La fièvre chez les granulopéniques. Attitudes thérapeutiques
Identifieur interne : 000E30 ( Istex/Corpus ); précédent : 000E29; suivant : 000E31La fièvre chez les granulopéniques. Attitudes thérapeutiques
Auteurs : M. Rey ; J. Beytout ; M. F. Petit ; Ph. Travade ; J. Sirot ; J. L. DelpouxSource :
- Medecine et Maladies Infectieuses [ 0399-077X ] ; 1985.
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- KwdEn :
Abstract
Resume: Evénement fréquent et redouté des situations granulopéniques de toute origine, la fièvre est le plus souvent liée à une infection bactérienne surtout, fongique parfois. Sa survenue impose d'urgence une antibiothérapie présomptive, couvrant à priori les entérobactéries, le pyocyanique, les staphylocoques, les streptocoques, éventuellement guidée par la suveillance microbiologique préalable du patient et des infections hospitalières environnantes. Une association synergique, bactéricide, à large spectre, est indiquée. En attendant la mise à l'épreuve de molécules nouvelles, on utilise le plus souvent une betalactamine associée à un aminoside. Au cas où l'infection est secondairement documentée, l'antibiothérapie initiale est ajustée aux données bactériocliniques. La persistance au 4ème jour d'une fièvre isolée, ou associée à une pneumopathie, peut faire ajouter l'amphotéricine B dans l'hypothèse d'une mycose, difficile à prouver. Les transfusions de granulocytes sont l'objet de controverses.
Summary: Fever happens quite often among patients with granulopenia of several origins ; the fever is mostly related to bacterial infections, sometimes to fungal infections. Its outcome needs in emergency the use of an empirical antibiotherapy aimed either on Gram-negative bacilli, enterobacteries and Pseudomonas, or on staphylococci and streptococci. Patients microbiological follow up and surrounding nosocomial infections survey may help in the choice of the antibiotherapy. The antibiotics need to have wide range activity, to be bactericidal and synergistic in order to be associated in the treatment of granulopenic febrile patients : expecting well assessed new drugs, the associations mainly employed in first purpose are betalactamines with aminoglycosides. If the infection becomes documented, the initial antibiotherapy must be adapted following clinical and bacteriological data. A fever related to a pneumopathy and a fever of unknown origin persisting later than 4 days suggest a possible fungal infection and amphotericin B may be added. Granulocytes transfusions are a point of controversy.
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DOI: 10.1016/S0399-077X(85)80299-7
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ISTEX:F461880DE510CE8A978E7C1A802A122ADE289DE9Le document en format XML
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Delpoux</name><affiliation><mods:affiliation>Service des Maladies Infectieuses et tropicales, Centre Hospitalier Universitaire Hôtel-Dieu, F-63000 Clermont-Ferrand, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Medecine et Maladies Infectieuses</title><title level="j" type="abbrev">MEDMAL</title><idno type="ISSN">0399-077X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985">1985</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="220">220</biblScope><biblScope unit="page" to="229">229</biblScope></imprint><idno type="ISSN">0399-077X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0399-077X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Fever</term><term>Granulopenia</term></keywords></textClass><langUsage><language ident="fr">fr</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">Resume: Evénement fréquent et redouté des situations granulopéniques de toute origine, la fièvre est le plus souvent liée à une infection bactérienne surtout, fongique parfois. Sa survenue impose d'urgence une antibiothérapie présomptive, couvrant à priori les entérobactéries, le pyocyanique, les staphylocoques, les streptocoques, éventuellement guidée par la suveillance microbiologique préalable du patient et des infections hospitalières environnantes. Une association synergique, bactéricide, à large spectre, est indiquée. En attendant la mise à l'épreuve de molécules nouvelles, on utilise le plus souvent une betalactamine associée à un aminoside. Au cas où l'infection est secondairement documentée, l'antibiothérapie initiale est ajustée aux données bactériocliniques. La persistance au 4ème jour d'une fièvre isolée, ou associée à une pneumopathie, peut faire ajouter l'amphotéricine B dans l'hypothèse d'une mycose, difficile à prouver. Les transfusions de granulocytes sont l'objet de controverses.</div><div type="abstract" xml:lang="en">Summary: Fever happens quite often among patients with granulopenia of several origins ; the fever is mostly related to bacterial infections, sometimes to fungal infections. Its outcome needs in emergency the use of an empirical antibiotherapy aimed either on Gram-negative bacilli, enterobacteries and Pseudomonas, or on staphylococci and streptococci. Patients microbiological follow up and surrounding nosocomial infections survey may help in the choice of the antibiotherapy. The antibiotics need to have wide range activity, to be bactericidal and synergistic in order to be associated in the treatment of granulopenic febrile patients : expecting well assessed new drugs, the associations mainly employed in first purpose are betalactamines with aminoglycosides. If the infection becomes documented, the initial antibiotherapy must be adapted following clinical and bacteriological data. A fever related to a pneumopathy and a fever of unknown origin persisting later than 4 days suggest a possible fungal infection and amphotericin B may be added. Granulocytes transfusions are a point of controversy.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>M. Rey</name><affiliations><json:string>Service des Maladies Infectieuses et tropicales, Centre Hospitalier Universitaire Hôtel-Dieu, F-63000 Clermont-Ferrand, France</json:string></affiliations></json:item><json:item><name>J. Beytout</name><affiliations><json:string>Service des Maladies Infectieuses et tropicales, Centre Hospitalier Universitaire Hôtel-Dieu, F-63000 Clermont-Ferrand, France</json:string></affiliations></json:item><json:item><name>M.F. Petit</name><affiliations><json:string>Service des Maladies Infectieuses et tropicales, Centre Hospitalier Universitaire Hôtel-Dieu, F-63000 Clermont-Ferrand, France</json:string></affiliations></json:item><json:item><name>Ph. Travade</name><affiliations><json:string>Laboratoire d'Hématologie, CHU Hôtel-Dieu, Clermont-Ferrand France</json:string></affiliations></json:item><json:item><name>J. Sirot</name><affiliations><json:string>Laboratoire de Microbiologie, CHU Hôtel-Dieu, Clermont-Ferrand France</json:string></affiliations></json:item><json:item><name>J.L. 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Sa survenue impose d'urgence une antibiothérapie présomptive, couvrant à priori les entérobactéries, le pyocyanique, les staphylocoques, les streptocoques, éventuellement guidée par la suveillance microbiologique préalable du patient et des infections hospitalières environnantes. Une association synergique, bactéricide, à large spectre, est indiquée. En attendant la mise à l'épreuve de molécules nouvelles, on utilise le plus souvent une betalactamine associée à un aminoside. Au cas où l'infection est secondairement documentée, l'antibiothérapie initiale est ajustée aux données bactériocliniques. La persistance au 4ème jour d'une fièvre isolée, ou associée à une pneumopathie, peut faire ajouter l'amphotéricine B dans l'hypothèse d'une mycose, difficile à prouver. Les transfusions de granulocytes sont l'objet de controverses.</abstract><qualityIndicators><refBibsNative>true</refBibsNative><abstractWordCount>133</abstractWordCount><abstractCharCount>1012</abstractCharCount><keywordCount>4</keywordCount><score>8.596</score><pdfWordCount>6214</pdfWordCount><pdfCharCount>39742</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>612 x 807 pts</pdfPageSize></qualityIndicators><title>La fièvre chez les granulopéniques. 