. Zhang, D. S. Conklin, G. J. Hannon, T. A. Rosenquist, Nat. Struct. Biol. 2003, 10, 91–92.</note><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Carmell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. S.</namePart><namePart type="family">Conklin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. J.</namePart><namePart type="family">Hannon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. A.</namePart><namePart type="family">Rosenquist</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>91</start><end>92</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit79"><titleInfo><title>Proc. Natl. Acad. Sci. USA</title></titleInfo><genre>journal-article</genre><note type="citation/reference">G. Tiscornia, O. Singer, M. Ikawa, I. M. Verma, Proc. Natl. Acad. Sci. USA 2003, 100, 1844–1848.</note><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Tiscornia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Singer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Ikawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. M.</namePart><namePart type="family">Verma</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>100</number></detail><extent unit="pages"><start>1844</start><end>1848</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit80"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. Seibler, B. Kuter‐Luks, H. Kern, S. Streu, L. Plum, J. Mauer, R. Kuhn, J. C. Bruning, F. Schwenk, Nucleic Acids Res. 2005, 33, e67.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Seibler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Kuter‐Luks</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Kern</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Streu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Plum</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Mauer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Kuhn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. C.</namePart><namePart type="family">Bruning</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Schwenk</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><extent unit="pages"><start>67</start></extent></part></relatedItem><relatedItem type="references" displayLabel="cit81"><titleInfo><title>Mol. Cell. Neurosci.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. Christoph, G. Bahrenberg, J. De Vry, W. Englberger, V. A. Erdmann, M. Frech, B. Kogel, T. Rohl, K. Schiene, W. Schroder, J. Seibler, J. Kurreck, Mol. Cell. Neurosci. 2008, 37, 579–589.</note><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Christoph</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Bahrenberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">De Vry</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Englberger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. A.</namePart><namePart type="family">Erdmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Frech</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Kogel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Rohl</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Schiene</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Schroder</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Seibler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kurreck</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>579</start><end>589</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit82"><titleInfo><title>J. Pharmacol. Exp. Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">P. Honore, C. T. Wismer, J. Mikusa, C. Z. Zhu, C. Zhong, D. M. Gauvin, A. Gomtsyan, R. El Kouhen, C. H. Lee, K. Marsh, J. P. Sullivan, C. R. Faltynek, M. F. Jarvis, J. Pharmacol. Exp. Ther. 2005, 314, 410–421.</note><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Honore</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. T.</namePart><namePart type="family">Wismer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Mikusa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. Z.</namePart><namePart type="family">Zhu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Zhong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. M.</namePart><namePart type="family">Gauvin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Gomtsyan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">El Kouhen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. H.</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Marsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. P.</namePart><namePart type="family">Sullivan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. R.</namePart><namePart type="family">Faltynek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. F.</namePart><namePart type="family">Jarvis</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>314</number></detail><extent unit="pages"><start>410</start><end>421</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit83"><titleInfo><title>FEBS Lett.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H. Hasuwa, K. Kaseda, T. Einarsdottir, M. Okabe, FEBS Lett. 2002, 532, 227–230.</note><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Hasuwa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Kaseda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Einarsdottir</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Okabe</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>532</number></detail><extent unit="pages"><start>227</start><end>230</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit84"><titleInfo><title>Proc. Natl. Acad. Sci. USA</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. C. Golding, C. R. Long, M. A. Carmell, G. J. Hannon, M. E. Westhusin, Proc. Natl. Acad. Sci. USA 2006, 103, 5285–5290.</note><name type="personal"><namePart type="given">M. C.</namePart><namePart type="family">Golding</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. R.</namePart><namePart type="family">Long</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Carmell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. J.</namePart><namePart type="family">Hannon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. E.</namePart><namePart type="family">Westhusin</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>103</number></detail><extent unit="pages"><start>5285</start><end>5290</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit85"><titleInfo><title>Mol. Cell</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Y. Zeng, E. J. Wagner, B. R. Cullen, Mol. Cell 2002, 9, 1327–1333.</note><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Zeng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. J.</namePart><namePart type="family">Wagner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. R.</namePart><namePart type="family">Cullen</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>1327</start><end>1333</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit86"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. Boden, O. Pusch, R. Silbermann, F. Lee, L. Tucker, B. Ramratnam, Nucleic Acids Res. 2004, 32, 1154–1158.</note><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Boden</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Pusch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Silbermann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Tucker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Ramratnam</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>1154</start><end>1158</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit87"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">K. H. Chung, C. C. Hart, S. Al‐Bassam, A. Avery, J. Taylor, P. D. Patel, A. B. Vojtek, D. L. Turner, Nucleic Acids Res. 2006, 34, e53.</note><name type="personal"><namePart type="given">K. H.</namePart><namePart type="family">Chung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. C.</namePart><namePart type="family">Hart</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Al‐Bassam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Avery</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Taylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. D.</namePart><namePart type="family">Patel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. B.</namePart><namePart type="family">Vojtek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. L.</namePart><namePart type="family">Turner</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>53</start></extent></part></relatedItem><relatedItem type="references" displayLabel="cit88"><titleInfo><title>Nat. Protoc.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. K. Rao, M. F. Wilkinson, Nat. Protoc. 2006, 1, 1494–1501.</note><name type="personal"><namePart type="given">M. K.</namePart><namePart type="family">Rao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. F.</namePart><namePart type="family">Wilkinson</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>1494</start><end>1501</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit89"><titleInfo><title>Nat. Protoc.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. Kappel, Y. Matthess, M. Kaufmann, K. Strebhardt, Nat. Protoc. 2007, 2, 3257–3269.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kappel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Matthess</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Kaufmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Strebhardt</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>3257</start><end>3269</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit90"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. Kappel, Y. Matthess, B. Zimmer, M. Kaufmann, K. Strebhardt, Nucleic Acids Res. 2006, 34, 4527–4536.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kappel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Matthess</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Zimmer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Kaufmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Strebhardt</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>4527</start><end>4536</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit91"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. Seibler, A. Kleinridders, B. Kuter‐Luks, S. Niehaves, J. C. Bruning, F. Schwenk, Nucleic Acids Res. 2007, 35, e54.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Seibler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Kleinridders</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Kuter‐Luks</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Niehaves</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. C.</namePart><namePart type="family">Bruning</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Schwenk</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>54</start></extent></part></relatedItem><relatedItem type="references" displayLabel="cit92"><titleInfo><title>H. Fechner, J. Kurreck in Therapeutic Oligonucleotides (Ed.: J. Kurreck), Royal Society of Chemistry Publishing, Cambridge 2008, pp. 267–295.</title></titleInfo><note type="citation/reference">H. Fechner, J. Kurreck in Therapeutic Oligonucleotides (Ed.: J. Kurreck), Royal Society of Chemistry Publishing, Cambridge 2008, pp. 267–295.