Inhibition of Herpes Simplex Virus 1 Reproduction with Hydrophobized Antisense Oligonucleotides
Identifieur interne : 000D58 ( Istex/Corpus ); précédent : 000D57; suivant : 000D59Inhibition of Herpes Simplex Virus 1 Reproduction with Hydrophobized Antisense Oligonucleotides
Auteurs : S. V. Vinogradov ; Y. Suzdaltseva ; V. Y. Alakhov ; A. V. KabanovSource :
- Biochemical and Biophysical Research Communications [ 0006-291X ] ; 1994.
Abstract
Abstract: Antisense oligonucleotides were modified by their ends with hydrophobic substituents which permitted enhancing their activity. The effect of hydrophobized oligonucleotides on reproduction of Herpes Simplex Virus type 1 in Vero cells was studied. Two types of oligonucleotides were used: a 12-mer complementary to the splicing site 983-994 of early mRNA-5 of the virus and 19-mer complementary to the site of mRNA that encodes the virus DNA-polymerase. These oligonucleotides were modified by 5′-ends with n-undecyl or cholesteryl moieties and by 3′-ends with acridine or 1,7-heptanediol. In comparison with the unnmodified oligonucleotides the hydrophobized ones were significantly more active and inhibited HSV-1 infection at micromolar concentrations.
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DOI: 10.1006/bbrc.1994.2275
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The effect of hydrophobized oligonucleotides on reproduction of Herpes Simplex Virus type 1 in Vero cells was studied. Two types of oligonucleotides were used: a 12-mer complementary to the splicing site 983-994 of early mRNA-5 of the virus and 19-mer complementary to the site of mRNA that encodes the virus DNA-polymerase. These oligonucleotides were modified by 5′-ends with n-undecyl or cholesteryl moieties and by 3′-ends with acridine or 1,7-heptanediol. In comparison with the unnmodified oligonucleotides the hydrophobized ones were significantly more active and inhibited HSV-1 infection at micromolar concentrations.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>S.V. Vinogradov</name><affiliations><json:string>Moscow Inst Biotechnol Inc, Moscow 119899, Russia and Moscow MV Lomonosov State Univ, Fac Chem, Moscow 119899, Russia</json:string></affiliations></json:item><json:item><name>Y. 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The effect of hydrophobized oligonucleotides on reproduction of Herpes Simplex Virus type 1 in Vero cells was studied. Two types of oligonucleotides were used: a 12-mer complementary to the splicing site 983-994 of early mRNA-5 of the virus and 19-mer complementary to the site of mRNA that encodes the virus DNA-polymerase. These oligonucleotides were modified by 5′-ends with n-undecyl or cholesteryl moieties and by 3′-ends with acridine or 1,7-heptanediol. 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The effect of hydrophobized oligonucleotides on reproduction of Herpes Simplex Virus type 1 in Vero cells was studied. Two types of oligonucleotides were used: a 12-mer complementary to the splicing site 983-994 of early mRNA-5 of the virus and 19-mer complementary to the site of mRNA that encodes the virus DNA-polymerase. These oligonucleotides were modified by 5′-ends with n-undecyl or cholesteryl moieties and by 3′-ends with acridine or 1,7-heptanediol. 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