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Attitudes thérapeutiques</title><title level="a" type="alt" xml:lang="en">Therapy in febrile granulocytopenic patients</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1985</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>Communication présentée au Congrès de la Société de Pathologie infectieuse de Langue française, tenu à Rennes le 31 Mai et le 1er Juin 1985, sous le titre : «Infections chez les Immunodéprimés.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="fr">La fièvre chez les granulopéniques. Attitudes thérapeutiques</title><title level="a" type="alt" xml:lang="en">Therapy in febrile granulocytopenic patients</title><author xml:id="author-0000"><persName><forename type="first">M.</forename><surname>Rey</surname></persName><affiliation>Service des Maladies Infectieuses et tropicales, Centre Hospitalier Universitaire Hôtel-Dieu, F-63000 Clermont-Ferrand, France</affiliation></author><author xml:id="author-0001"><persName><forename type="first">J.</forename><surname>Beytout</surname></persName><affiliation>Service des Maladies Infectieuses et tropicales, Centre Hospitalier Universitaire Hôtel-Dieu, F-63000 Clermont-Ferrand, France</affiliation></author><author xml:id="author-0002"><persName><forename type="first">M.F.</forename><surname>Petit</surname></persName><affiliation>Service des Maladies Infectieuses et tropicales, Centre Hospitalier Universitaire Hôtel-Dieu, F-63000 Clermont-Ferrand, France</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Ph.</forename><surname>Travade</surname></persName><affiliation>Laboratoire d'Hématologie, CHU Hôtel-Dieu, Clermont-Ferrand France</affiliation></author><author xml:id="author-0004"><persName><forename type="first">J.</forename><surname>Sirot</surname></persName><affiliation>Laboratoire de Microbiologie, CHU Hôtel-Dieu, Clermont-Ferrand France</affiliation></author><author xml:id="author-0005"><persName><forename type="first">J.L.</forename><surname>Delpoux</surname></persName><affiliation>Service des Maladies Infectieuses et tropicales, Centre Hospitalier Universitaire Hôtel-Dieu, F-63000 Clermont-Ferrand, France</affiliation></author><idno type="istex">F461880DE510CE8A978E7C1A802A122ADE289DE9</idno><idno type="ark">ark:/67375/6H6-GMX59Q5V-C</idno><idno type="DOI">10.1016/S0399-077X(85)80299-7</idno><idno type="PII">S0399-077X(85)80299-7</idno><idno type="article-id">85802997</idno></analytic><monogr><title level="j">Medecine et Maladies Infectieuses</title><title level="j" type="abbrev">MEDMAL</title><idno type="pISSN">0399-077X</idno><idno type="PII">S0399-077X(85)X8292-9</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985"></date><biblScope unit="volume">15</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="220">220</biblScope><biblScope unit="page" to="229">229</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1985</date></creation><langUsage><language ident="fr">fr</language></langUsage><abstract xml:lang="fr"><p>Resume: Evénement fréquent et redouté des situations granulopéniques de toute origine, la fièvre est le plus souvent liée à une infection bactérienne surtout, fongique parfois. Sa survenue impose d'urgence une antibiothérapie présomptive, couvrant à priori les entérobactéries, le pyocyanique, les staphylocoques, les streptocoques, éventuellement guidée par la suveillance microbiologique préalable du patient et des infections hospitalières environnantes. Une association synergique, bactéricide, à large spectre, est indiquée. En attendant la mise à l'épreuve de molécules nouvelles, on utilise le plus souvent une betalactamine associée à un aminoside. Au cas où l'infection est secondairement documentée, l'antibiothérapie initiale est ajustée aux données bactériocliniques. La persistance au 4ème jour d'une fièvre isolée, ou associée à une pneumopathie, peut faire ajouter l'amphotéricine B dans l'hypothèse d'une mycose, difficile à prouver. Les transfusions de granulocytes sont l'objet de controverses.</p></abstract><abstract xml:lang="en"><p>Summary: Fever happens quite often among patients with granulopenia of several origins ; the fever is mostly related to bacterial infections, sometimes to fungal infections. Its outcome needs in emergency the use of an empirical antibiotherapy aimed either on Gram-negative bacilli, enterobacteries and Pseudomonas, or on staphylococci and streptococci. Patients microbiological follow up and surrounding nosocomial infections survey may help in the choice of the antibiotherapy. The antibiotics need to have wide range activity, to be bactericidal and synergistic in order to be associated in the treatment of granulopenic febrile patients : expecting well assessed new drugs, the associations mainly employed in first purpose are betalactamines with aminoglycosides. If the infection becomes documented, the initial antibiotherapy must be adapted following clinical and bacteriological data. A fever related to a pneumopathy and a fever of unknown origin persisting later than 4 days suggest a possible fungal infection and amphotericin B may be added. Granulocytes transfusions are a point of controversy.</p></abstract><textClass xml:lang="fr"><keywords scheme="keyword"><list><head>Mots-clés</head><item><term>Fièvre</term></item><item><term>Granulopénie</term></item></list></keywords></textClass><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key-words</head><item><term>Fever</term></item><item><term>Granulopenia</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1985">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-GMX59Q5V-C/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="fr" docsubtype="fla"><item-info><jid>MEDMAL</jid><aid>85802997</aid><ce:pii>S0399-077X(85)80299-7</ce:pii><ce:doi>10.1016/S0399-077X(85)80299-7</ce:doi><ce:copyright type="unknown" year="1985"></ce:copyright></item-info><head><ce:article-footnote><ce:label>*</ce:label><ce:note-para>Communication présentée au Congrès de la Société de Pathologie infectieuse de Langue française, tenu à Rennes le 31 Mai et le 1er Juin 1985, sous le titre : «Infections chez les Immunodéprimés.</ce:note-para></ce:article-footnote><ce:title>La fièvre chez les granulopéniques. Attitudes thérapeutiques</ce:title><ce:alt-title xml:lang="en">Therapy in febrile granulocytopenic patients</ce:alt-title><ce:author-group><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Rey</ce:surname><ce:cross-ref refid="aff1"><ce:sup>**</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.</ce:given-name><ce:surname>Beytout</ce:surname><ce:cross-ref refid="aff1"><ce:sup>**</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.F.</ce:given-name><ce:surname>Petit</ce:surname><ce:cross-ref refid="aff1"><ce:sup>**</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Ph.</ce:given-name><ce:surname>Travade</ce:surname><ce:cross-ref refid="aff2"><ce:sup>***</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.</ce:given-name><ce:surname>Sirot</ce:surname><ce:cross-ref refid="aff3"><ce:sup>****</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.L.</ce:given-name><ce:surname>Delpoux</ce:surname><ce:cross-ref refid="aff1"><ce:sup>**</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>**</ce:label><ce:textfn>Service des Maladies Infectieuses et tropicales, Centre Hospitalier Universitaire Hôtel-Dieu, F-63000 Clermont-Ferrand, France</ce:textfn></ce:affiliation><ce:affiliation id="aff2"><ce:label>***</ce:label><ce:textfn>Laboratoire d'Hématologie, CHU Hôtel-Dieu, Clermont-Ferrand France</ce:textfn></ce:affiliation><ce:affiliation id="aff3"><ce:label>****</ce:label><ce:textfn>Laboratoire de Microbiologie, CHU Hôtel-Dieu, Clermont-Ferrand France</ce:textfn></ce:affiliation></ce:author-group><ce:abstract id="ab1" class="author" xml:lang="fr"><ce:section-title>Resume</ce:section-title><ce:abstract-sec><ce:simple-para>Evénement fréquent et redouté des situations granulopéniques de toute origine, la fièvre est le plus souvent liée à une infection bactérienne surtout, fongique parfois. Sa survenue impose d'urgence une antibiothérapie présomptive, couvrant à priori les entérobactéries, le pyocyanique, les staphylocoques, les streptocoques, éventuellement guidée par la suveillance microbiologique préalable du patient et des infections hospitalières environnantes. Une association synergique, bactéricide, à large spectre, est indiquée. En attendant la mise à l'épreuve de molécules nouvelles, on utilise le plus souvent une betalactamine associée à un aminoside. Au cas où l'infection est secondairement documentée, l'antibiothérapie initiale est ajustée aux données bactériocliniques. La persistance au 4ème jour d'une fièvre isolée, ou associée à une pneumopathie, peut faire ajouter l'amphotéricine B dans l'hypothèse d'une mycose, difficile à prouver. Les transfusions de granulocytes sont l'objet de controverses.