</note><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Fechner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kurreck</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><role><roleTerm type="text">editor</roleTerm></role></name><genre>book</genre><originInfo><publisher>Royal Society of Chemistry Publishing</publisher><place><placeTerm type="text">Cambridge</placeTerm></place></originInfo><part><date>2008</date><extent unit="pages"><start>267</start><end>295</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit93"><titleInfo><title>EMBO Rep.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">L. Fritsch, L. A. Martinez, R. Sekhri, I. Naguibneva, M. Gerard, M. Vandromme, L. Schaeffer, A. Harel‐Bellan, EMBO Rep. 2004, 5, 178–182.</note><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Fritsch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. A.</namePart><namePart type="family">Martinez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Sekhri</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Naguibneva</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Gerard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Vandromme</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Schaeffer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Harel‐Bellan</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>178</start><end>182</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit94"><titleInfo><title>J. Mol. Biol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. Schubert, H. P. Grunert, H. Zeichhardt, D. Werk, V. A. Erdmann, J. Kurreck, J. Mol. Biol. 2005, 346, 457–465.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Schubert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. P.</namePart><namePart type="family">Grunert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Zeichhardt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Werk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. A.</namePart><namePart type="family">Erdmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kurreck</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>346</number></detail><extent unit="pages"><start>457</start><end>465</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit95"><titleInfo><title>Proc. Natl. Acad. Sci. USA</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. Semizarov, L. Frost, A. Sarthy, P. Kroeger, D. N. Halbert, S. W. Fesik, Proc. Natl. Acad. Sci. USA 2003, 100, 6347–6352.</note><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Semizarov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Frost</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Sarthy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Kroeger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. N.</namePart><namePart type="family">Halbert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. W.</namePart><namePart type="family">Fesik</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>100</number></detail><extent unit="pages"><start>6347</start><end>6352</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit96"><titleInfo><title>Nat. Biotechnol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. L. Jackson, S. R. Bartz, J. Schelter, S. V. Kobayashi, J. Burchard, M. Mao, B. Li, G. Cavet, P. S. Linsley, Nat. Biotechnol. 2003, 21, 635–637.</note><name type="personal"><namePart type="given">A. L.</namePart><namePart type="family">Jackson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. R.</namePart><namePart type="family">Bartz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Schelter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. V.</namePart><namePart type="family">Kobayashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Burchard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Mao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Cavet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. S.</namePart><namePart type="family">Linsley</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>635</start><end>637</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit97"><titleInfo><title>RNA</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Y. Fedorov, E. M. Anderson, A. Birmingham, A. Reynolds, J. Karpilow, K. Robinson, D. Leake, W. S. Marshall, A. Khvorova, RNA 2006, 12, 1188–1196.</note><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Fedorov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. M.</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Birmingham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Reynolds</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Karpilow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Robinson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Leake</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. S.</namePart><namePart type="family">Marshall</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Khvorova</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>1188</start><end>1196</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit98"><titleInfo><title>Nat. Methods</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. Birmingham, E. M. Anderson, A. Reynolds, D. Ilsley‐Tyree, D. Leake, Y. Fedorov, S. Baskerville, E. Maksimova, K. Robinson, J. Karpilow, W. S. Marshall, A. Khvorova, Nat. Methods 2006, 3, 199–204.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Birmingham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. M.</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Reynolds</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Ilsley‐Tyree</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Leake</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Fedorov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Baskerville</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Maksimova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Robinson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Karpilow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. S.</namePart><namePart type="family">Marshall</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Khvorova</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>199</start><end>204</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit99"><titleInfo><title>RNA</title></titleInfo><genre>journal-article</genre><note type="citation/reference">E. M. Anderson, A. Birmingham, S. Baskerville, A. Reynolds, E. Maksimova, D. Leake, Y. Fedorov, J. Karpilow, A. Khvorova, RNA 2008, 14, 853–861.</note><name type="personal"><namePart type="given">E. M.</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Birmingham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Baskerville</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Reynolds</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Maksimova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Leake</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Fedorov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Karpilow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Khvorova</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>853</start><end>861</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit100"><titleInfo><title>RNA</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. L. Jackson, J. Burchard, D. Leake, A. Reynolds, J. Schelter, J. Guo, J. M. Johnson, L. Lim, J. Karpilow, K. Nichols, W. Marshall, A. Khvorova, P. S. Linsley, RNA 2006, 12, 1197–1205.</note><name type="personal"><namePart type="given">A. L.</namePart><namePart type="family">Jackson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Burchard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Leake</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Reynolds</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Schelter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Guo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. M.</namePart><namePart type="family">Johnson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Lim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Karpilow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Nichols</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Marshall</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Khvorova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. S.</namePart><namePart type="family">Linsley</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>1197</start><end>1205</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit101"><titleInfo><title>Nat. Cell Biol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">C. A. Sledz, M. Holko, M. J. de Veer, R. H. Silverman, B. R. Williams, Nat. Cell Biol. 2003, 5, 834–839.</note><name type="personal"><namePart type="given">C. A.</namePart><namePart type="family">Sledz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Holko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. J.</namePart><namePart type="family">de Veer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. H.</namePart><namePart type="family">Silverman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. R.</namePart><namePart type="family">Williams</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>834</start><end>839</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit102"><titleInfo><title>Nat. Genet.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. J. Bridge, S. Pebernard, A. Ducraux, A. L. Nicoulaz, R. Iggo, Nat. Genet. 2003, 34, 263–264.</note><name type="personal"><namePart type="given">A. J.</namePart><namePart type="family">Bridge</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Pebernard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Ducraux</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. L.</namePart><namePart type="family">Nicoulaz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Iggo</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>263</start><end>264</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit103"><titleInfo><title>Nat. Med.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">V. Hornung, M. Guenthner‐Biller, C. Bourquin, A. Ablasser, M. Schlee, S. Uematsu, A. Noronha, M. Manoharan, S. Akira, A. de Fougerolles, S. Endres, G. Hartmann, Nat. Med. 2005, 11, 263–270.</note><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Hornung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Guenthner‐Biller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Bourquin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Ablasser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Schlee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Uematsu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Noronha</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Manoharan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Akira</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">de Fougerolles</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Endres</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Hartmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>263</start><end>270</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit104"><titleInfo><title>Nat. Biotechnol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. D. Judge, V. Sood, J. R. Shaw, D. Fang, K. McClintock, I. MacLachlan, Nat. Biotechnol. 