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:abstract id="ab2" class="author" xml:lang="en"><ce:section-title>Summary</ce:section-title><ce:abstract-sec><ce:simple-para>Fever happens quite often among patients with granulopenia of several origins ; the fever is mostly related to bacterial infections, sometimes to fungal infections. Its outcome needs in emergency the use of an empirical antibiotherapy aimed either on Gram-negative bacilli, enterobacteries and Pseudomonas, or on staphylococci and streptococci. Patients microbiological follow up and surrounding nosocomial infections survey may help in the choice of the antibiotherapy. The antibiotics need to have wide range activity, to be bactericidal and synergistic in order to be associated in the treatment of granulopenic febrile patients : expecting well assessed new drugs, the associations mainly employed in first purpose are betalactamines with aminoglycosides. If the infection becomes documented, the initial antibiotherapy must be adapted following clinical and bacteriological data. A fever related to a pneumopathy and a fever of unknown origin persisting later than 4 days suggest a possible fungal infection and amphotericin B may be added. Granulocytes transfusions are a point of controversy.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword" xml:lang="fr"><ce:section-title>Mots-clés</ce:section-title><ce:keyword><ce:text>Fièvre</ce:text></ce:keyword><ce:keyword><ce:text>Granulopénie</ce:text></ce:keyword></ce:keywords><ce:keywords class="keyword" xml:lang="en"><ce:section-title>Key-words</ce:section-title><ce:keyword><ce:text>Fever</ce:text></ce:keyword><ce:keyword><ce:text>Granulopenia</ce:text></ce:keyword></ce:keywords></head><tail><ce:bibliography><ce:section-title>Bibliographie</ce:section-title><ce:bibliography-sec><ce:bib-reference id="bib1"><ce:label>1.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Aisner</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Schimpff</ce:surname><ce:given-name>S.C.</ce:given-name></sb:author><sb:author><ce:surname>Sutherland</ce:surname><ce:given-name>J.C.</ce:given-name></sb:author><sb:author><ce:surname>Young</ce:surname><ce:given-name>V.M.</ce:given-name></sb:author><sb:author><ce:surname>Wiernik</ce:surname><ce:given-name>P.H.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle><ce:italic>Torulopsis glabrata</ce:italic> infections in patients with cancer</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>61</sb:volume-nr></sb:series><sb:date>1976</sb:date></sb:issue><sb:pages><sb:first-page>23</sb:first-page><sb:last-page>38</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib2"><ce:label>2.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Armstrong</ce:surname><ce:given-name>D.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Protected environments are discomforting and expensive and do not offer meaningful protection</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>76</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>665</sb:first-page><sb:last-page>689</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib3"><ce:label>3.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Bodey</ce:surname><ce:given-name>G.P.</ce:given-name></sb:author><sb:author><ce:surname>Buckley</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Sathe</ce:surname><ce:given-name>Y.S.</ce:given-name></sb:author><sb:author><ce:surname>Freireich</ce:surname><ce:given-name>E.M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Quantitative relationships between circulating leucocytes and infection in patients with acute leukemia</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Ann. Inter. Med.</sb:maintitle></sb:title><sb:volume-nr>64</sb:volume-nr></sb:series><sb:issue-nr>2</sb:issue-nr><sb:date>1966</sb:date></sb:issue><sb:pages><sb:first-page>328</sb:first-page><sb:last-page>339</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib4"><ce:label>4.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Bodey</ce:surname><ce:given-name>G.P.</ce:given-name></sb:author><sb:author><ce:surname>Ketchel</ce:surname><ce:given-name>S.J.</ce:given-name></sb:author><sb:author><ce:surname>Rodriguez</ce:surname><ce:given-name>V.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>A randomized study of carbenicillin plus cefamandole or tobramycin in the treatment of febrile episodes in cancer patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>67</sb:volume-nr></sb:series><sb:date>1979</sb:date></sb:issue><sb:pages><sb:first-page>608</sb:first-page><sb:last-page>616</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib5"><ce:label>5.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Bodey</ce:surname><ce:given-name>G.P.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Candidiasis in cancer patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>75</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>13</sb:first-page><sb:last-page>19</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib6"><ce:label>6.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Bodey</ce:surname><ce:given-name>G.P.</ce:given-name></sb:author><sb:author><ce:surname>Fainstein</ce:surname><ce:given-name>V.</ce:given-name></sb:author><sb:author><ce:surname>Bolivar</ce:surname><ce:given-name>R.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Ceftizoxime treatment of infections in cancer patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:title><sb:maintitle>13th Intern. Congress Chemotherapy</sb:maintitle></sb:title><sb:conference>Vienne 28 august-2 sept</sb:conference><sb:date>1983</sb:date></sb:edited-book></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib7"><ce:label>7.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Bodey</ce:surname><ce:given-name>G.P.</ce:given-name></sb:author><sb:author><ce:surname>Bolivar</ce:surname><ce:given-name>R.</ce:given-name></sb:author><sb:author><ce:surname>Fainstein</ce:surname><ce:given-name>V.</ce:given-name></sb:author><sb:author><ce:surname>Jadeja</ce:surname><ce:given-name>L.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Piperacilline plus vancomycin in the treatment of infection in neutropenic cancer patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:title><sb:maintitle>13th Intern. Congress Chemotherapy</sb:maintitle></sb:title><sb:conference>Vienne 28 august–2 sept</sb:conference><sb:date>1983</sb:date></sb:edited-book></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib8"><ce:label>8.</ce:label><sb:reference><sb:contribution langtype="iso" xml:lang="fr"><sb:authors><sb:author><ce:surname>Bougnoux</ce:surname><ce:given-name>Ph.</ce:given-name></sb:author><sb:author><ce:surname>Andremont</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Le Floch</ce:surname><ce:given-name>O.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Bactériémies et aplasies</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Rev. Méd. de Tours</sb:maintitle></sb:title><sb:volume-nr>14</sb:volume-nr></sb:series><sb:date>1980</sb:date></sb:issue><sb:pages><sb:first-page>1029</sb:first-page><sb:last-page>1034</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib9"><ce:label>9.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Brown</ce:surname><ce:given-name>A.E.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Neutropenia, fever and infection</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>76</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>421</sb:first-page><sb:last-page>428</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib10"><ce:label>10.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Clift</ce:surname><ce:given-name>R.A.</ce:given-name></sb:author><sb:author><ce:surname>Buckner</ce:surname><ce:given-name>C.D.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Granulocyte transfusions</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>76</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>631</sb:first-page><sb:last-page>635</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib11"><ce:label>11.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Cohen</ce:surname><ce:given-name>M.L.</ce:given-name></sb:author><sb:author><ce:surname>Murphy</ce:surname><ce:given-name>M.T.</ce:given-name></sb:author><sb:author><ce:surname>Counts</ce:surname><ce:given-name>G.W.</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>Prediction by surveillance cultures of bacteremia among neutropenic patients treated in a protective environment</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Journ. Infect. Dis.</sb:maintitle></sb:title><sb:volume-nr>147</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>789</sb:first-page><sb:last-page>793</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib12"><ce:label>12.</ce:label><sb:reference><sb:contribution langtype="iso" xml:lang="fr"><sb:authors><sb:author><ce:surname>Dao</ce:surname><ce:given-name>Ch.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Infections des agranulocytoses et leur traitement</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Sem. Hop. Paris</sb:maintitle></sb:title><sb:volume-nr>51</sb:volume-nr></sb:series><sb:issue-nr>10</sb:issue-nr><sb:date>1975</sb:date></sb:issue><sb:pages><sb:first-page>677</sb:first-page><sb:last-page>684</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib13"><ce:label>13.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>De Clerck</ce:surname><ce:given-name>Y.A.</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>Septicemia in children with leukemia</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Amer. J. Pediatr. Hematol. Oncol.</sb:maintitle></sb:title><sb:volume-nr>2</sb:volume-nr></sb:series><sb:date>1980</sb:date></sb:issue><sb:pages><sb:first-page>291</sb:first-page><sb:last-page>297</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib14"><ce:label>14.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>De Jongh</ce:surname><ce:given-name>C.A.</ce:given-name></sb:author><sb:author><ce:surname>Wade</ce:surname><ce:given-name>J.C.</ce:given-name></sb:author><sb:author><ce:surname>Schimpff</ce:surname><ce:given-name>S.C.</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>Empiric antibiotic therapy for suspected infection in granulopenic cancer patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Ann. J. Med.</sb:maintitle></sb:title><sb:volume-nr>73</sb:volume-nr></sb:series><sb:date>1982</sb:date></sb:issue><sb:pages><sb:first-page>89</sb:first-page><sb:last-page>96</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib15"><ce:label>15.</ce:label><sb:reference><sb:comment>178 p</sb:comment><sb:contribution langtype="iso" xml:lang="fr"><sb:authors><sb:author><ce:surname>Delpoux</ce:surname><ce:given-name>J.L.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Les infections chez le sujet granulopénique, Thèse médecine Clermont-Ferrand</sb:maintitle></sb:title></sb:contribution><sb:host><sb:book><sb:date>1984</sb:date></sb:book></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib16"><ce:label>16.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:collaboration>EORTC Intern Antimicrob Therapy Project Group Three</sb:collaboration></sb:authors><sb:title><sb:maintitle>Antibiotic regimens in the treatment of infection in febrile granulocytopenic patients with cancer</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Infect. Dis.</sb:maintitle></sb:title><sb:volume-nr>137</sb:volume-nr></sb:series><sb:issue-nr>1</sb:issue-nr><sb:date>1978</sb:date></sb:issue><sb:pages><sb:first-page>14</sb:first-page><sb:last-page>29</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib17"><ce:label>17.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:collaboration>EORTC Intern. Antimicrob. Therapy Project. Group</sb:collaboration></sb:authors><sb:title><sb:maintitle>Early granulocyte transfusions in high risk febrile neutropenic patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Schweiz med. Wschr.</sb:maintitle></sb:title><sb:volume-nr>113</sb:volume-nr></sb:series><sb:issue-nr>suppl. 14</sb:issue-nr><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>46</sb:first-page><sb:last-page>48</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib18"><ce:label>18.</ce:label><sb:reference><sb:contribution langtype="iso" xml:lang="fr"><sb:authors><sb:author><ce:surname>Fiere</ce:surname><ce:given-name>D.</ce:given-name></sb:author><sb:author><ce:surname>Vuvan</ce:surname><ce:given-name>H.</ce:given-name></sb:author><sb:author><ce:surname>Guyotat</ce:surname><ce:given-name>D.</ce:given-name></sb:author><sb:author><ce:surname>French</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Gonnaud</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Extra</ce:surname><ce:given-name>J.M.</ce:given-name></sb:author><sb:author><ce:surname>Imbert</ce:surname><ce:given-name>Cl.</ce:given-name></sb:author><sb:author><ce:surname>Coiffier</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Bryon</ce:surname><ce:given-name>P.A.</ce:given-name></sb:author><sb:author><ce:surname>Rebattu</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Viala</ce:surname><ce:given-name>J.J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Une association antibiotique empirique secondaire au cours des traitements chimiothérapiques aplasiants des hémopathies aiguës</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Sem. Hop. Paris</sb:maintitle></sb:title><sb:volume-nr>3</sb:volume-nr></sb:series><sb:date>1982</sb:date></sb:issue><sb:pages><sb:first-page>139</sb:first-page><sb:last-page>142</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib19"><ce:label>19.</ce:label><sb:reference><sb:contribution langtype="iso" xml:lang="fr"><sb:authors><sb:author><ce:surname>Gastaut</ce:surname><ce:given-name>J.A.</ce:given-name></sb:author><sb:author><ce:surname>Maraninchi</ce:surname><ce:given-name>D.</ce:given-name></sb:author><sb:author><ce:surname>Bagarry Liegey</ce:surname><ce:given-name>D.</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>Incidence, pronostic et prévention des septicémies chez les malades traités pour leucémie aiguë</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Nouv. Presse Med.</sb:maintitle></sb:title><sb:volume-nr>11</sb:volume-nr></sb:series><sb:issue-nr>8</sb:issue-nr><sb:date>1982</sb:date></sb:issue><sb:pages><sb:first-page>579</sb:first-page><sb:last-page>582</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib20"><ce:label>20.</ce:label><sb:reference><sb:contribution langtype="iso" xml:lang="fr"><sb:authors><sb:author><ce:surname>Guy</ce:surname><ce:given-name>H.</ce:given-name></sb:author><sb:author><ce:surname>Chavanet</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Portier</ce:surname><ce:given-name>H.</ce:given-name></sb:author><sb:author><ce:surname>Kazmierczak</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Cortet</ce:surname><ce:given-name>P.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Traitement par une association céfotaxime-amikacine des épisodes infectieux des leucémies aiguës de l'adulte en aplasie thérapeutique</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Nouv. Presse Méd.</sb:maintitle></sb:title><sb:volume-nr>10</sb:volume-nr></sb:series><sb:issue-nr>8</sb:issue-nr><sb:date>1981</sb:date></sb:issue><sb:pages><sb:first-page>654</sb:first-page><sb:last-page>656</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib21"><ce:label>21.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Hann</ce:surname><ce:given-name>I.</ce:given-name></sb:author><sb:author><ce:surname>Noore</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Grant</ce:surname><ce:given-name>Ph.</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>The result of empirical antibiotic treatment in febrile neutropenic patients with 4 betalactam aminoglycoside combinations</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. antimicrob. chemother.</sb:maintitle></sb:title><sb:volume-nr>11</sb:volume-nr></sb:series><sb:issue-nr>suppl. C</sb:issue-nr><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>57</sb:first-page><sb:last-page>63</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib22"><ce:label>22.</ce:label><sb:reference><sb:contribution langtype="iso" xml:lang="fr"><sb:authors><sb:author><ce:surname>Howard</ce:surname><ce:given-name>M.W.