2005, 23, 457–462.</note><name type="personal"><namePart type="given">A. D.</namePart><namePart type="family">Judge</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Sood</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. R.</namePart><namePart type="family">Shaw</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Fang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">McClintock</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">MacLachlan</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>457</start><end>462</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit105"><titleInfo><title>Mol. Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. Schlee, V. Hornung, G. Hartmann, Mol. Ther. 2006, 14, 463–470.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Schlee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Hornung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Hartmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>463</start><end>470</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit106"><titleInfo><title>E. Uhlmann in Therapeutic Oligonucleotides (Ed.: J. Kurreck), Royal Society of Chemistry Publishing, Cambridge, 2008, pp. 142–162.</title></titleInfo><note type="citation/reference">E. Uhlmann in Therapeutic Oligonucleotides (Ed.: J. Kurreck), Royal Society of Chemistry Publishing, Cambridge, 2008, pp. 142–162.</note><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Uhlmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><role><roleTerm type="text">editor</roleTerm></role></name><genre>book</genre><originInfo><publisher>Royal Society of Chemistry Publishing</publisher><place><placeTerm type="text">Cambridge</placeTerm></place></originInfo><part><date>2008</date><extent unit="pages"><start>142</start><end>162</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit107"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. E. Kleinman, K. Yamada, A. Takeda, V. Chandrasekaran, M. Nozaki, J. Z. Baffi, R. J. Albuquerque, S. Yamasaki, M. Itaya, Y. Pan, B. Appukuttan, D. Gibbs, Z. Yang, K. Kariko, B. K. Ambati, T. A. Wilgus, L. A. DiPietro, E. Sakurai, K. Zhang, J. R. Smith, E. W. Taylor, J. Ambati, Nature 2008, 452, 591–597.</note><name type="personal"><namePart type="given">M. E.</namePart><namePart type="family">Kleinman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Yamada</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Takeda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Chandrasekaran</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Nozaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. Z.</namePart><namePart type="family">Baffi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. J.</namePart><namePart type="family">Albuquerque</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Yamasaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Itaya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Pan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Appukuttan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Gibbs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Kariko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. K.</namePart><namePart type="family">Ambati</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. A.</namePart><namePart type="family">Wilgus</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. A.</namePart><namePart type="family">DiPietro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Sakurai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. R.</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. W.</namePart><namePart type="family">Taylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Ambati</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>452</number></detail><extent unit="pages"><start>591</start><end>597</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit108"><titleInfo><title>J. Biol. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. Saxena, Z. O. Jonsson, A. Dutta, J. Biol. Chem. 2003, 278, 44312–44319.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Saxena</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z. O.</namePart><namePart type="family">Jonsson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Dutta</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>278</number></detail><extent unit="pages"><start>44312</start><end>44319</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit109"><titleInfo><title>Genes Dev.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. G. Doench, C. P. Petersen, P. A. Sharp, Genes Dev. 2003, 17, 438–442.</note><name type="personal"><namePart type="given">J. G.</namePart><namePart type="family">Doench</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. P.</namePart><namePart type="family">Petersen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. A.</namePart><namePart type="family">Sharp</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>438</start><end>442</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit110"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. Grimm, K. L. Streetz, C. L. Jopling, T. A. Storm, K. Pandey, C. R. Davis, P. Marion, F. Salazar, M. A. Kay, Nature 2006, 441, 537–541.</note><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Grimm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. L.</namePart><namePart type="family">Streetz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. L.</namePart><namePart type="family">Jopling</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. A.</namePart><namePart type="family">Storm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Pandey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. R.</namePart><namePart type="family">Davis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Marion</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Salazar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Kay</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>441</number></detail><extent unit="pages"><start>537</start><end>541</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit111"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. John, R. Constien, A. Akinc, M. Goldberg, Y. A. Moon, M. Spranger, P. Hadwiger, J. Soutschek, H. P. Vornlocher, M. Manoharan, M. Stoffel, R. Langer, D. G. Anderson, J. D. Horton, V. Koteliansky, D. Bumcrot, Nature 2007, 449, 745–747.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">John</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Constien</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Akinc</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Goldberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y. A.</namePart><namePart type="family">Moon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Spranger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Hadwiger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Soutschek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. P.</namePart><namePart type="family">Vornlocher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Manoharan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Stoffel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Langer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. G.</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. D.</namePart><namePart type="family">Horton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Koteliansky</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Bumcrot</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>449</number></detail><extent unit="pages"><start>745</start><end>747</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit112"><titleInfo><title>Nat. Med.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">V. Bitko, A. Musiyenko, O. Shulyayeva, S. Barik, Nat. Med. 2005, 11, 50–55.</note><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Bitko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Musiyenko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Shulyayeva</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Barik</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>50</start><end>55</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit113"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. P. McCaffrey, L. Meuse, T. T. Pham, D. S. Conklin, G. J. Hannon, M. A. Kay, Nature 2002, 418, 38–39.</note><name type="personal"><namePart type="given">A. P.</namePart><namePart type="family">McCaffrey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Meuse</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. T.</namePart><namePart type="family">Pham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. S.</namePart><namePart type="family">Conklin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. J.</namePart><namePart type="family">Hannon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Kay</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>418</number></detail><extent unit="pages"><start>38</start><end>39</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit114"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">R. Juliano, M. R. Alam, V. Dixit, H. Kang, Nucleic Acids Res. 2008, 36, 4158–4171.</note><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Juliano</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. R.</namePart><namePart type="family">Alam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Dixit</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Kang</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>4158</start><end>4171</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit115"><titleInfo><title>Nat. Biotechnol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. V. Morrissey, J. A. Lockridge, L. Shaw, K. Blanchard, K. Jensen, W. Breen, K. Hartsough, L. Machemer, S. Radka, V. Jadhav, N. Vaish, S. Zinnen, C. Vargeese, K. Bowman, C. S. Shaffer, L. B. Jeffs, A. Judge, I. MacLachlan, B. Polisky, Nat. Biotechnol. 2005, 23, 1002–1007.</note><name type="personal"><namePart type="given">D. V.</namePart><namePart type="family">Morrissey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. A.</namePart><namePart type="family">Lockridge</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Shaw</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Blanchard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Jensen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Breen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Hartsough</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Machemer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Radka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Jadhav</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Vaish</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Zinnen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Vargeese</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Bowman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. S.</namePart><namePart type="family">Shaffer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. B.