</ce:given-name></sb:author><sb:author><ce:surname>Strass</ce:surname><ce:given-name>R.G.</ce:given-name></sb:author><sb:author><ce:surname>Johnston</ce:surname><ce:given-name>R.B.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Infections in patients with neutropénie</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Dis. Child.</sb:maintitle></sb:title><sb:volume-nr>131</sb:volume-nr></sb:series><sb:date>1977</sb:date></sb:issue><sb:pages><sb:first-page>788</sb:first-page><sb:last-page>790</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib23"><ce:label>23.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Infections In The Immunocompromised Host</ce:surname></sb:author></sb:authors></sb:contribution><sb:host><sb:edited-book><sb:title><sb:maintitle>3rd Intern. Symposium on</sb:maintitle></sb:title><sb:conference>Toronto, 24–28 June</sb:conference><sb:date>1984</sb:date></sb:edited-book></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib24"><ce:label>24.</ce:label><sb:reference><sb:contribution langtype="iso" xml:lang="fr"><sb:authors><sb:author><ce:surname>Jacquillat</ce:surname><ce:given-name>Cl.</ce:given-name></sb:author><sb:author><ce:surname>Khayat</ce:surname><ce:given-name>D.</ce:given-name></sb:author><sb:author><ce:surname>Maral</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Place de l'Azlocilline dans le traitement des malades immunodéprimés</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Presse Med.</sb:maintitle></sb:title><sb:volume-nr>13</sb:volume-nr></sb:series><sb:issue-nr>13</sb:issue-nr><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>838</sb:first-page><sb:last-page>840</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib25"><ce:label>25.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Javier</ce:surname><ce:given-name>G.</ce:given-name></sb:author><sb:author><ce:surname>Ortega</ce:surname><ce:given-name>J.J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Empiric therapy with Cefotaxime and Amikacin in febrile children with leukemia</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:title><sb:maintitle>13th Intern. Congr. Chemoth.</sb:maintitle></sb:title><sb:conference>Vienna</sb:conference><sb:date>1983</sb:date></sb:edited-book></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib26"><ce:label>26.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Joshi</ce:surname><ce:given-name>J.H.</ce:given-name></sb:author><sb:author><ce:surname>Schimpff</ce:surname><ce:given-name>S.C.</ce:given-name></sb:author><sb:author><ce:surname>Tenney</ce:surname><ce:given-name>J.H.</ce:given-name></sb:author><sb:author><ce:surname>Newman</ce:surname><ce:given-name>K.A.</ce:given-name></sb:author><sb:author><ce:surname>de Jongh</ce:surname><ce:given-name>C.A.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Can antibacterial therapy be discontinued in persistently febrile granulocytopenic cancer patients ?</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Ann. J. Med.</sb:maintitle></sb:title><sb:volume-nr>76</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>450</sb:first-page><sb:last-page>457</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib27"><ce:label>27.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Klastersky</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Zinner</ce:surname><ce:given-name>SH</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Synergistic combinations of antibiotics in Gram-negatif bacilly infections</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Rev. Inf. Dis.</sb:maintitle></sb:title><sb:volume-nr>4</sb:volume-nr></sb:series><sb:date>1982</sb:date></sb:issue><sb:pages><sb:first-page>294</sb:first-page><sb:last-page>301</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib28"><ce:label>28.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Klastersky</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Management of infection in granulopenic patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Antimicrob. Chemother.</sb:maintitle></sb:title><sb:volume-nr>12</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>102</sb:first-page><sb:last-page>104</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib29"><ce:label>29.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Klastersky</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Perspectives and controversies in the prevention of infection in granulopenic patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Eur. J. Clin. Microbiol.</sb:maintitle></sb:title><sb:volume-nr>2</sb:volume-nr></sb:series><sb:issue-nr>2</sb:issue-nr><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>91</sb:first-page><sb:last-page>94</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib30"><ce:label>30.</ce:label><sb:reference><sb:comment>250 p</sb:comment><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Klastersky</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Staquet</ce:surname><ce:given-name>M.J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Combination antibiotic therapy in the compromised Host, EORTC monograph series n<ce:sup loc="post">o</ce:sup> 9</sb:maintitle></sb:title></sb:contribution><sb:host><sb:book><sb:date>1983</sb:date><sb:publisher><sb:name>Raven Press</sb:name><sb:location>Amsterdam</sb:location></sb:publisher></sb:book></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib31"><ce:label>31.</ce:label><sb:reference><sb:contribution langtype="iso" xml:lang="fr"><sb:authors><sb:author><ce:surname>Klastersky</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>L'antibiothérapie empirique chez les malades granulopéniques</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Presse Med.</sb:maintitle></sb:title><sb:volume-nr>13</sb:volume-nr></sb:series><sb:issue-nr>17</sb:issue-nr><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>1067</sb:first-page><sb:last-page>1069</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib32"><ce:label>32.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Lagast</ce:surname><ce:given-name>H.</ce:given-name></sb:author><sb:author><ce:surname>Meunier</ce:surname><ce:given-name>F.</ce:given-name></sb:author><sb:author><ce:surname>Weerts</ce:surname><ce:given-name>D.</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>(EORTC Antimicrob. Therapy, Project group) A cooperative trial of a short course versus a regular course of amikacin in combination with ceftazidime as empiric treatment in febrile neutropenic patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:title><sb:maintitle>3rd Intern Symposium on Infections in the immunocompromised host</sb:maintitle></sb:title><sb:conference>Toronto 24–28</sb:conference><sb:date>1984</sb:date></sb:edited-book></sb:host><sb:comment>6</sb:comment></sb:reference></ce:bib-reference><ce:bib-reference id="bib33"><ce:label>33.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Lauver</ce:surname><ce:given-name>G.J.</ce:given-name></sb:author><sb:author><ce:surname>Hasan</ce:surname><ce:given-name>F.M.</ce:given-name></sb:author><sb:author><ce:surname>Morgan</ce:surname><ce:given-name>R.B.</ce:given-name></sb:author><sb:author><ce:surname>Campell</ce:surname><ce:given-name>S.C.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The usefulness of fiberoptic bronchoscopy in evaluating new pulmonary lesions in the compromised host</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>66</sb:volume-nr></sb:series><sb:date>1979</sb:date></sb:issue><sb:pages><sb:first-page>580</sb:first-page><sb:last-page>585</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib34"><ce:label>34.</ce:label><sb:reference><sb:contribution langtype="iso" xml:lang="fr"><sb:authors><sb:author><ce:surname>Loiseau-Marolleau</ce:surname><ce:given-name>M.L.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Contribution à l'étude de l'infection au cours des leucémies aiguës (étude de 139 cas). Signification des hémocultures positives</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Path. Biol.</sb:maintitle></sb:title><sb:volume-nr>18</sb:volume-nr></sb:series><sb:date>1970</sb:date></sb:issue><sb:pages><sb:first-page>1089</sb:first-page><sb:last-page>1096</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib35"><ce:label>35.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Love</ce:surname><ce:given-name>L.J.</ce:given-name></sb:author><sb:author><ce:surname>Schimpff</ce:surname><ce:given-name>S.C.</ce:given-name></sb:author><sb:author><ce:surname>Hahn</ce:surname><ce:given-name>D.M.</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>Randomized trial of empiric antibiotic therapy with ticarcillin in combination with gentamicin, amikacin or netilmicin in febrile patients with granulocytopenia and cancer</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>66</sb:volume-nr></sb:series><sb:date>1979</sb:date></sb:issue><sb:pages><sb:first-page>603</sb:first-page><sb:last-page>610</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib36"><ce:label>36.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Love</ce:surname><ce:given-name>L.J.</ce:given-name></sb:author><sb:author><ce:surname>Schimpff</ce:surname><ce:given-name>S.C.</ce:given-name></sb:author><sb:author><ce:surname>Schiffer</ce:surname><ce:given-name>C.A.</ce:given-name></sb:author><sb:author><ce:surname>Wiernik</ce:surname><ce:given-name>P.H.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Improved prognosis for granylocytopenic patients with Gram-negative bacteremia</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>68</sb:volume-nr></sb:series><sb:date>1980</sb:date></sb:issue><sb:pages><sb:first-page>643</sb:first-page><sb:last-page>648</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib37"><ce:label>37.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Lumish</ce:surname><ce:given-name>R.M.</ce:given-name></sb:author><sb:author><ce:surname>Norden</ce:surname><ce:given-name>C.W.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Therapy of neutropenic rats infected with Pseudomonas aeruginosa</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Journ. Infect. Dis.</sb:maintitle></sb:title><sb:volume-nr>133</sb:volume-nr></sb:series><sb:issue-nr>5</sb:issue-nr><sb:date>1976</sb:date></sb:issue><sb:pages><sb:first-page>538</sb:first-page><sb:last-page>547</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib38"><ce:label>38.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Lowder</ce:surname><ce:given-name>J.N.</ce:given-name></sb:author><sb:author><ce:surname>Lazarus</ce:surname><ce:given-name>H.M.</ce:given-name></sb:author><sb:author><ce:surname>Herzig</ce:surname><ce:given-name>R.H.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Bacteremias and fungemias in oncologic patients with central venous catheters</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Arch. Intern. Med.</sb:maintitle></sb:title><sb:volume-nr>142</sb:volume-nr></sb:series><sb:date>1982</sb:date></sb:issue><sb:pages><sb:first-page>1456</sb:first-page><sb:last-page>1459</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib39"><ce:label>39.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Newman</ce:surname><ce:given-name>K.A.</ce:given-name></sb:author><sb:author><ce:surname>Schimpff</ce:surname><ce:given-name>S.C.</ce:given-name></sb:author><sb:author><ce:surname>Wiernik</ce:surname><ce:given-name>P.H.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Lessons learned from surveillance cultures in patients with acute nonlymphocytic leukemia. Usefulness for epidemiologic, preventive and therapeutic research</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>70</sb:volume-nr></sb:series><sb:date>1981</sb:date></sb:issue><sb:pages><sb:first-page>423</sb:first-page><sb:last-page>431</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib40"><ce:label>40.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Newman</ce:surname><ce:given-name>K.</ce:given-name></sb:author><sb:author><ce:surname>Tenney</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>de Jongh</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Joshi</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Schimpff</ce:surname><ce:given-name>S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Gram negative bacteremia in cancer patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:title><sb:maintitle>13th Intern. Congress Chemotherapy</sb:maintitle></sb:title><sb:conference>Vienna, 28 august–2 sept</sb:conference><sb:date>1983</sb:date></sb:edited-book></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib41"><ce:label>41.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Pizzo</ce:surname><ce:given-name>P.A.</ce:given-name></sb:author><sb:author><ce:surname>Robichaud</ce:surname><ce:given-name>K.J.</ce:given-name></sb:author><sb:author><ce:surname>Gill</ce:surname><ce:given-name>F.A.</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>Duration of empiric antibiotic therapy in granulocytopenic patients with cancer</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>67</sb:volume-nr></sb:series><sb:date>1979</sb:date></sb:issue><sb:pages><sb:first-page>194</sb:first-page><sb:last-page>200</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib42"><ce:label>42.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Pizzo</ce:surname><ce:given-name>P.A.</ce:given-name></sb:author><sb:author><ce:surname>Robichaud</ce:surname><ce:given-name>K.J.</ce:given-name></sb:author><sb:author><ce:surname>Gill</ce:surname><ce:given-name>F.A.</ce:given-name></sb:author><sb:author><ce:surname>Witebsky</ce:surname><ce:given-name>F.G.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>72</sb:volume-nr></sb:series><sb:date>1982</sb:date></sb:issue><sb:pages><sb:first-page>102</sb:first-page><sb:last-page>111</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib43"><ce:label>43.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Pizzo</ce:surname><ce:given-name>P.A.</ce:given-name></sb:author><sb:author><ce:surname>Commers</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Cotton</ce:surname><ce:given-name>D.</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>Approaching the controversies in antibacterial management of cancer patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>76</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>436</sb:first-page><sb:last-page>449</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib44"><ce:label>44.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Rogers</ce:surname><ce:given-name>T.R.</ce:given-name></sb:author><sb:author><ce:surname>Petrou</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Bakhtiar</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>White</ce:surname><ce:given-name>S.</ce:given-name></sb:author><sb:author><ce:surname>Selwyn</ce:surname><ce:given-name>S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Rational approach to antimicrobial therapy and prophylaxis infection in neutropenic marrow transplant patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:title><sb:maintitle>13th Intern. Congress of Chemotherapy</sb:maintitle></sb:title><sb:conference>Vienna, 28 augus–2 sept.</sb:conference><sb:date>1983</sb:date></sb:edited-book></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib45"><ce:label>45.</ce:label><sb:reference><sb:comment>653 p</sb:comment><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Rubin</ce:surname><ce:given-name>R.H.</ce:given-name></sb:author><sb:author><ce:surname>Young</ce:surname><ce:given-name>L.S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Clinical approach to infection in the compromised host</sb:maintitle></sb:title></sb:contribution><sb:host><sb:book><sb:date>1981</sb:date><sb:publisher><sb:name>Plenum medical Book Cy</sb:name><sb:location>N-Y</sb:location></sb:publisher></sb:book></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib46"><ce:label>46.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Ruhl</ce:surname><ce:given-name>H.</ce:given-name></sb:author><sb:author><ce:surname>Sieber</ce:surname><ce:given-name>G.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Basic clinical factors limiting the effect of antibacterial treatment in granulopenic patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:title><sb:maintitle>13th Intern. Congress Chemotherapy</sb:maintitle></sb:title><sb:conference>Vienne 28 august–2 sept.</sb:conference><sb:date>1983</sb:date></sb:edited-book></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib47"><ce:label>47.</ce:label><sb:reference><sb:contribution langtype="iso" xml:lang="fr"><sb:authors><sb:author><ce:surname>Schaison</ce:surname><ce:given-name>D.