</namePart><namePart type="family">Jeffs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Judge</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">MacLachlan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Polisky</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>1002</start><end>1007</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit116"><titleInfo><title>Proc. Natl. Acad. Sci. USA</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Q. Ge, L. Filip, A. Bai, T. Nguyen, H. N. Eisen, J. Chen, Proc. Natl. Acad. Sci. USA 2004, 101, 8676–8681.</note><name type="personal"><namePart type="given">Q.</namePart><namePart type="family">Ge</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Filip</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Bai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Nguyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. N.</namePart><namePart type="family">Eisen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>101</number></detail><extent unit="pages"><start>8676</start><end>8681</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit117"><titleInfo><title>Nat. Med.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Z. Medarova, W. Pham, C. Farrar, V. Petkova, A. Moore, Nat. Med. 2007, 13, 372–377.</note><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Medarova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Pham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Farrar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Petkova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Moore</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>372</start><end>377</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit118"><titleInfo><title>Angew. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Z. Liu, M. Winters, M. Holodniy, H. Dai, Angew. Chem. 2007, 119, 2069–2073;</note><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Winters</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Holodniy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Dai</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>119</number></detail><extent unit="pages"><start>2069</start><end>2073</end></extent></part><titleInfo><title>Angew. Chem. Int. Ed.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Angew. Chem. Int. Ed. 2007, 46, 2023–2027.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>2023</start><end>2027</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit120"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. Soutschek, A. Akinc, B. Bramlage, K. Charisse, R. Constien, M. Donoghue, S. Elbashir, A. Geick, P. Hadwiger, J. Harborth, M. John, V. Kesavan, G. Lavine, R. K. Pandey, T. Racie, K. G. Rajeev, I. Rohl, I. Toudjarska, G. Wang, S. Wuschko, D. Bumcrot, V. Koteliansky, S. Limmer, M. Manoharan, H. P. Vornlocher, Nature 2004, 432, 173–178.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Soutschek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Akinc</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Bramlage</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Charisse</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Constien</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Donoghue</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Elbashir</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Geick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Hadwiger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Harborth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">John</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Kesavan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Lavine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. K.</namePart><namePart type="family">Pandey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Racie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. G.</namePart><namePart type="family">Rajeev</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Rohl</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Toudjarska</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Wuschko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Bumcrot</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Koteliansky</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Limmer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Manoharan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. P.</namePart><namePart type="family">Vornlocher</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>432</number></detail><extent unit="pages"><start>173</start><end>178</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit121"><titleInfo><title>Blood Cells Mol. Dis.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. J. Turner, S. Jones, M. M. Fabani, G. Ivanova, A. A. Arzumanov, M. J. Gait, Blood Cells Mol. Dis. 2007, 38, 1–7.</note><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">Turner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Jones</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. M.</namePart><namePart type="family">Fabani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Ivanova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. A.</namePart><namePart type="family">Arzumanov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. J.</namePart><namePart type="family">Gait</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><extent unit="pages"><start>1</start><end>7</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit122"><titleInfo><title>EMBO Rep.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. Overhoff, G. Sczakiel, EMBO Rep. 2005, 6, 1176–1181.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Overhoff</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Sczakiel</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>1176</start><end>1181</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit123"><titleInfo><title>Nat. Biotechnol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">E. Song, P. Zhu, S. K. Lee, D. Chowdhury, S. Kussman, D. M. Dykxhoorn, Y. Feng, D. Palliser, D. B. Weiner, P. Shankar, W. A. Marasco, J. Lieberman, Nat. Biotechnol. 2005, 23, 709–717.</note><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Song</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Zhu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. K.</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Chowdhury</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kussman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. M.</namePart><namePart type="family">Dykxhoorn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Feng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Palliser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. B.</namePart><namePart type="family">Weiner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Shankar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. A.</namePart><namePart type="family">Marasco</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Lieberman</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>709</start><end>717</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit124"><titleInfo><title>Nucleic Acids Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. C. Chu, K. Y. Twu, A. D. Ellington, M. Levy, Nucleic Acids Res. 2006, 34, e73.</note><name type="personal"><namePart type="given">T. C.</namePart><namePart type="family">Chu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. Y.</namePart><namePart type="family">Twu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. D.</namePart><namePart type="family">Ellington</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Levy</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>73</start></extent></part></relatedItem><relatedItem type="references" displayLabel="cit125"><titleInfo><title>Nat. Biotechnol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. O. McNamara II, E. R. Andrechek, Y. Wang, K. D. Viles, R. E. Rempel, E. Gilboa, B. A. Sullenger, P. H. Giangrande, Nat. Biotechnol. 2006, 24, 1005–1015.</note><name type="personal"><namePart type="given">J. O.</namePart><namePart type="family">McNamara II</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. R.</namePart><namePart type="family">Andrechek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. D.</namePart><namePart type="family">Viles</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. E.</namePart><namePart type="family">Rempel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Gilboa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. A.</namePart><namePart type="family">Sullenger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. H.</namePart><namePart type="family">Giangrande</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>1005</start><end>1015</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit126"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">P. Kumar, H. Wu, J. L. McBride, K. E. Jung, M. H. Kim, B. L. Davidson, S. K. Lee, P. Shankar, N. Manjunath, Nature 2007, 448, 39–43.</note><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Kumar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. L.</namePart><namePart type="family">McBride</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. E.</namePart><namePart type="family">Jung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. H.</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. L.</namePart><namePart type="family">Davidson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. K.</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Shankar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Manjunath</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>448</number></detail><extent unit="pages"><start>39</start><end>43</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit127"><titleInfo><title>RNA</title></titleInfo><genre>journal-article</genre><note type="citation/reference">K. Zhang, Q. Wang, Y. Xie, G. Mor, E. Sega, P. S. Low, Y. Huang, RNA 2008, 14, 577–583.</note><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Q.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Xie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Mor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Sega</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. S.</namePart><namePart type="family">Low</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Huang</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>577</start><end>583</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit128"><titleInfo><title>J. Clin. Invest.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. Akhtar, I. F. Benter, J. Clin. Invest. 2007, 117, 3623–3632.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Akhtar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. F.</namePart><namePart type="family">Benter</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>117</number></detail><extent unit="pages"><start>3623</start><end>3632</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit129"><titleInfo><title>C. Reinsch, E. Siepi, A. Dieckmann, S. Panzner in Therapeutic Oligonucleotides (Ed.: J. Kurreck), Royal Society of Chemistry Publishing, Cambridge, 2008, pp. 226–240.