</ce:given-name></sb:author><sb:author><ce:surname>Weil</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Backés</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Jacquillat</ce:surname><ce:given-name>Cl.</ce:given-name></sb:author><sb:author><ce:surname>Bussel</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Perol</ce:surname><ce:given-name>Y.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Complications infectieuses observées lors de l'emploi des médications antimitotiques en hématologie</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Sem. Hop. Paris</sb:maintitle></sb:title><sb:volume-nr>52</sb:volume-nr></sb:series><sb:issue-nr>2</sb:issue-nr><sb:date>1976</sb:date></sb:issue><sb:pages><sb:first-page>99</sb:first-page><sb:last-page>103</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib48"><ce:label>48.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Sculier</ce:surname><ce:given-name>J.P.</ce:given-name></sb:author><sb:author><ce:surname>Klastersky</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Significance of serum bactericidal activity in Gram-negative bacilliary bacteremia in patients with and without granulocytopenia</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med</sb:maintitle></sb:title><sb:volume-nr>76</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>429</sb:first-page><sb:last-page>435</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib49"><ce:label>49.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Schimpff</ce:surname><ce:given-name>S.C.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Infections in the compromised host. Infections in patients with acute leucemia, in Principles and Practice of Infectious Diseases</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:date>1979</sb:date><sb:publisher><sb:name>Mandell, Douglas and Bennett, J. Wiley</sb:name><sb:location>NY-London</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>2257</sb:first-page><sb:last-page>2278</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib50"><ce:label>50.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Sicles</ce:surname><ce:given-name>E.A.</ce:given-name></sb:author><sb:author><ce:surname>Greene</ce:surname><ce:given-name>W.H.</ce:given-name></sb:author><sb:author><ce:surname>Wiernik</ce:surname><ce:given-name>P.H.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Clinical presentation of infection in granulocytopenic patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Arch. Intern. Med.</sb:maintitle></sb:title><sb:volume-nr>135</sb:volume-nr></sb:series><sb:date>1975</sb:date></sb:issue><sb:pages><sb:first-page>715</sb:first-page><sb:last-page>719</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib51"><ce:label>51.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Singer</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Kaplan</ce:surname><ce:given-name>M.H.</ce:given-name></sb:author><sb:author><ce:surname>Armstrong</ce:surname><ce:given-name>D.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Bacteremia and fungemia complicating neoplastic disease. A study of 364 cases</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>62</sb:volume-nr></sb:series><sb:date>1977</sb:date></sb:issue><sb:pages><sb:first-page>731</sb:first-page><sb:last-page>742</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib52"><ce:label>52.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Stamm</ce:surname><ce:given-name>W.E.</ce:given-name></sb:author><sb:author><ce:surname>Tompkins</ce:surname><ce:given-name>L.S.</ce:given-name></sb:author><sb:author><ce:surname>Wagner</ce:surname><ce:given-name>K.F.</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>Infection due to <ce:italic>Corynebacterium Sp.</ce:italic> in Marrow Transplant Patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Ann. Intern. Med.</sb:maintitle></sb:title><sb:volume-nr>91</sb:volume-nr></sb:series><sb:date>1979</sb:date></sb:issue><sb:pages><sb:first-page>167</sb:first-page><sb:last-page>173</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib53"><ce:label>53.</ce:label><sb:reference><sb:contribution langtype="iso" xml:lang="fr"><sb:authors><sb:author><ce:surname>Tancrede</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Azizi</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Raibaud</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Ducluzeau</ce:surname><ce:given-name>R.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Conséquences de la destruction des barrières écologiques de la flore du tube digestif par des antibiotiques. Perturbations des relations entre l'hote et les bactéries potentiellement pathogènes</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Med. Mal. Infect.</sb:maintitle></sb:title><sb:volume-nr>7</sb:volume-nr></sb:series><sb:date>1977</sb:date></sb:issue><sb:pages><sb:first-page>145</sb:first-page><sb:last-page>149</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib54"><ce:label>54.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Van Der Voet</ce:surname><ce:given-name>G.B.</ce:given-name></sb:author><sb:author><ce:surname>Mattic</ce:surname><ce:given-name>H.</ce:given-name></sb:author><sb:author><ce:surname>Van Der Furth</ce:surname><ce:given-name>R.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Quantitative determination of the effect of granulocytes on the course of experimental infection during antibiotic treatment</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Infection</sb:maintitle></sb:title><sb:volume-nr>12</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>1</sb:first-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib55"><ce:label>55.</ce:label><sb:reference><sb:contribution langtype="iso" xml:lang="fr"><sb:authors><sb:author><ce:surname>Vilde</ce:surname><ce:given-name>J.L.</ce:given-name></sb:author><sb:author><ce:surname>Huchon</ce:surname><ce:given-name>A.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Les infections pulmonaires chez les immunodéprimés</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Rev. Prat.</sb:maintitle></sb:title><sb:volume-nr>29</sb:volume-nr></sb:series><sb:issue-nr>27</sb:issue-nr><sb:date>1979</sb:date></sb:issue><sb:pages><sb:first-page>2203</sb:first-page><sb:last-page>2215</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib56"><ce:label>56.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Wade</ce:surname><ce:given-name>J.C.</ce:given-name></sb:author><sb:author><ce:surname>Schimpff</ce:surname><ce:given-name>S.C.</ce:given-name></sb:author><sb:author><ce:surname>Newman</ce:surname><ce:given-name>K.A.</ce:given-name></sb:author><sb:et-al></sb:et-al></sb:authors><sb:title><sb:maintitle>Piperacillin or ticarcillin plus amikacin. A double-blind prospective comparison of empiric antibiotic therapy for febrile granulocytopenic cancer patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>71</sb:volume-nr></sb:series><sb:date>1981</sb:date></sb:issue><sb:pages><sb:first-page>983</sb:first-page><sb:last-page>990</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib57"><ce:label>57.</ce:label><sb:reference><sb:comment>J. Klastersky and MJ Staquet</sb:comment><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Wade</ce:surname><ce:given-name>J.C.</ce:given-name></sb:author><sb:author><ce:surname>Schimpff</ce:surname><ce:given-name>S.C.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Antibiotic therapy for febrile granulocytopenic patients in Combination antibiotic therapy in the compromised host</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:date>1982</sb:date><sb:publisher><sb:name>Raven Press N-Y</sb:name><sb:location>N.Y</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>125</sb:first-page><sb:last-page>146</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib58"><ce:label>58.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Wingard</ce:surname><ce:given-name>J.R.</ce:given-name></sb:author><sb:author><ce:surname>Merz</ce:surname><ce:given-name>W.G.</ce:given-name></sb:author><sb:author><ce:surname>Saral</ce:surname><ce:given-name>R.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle><ce:italic>Candida tropicalis :</ce:italic> a major pathogen in immunocompromised patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Ann. Intern. Med.</sb:maintitle></sb:title><sb:volume-nr>91</sb:volume-nr></sb:series><sb:date>1979</sb:date></sb:issue><sb:pages><sb:first-page>539</sb:first-page><sb:last-page>543</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib59"><ce:label>59.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Winston</ce:surname><ce:given-name>D.J.</ce:given-name></sb:author><sb:author><ce:surname>Ho</ce:surname><ce:given-name>W.G.</ce:given-name></sb:author><sb:author><ce:surname>Young</ce:surname><ce:given-name>S.L.</ce:given-name></sb:author><sb:author><ce:surname>Hewitt</ce:surname><ce:given-name>W.L.</ce:given-name></sb:author><sb:author><ce:surname>Gale</ce:surname><ce:given-name>R.P.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Piperacillin plus amikacin therapy v carbenicillin plus amikacin therapy in febrile, granulocytopenic patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Arch. Intern. Med.</sb:maintitle></sb:title><sb:volume-nr>142</sb:volume-nr></sb:series><sb:date>1982</sb:date></sb:issue><sb:pages><sb:first-page>1663</sb:first-page><sb:last-page>1667</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib60"><ce:label>60.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Wright</ce:surname><ce:given-name>D.G.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Leukocyte transfusions : thinking twice</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>76</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>637</sb:first-page><sb:last-page>644</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib61"><ce:label>61.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Young</ce:surname><ce:given-name>V.M.</ce:given-name></sb:author><sb:author><ce:surname>Mers</ce:surname><ce:given-name>W.F.</ce:given-name></sb:author><sb:author><ce:surname>Moody</ce:surname><ce:given-name>M.R.</ce:given-name></sb:author><sb:author><ce:surname>Schimpff</ce:surname><ce:given-name>S.C.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The emergence of coryneform bacteria. As a cause of nosocomial infections in compromised hosts</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>70</sb:volume-nr></sb:series><sb:date>1981</sb:date></sb:issue><sb:pages><sb:first-page>646</sb:first-page><sb:last-page>650</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib62"><ce:label>62.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Young</ce:surname><ce:given-name>L.S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Nosocomial infections in the immunocompromised adult</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. J. Med.</sb:maintitle></sb:title><sb:volume-nr>70</sb:volume-nr></sb:series><sb:date>1981</sb:date></sb:issue><sb:pages><sb:first-page>398</sb:first-page><sb:last-page>404</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="fr"><title>La fièvre chez les granulopéniques. Attitudes thérapeutiques</title></titleInfo><titleInfo type="alternative" lang="fr" contentType="CDATA"><title>La fièvre chez les granulopéniques. Attitudes thérapeutiques</title></titleInfo><titleInfo type="translated" lang="en"><title>Therapy in febrile granulocytopenic patients</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Rey</namePart><affiliation>Service des Maladies Infectieuses et tropicales, Centre Hospitalier Universitaire Hôtel-Dieu, F-63000 Clermont-Ferrand, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Beytout</namePart><affiliation>Service des Maladies Infectieuses et tropicales, Centre Hospitalier Universitaire Hôtel-Dieu, F-63000 Clermont-Ferrand, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.F.</namePart><namePart type="family">Petit</namePart><affiliation>Service des Maladies Infectieuses et tropicales, Centre Hospitalier Universitaire Hôtel-Dieu, F-63000 Clermont-Ferrand, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ph.</namePart><namePart type="family">Travade</namePart><affiliation>Laboratoire d'Hématologie, CHU Hôtel-Dieu, Clermont-Ferrand France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Sirot</namePart><affiliation>Laboratoire de Microbiologie, CHU Hôtel-Dieu, Clermont-Ferrand France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.L.</namePart><namePart type="family">Delpoux</namePart><affiliation>Service des Maladies Infectieuses et tropicales, Centre Hospitalier Universitaire Hôtel-Dieu, F-63000 Clermont-Ferrand, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1985</dateIssued><copyrightDate encoding="w3cdtf">1985</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">fre</languageTerm><languageTerm type="code" authority="rfc3066">fr</languageTerm></language><abstract lang="fr">Resume: Evénement fréquent et redouté des situations granulopéniques de toute origine, la fièvre est le plus souvent liée à une infection bactérienne surtout, fongique parfois. Sa survenue impose d'urgence une antibiothérapie présomptive, couvrant à priori les entérobactéries, le pyocyanique, les staphylocoques, les streptocoques, éventuellement guidée par la suveillance microbiologique préalable du patient et des infections hospitalières environnantes. Une association synergique, bactéricide, à large spectre, est indiquée. En attendant la mise à l'épreuve de molécules nouvelles, on utilise le plus souvent une betalactamine associée à un aminoside. Au cas où l'infection est secondairement documentée, l'antibiothérapie initiale est ajustée aux données bactériocliniques. La persistance au 4ème jour d'une fièvre isolée, ou associée à une pneumopathie, peut faire ajouter l'amphotéricine B dans l'hypothèse d'une mycose, difficile à prouver. Les transfusions de granulocytes sont l'objet de controverses.</abstract><abstract lang="en">Summary: Fever happens quite often among patients with granulopenia of several origins ; the fever is mostly related to bacterial infections, sometimes to fungal infections. Its outcome needs in emergency the use of an empirical antibiotherapy aimed either on Gram-negative bacilli, enterobacteries and Pseudomonas, or on staphylococci and streptococci. Patients microbiological follow up and surrounding nosocomial infections survey may help in the choice of the antibiotherapy. The antibiotics need to have wide range activity, to be bactericidal and synergistic in order to be associated in the treatment of granulopenic febrile patients : expecting well assessed new drugs, the associations mainly employed in first purpose are betalactamines with aminoglycosides. If the infection becomes documented, the initial antibiotherapy must be adapted following clinical and bacteriological data. A fever related to a pneumopathy and a fever of unknown origin persisting later than 4 days suggest a possible fungal infection and amphotericin B may be added. Granulocytes transfusions are a point of controversy.</abstract><note>Communication présentée au Congrès de la Société de Pathologie infectieuse de Langue française, tenu à Rennes le 31 Mai et le 1er Juin 1985, sous le titre : «Infections chez les Immunodéprimés.</note><subject lang="fr"><genre>Mots-clés</genre><topic>Fièvre</topic><topic>Granulopénie</topic></subject><subject lang="en"><genre>Key-words</genre><topic>Fever</topic><topic>Granulopenia</topic></subject><relatedItem type="host"><titleInfo><title>Medecine et Maladies Infectieuses</title></titleInfo><titleInfo type="abbreviated"><title>MEDMAL</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1985</dateIssued></originInfo><identifier type="ISSN">0399-077X</identifier><identifier type="PII">S0399-077X(85)X8292-9</identifier><part><date>1985</date><detail type="volume"><number>15</number><caption>vol.</caption></detail><detail type="issue"><number>5</number><caption>no.</caption></detail><extent unit="issue-pages"><start>178</start><end>262</end></extent><extent unit="pages"><start>220</start><end>229</end></extent></part></relatedItem><identifier type="istex">F461880DE510CE8A978E7C1A802A122ADE289DE9</identifier><identifier type="ark">ark:/67375/6H6-GMX59Q5V-C</identifier><identifier type="DOI">10.1016/S0399-077X(85)80299-7</identifier><identifier type="PII">S0399-077X(85)80299-7</identifier><identifier type="ArticleID">85802997</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-GMX59Q5V-C/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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