</title></titleInfo><note type="citation/reference">C. Reinsch, E. Siepi, A. Dieckmann, S. Panzner in Therapeutic Oligonucleotides (Ed.: J. Kurreck), Royal Society of Chemistry Publishing, Cambridge, 2008, pp. 226–240.</note><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Reinsch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Siepi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Dieckmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Panzner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><role><roleTerm type="text">editor</roleTerm></role></name><genre>book</genre><originInfo><publisher>Royal Society of Chemistry Publishing</publisher><place><placeTerm type="text">Cambridge</placeTerm></place></originInfo><part><date>2008</date><extent unit="pages"><start>226</start><end>240</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit130"><titleInfo><title>I. MacLachlan in Therapeutic Oligonucleotides (Ed.: J. Kurreck), Royal Society of Chemistry Publishing, Cambridge, 2008, pp. 241–266.</title></titleInfo><note type="citation/reference">I. MacLachlan in Therapeutic Oligonucleotides (Ed.: J. Kurreck), Royal Society of Chemistry Publishing, Cambridge, 2008, pp. 241–266.</note><name type="personal"><namePart type="given">I.</namePart><namePart type="family">MacLachlan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><role><roleTerm type="text">editor</roleTerm></role></name><genre>book</genre><originInfo><publisher>Royal Society of Chemistry Publishing</publisher><place><placeTerm type="text">Cambridge</placeTerm></place></originInfo><part><date>2008</date><extent unit="pages"><start>241</start><end>266</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit131"><titleInfo><title>J. Gene Med.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. L. Edelstein, M. R. Abedi, J. Wixon, J. Gene Med. 2007, 9, 833–842.</note><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Edelstein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. R.</namePart><namePart type="family">Abedi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wixon</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>833</start><end>842</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit132"><titleInfo><title>D. Grimm, M. A. Kay, Hematology Am. Soc. Hematol. Educ. Program 2007, 473–481.</title></titleInfo><genre>other</genre></relatedItem><relatedItem type="references" displayLabel="cit133"><titleInfo><title>Science</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. Cavazzana‐Calvo, S. Hacein‐Bey, G. de Saint Basile, F. Gross, E. Yvon, P. Nusbaum, F. Selz, C. Hue, S. Certain, J. L. Casanova, P. Bousso, F. L. Deist, A. Fischer, Science 2000, 288, 669–672.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Cavazzana‐Calvo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Hacein‐Bey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. de Saint</namePart><namePart type="family">Basile</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Gross</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Yvon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Nusbaum</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Selz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Hue</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Certain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. L.</namePart><namePart type="family">Casanova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Bousso</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. L.</namePart><namePart type="family">Deist</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Fischer</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>288</number></detail><extent unit="pages"><start>669</start><end>672</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit134"><titleInfo><title>Science</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. Hacein‐Bey‐Abina, C. Von Kalle, M. Schmidt, M. P. McCormack, N. Wulffraat, P. Leboulch, A. Lim, C. S. Osborne, R. Pawliuk, E. Morillon, R. Sorensen, A. Forster, P. Fraser, J. I. Cohen, G. de Saint Basile, I. Alexander, U. Wintergerst, T. Frebourg, A. Aurias, D. Stoppa‐Lyonnet, S. Romana, I. Radford‐Weiss, F. Gross, F. Valensi, E. Delabesse, E. Macintyre, F. Sigaux, J. Soulier, L. E. Leiva, M. Wissler, C. Prinz, T. H. Rabbitts, F. Le Deist, A. Fischer, M. Cavazzana‐Calvo, Science 2003, 302, 415–419.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Hacein‐Bey‐Abina</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Von Kalle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Schmidt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. P.</namePart><namePart type="family">McCormack</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Wulffraat</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Leboulch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Lim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. S.</namePart><namePart type="family">Osborne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Pawliuk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Morillon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Sorensen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Forster</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Fraser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. I.</namePart><namePart type="family">Cohen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">de Saint Basile</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Alexander</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Wintergerst</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Frebourg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Aurias</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Stoppa‐Lyonnet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Romana</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Radford‐Weiss</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Gross</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Valensi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Delabesse</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Macintyre</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Sigaux</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Soulier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. E.</namePart><namePart type="family">Leiva</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Wissler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Prinz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. H.</namePart><namePart type="family">Rabbitts</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Le Deist</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Fischer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Cavazzana‐Calvo</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>302</number></detail><extent unit="pages"><start>415</start><end>419</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit135"><titleInfo><title>Hum. Gene Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. Abbas‐Terki, W. Blanco‐Bose, N. Deglon, W. Pralong, P. Aebischer, Hum. Gene Ther. 2002, 13, 2197–2201.</note><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Abbas‐Terki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Blanco‐Bose</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Deglon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Pralong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Aebischer</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>2197</start><end>2201</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit136"><titleInfo><title>Cancer Cell</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. R. Brummelkamp, R. Bernards, R. Agami, Cancer Cell 2002, 2, 243–247.</note><name type="personal"><namePart type="given">T. R.</namePart><namePart type="family">Brummelkamp</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Bernards</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Agami</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>243</start><end>247</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit137"><titleInfo><title>Mol. Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. D. Henry, P. van der Wegen, H. J. Metselaar, H. W. Tilanus, B. J. Scholte, L. J. van der Laan, Mol. Ther. 2006, 14, 485–493.</note><name type="personal"><namePart type="given">S. D.</namePart><namePart type="family">Henry</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">van der Wegen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. J.</namePart><namePart type="family">Metselaar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. W.</namePart><namePart type="family">Tilanus</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. J.</namePart><namePart type="family">Scholte</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. J.</namePart><namePart type="family">van der Laan</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>485</start><end>493</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit138"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. Lehrman, Nature 1999, 401, 517–518.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Lehrman</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>401</number></detail><extent unit="pages"><start>517</start><end>518</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit139"><titleInfo><title>Gene Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">R. Alba, A. Bosch, M. Chillon, Gene Ther. 2005, 12 Suppl 1, S18–27.</note><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Alba</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Bosch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Chillon</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><extent unit="pages"><start>18</start><end>27</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit140"><titleInfo><title>J. Virol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">W. Chen, M. Liu, Y. Jiao, W. Yan, X. Wei, J. Chen, L. Fei, Y. Liu, X. Zuo, F. Yang, Y. Lu, Z. Zheng, J. Virol. 2006, 80, 3559–3566.</note><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Jiao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Yan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Wei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Fei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Zuo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Lu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Zheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>80</number></detail><extent unit="pages"><start>3559</start><end>3566</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit141"><titleInfo><title>Gene Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H. Fechner, L. Suckau, J. Kurreck, I. Sipo, X. Wang, S. Pinkert, S. Loschen, J. Rekittke, S. Weger, D. Dekkers, R. Vetter, V. A. Erdmann, H. P. Schultheiss, M. Paul, J. Lamers, W. Poller, Gene Ther. 2007, 14, 211–218.</note><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Fechner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Suckau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kurreck</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Sipo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Pinkert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Loschen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Rekittke</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Weger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Dekkers</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Vetter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. A.</namePart><namePart type="family">Erdmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. P.</namePart><namePart type="family">Schultheiss</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Paul</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Lamers</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Poller</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>211</start><end>218</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit142"><titleInfo><title>Curr. Gene Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. Grimm, M. A. Kay, Curr. Gene Ther. 2003, 3, 281–304.</note><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Grimm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Kay</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>281</start><end>304</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit143"><titleInfo><title>Gene Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Z. Wang, H. I. Ma, J. Li, L. Sun, J. Zhang, X. Xiao, Gene Ther. 2003, 10, 2105–2111.</note><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. I.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Sun</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Xiao</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>2105</start><end>2111</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit144"><titleInfo><title>Nat. Med.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. D. Hommel, R. M. Sears, D. Georgescu, D. L. Simmons, R. J. DiLeone, Nat. Med. 2003, 9, 1539–1544.</note><name type="personal"><namePart type="given">J. D.</namePart><namePart type="family">Hommel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. M.</namePart><namePart type="family">Sears</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Georgescu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. L.</namePart><namePart type="family">Simmons</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. J.</namePart><namePart type="family">DiLeone</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>1539</start><end>1544</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit145"><titleInfo><title>Mitochondrion</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Z. Han, M. Gorbatyuk, J. Thomas, Jr., A. S. Lewin, A. Srivastava, P. W. Stacpoole, Mitochondrion 2007, 7, 253–259.</note><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Han</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Gorbatyuk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Thomas Jr.</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. S.</namePart><namePart type="family">Lewin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Srivastava</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. W.</namePart><namePart type="family">Stacpoole</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>253</start><end>259</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit146"><titleInfo><title>FASEB J.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">C. Warnecke, Z. Zaborowska, J. Kurreck, V. A. Erdmann, U. Frei, M. Wiesener, K. U. Eckardt, FASEB J. 2004, 18, 1462–1464.</note><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Warnecke</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Zaborowska</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kurreck</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. A.</namePart><namePart type="family">Erdmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Frei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Wiesener</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. U.</namePart><namePart type="family">Eckardt</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>1462</start><end>1464</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit147"><titleInfo><title>Drug Discovery Today</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. Chatterjee‐Kishore, C. P. Miller, Drug Discovery Today 2005, 10, 1559–1565.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Chatterjee‐Kishore</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. P.</namePart><namePart type="family">Miller</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>1559</start><end>1565</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit148"><titleInfo><title>Nat. Cell Biol. 2003, 5, 489–490.</title></titleInfo><genre>other</genre></relatedItem><relatedItem type="references" displayLabel="cit149"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">T. R. Brummelkamp, S. M. Nijman, A. M. Dirac, R. Bernards, Nature 2003, 424, 797–801.</note><name type="personal"><namePart type="given">T. R.</namePart><namePart type="family">Brummelkamp</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. M.</namePart><namePart type="family">Nijman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. M.</namePart><namePart type="family">Dirac</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Bernards</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>424</number></detail><extent unit="pages"><start>797</start><end>801</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit150"><titleInfo><title>Br. J. Dermatol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H. M. Oosterkamp, H. Neering, S. M. Nijman, A. M. Dirac, W. J. Mooi, R. Bernards, T. R. Brummelkamp, Br. J. Dermatol. 2006, 155, 182–185.</note><name type="personal"><namePart type="given">H. M.</namePart><namePart type="family">Oosterkamp</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Neering</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. M.</namePart><namePart type="family">Nijman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. M.</namePart><namePart type="family">Dirac</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. J.</namePart><namePart type="family">Mooi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Bernards</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. R.</namePart><namePart type="family">Brummelkamp</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>155</number></detail><extent unit="pages"><start>182</start><end>185</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit151"><titleInfo><title>Science</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. L. Brass, D. M. Dykxhoorn, Y. Benita, N. Yan, A. Engelman, R. J. Xavier, J. Lieberman, S. J. Elledge, Science 2008, 319, 921–926.</note><name type="personal"><namePart type="given">A. L.</namePart><namePart type="family">Brass</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. M.</namePart><namePart type="family">Dykxhoorn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Benita</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Yan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Engelman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. J.</namePart><namePart type="family">Xavier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Lieberman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. J.</namePart><namePart type="family">Elledge</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>319</number></detail><extent unit="pages"><start>921</start><end>926</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit152"><titleInfo><title>Science</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. R. Schlabach, J. Luo, N. L. Solimini, G. Hu, Q. Xu, M. Z. Li, Z. Zhao, A. Smogorzewska, M. E. Sowa, X. L. Ang, T. F. Westbrook, A. C. Liang, K. Chang, J. A. Hackett, J. W. Harper, G. J. Hannon, S. J. Elledge, Science 2008, 319, 620–624.</note><name type="personal"><namePart type="given">M. R.</namePart><namePart type="family">Schlabach</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Luo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N. L.</namePart><namePart type="family">Solimini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Hu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Q.</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. Z.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Zhao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Smogorzewska</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. E.</namePart><namePart type="family">Sowa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X. L.</namePart><namePart type="family">Ang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. F.</namePart><namePart type="family">Westbrook</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. C.</namePart><namePart type="family">Liang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Chang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. A.</namePart><namePart type="family">Hackett</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. W.</namePart><namePart type="family">Harper</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. J.</namePart><namePart type="family">Hannon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. J.</namePart><namePart type="family">Elledge</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>319</number></detail><extent unit="pages"><start>620</start><end>624</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit153"><titleInfo><title>Cell</title></titleInfo><genre>journal-article</genre><note type="citation/reference">N. Wajapeyee, R. W. Serra, X. Zhu, M. Mahalingam, M. R. Green, Cell 2008, 132, 363–374.</note><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Wajapeyee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. W.</namePart><namePart type="family">Serra</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Zhu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Mahalingam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. R.</namePart><namePart type="family">Green</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>132</number></detail><extent unit="pages"><start>363</start><end>374</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit154"><titleInfo><title>Annu. Rev. Med.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. T. Crooke, Annu. Rev. Med. 2004, 55, 61–95.</note><name type="personal"><namePart type="given">S. T.</namePart><namePart type="family">Crooke</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>55</number></detail><extent unit="pages"><start>61</start><end>95</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit155"><titleInfo><title>Curr. Drug Targets</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. Schubert, J. Kurreck, Curr. Drug Targets 2004, 5, 667–681.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Schubert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kurreck</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>667</start><end>681</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit156"><titleInfo><title>Hum. Gene Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. Haussecker, Hum. Gene Ther. 2008, 19, 451–462.</note><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Haussecker</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>451</start><end>462</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit157"><titleInfo><title>Gene Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. Shen, R. Samul, R. L. Silva, H. Akiyama, H. Liu, Y. Saishin, S. F. Hackett, S. Zinnen, K. Kossen, K. Fosnaugh, C. Vargeese, A. Gomez, K. Bouhana, R. Aitchison, P. Pavco, P. A. Campochiaro, Gene Ther. 2006, 13, 225–234.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Shen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Samul</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. L.</namePart><namePart type="family">Silva</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Akiyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Saishin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. F.</namePart><namePart type="family">Hackett</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Zinnen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Kossen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Fosnaugh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Vargeese</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Gomez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Bouhana</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Aitchison</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Pavco</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. A.</namePart><namePart type="family">Campochiaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>225</start><end>234</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit158"><titleInfo><title>BMC Microbiol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">V. Bitko, S. Barik, BMC Microbiol. 2001, 1, 34.</note><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Bitko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Barik</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>34</start></extent></part></relatedItem><relatedItem type="references" displayLabel="cit159"><titleInfo><title>Nat. Biotechnol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Review: J. Haasnoot, E. M. Westerhout, B. Berkhout, Nat. Biotechnol. 2007, 25, 1435–1443.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Haasnoot</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. M.</namePart><namePart type="family">Westerhout</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Berkhout</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>1435</start><end>1443</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit160"><titleInfo><title>Nat. Struct. Mol. Biol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">K. M. Brown, C. Y. Chu, T. M. Rana, Nat. Struct. Mol. Biol. 2005, 12, 469–470.</note><name type="personal"><namePart type="given">K. M.</namePart><namePart type="family">Brown</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. Y.</namePart><namePart type="family">Chu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. M.</namePart><namePart type="family">Rana</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>469</start><end>470</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit161"><titleInfo><title>J. Virol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">L. Gitlin, J. K. Stone, R. Andino, J. Virol. 2005, 79, 1027–1035.</note><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Gitlin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. K.</namePart><namePart type="family">Stone</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Andino</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>1027</start><end>1035</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit162"><titleInfo><title>J. Virol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. Boden, O. Pusch, F. Lee, L. Tucker, B. Ramratnam, J. Virol. 2003, 77, 11531–11535.</note><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Boden</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Pusch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Tucker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Ramratnam</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>77</number></detail><extent unit="pages"><start>11531</start><end>11535</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit163"><titleInfo><title>J. Virol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. T. Das, T. R. Brummelkamp, E. M. Westerhout, M. Vink, M. Madiredjo, R. Bernards, B. Berkhout, J. Virol. 2004, 78, 2601–2605.</note><name type="personal"><namePart type="given">A. T.</namePart><namePart type="family">Das</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. R.</namePart><namePart type="family">Brummelkamp</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. M.</namePart><namePart type="family">Westerhout</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Vink</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Madiredjo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Bernards</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Berkhout</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><extent unit="pages"><start>2601</start><end>2605</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit164"><titleInfo><title>J. Virol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">K. J. von Eije, O. ter Brake, B. Berkhout, J. Virol. 2008, 82, 2895–2903.</note><name type="personal"><namePart type="given">K. J.</namePart><namePart type="family">von Eije</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.</namePart><namePart type="family">ter Brake</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Berkhout</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>82</number></detail><extent unit="pages"><start>2895</start><end>2903</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit165"><titleInfo><title>Oligonucleotides</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. Merl, R. Wessely, Oligonucleotides 2007, 17, 44–53.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Merl</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Wessely</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>44</start><end>53</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit166"><titleInfo><title>J. Gen. Virol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H. S. Lee, J. Ahn, Y. Jee, I. S. Seo, E. J. Jeon, E. S. Jeon, C. H. Joo, Y. K. Kim, H. Lee, J. Gen. Virol. 2007, 88, 2003–2012.</note><name type="personal"><namePart type="given">H. S.</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Ahn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Jee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. S.</namePart><namePart type="family">Seo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. J.</namePart><namePart type="family">Jeon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. S.</namePart><namePart type="family">Jeon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. H.</namePart><namePart type="family">Joo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y. K.</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>88</number></detail><extent unit="pages"><start>2003</start><end>2012</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit167"><titleInfo><title>Mol. Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">O. T. Brake, K. Hooft, Y. P. Liu, M. Centlivre, K. Jasmijn von Eije, B. Berkhout, Mol. Ther. 2008, 16, 557–564.</note><name type="personal"><namePart type="given">O. T.</namePart><namePart type="family">Brake</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Hooft</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y. P.</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Centlivre</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. Jasmijn von</namePart><namePart type="family">Eije</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Berkhout</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>557</start><end>564</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit168"><titleInfo><title>Gene Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. Anderson, R. Akkina, Gene Ther. 2007, 14, 1287–1297.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Akkina</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>1287</start><end>1297</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit169"><titleInfo><title>Cell</title></titleInfo><genre>journal-article</genre><note type="citation/reference">C. B. Coyne, J. M. Bergelson, Cell 2006, 124, 119–131.</note><name type="personal"><namePart type="given">C. B.</namePart><namePart type="family">Coyne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. M.</namePart><namePart type="family">Bergelson</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>124</number></detail><extent unit="pages"><start>119</start><end>131</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit170"><titleInfo><title>Gene Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H. Fechner, S. Pinkert, X. Wang, I. Sipo, L. Suckau, J. Kurreck, A. Dorner, K. Sollerbrant, H. Zeichhardt, H. P. Grunert, R. Vetter, H. P. Schultheiss, W. Poller, Gene Ther. 2007, 14, 960–971.</note><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Fechner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Pinkert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Sipo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Suckau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kurreck</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Dorner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Sollerbrant</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Zeichhardt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. P.</namePart><namePart type="family">Grunert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Vetter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. P.</namePart><namePart type="family">Schultheiss</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Poller</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>960</start><end>971</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit171"><titleInfo><title>Biol. Chem.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. Werk, S. Schubert, V. Lindig, H. P. Grunert, H. Zeichhardt, V. A. Erdmann, J. Kurreck, Biol. Chem. 2005, 386, 857–863.</note><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Werk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Schubert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Lindig</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. P.</namePart><namePart type="family">Grunert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Zeichhardt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. A.</namePart><namePart type="family">Erdmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kurreck</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>386</number></detail><extent unit="pages"><start>857</start><end>863</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit172"><titleInfo><title>Mol. Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">M. J. Li, J. Kim, S. Li, J. Zaia, J. K. Yee, J. Anderson, R. Akkina, J. J. Rossi, Mol. Ther. 2005, 12, 900–909.</note><name type="personal"><namePart type="given">M. J.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Zaia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. K.</namePart><namePart type="family">Yee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Akkina</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">Rossi</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>900</start><end>909</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit173"><titleInfo><title>L. Scherer, M. S. Weinberg, J. J. Rossiin Therapeutic Oligonucleotides (Ed.: J. Kurreck), Royal Society of Chemistry Publishing, Cambridge, 2008, pp. 316–328.</title></titleInfo><note type="citation/reference">L. Scherer, M. S. Weinberg, J. J. Rossiin Therapeutic Oligonucleotides (Ed.: J. Kurreck), Royal Society of Chemistry Publishing, Cambridge, 2008, pp. 316–328.</note><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Scherer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. S.</namePart><namePart type="family">Weinberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">Rossi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><role><roleTerm type="text">editor</roleTerm></role></name><genre>book</genre><originInfo><publisher>Royal Society of Chemistry Publishing</publisher><place><placeTerm type="text">Cambridge</placeTerm></place></originInfo><part><date>2008</date><extent unit="pages"><start>316</start><end>328</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit174"><titleInfo><title>Antiviral Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. Devincenzo, J. E. Cehelsky, R. Alvarez, S. Elbashir, J. Harborth, I. Toudjarska, L. Nechev, V. Murugaiah, A. V. Vliet, A. K. Vaishnaw, R. Meyers, Antiviral Res. 2008, 77, 225–231.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Devincenzo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. E.</namePart><namePart type="family">Cehelsky</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Alvarez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Elbashir</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Harborth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Toudjarska</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Nechev</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Murugaiah</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. V.</namePart><namePart type="family">Vliet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. K.</namePart><namePart type="family">Vaishnaw</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Meyers</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>77</number></detail><extent unit="pages"><start>225</start><end>231</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit175"><titleInfo><title>Gene Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">S. I. Pai, Y. Y. Lin, B. Macaes, A. Meneshian, C. F. Hung, T. C. Wu, Gene Ther. 2006, 13, 464–477.</note><name type="personal"><namePart type="given">S. I.</namePart><namePart type="family">Pai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y. Y.</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Macaes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Meneshian</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. F.</namePart><namePart type="family">Hung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. C.</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>464</start><end>477</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit176"><titleInfo><title>Cancer Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">H. Wu, W. N. Hait, J. M. Yang, Cancer Res. 2003, 63, 1515–1519.</note><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. N.</namePart><namePart type="family">Hait</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. M.</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>63</number></detail><extent unit="pages"><start>1515</start><end>1519</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit177"><titleInfo><title>Gene Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">A. Santel, M. Aleku, O. Keil, J. Endruschat, V. Esche, B. Durieux, K. Loffler, M. Fechtner, T. Rohl, G. Fisch, S. Dames, W. Arnold, K. Giese, A. Klippel, J. Kaufmann, Gene Ther. 2006, 13, 1360–1370.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Santel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Aleku</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Keil</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Endruschat</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Esche</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Durieux</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Loffler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Fechtner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Rohl</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Fisch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Dames</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Arnold</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Giese</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Klippel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kaufmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>1360</start><end>1370</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit178"><titleInfo><title>Cancer Res.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Y. A. Zhang, J. Nemunaitis, S. K. Samuel, P. Chen, Y. Shen, A. W. Tong, Cancer Res. 2006, 66, 9736–9743.</note><name type="personal"><namePart type="given">Y. A.</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Nemunaitis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. K.</namePart><namePart type="family">Samuel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Shen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. W.</namePart><namePart type="family">Tong</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>66</number></detail><extent unit="pages"><start>9736</start><end>9743</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit179"><titleInfo><title>Cancer Biol. Ther.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">R. Zukiel, S. Nowak, E. Wyszko, K. Rolle, I. Gawronska, M. Z. Barciszewska, J. Barciszewski, Cancer Biol. Ther. 2006, 5, 1002–1007.</note><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Zukiel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Nowak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Wyszko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Rolle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Gawronska</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. Z.</namePart><namePart type="family">Barciszewska</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Barciszewski</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>1002</start><end>1007</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit180"><titleInfo><title>Nat. Rev. Genet.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">D. H. Kim, J. J. Rossi, Nat. Rev. Genet. 2007, 8, 173–184.</note><name type="personal"><namePart type="given">D. H.</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">Rossi</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>173</start><end>184</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit181"><titleInfo><title>Science</title></titleInfo><genre>journal-article</genre><note type="citation/reference">P. G. Komarov, E. A. Komarova, R. V. Kondratov, K. Christov‐Tselkov, J. S. Coon, M. V. Chernov, A. V. Gudkov, Science 1999, 285, 1733–1737.</note><name type="personal"><namePart type="given">P. G.</namePart><namePart type="family">Komarov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. A.</namePart><namePart type="family">Komarova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. V.</namePart><namePart type="family">Kondratov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Christov‐Tselkov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. S.</namePart><namePart type="family">Coon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. V.</namePart><namePart type="family">Chernov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. V.</namePart><namePart type="family">Gudkov</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>285</number></detail><extent unit="pages"><start>1733</start><end>1737</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit182"><titleInfo><title>J. Invest. Dermatol.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">F. J. Smith, R. P. Hickerson, J. M. Sayers, R. E. Reeves, C. H. Contag, D. Leake, R. L. Kaspar, W. H. McLean, J. Invest. Dermatol. 2008, 128, 50–58.</note><name type="personal"><namePart type="given">F. J.</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. P.</namePart><namePart type="family">Hickerson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. M.</namePart><namePart type="family">Sayers</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. E.</namePart><namePart type="family">Reeves</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. H.</namePart><namePart type="family">Contag</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Leake</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. L.</namePart><namePart type="family">Kaspar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. H.</namePart><namePart type="family">McLean</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>128</number></detail><extent unit="pages"><start>50</start><end>58</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit183"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">J. Elmén, M. Lindow, S. Schutz, M. Lawrence, A. Petri, S. Obad, M. Lindholm, M. Hedtjarn, H. F. Hansen, U. Berger, S. Gullans, P. Kearney, P. Sarnow, E. M. Straarup, S. Kauppinen, Nature 2008, 452, 896–899.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Elmén</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Lindow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Schutz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Lawrence</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Petri</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Obad</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Lindholm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hedtjarn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. F.</namePart><namePart type="family">Hansen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Berger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Gullans</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Kearney</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Sarnow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. M.</namePart><namePart type="family">Straarup</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kauppinen</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>452</number></detail><extent unit="pages"><start>896</start><end>899</end></extent></part></relatedItem><identifier type="istex">6658B554E5216527EDB4F6F6F8029DE4471EEA0B</identifier><identifier type="ark">ark:/67375/WNG-4WC0FXHR-7</identifier><identifier type="DOI">10.1002/anie.200802092</identifier><identifier type="ArticleID">ANIE200802092</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 WILEY‐VCH Verlag GmbH & Co. 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